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Background: Urinary tract infection (UTI) in infants is a common, potentially life-threatening bacterial infection, and must be managed carefully through the entire chain of care from diagnosis, choice of treatment, follow-up and risk stratification of future complications. This Swedish nationwide study of infant UTI was conducted to evaluate the current management of infant UTI, yield of investigations and the Swedish UTI guidelines' ability to detect abnormalities of importance in the urinary tract., Methods: Infants < 1 year with a first episode of UTI were included in a prospective multicenter study. Treatment and follow-up were provided by local pediatricians. Clinical and laboratory findings and imaging results were reported to the coordinating center. The current management and results were compared with a previous Swedish study., Results: One thousand three hundred six infants were included. Urine sampling was performed with clean catch technique in 93% of patients. Initial oral antibiotic treatment was used in 63%, predominantly third generation cephalosporines. Permanent kidney abnormalities were found in 10% and dilating vesicoureteral reflux (VUR) in 8%. Higher rates of male gender, non-E. coli infection and ultrasound dilatation were seen in infants < 1 month. UTI recurrences were reported in 18%., Conclusions: Infant UTI is still generating a considerable amount of follow-up examinations. There is a significant shift towards clean catch as the main urine sampling method. Voiding cystourethrography is performed less frequently reducing the findings of low grade VUR. The incidence of renal scarring is comparable with earlier studies which suggests that the Swedish guidelines are able to identify individuals with risk for long-term complications., (© 2024. The Author(s).)

Abstract: Restless legs syndrome/Willis-Ekbom disease (RLS/WED) causes a strong urge to move legs while resting. Restless legs syndrome/WED is an often-inherited disease occurring in 3% to 10% of adult populations, increasing with age. Severity varies from mild disturbance of sleep to painful restless legs and arms, loss of sleep, fatigue, and risk of suicide. Dopaminergic drugs relieve symptoms, but cause augmentation, ie, initially helpful but later increase the burden of symptoms. Oral gabapentinoids and opioids are often added, but opioid tolerance and adverse effects are common. With the high prevalence and incomplete help from oral drugs, significant unmet needs exist for effective therapy for severe RLS/WED. Ongoing spinal intrathecal infusion of low-dose morphine is effective, but not generally recognized, as only 12 cases have been published since 2002. We report 7 patients suffering from severe RLS/WED, who had no relief from oral dopaminergic, gabapentinoid, or opioid drugs; they all had excellent relief during ongoing spinal intrathecal infusion of morphine at only 1 to 5 μg/h, ongoing for 1 to 21 years without need of higher doses of morphine.. We suggest that morphine may be transported with the cerebrospinal fluid reaching and readjusting malfunctioning dopamine neuronal systems in the brain and spinal cord. The effects last only as long as the infusion continues. A patient with RLS/WED and persistent genital arousal disorder (PGAD) was relieved of both RLS/WED and PGAD symptoms. These case reports suggest that intrathecal infusion of low-dose morphine is an effective treatment of severe RLS., (Copyright © 2024 International Association for the Study of Pain.)

School-based physical activity (PA) interventions stand out as a highly valued knowledge technology in relation to attempts to promote daily physical activity (DPA) among school youth. The purpose of the paper is to explore technologies of knowledge that guide school-based PA interventions in lower secondary schools and discuss their power-related implications. Foucault's notion of discourse as the ensemble of regulated, deliberate, and finalised ways of doing things underpins the analysis of six school-based PA intervention studies that were identified in the literature between the years 2003 and 2021. The analysis concerned the scientific domain of the studies, their justification of school-based PA interventions, the purpose and results of the interventions, and problems with implementing the interventions. The analysis indicated a distinct narrative where researchers within medical science and psychology proposed that (a) young people's level of PA is too low and therefore they are increasingly exposed to the risk of lifestyle diseases; (b) schools appear as the obvious context for attempts to increase the PA of young people, for example through interventions; (c) contextual factors are often pointed out as significant for the success of the interventions, yet these factors are not systematically placed under the research magnifying glass; (d) few studies demonstrate any tangible change in student behaviour because of the interventions; (e) non-occurring behaviour changes are explained by contextual factors, or that school staff simply do not adhere enough to the intervention efforts. These results are discussed through Foucault's concept of governmentality, that is, the integration of technologies of knowledge, power, and the self. It is concluded that the examined research gain function within a neoliberal governmentality where scientific knowledge aims to change the individual self, rather than to change the social structures in which individuals live their lives. [ABSTRACT FROM AUTHOR]

