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39 results on '"Iwasaki, Akiko"'

2. SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity

Author

Peña-Hernández, Mario A., Alfajaro, Mia Madel, Filler, Renata B., Moriyama, Miyu, Keeler, Emma L., Ranglin, Zara E., Kong, Yong, Mao, Tianyang, Menasche, Bridget L., Mankowski, Madeleine C., Zhao, Zhe, Vogels, Chantal B. F., Hahn, Anne M., Kalinich, Chaney C., Zhang, Shuo, Huston, Nicholas, Wan, Han, Araujo-Tavares, Rafael, Lindenbach, Brett D., Homer, Robert, Pyle, Anna Marie, Martinez, David R., Grubaugh, Nathan D., Israelow, Benjamin, Iwasaki, Akiko, and Wilen, Craig B.

Published
2024
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3. IgM N-glycosylation correlates with COVID-19 severity and rate of complement deposition

Author

Ozonoff, Al, Ehrlich, Lauren IR, Melamed, Esther, Sesma, Ana Fernandez, Simon, Viviana, Pulendran, Bali, Nadeau, Kari C, Davis, Mark M, McCoey, Grace A, Sekaly, Rafick, Baden, Lindsey R, Levy, Ofer, Schaenman, Joanna, Reed, Elaine F, Shaw, Albert C, Hafler, David A, Montgomery, Ruth R, Kleinstein, Steven H, Becker, Patrice M, Augustine, Alison D, Calfee, Carolyn S, Erle, David J, DeBakey, Michael E, Corry, David B, Kheradmand, Farrah, Atkinson, Mark A, Brakenridge, Scott C, Higuita, Nelson I Agudelo, Metcalf, Jordan P, Hough, Catherine L, Messer, William B, Kraft, Monica, Bime, Chris, Peters, Bjoern, Milliren, Carly E, Syphurs, Caitlin, McEnaney, Kerry, Barton, Brenda, Lentucci, Claudia, Saluvan, Mehmet, Chang, Ana C, Hoch, Annmarie, Albert, Marisa, Shaheen, Tanzia, Kho, Alvin T, Liu, Shanshan, Thomas, Sanya, Chen, Jing, Murphy, Maimouna D, Cooney, Mitchell, Hayati, Arash Nemati, Bryant, Robert, Abraham, James, Jayavelu, Naresh Doni, Presnell, Scott, Jancsyk, Tomasz, Maguire, Cole, Qi, Jingjing, Lee, Brian, Fourati, Slim, Esserman, Denise A, Guan, Leying, Gygi, Jeremy, Pawar, Shrikant, Brito, Anderson, Fragiadakis, Gabriela K, Patel, Ravi, Overton, James A, Vita, Randi, Westendorf, Kerstin, Shannon, Casey P, Tebbutt, Scott J, Thyagarajan, Rama V, Rousseau, Justin F, Wylie, Dennis, Triplett, Todd A, Kojic, Erna, Chinthrajah, Sharon, Ahuja, Neera, Rogers, Angela J, Artandi, Maja, Geng, Linda, Yendewa, George, Powell, Debra L, Kim, James N, Simmons, Brent, Goonewardene, I Michael, Smith, Cecilia M, Martens, Mark, Sherman, Amy C, Walsh, Stephen R, Issa, Nicolas C, Salehi-Rad, Ramin, Dela Cruz, Charles, Farhadian, Shelli, Iwasaki, Akiko, Ko, Albert I, Anderson, Evan J, Mehta, Aneesh K, and Sevransky, Jonathan E

Subjects
Biological Sciences, Biomedical and Clinical Sciences, Immunology, Infectious Diseases, Coronaviruses, Lung, Emerging Infectious Diseases, Inflammatory and immune system, Good Health and Well Being, Humans, COVID-19, Glycosylation, SARS-CoV-2, Glycosyltransferases, Complement System Proteins, Immunoglobulin M, IMPACC Network
Abstract

The glycosylation of IgG plays a critical role during human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, activating immune cells and inducing cytokine production. However, the role of IgM N-glycosylation has not been studied during human acute viral infection. The analysis of IgM N-glycosylation from healthy controls and hospitalized coronavirus disease 2019 (COVID-19) patients reveals increased high-mannose and sialylation that correlates with COVID-19 severity. These trends are confirmed within SARS-CoV-2-specific immunoglobulin N-glycan profiles. Moreover, the degree of total IgM mannosylation and sialylation correlate significantly with markers of disease severity. We link the changes of IgM N-glycosylation with the expression of Golgi glycosyltransferases. Lastly, we observe antigen-specific IgM antibody-dependent complement deposition is elevated in severe COVID-19 patients and modulated by exoglycosidase digestion. Taken together, this work links the IgM N-glycosylation with COVID-19 severity and highlights the need to understand IgM glycosylation and downstream immune function during human disease.

