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Electron emission from micro-protrusions on the surface of metal electrodes is crucial for vacuum breakdown. The emission characteristics of cathode micro-protrusions and the impact of the space charge effect are investigated in this study, with a comparison to the Murphy–Good (MG) theory analysis. Precise calculations of the emission current density and the Nottingham effect are achieved. A thermal-field emission model for copper micro-protrusion is established to analyze emission characteristics and clarify the mismatches between the results of simulations and MG theory. The results indicate that, for copper micro-protrusions, before breakdown, the emission current is primarily field emission, with thermal emission constituting only 7% of the total. The Nottingham effect results in consistent heating during this phase. The field enhancement factor obtained through the MG theory (γ MG) is slightly smaller than that derived from the geometric model (γ geom). This is because γ geom reflects the characteristics of the apex of the protrusion, while γ MG reflects the characteristics of the entire electron emission region. The space charge effect bends the MG plot curve and decreases its slope, making it impossible to analyze the emission current using MG theory at this point, which is consistent with the theoretical derivations recorded in the current literature. [ABSTRACT FROM AUTHOR]

The process of developing new drugs is arduous and costly, particularly for targets classified as "difficult-to-drug." Macrocycles show a particular ability to modulate difficult-to-drug targets, including protein-protein interactions, while still allowing oral administration. However, the determination of membrane permeability, critical for reaching intracellular targets and for oral bioavailability, is laborious and expensive. In silico methods are a cost-effective alternative, enabling predictions prior to compound synthesis. Here, we present a comprehensive online database (https://swemacrocycledb.com/), housing 5638 membrane permeability datapoints for 4216 nonpeptidic macrocycles, curated from the literature, patents, and bioactivity repositories. In addition, we present a new descriptor, the "amide ratio" (AR), that quantifies the peptidic nature of macrocyclic compounds, enabling the classification of peptidic, semipeptidic, and nonpeptidic macrocycles. Overall, this resource fills a gap among existing databases, offering valuable insights into the membrane permeability of nonpeptidic and semipeptidic macrocycles, and facilitating predictions for drug discovery projects. [ABSTRACT FROM AUTHOR]

Metastasis, the leading cause of mortality in cancer patients, presents challenges for conventional photodynamic therapy (PDT) due to its reliance on localized light and oxygen application to tumors. To overcome these limitations, a self-sustained organelle-mimicking nanoreactor is developed here with programmable DNA switches that enables bio-chem-photocatalytic cascade-driven starvation-photodynamic synergistic therapy against tumor metastasis. Emulating the compartmentalization and positional assembly strategies found in living cells, this nano-organelle reactor allows quantitative co-compartmentalization of multiple functional modules for the designed self-illuminating chemiexcited PDT system. Within the space-confined nanoreactor, biofuel glucose is converted to hydrogen peroxide (H 2 O 2 ) which enhances luminol-based chemiluminescence (CL), consequently driving the generation of photochemical singlet oxygen ( 1 O 2 ) via chemiluminescence resonance energy transfer. Meanwhile, hemoglobin functions as a synchronized oxygen supplier for both glucose oxidation and PDT, while also exhibiting peroxidase-like activity to produce hydroxyl radicals (·OH). Crucially, the nanoreactor keeps switching off in normal tissues, with on-demand activation in tumors through toehold-mediated strand displacement. These findings demonstrate that this nanoreactor, which is self-sufficient in light and oxygen and precise in striking tumors, presents a promising paradigm for managing highly metastatic cancers., (© 2025 The Author(s). Advanced Materials published by Wiley‐VCH GmbH.)