The X-ray column density ( N HX ) of gamma-ray bursts (GRBs) can probe the local environment of their progenitors over a wide redshift range. Previous work has suggested an increasing trend as a function of redshift. The relevance of this current analysis relies on investigating the selection bias method, such as the effect of the X-ray spectrum in high-redshift GRBs, which complicates the measurement of small N HX ; this has yet to be fully evaluated or discussed elsewhere. In this work, we evaluated these effects through simulations to define appropriate observational limits in the N HX versus redshift plane. We then applied a one-sided nonparametric method developed by Efron and Petrosian. Within the framework of this method, we investigated the redshift dependence of N HX and the local distribution function. Our results show that the evolution of N HX with redshift firmly exists with a significance of more than four sigma and follows a power law of (1 + z) 1.39 (+ 0.22 , − 0.27) . Based on these analyses and previous studies, the GRB progenitor mass varies but is more massive in the high-redshift environment and has a higher gas column density. This suggests that part of the luminosity evolution of GRBs, which has been widely reported, may be due to the evolution of the progenitor's mass. Using the same method, we demonstrate that optically dark GRBs show a consistent evolution: (1 + z) 1.15 (+ 0.67 , − 0.83) . By applying the Kolmogorov–Smirnov (KS) test, it is shown that optically dark GRBs have statistically identical flux and photon index distributions compared to normal GRBs, but the N HX is systematically larger. This result suggests that the darkness of some GRB populations is not due to an intrinsic mechanism, but rather because a higher density surrounds them. [ABSTRACT FROM AUTHOR]

Background and Study Aim The physical development of high school students is often hindered by the limitations of traditional physical education programs, which may not fully engage students or promote balanced physical growth. In light of these concerns, the need to explore alternative educational models that can enhance students' physical development has become evident. The purpose of this article is to evaluate the potential effectiveness of a physical education curriculum following the Sports Club model in improving the physical development of high school students. Material and Methods A total of 84 female 10th-grade students participated in the study. They were divided into two groups: an experimental group of 42 students following the Sports Club model and a control group of 42 students following the current physical education curriculum. The experiment lasted for 17 weeks. Both groups completed initial and final physical fitness tests. These tests included the 30-second sit-up test (to assess core strength), the 30-meter sprint test (to measure speed), the 4 × 10-meter shuttle run test (to evaluate agility), the standing long jump test (to measure explosive leg power), and the 5-minute running field test (to assess endurance). Results The female students in the experimental group demonstrated greater physical development compared to the control group in all five assessment tests. The experimental group showed the most significant improvement in the 30-second sit-up test, with a growth rate of 26.71%. The lowest growth was observed in the 5-minute running field test, at 9.92%. In contrast, the control group showed its highest improvement in the 30-second sit-up test, with a growth rate of 9.44%. However, there was minimal to no improvement in the 4 × 10-meter shuttle run and the 5-minute running field test for the control group. Conclusions The Sports Club model improved students' physical fitness more effectively compared to the current curriculum, offering greater benefits in all tested areas. It is recommended that teachers further integrate and refine the implementation of the Sports Club model in future physical education programs to enhance teaching effectiveness. [ABSTRACT FROM AUTHOR]

Owing to the requirements for high performance and long life, the friction and wear problems of rolling piston type rotary compressors have drawn much attention. Various theoretical models have been developed and improved to reveal the inner state of the compressor and obtain the optimization schemes. However, there remain some disadvantages and research gaps in the corresponding modeling and mixed lubrication analyses, and a comprehensive summary is lacking. To have a better understanding of the research status, this paper reviews the theoretical model development and mixed lubrication analyses of the compressor in the past decades. The determination of compression pressure, the modeling process of moving components, and the key findings are presented in detail. On this basis, some important influencing factors and the problems remaining to be solved are also discussed. This paper provides multifaceted guidance for manufacturers and researchers to conduct further theoretical analysis and optimal design. [ABSTRACT FROM AUTHOR]