Published
2024

4. Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study

Author

McEnaney, Kerry, Barton, Brenda, Lentucci, Claudia, Saluvan, Mehmet, Chang, Ana C, Hoch, Annmarie, Albert, Marisa, Shaheen, Tanzia, Kho, Alvin T, Thomas, Sanya, Chen, Jing, Murphy, Maimouna D, Cooney, Mitchell, Hayati, Arash Nemati, Bryant, Robert, Abraham, James, Presnell, Scott, Jancsyk, Tomasz, Maguire, Cole, Lee, Brian, Fourati, Slim, Esserman, Denise A, Guan, Leying, Gygi, Jeremy, Pawar, Shrikant, Brito, Anderson, Fragiadakis, Gabriela K, Patel, Ravi, Tebbutt, Scott J, Overton, James A, Vita, Randi, Westendorf, Kerstin, Thyagarajan, Rama V, Rousseau, Justin F, Wylie, Dennis, Triplett, Todd A, Kojic, Erna, Chinthrajah, Sharon, Ahuja, Neera, Rogers, Angela J, Artandi, Maja, Yendewa, George, Powell, Debra L, Kim, James N, Simmons, Brent, Goonewardene, I Michael, Smith, Cecilia M, Martens, Mark, Sherman, Amy C, Walsh, Stephen R, Issa, Nicolas C, Salehi-Rad, Ramin, Dela Cruz, Charles, Farhadian, Shelli, Iwasaki, Akiko, Ko, Albert I, Anderson, Evan J, Mehta, Aneesh K, Sevransky, Jonathan E, Leligdowicz, Aleksandra, Matthay, Michael A, Singer, Jonathan P, Kangelaris, Kirsten N, Hendrickson, Carolyn M, Krummel, Matthew F, Woodruff, Prescott G, Anderson, Matthew L, Guirgis, Faheem W, Drevets, Douglas A, Brown, Brent R, Siegel, Sarah AR, Lu, Zhengchun, Mosier, Jarrod, Kimura, Hiroki, Khor, Bernard, Rahman, Adeeb, Stadlbauer, Daniel, Dutta, Jayeeta, Gonzalez-Reiche, Ana Silvia, van de Guchte, Adriana, Carreño, Juan Manuel, Singh, Gagandeep, Raskin, Ariel, Tcheou, Johnstone, Bielak, Dominika, Kawabata, Hisaaki, Xie, Hui, Kelly, Geoffrey, Patel, Manishkumar, Nie, Kai, Yellin, Temima, Fried, Miriam, Sullivan, Leeba, Morris, Sara, Sieg, Scott, van Zalm, Patrick, Fatou, Benoit, Mendez, Kevin, Lasky-Su, Jessica, and Hutton, Scott R

Subjects
Health Services and Systems, Biomedical and Clinical Sciences, Health Sciences, Prevention, Vaccine Related, Emerging Infectious Diseases, Biodefense, Brain Disorders, Infectious Diseases, Lung, Good Health and Well Being, Female, Humans, SARS-CoV-2, COVID-19, B-Lymphocytes, Body Fluids, Disease Progression, Phenotype, IMPACC Network
Abstract

Post-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.

Published
2024

6. Compartmentalized ocular lymphatic system mediates eye–brain immunity

Author

Yin, Xiangyun, Zhang, Sophia, Lee, Ju Hyun, Dong, Huiping, Mourgkos, George, Terwilliger, Gordon, Kraus, Aurora, Geraldo, Luiz Henrique, Poulet, Mathilde, Fischer, Suzanne, Zhou, Ting, Mohammed, Farrah Shalima, Zhou, Jiangbing, Wang, Yongfu, Malloy, Seth, Rohner, Nicolas, Sharma, Lokesh, Salinas, Irene, Eichmann, Anne, Thomas, Jean-Leon, Saltzman, W. Mark, Huttner, Anita, Zeiss, Caroline, Ring, Aaron, Iwasaki, Akiko, and Song, Eric

Published
2024
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11. Long COVID Characteristics and Experience: A Descriptive Study From the Yale LISTEN Research Cohort

Author

Sawano, Mitsuaki, Wu, Yilun, Shah, Rishi M., Zhou, Tianna, Arun, Adith S., Khosla, Pavan, Kaleem, Shayaan, Vashist, Anushree, Bhattacharjee, Bornali, Ding, Qinglan, Lu, Yuan, Caraballo, César, Warner, Frederick, Huang, Chenxi, Herrin, Jeph, Putrino, David, Michelsen, Teresa, Fisher, Liza, Adinig, Cynthia, Iwasaki, Akiko, and Krumholz, Harlan M.

Published
2024
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12. The PAX LC Trial: A Decentralized, Phase 2, Randomized, Double-Blind Study of Nirmatrelvir/Ritonavir Compared with Placebo/Ritonavir for Long COVID

Author

Krumholz, Harlan M., Sawano, Mitsuaki, Bhattacharjee, Bornali, Caraballo, César, Khera, Rohan, Li, Shu-Xia, Herrin, Jeph, Coppi, Andreas, Holub, Julie, Henriquez, Yashira, Johnson, Maria A., Goddard, Theresa B., Rocco, Erica, Hummel, Amy C., AL Mouslmani, Mohammad, Putrino, David F., Carr, Kevin D., Carvajal-Gonzalez, Santos, Charnas, Lawrence, De Jesus, Magdia, Ziegler, Frank W., III, and Iwasaki, Akiko

Published
2024
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14. Supplementary Data S1 from Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)

Author

Sheth, Sangini S., primary, Oh, Ji Eun, primary, Bellone, Stefania, primary, Siegel, Eric R., primary, Greenman, Michelle, primary, Mutlu, Levent, primary, McNamara, Blair, primary, Pathy, Shefali, primary, Clark, Mitchell, primary, Azodi, Masoud, primary, Altwerger, Gary, primary, Andikyan, Vaagn, primary, Huang, Gloria, primary, Ratner, Elena, primary, Kim, Daniel J., primary, Iwasaki, Akiko, primary, Levi, Angelique W., primary, Buza, Natalia, primary, Hui, Pei, primary, Flaherty, Sean, primary, Schwartz, Peter E., primary, and Santin, Alessandro D., primary

Published
2024
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15. Supplementary Table S1 from Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)

Author

Sheth, Sangini S., primary, Oh, Ji Eun, primary, Bellone, Stefania, primary, Siegel, Eric R., primary, Greenman, Michelle, primary, Mutlu, Levent, primary, McNamara, Blair, primary, Pathy, Shefali, primary, Clark, Mitchell, primary, Azodi, Masoud, primary, Altwerger, Gary, primary, Andikyan, Vaagn, primary, Huang, Gloria, primary, Ratner, Elena, primary, Kim, Daniel J., primary, Iwasaki, Akiko, primary, Levi, Angelique W., primary, Buza, Natalia, primary, Hui, Pei, primary, Flaherty, Sean, primary, Schwartz, Peter E., primary, and Santin, Alessandro D., primary

Published
2024
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16. Supplementary Figure S1 from Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)

Author

Sheth, Sangini S., primary, Oh, Ji Eun, primary, Bellone, Stefania, primary, Siegel, Eric R., primary, Greenman, Michelle, primary, Mutlu, Levent, primary, McNamara, Blair, primary, Pathy, Shefali, primary, Clark, Mitchell, primary, Azodi, Masoud, primary, Altwerger, Gary, primary, Andikyan, Vaagn, primary, Huang, Gloria, primary, Ratner, Elena, primary, Kim, Daniel J., primary, Iwasaki, Akiko, primary, Levi, Angelique W., primary, Buza, Natalia, primary, Hui, Pei, primary, Flaherty, Sean, primary, Schwartz, Peter E., primary, and Santin, Alessandro D., primary

Published
2024
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17. Data from Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)