In Swedish school health services, local initiatives have been taken to use physical activity on prescription (PAP) to encourage physically inactive children to become more active. Previous research shows that interprofessional collaboration plays a crucial role in promoting physical activity in children, as well as in promoting health in schools. However, there is a lack of knowledge about PAP for children in the school setting, including how medical and educational staff can work together to encourage children who have been recommended PAP. Therefore, this study aims to explore the perceived facilitators and barriers concerning interprofessional collaboration regarding physical activity on prescription in the school setting, as viewed from the professionals' perspectives. Semi-structured interviews were conducted with 21 professionals who work with the method in school settings. The data were analyzed using Reflexive Thematic Analysis. The results reveal both barriers and facilitators for interprofessional collaboration on PAP in the school setting, as perceived by professionals. Organizational and structural obstacles within school institutions hinder collaboration, while a shared commitment to PAP, characterized by consensus-building, acts as a facilitating factor. PAP for children in a school setting is still an unexplored area and further research is required. [ABSTRACT FROM AUTHOR]

School nurses are in a key position to promote children's physical activity. They engage all children in health dialogues and use different approaches to inform children about physical activity and motivate them to change their physical activity level. In a school context, it is important to explore and problematize school nurses' views of children's physical activity and the influence of these views on their professional practice in the school health service. Identifying and problematizing school nurses' views of physical activity would enable them to create improved guidelines and equivalent ways of working in the future. Therefore, this study aims to discursively explore Swedish school nurses' views on school children's physical activity and its promotion and elucidate them through a discursive framework based on sensitizing concepts. This study uses a qualitative research design with a constructivist grounded theory approach. Semi-structured interviews were conducted with 24 school nurses. The analysis resulted in a core category describing how school nurses use intertwined views to lead children from sedentarity to physical activity. Furthermore, the school nurses' practices were identified in three categories: fostering everyday movement as a tool for health, battling children's sedentarity under difficult conditions, and promoting everyday movement and compensating for unequal access. The results indicate that school nurses lack common and clear guidelines for their mission to promote physical activity to children, which may lead to inequality in access to physical activity for children and young people. [ABSTRACT FROM AUTHOR]

Bottom currents play a major role in deep‐sea sedimentation, but their significance in the burial of organic carbon is poorly quantified at a global scale. Here we show that Holocene fluxes of organic carbon into the contourite drifts are high, with a global average of 0.09 g cm−2 Kyr−1. At individual drift sites, fluxes are commonly 1–2 orders of magnitude greater than rates in surrounding areas and in global depth‐similar zones. These high fluxes of organic carbon into the contourite drifts are due to high rates of sedimentation. Over the past 50 million years, sedimentation rates at the studied contourite drift sites have overall increased, coincident with decreasing atmospheric CO2 and a cooling global climate. Our work suggests that a ramp‐up of the bottom‐current carbon pump has accelerated removal of CO2 from the atmosphere and oceanic water, thus contributing to the overall global cooling after the Eocene Thermal Maximum. Plain Language Summary: Bottom currents play a major role in deep‐sea sedimentation, but their significance in the burial of organic carbon is poorly quantified at a global scale. Here we examine data from modern contourite drifts (large‐scale, alongslope‐trending bottom‐current deposits) across the globe and show modern fluxes of organic carbon into the drifts are high, with a global average of 0.09 g cm−2 Kyr−1. At individual drift sites, fluxes are commonly 1 to 2 orders of magnitude greater than rates in surrounding areas and in global depth‐similar zones. These high fluxes of organic carbon into the drifts are due to high rates of sedimentation in these deepwater environments, which are driven primarily by vigorous bottom currents—in other words, by a bottom‐current pump that is highly efficient at burying organic carbon. Our work suggests that a ramp‐up of the bottom‐current carbon pump, attributable to progressive intensification of global ocean circulation over the past 50 million years, has accelerated removal of CO2 from the atmosphere and oceanic water, thus contributing to the global cooling after the Eocene Thermal Maximum. Sedimentary records of past organic carbon fluxes in contourite drifts over geologic time could well prove useful in informing predictions of future climate. Key Points: Modern fluxes of organic carbon into the contourite drifts are high, with a global average of 0.09 g cm−2 Kyr−1The fluxes into the drifts are commonly 1–2 orders of magnitude greater than rates in surrounding areas and in global depth‐similar zonesOver the past 50 million years, the bottom‐current pump has accelerated removal of carbon from the oceanic water [ABSTRACT FROM AUTHOR]