Author

Sheth, Sangini S., primary, Oh, Ji Eun, primary, Bellone, Stefania, primary, Siegel, Eric R., primary, Greenman, Michelle, primary, Mutlu, Levent, primary, McNamara, Blair, primary, Pathy, Shefali, primary, Clark, Mitchell, primary, Azodi, Masoud, primary, Altwerger, Gary, primary, Andikyan, Vaagn, primary, Huang, Gloria, primary, Ratner, Elena, primary, Kim, Daniel J., primary, Iwasaki, Akiko, primary, Levi, Angelique W., primary, Buza, Natalia, primary, Hui, Pei, primary, Flaherty, Sean, primary, Schwartz, Peter E., primary, and Santin, Alessandro D., primary

Published
2024
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18. Randomized Phase II Trial of Imiquimod with or without 9-Valent HPV Vaccine versus Observation in Patients with High-grade Pre-neoplastic Cervical Lesions (NCT02864147)

Author

Sheth, Sangini S., primary, Oh, Ji Eun, additional, Bellone, Stefania, additional, Siegel, Eric R., additional, Greenman, Michelle, additional, Mutlu, Levent, additional, McNamara, Blair, additional, Pathy, Shefali, additional, Clark, Mitchell, additional, Azodi, Masoud, additional, Altwerger, Gary, additional, Andikyan, Vaagn, additional, Huang, Gloria, additional, Ratner, Elena, additional, Kim, Daniel J., additional, Iwasaki, Akiko, additional, Levi, Angelique W., additional, Buza, Natalia, additional, Hui, Pei, additional, Flaherty, Sean, additional, Schwartz, Peter E., additional, and Santin, Alessandro D., additional

Published
2024
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19. Sex differences in symptomatology and immune profiles of Long COVID

Author

Silva, Julio, primary, Takahashi, Takehiro, additional, Wood, Jamie, additional, Lu, Peiwen, additional, Tabachnikova, Alexandra, additional, Gehlhausen, Jeff R., additional, Greene, Kerrie, additional, Bhattacharjee, Bornali, additional, Monteiro, Valter Silva, additional, Lucas, Carolina, additional, Dhodapkar, Rahul M., additional, Tabacof, Laura, additional, Peña-Hernandez, Mario, additional, Kamath, Kathy, additional, Mao, Tianyang, additional, Mccarthy, Dayna, additional, Medzhitov, Ruslan, additional, van Dijk, David, additional, Krumholz, Harlan M., additional, Guan, Leying, additional, Putrino, David, additional, and Iwasaki, Akiko, additional

Published
2024
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21. Post-Acute sequelae of COVID-19 in pediatric patients within the United States: A Scoping Review

Author

Miller, Christine M, Borre, Carla, Green, Alex, Funaro, Melissa, Oliveira, Carlos R, and Iwasaki, Akiko

Abstract

A subset of children and adolescents experience recurrent or persistent symptoms following SARS-CoV-2 infection, known as post-acute sequelae of COVID-19 (PASC), however the clinical epidemiology within the United States (US) is not yet well understood. This scoping review aims to synthesize the clinical epidemiology of pediatric PASC in the US. A comprehensive literature search was conducted and databases were queried from inception until January 29, 2024. Studies including US children and adolescents < 21 years old were considered. From 1028 studies identified, 29 met the inclusion criteria. Prevalence of PASC ranged from less than 1% to 27%. Risk factors included older age, female sex, asthma, obesity, and severe initial infection. Common symptoms were dyspnea, fatigue, headaches, and chest pain. A multidisciplinary approach for diagnosis and management was common across studies. Most studies had a high risk of bias and were limited by a lack of standardized definitions and short follow-up duration. This review establishes a foundation for understanding pediatric PASC and highlights the critical need for continued research to optimize prevention and treatment strategies.

Published
2024
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22. Experimental Urethral Infection with Neisseria gonorrhoeae

Author

Waltmann, Andreea, Duncan, Joseph A., Pier, Gerald B., Cywes-Bentley, Colette, Cohen, Myron S., Hobbs, Marcia M., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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23. Controlled Human Malaria Infection Studies in Africa—Past, Present, and Future

Author

Kibwana, Elizabeth, Kapulu, Melissa, Bejon, Philip, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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24. Controlled Human Infection Challenge Studies with RSV

Author

Dayananda, Pete, Chiu, Christopher, Openshaw, Peter, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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25. Human Challenge Studies for Cholera

Author

Cohen, Mitchell B., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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26. Controlled Human Infection with Bordetella pertussis

Author

de Graaf, H., Gbesemete, D., Read, R. C., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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27. The Controlled Human Infection Model for Enterotoxigenic Escherichia coli

Author

Porter, Chad K., Talaat, Kawsar R., Isidean, Sandra D., Kardinaal, Alwine, Chakraborty, Subhra, Gutiérrez, Ramiro L., Sack, David A., Bourgeois, A. Louis, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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28. Shigella-Controlled Human Infection Models: Current and Future Perspectives

Author

Clarkson, Kristen A., Porter, Chad K., Talaat, Kawsar R., Kapulu, Melissa C., Chen, Wilbur H., Frenck, Robert W., Jr., Bourgeois, A. Louis, Kaminski, Robert W., Martin, Laura B., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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29. Challenges in Developing a Controlled Human Tuberculosis Challenge Model

Author

Jackson, Susan, McShane, Helen, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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30. The Background, Role and Approach for Development of a Controlled Human Infection Model for Nontyphoidal Salmonella

Author

MacLennan, Calman A., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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31. A Brief History of Human Challenge Studies (1900–2021) Emphasising the Virology, Regulatory and Ethical Requirements, Raison D’etre, Ethnography, Selection of Volunteers and Unit Design

Author

Oxford, J. S., Catchpole, A., Mann, A., Bell, A., Noulin, N., Gill, D., Oxford, J. R., Gilbert, A., Balasingam, Shobana, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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32. Helicobacter pylori

Author

Graham, David Y., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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33. Human Challenge Studies with Coronaviruses Old and New

Author

McKendry, Richard, Lemm, Nana-Marie, Papargyris, Loukas, Chiu, Christopher, Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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34. Human Challenge Studies for Vaccine Development : Regulatory Aspects of Human Challenge Studies

Author

Baylor, Norman W., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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35. Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development : The Human Hookworm Vaccination/Challenge Model (HVCM)

Author

Pritchard, David I., Diemert, David, Bottazzi, Maria Elena, Hawdon, John M., Correa-Oliveira, Rodrigo, Bethony, Jeffrey M., Capron, A., Series Editor, Cooper, Max D., Series Editor, Hogle, J.M., Series Editor, Zinkernagel, R., Series Editor, Ito, Y., Series Editor, Koprowski, Hilary, Honorary Editor, McConnell, I., Series Editor, Melchers, Fritz, Series Editor, Oldstone, Michael B. A., Series Editor, Olsnes, Sjur, Series Editor, Potter, Kevin L., Series Editor, Saedler, H., Series Editor, Vogt, Peter K., Series Editor, Wagner, Hermann, Series Editor, Wilson, I., Series Editor, Hofschneider, P.H., Series Editor, Rott, R., Series Editor, Schweiger, H. G, Series Editor, Clarke, A., Series Editor, Eisen, H., Series Editor, Goebel, W., Series Editor, Nussenzweig, V., Series Editor, Doerr, R., Series Editor, Henle, W., Series Editor, Meyer, K. F., Series Editor, Nauck, E.G., Series Editor, Pappenheimer Jr., A. M., Series Editor, Schlossberg, H., Series Editor, Tomcsik, J., Series Editor, Kikuth, W., Series Editor, Arber, W., Series Editor, Virgin, Herbert W., Series Editor, Collier, R. John, Series Editor, Kawaoka, Yoshihiro, Series Editor, Svanborg, Catharina, Series Editor, Gleba, Yuri Y., Series Editor, Ahmed, Rafi, Series Editor, Akira, Shizuo, Series Editor, Aktories, Klaus, Series Editor, Casadevall, Arturo, Series Editor, Compans, Richard W., Series Editor, Damaso, Clarissa, Series Editor, Galan, Jorge E., Series Editor, Garcia-Sastre, Adolfo, Series Editor, Iwasaki, Akiko, Series Editor, Palme, Klaus, Series Editor, Rappuoli, Rino, Series Editor, Honjo, Tasuku, Series Editor, Rodrigues, Marcio L, Series Editor, Weber, Olaf, Series Editor, Bagnoli, Fabio, editor, Del Giudice, Giuseppe, editor, and Phogat, Sanjay K., editor

Published
2024
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36. A causal link between autoantibodies and neurological symptoms in long COVID.