A method for the radiosynthesis of 18F-labelled aryl trifluoromethyl ketones starting from widely available Weinreb amides using [18F]fluoroform is presented. The method uses potassium hexamethyldisilazane as base and delivers products in high molar activity (up to 24 GBq μmol−1) and excellent radiochemical conversions. The applicability for PET tracer synthesis is demonstrated by the radiosynthesis of ten (hetero)aryl trifluoromethylketones, bearing electron-withdrawing and -donating substituents including a derivative of bioactive probenecid. [ABSTRACT FROM AUTHOR]

In the case of the journal-bearing system under a mixed or boundary lubrication regime, the deformation of the bearing, the flow of the lubricating medium, and the contact of the asperities should be taken into account. The lubrication problem at the journal-shaft interface is a complicated fluid–solid coupling problem. In this study, a new approach is proposed to analyze the dynamic fluid–solid coupling problem of journal bearings. The dynamic fluid–solid coupling problem is solved by the presented non-linear hybrid conjugate gradient method, which is based on the principle of pressure balance in the lubrication zone. One transient mixed lubrication model was developed to analyze the journal-bearing performance by considering the effects of skewness and kurtosis and the mass-conserving cavitation. According to the simulated results from the journal-bearing systems under the start-up condition, it can be found that the bearing performance is sensitive to the value of skewness or kurtosis and the degree of misalignment. Within a certain range, these cases with more negative skewness or lower kurtosis are conducive to decreasing friction loss and lift-off time. The developed model can be effectively used to track the performance of journal bearings. [ABSTRACT FROM AUTHOR]

Simple Summary: The accurate diagnosis of Barrett's esophagus (BE) and accurate grading of BE-associated dysplasia are essential for the optimal management of BE patients during surveillance. However, the diagnosis of BE may be missed, and the grading of BE–dysplasia has poor reproducibility and intra- and interobserver variability. Thus, well-defined biomarker testing remains indispensable. We conducted immunohistochemistry tests of a panel of biomarkers and discovered that MUC2 and TFF3 are specific diagnostic markers for BE. Moreover, the aberrant expressions of p53, p16, cyclin D1, Ki-67, beta-catenin, and MCM2 are significantly associated with LGD, HGD, and EAC histology with a high sensitivity and specificity and can be used to predict the risk of neoplastic changes and progression. Background: Barrett's esophagus (BE) is a pre-neoplastic condition associated with an increased risk of esophageal adenocarcinoma (EAC). The accurate diagnosis of BE and grading of dysplasia can help to optimize the management of patients with BE. However, BE may be missed and the accurate grading of dysplasia based on a routine histology has a considerable intra- and interobserver variability. Thus, well-defined biomarker testing remains indispensable. The aim of our study was to identify routinely applicable and relatively specific biomarkers for an accurate diagnosis of BE, as well as determining biomarkers to predict the risk of progression in BE–dysplasia. Methods: Retrospectively, we performed immunohistochemistry to test mucin 2(MUC2), trefoil factor 3 (TFF3), p53, p16, cyclin D1, Ki-67, beta-catenin, and minichromosome maintenance (MCM2) in biopsies. Prospectively, to identify chromosomal alterations, we conducted fluorescent in situ hybridization testing on fresh brush samples collected at the time of endoscopy surveillance. Results: We discovered that MUC2 and TFF3 are specific markers for the diagnosis of BE. Aberrant expression, including the loss and strong overexpression of p53, Ki-67, p16, beta-catenin, cyclin D1, and MCM2, was significantly associated with low-grade dysplasia (LGD), high-grade dysplasia (HGD), and EAC histology, with a relatively high risk of neoplastic changes. Furthermore, the aberrant expressions of p53 and p16 in BE-indefinite dysplasia (IND) progressor cohorts predicted the risk of progression. Conclusions: Assessing the biomarkers would be a suitable adjunct to accurate BE histology diagnoses and improve the accuracy of BE–dysplasia grading, thus reducing interobserver variability, particularly of LGD and risk prediction. [ABSTRACT FROM AUTHOR]

General reductions in lubricant viscosities and increasing loads in machine components highlight the role of tribofilms in providing surface protection against scuffing. However, the relationship between the scuffing process and the growth and removal of tribofilm is not well understood. In this study, a multiphysics coupling model, which includes hydrodynamic lubrication, asperity contact, thermal effect, tribochemistry reaction, friction, and surface wear, was developed to capture the initiation of surface scuffing. Simulations and experiments for a piston ring and cylinder liner contact were conducted following a step-load sequence under different temperature conditions. The results show that high temperature and extreme load could induce the lubricant film collapse, which in turn triggers the breakdown of the tribofilm due to the significantly increased removal process. The failures of both lubricant film and tribofilm progress instantaneously in a coupling way, which finally leads to severe scuffing. [ABSTRACT FROM AUTHOR]

In this work, a new method to solve the Reynolds equation including mass-conserving cavitation by using the physics informed neural networks (PINNs) is proposed. The complementarity relationship between the pressure and the void fraction is used. There are several difficulties in problem solving, and the solutions are provided. Firstly, the difficulty for considering the pressure inequality constraint by PINNs is solved by transferring it into one equality constraint without introducing error. While the void fraction inequality constraint is considered by using the hard constraint with the max-min function. Secondly, to avoid the fluctuation of the boundary value problems, the hard constraint method is also utilized to apply the boundary pressure values and the corresponding functions are provided. Lastly, for avoiding the trivial solution the limitation for the mean value of the void fraction is applied. The results are validated against existing data, and both the incompressible and compressible lubricant are considered. Good agreement can be found for both the domain and domain boundaries. [ABSTRACT FROM AUTHOR]

Aiming to improve the comprehensive performance of the journal bearing system, this paper presents a multi-objective adaptive scale texture optimization design approach. A mixed lubrication model for the textured journal bearing system is established by considering the effects of cavitation and roughness. The geometrical parameters of the textures were co-optimized using a multi-objective grey wolf optimizer to obtain the optimal texture schemes that are suitable for different operating conditions. Through this approach, the influences of different texture schemes under transient operating conditions can be investigated. According to the results, it was found that different texture schemes result in different friction reduction effects. Proper surface texture is beneficial in increasing the minimum oil film thickness and reducing the possibility of asperity contact. The adaptive scale texture exhibits strong adaptability and achieves significant hydrodynamic effects. Therefore, the developed approach provides valuable insights for the optimization design of journal bearing systems. [ABSTRACT FROM AUTHOR]

A novel distributed-vector-propulsion UAV (DVPUAV) is introduced in this paper, which has the capability of Vertical takeoff and landing (VTOL), and can realize relatively high-speed cruise. As the core of the DVPUAV, the propulsion wing designed under the guidance of the integration idea is not only a lifting body but also a propulsion device and a control mechanism. However, this kind of aircraft has a series of difficult problems with complex aero-propulsion coupling, flight modes switching, and so many inputs and control coupling. In order to describe this coupling effect to improve the accuracy of dynamics, an aero-propulsion coupling model is developed, considering both computation reliability and real-time. Afterward, a unique control framework is designed for the DVPUAV. By optimizing control logic, this control framework realizes the decoupling of longitudinal and lateral directional control and even the decoupling of roll and yaw control. Next, based on the Iterative linear quadratic regulator (ILQR), a new Model Predictive Control (MPC) controller with the ability to solve complex nonlinear problems is proposed which achieves the unification of the controller for the full flight envelope. Finally, the good performance of the control framework and controller is verified in the whole process of the flight simulation from take-off to landing. [ABSTRACT FROM AUTHOR]

As a rare complication of liver injury and certain interventions, bile can enter the bloodstream depending on the pressure gradient, resulting in bilhemia. Its micro-rheological and hemodynamic effects are still unclear. We aimed to study these parameters in experimental bilhemia models. Under general anesthesia, via laparotomy, bile was obtained by gallbladder puncture from pigs and by choledochal duct cannulation from rats. In vitro, 1 µL and 5 µL of bile were mixed with 500 µL of anticoagulated autologous blood. The systemic effect was also assessed (i.v. bile, 200 µL/bwkg). Hemodynamic and hematological parameters were monitored, and red blood cell (RBC) deformability and aggregation were determined. RBC deformability significantly decreased with the increasing bile concentration in vitro (1 µL: p = 0.033; 5 µL: p < 0.001) in both species. The RBC aggregation index values were concomitantly worsened (1 µL: p < 0.001; 5 µL: p < 0.001). The mean arterial pressure and heart rate decreased by 15.2 ± 6.9% and 4.6 ± 2.1% in rats (in 10.6 ± 2.6 s) and by 32.1 ± 14% and 25.2 ± 11.63% in pigs (in 48.3 ± 18.9 s). Restoration of the values was observed in 45 ± 9.5 s (rats) and 130 ± 20 s (pigs). Bilhemia directly affected the hemodynamic parameters and caused micro-rheological deterioration. The magnitude and dynamics of the changes were different for the two species. [ABSTRACT FROM AUTHOR]

Purpose: As the crucial support component of the propeller power system, the reliability of the operation of submersible pumps is influenced by the lubrication performance of water-lubricated thrust bearings. When the water-lubricated thrust bearings are under start-stop or heavy load conditions, the effect of surface morphology is crucial as the mixed lubrication regime is encountered. This paper aims to develop one mixed lubrication model for the water-lubricated thrust bearings to predict the effects of surface skewness, kurtosis and roughness orientation on the loading carrying capacity and tribological behavior. Design/methodology/approach: This paper developed one improved mixed lubrication model specifically for the water-lubricated thrust bearing system. In this model, the hydrodynamic model was improved by using the height of the rough surface and its probability density function, combined with the average flow model. The asperity contact model was improved by using the equation for the Pearson system of frequency curves to characterize the non-Gaussian aspect of surface roughness distribution. Findings: According to the results, negative skewness, large kurtosis and lateral surface pattern can improve the tribological performance of water-lubricated thrust bearings. Optimizing the surface morphology is a reasonable design method that can improve the performance of water-lubricated thrust bearings. Originality/value: In this paper, one mixed lubrication model specifically for the water-lubricated thrust bearing with the effect of surface roughness into consideration was developed. Based on the developed model, the effect of surface morphology on tribological behavior can be evaluated. Peer review: The peer review history for this article is available at: https://publons.com/publon/10.1108/ILT-08-2023-0247/ [ABSTRACT FROM AUTHOR]

The objective of the work is to identify the key factors that affect the slow adoption of Electric Vehicles (EV's) using the Analytic Hierarchy Process (AHP) approach. The data was collected first from a self-administered questionnaire focused on the four dimensions, i.e. cost, range, charging infrastructure and government incentives from 194 respondents. The result obtained was then used to rank the first and second factors out of 4 identified earlier from a robust systematic literature review. The four factors and ranking were tested by conducting a focus group interview with 6 experts and the results were then matched. Finally, AHP was employed and it is found that the cost and range are still the major obstacles. Manufacturers and governments can incorporate these results to work on reducing costs and adopting cutting-edge technologies to increase battery range. [ABSTRACT FROM AUTHOR]

Congenital nephrogenic diabetes insipidus (NDI; also known as arginine vasopressin resistance) is a rare inherited disorder of water homeostasis, caused by insensitivity of the distal nephron to arginine vasopressin. Consequently, the kidney loses its ability to concentrate urine, which leads to polyuria, polydipsia and the risk of hypertonic dehydration. The diagnosis and management of NDI are very challenging and require an integrated, multidisciplinary approach. Here, we present 36 recommendations for diagnosis, treatment and follow-up in both children and adults, as well as emergency management, genetic counselling and family planning, for patients with NDI. These recommendations were formulated and graded by an international group of experts in NDI from paediatric and adult nephrology, urology and clinical genetics from the European Rare Kidney Disease Reference Network and the European Society of Paediatric Nephrology, as well as patient advocates, and were validated by a voting panel in a Delphi process. The goal of these recommendations is to provide guidance to health care professionals who care for patients with NDI and to patients and their families. In addition, we emphasize the need for further research on different aspects of this potentially life-threatening disorder to support the development of evidence-based guidelines in the future., (© 2024. Springer Nature Limited.)

Metal seals play a crucial role in ensuring the dependable functioning of the bearing system in roller cone bits. Due to the intricate nature of downhole conditions, the microstructure design of sealing end faces, specifically the surface texture, is rarely used in metal seals. This study focuses on examining the applicability of surface texture technology in metal seals for cone bits to enhance the lubrication characteristics and friction and wear properties of liquid film between end faces. A multi-field coupling model of surface-textured metal seals was established and experimentally verified. The liquid film carrying the capacity and sealing performance of five different shapes of surface-textured end faces (circle, ellipse I (horizontal), ellipse II (vertical), triangle, and chevron) were investigated under varying rotational speeds and environmental pressures. The influences of texture parameters, including depth and area ratio, on the lubrication characteristics and friction reduction effects of surface-textured metal seals were investigated, and the microscopic wear morphology characteristics of the sealing end faces were analyzed. The results show that surface textures can effectively improve the liquid film state and comprehensive performance of metal seals. Specifically, triangle textures significantly enhance the hydrodynamic pressure effect and weaken the abrasive wear and adhesive wear of the end faces. However, when the environmental pressure is p ≥ 30 MPa, the surface textures gradually lose the advantages of dynamic lubrication but can still reduce friction. The proper texture depth and area ratio can achieve zero leakage (obtained theoretically) and minimal friction in metal seals. [ABSTRACT FROM AUTHOR]

The Elrod algorithm is widely used for the study of bearing cavitation problems. However, the potential instability of the algorithm makes it difficult to use in practical applications. A simplified Elrod algorithm based on a decoupled technique was developed. The new algorithm is well-regularized because the tough switch function used for the shear flow term is removed. The most significant advantage of the algorithm is the stability, unlike the traditional algorithm where the accuracy of results irregularly depends on the choice of grids. The numerical experiments, including a journal bearing and a surface-dimpled thrust bearing, show that the simplified Elrod algorithm converges consistently for all cases studied, while the traditional Elrod algorithm fails to converge for cases with a special number of grids. The simplified Elrod algorithm is considered to be a robust alternative to the traditional Elrod algorithm. [ABSTRACT FROM AUTHOR]

School grades are among the most common measurements used to analyze equality of outcome in education. Large or increasing 'gaps' in school grades between boys and girls and between students with different migration background are considered strong indicators of inequality. Based on students' school grades, several studies have shown that equality in Swedish schools has decreased during the last two decades. Although equality has been described as one of the most important goals in physical education (PE), studies that focus on equality of outcome are lacking. Moreover, there have been no studies that focus on equality of outcome since the 2011 implementation of a new school grading system in Sweden. Therefore, the aim of this study is to contribute with new knowledge on equality in PE in Sweden – in regard to gender and migration background. The study is based on register data for all students enrolled in Swedish schools during the years 2012–2016 from Grades 6 and 9 and Year 1 in upper secondary school (N = 1,294,990). Based on a cross-sectional approach, analyses were conducted to explore general trends in students' school grades in PE in the study period 2012–2016, and to calculate the percentage difference in PE grades between students with a Swedish background and both students with a foreign background and foreign-born students. After controlling for grade inflation, regression analyses with Wald tests were used to analyze how gender has moderated the relationship between migration background and school grades in PE in Sweden between 2012 and 2016. The results from this study suggest that (a) the intersection of gender and migration background is related to unequal school grades in PE, (b) there are gender equality issues in relation to students' school grades in PE and, (c) the most prominent equality issues concern the group foreign-born girls. [ABSTRACT FROM AUTHOR]

The development of new tracers for positron emission tomography (PET) is highly dependent on the available synthetic tools for their radiosynthesis. Herein, we present the radiosynthesis and application of [ 18 F]trifluoroiodomethane - the first reagent for broad scope radical [ 18 F]trifluoromethylation chemistry in high molar activity. CF 2 18 FI can be prepared from [ 18 F]fluoroform with 67±5 % AY and >99 % RCP. Its synthetic utility is demonstrated by the radiosynthesis of previously unprecedented 18 F-labeled α-trifluoromethyl ketones and 18 F-labeled trifluoromethyl sulfides, important motifs that are present in a range of bioactive compounds. Both protocols are Ru- and photo-mediated and proceed under mild reaction conditions. They show good functional group tolerance evidenced by the respective reaction scopes and make use of easily obtainable starting materials. The products can be isolated in 8.3-11.1 GBq/μmol (starting from ca. 5 GBq [ 18 F]fluoride). The applicability to PET tracer synthesis is shown by the radiolabeling of bioactive compounds, such as derivatives of probenecid and febuxostat. In a broader context, this work opens the door to the utilization of radical [ 18 F]trifluoromethylation chemistry for the radiolabeling of PET tracers in high molar activity., (© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)

Background: Febrile urinary tract infections (UTIs) are among the most severe bacterial infections in infants, in which a subset of patients develops complications. Identifying infants at risk of recurrent infections or kidney damage based on clinical signs is challenging. Previous observations suggest that genetic factors influence UTI outcomes and could serve as predictors of disease severity. In this study, we conducted a nationwide survey of infant genotypes to develop a strategy for infection management based on individual genetic risk. Our aims were to identify genetic susceptibility variants for renal scarring (RS) and genetic host factors predisposing to dilating vesicoureteral reflux (VUR) and recurrent UTIs., Methods: To assess genetic susceptibility, we collected and analyzed DNA from blood using exome genotyping. Disease-associated genetic variants were identified through bioinformatics analysis, including allelic frequency tests and odds ratio calculations. Kidney involvement was defined using dimercaptosuccinic acid (DMSA) scintigraphy., Results: In this investigation, a cohort comprising 1087 infants presenting with their first episode of febrile UTI was included. Among this cohort, a subset of 137 infants who underwent DMSA scanning was subjected to gene association analysis. Remarkable genetic distinctions were observed between patients with RS and those exhibiting resolved kidney involvement. Notably, the genetic signature indicative of renal scarring prominently featured mitochondrial genes., Conclusions: In this nationwide study of genetic susceptibility to RS after febrile UTIs in infancy, we identified a profile dominated by mitochondrial polymorphisms. This profile can serve as a predictor of future complications, including RS and recurrent UTIs., (© 2024. The Author(s).)

Aim: To evaluate changes in allograft kidney length in renal transplant recipients and the relationship with estimated glomerular filtration rate (eGFR)., Methods: This single-centre retrospective study of renal transplant recipients was conducted at Flinders Medical Centre (FMC) from January 2007 to June 2020. Donor and recipient details, renal allograft length from transplant ultrasounds at 0, 1, 3, 6 and 12 months were collected. The association between compensatory renal hypertrophy (CRH) and eGFR and its magnitude was analysed using multivariate multilevel mixed-effects linear regression models., Results: A total of 183 renal transplant recipients were studied. 100 of 175 recipients (62.9%) demonstrated an increase in renal length defined as any increase in maximal longitudinal diameter on serial ultrasounds. Twenty-three recipients (13.1%) had no change in transplant length and 42 recipients (24%) had a decrease in length. The mean increase in kidney length over the first 12 months was 0.57 cm. Ninety of 156 (57.7%) recipients with a renal ultrasound within a month post-transplant demonstrated a mean increase kidney length of 0.3 cm. Multivariate analysis demonstrated that eGFR increased by 2.5 mL/min/1.73 m 2 (95% CI 0.72- 4.4; p = .006) with every 1 cm increase in kidney length. Absolute changes in kidney length did not demonstrate any statistically significant correlation with eGFR in both complete case and multiple imputation analysis., Conclusion: An increase in transplant kidney length is common in renal transplant recipients and is associated with enhanced eGFR. However, further studies need to be performed to study the association of absolute change in kidney length and eGFR., (© 2024 The Authors. Nephrology published by John Wiley & Sons Australia, Ltd on behalf of Asian Pacific Society of Nephrology.)