Author

Santos Guedes de Sa K, Silva J, Bayarri-Olmos R, Brinda R, Alec Rath Constable R, Colom Diaz PA, Kwon DI, Rodrigues G, Wenxue L, Baker C, Bhattacharjee B, Wood J, Tabacof L, Liu Y, Putrino D, Horvath TL, and Iwasaki A

Abstract

Acute SARS-CoV-2 infection triggers the generation of diverse and functional autoantibodies (AABs), even after mild cases. Persistently elevated autoantibodies have been found in some individuals with long COVID (LC). Using a >21,000 human protein array, we identified diverse AAB targets in LC patients that correlated with their symptoms. Elevated AABs to proteins in the nervous system were found in LC patients with neurocognitive and neurological symptoms. Purified Immunoglobulin G (IgG) samples from these individuals reacted with human pons tissue and were cross-reactive with mouse sciatic nerves, spinal cord, and meninges. Antibody reactivity to sciatic nerves and meninges correlated with patient-reported headache and disorientation. Passive transfer of IgG from patients to mice led to increased sensitivity and pain, mirroring patient-reported symptoms. Similarly, mice injected with IgG showed loss of balance and coordination, reflecting donor-reported dizziness. Our findings suggest that targeting AABs could benefit some LC patients., Competing Interests: Declaration of interests A. I. co-founded RIGImmune, Xanadu Bio and PanV and is a member of the Board of Directors of Roche Holding Ltd and Genentech. All other authors declare no competing interests.

Published
2024
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37. Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract.

Author

Mao T, Kim J, Peña-Hernández MA, Valle G, Moriyama M, Luyten S, Ott IM, Gomez-Calvo ML, Gehlhausen JR, Baker E, Israelow B, Slade M, Sharma L, Liu W, Ryu C, Korde A, Lee CJ, Silva Monteiro V, Lucas C, Dong H, Yang Y, Gopinath S, Wilen CB, Palm N, Dela Cruz CS, and Iwasaki A

Subjects
Animals, Mice, Humans, COVID-19 immunology, COVID-19 prevention & control, COVID-19 virology, Respiratory Tract Infections immunology, Respiratory Tract Infections drug therapy, Respiratory Tract Infections virology, Respiratory Tract Infections prevention & control, Nasal Mucosa immunology, Nasal Mucosa virology, Nasal Mucosa drug effects, Disease Models, Animal, COVID-19 Drug Treatment, Mesocricetus, Female, Influenza A virus drug effects, Influenza A virus immunology, Neomycin pharmacology, Neomycin administration & dosage, Administration, Intranasal, Antiviral Agents pharmacology, Antiviral Agents administration & dosage, SARS-CoV-2 immunology, SARS-CoV-2 drug effects
Abstract

Respiratory virus infections in humans cause a broad-spectrum of diseases that result in substantial morbidity and mortality annually worldwide. To reduce the global burden of respiratory viral diseases, preventative and therapeutic interventions that are accessible and effective are urgently needed, especially in countries that are disproportionately affected. Repurposing generic medicine has the potential to bring new treatments for infectious diseases to patients efficiently and equitably. In this study, we found that intranasal delivery of neomycin, a generic aminoglycoside antibiotic, induces the expression of interferon-stimulated genes (ISGs) in the nasal mucosa that is independent of the commensal microbiota. Prophylactic or therapeutic administration of neomycin provided significant protection against upper respiratory infection and lethal disease in a mouse model of COVID-19. Furthermore, neomycin treatment protected Mx1 congenic mice from upper and lower respiratory infections with a highly virulent strain of influenza A virus. In Syrian hamsters, neomycin treatment potently mitigated contact transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In healthy humans, intranasal application of neomycin-containing Neosporin ointment was well tolerated and effective at inducing ISG expression in the nose in a subset of participants. These findings suggest that neomycin has the potential to be harnessed as a host-directed antiviral strategy for the prevention and treatment of respiratory viral infections., Competing Interests: Competing interests statement:A.I. co-founded and consults for RIGImmune, Xanadu Bio and PanV, consults for Paratus Sciences, InvisiShield Technologies, and is a member of the Board of Directors of Roche Holding Ltd.

Published
2024
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38. Sex differences in symptomatology and immune profiles of Long COVID.

Author

Silva J, Takahashi T, Wood J, Lu P, Tabachnikova A, Gehlhausen JR, Greene K, Bhattacharjee B, Monteiro VS, Lucas C, Dhodapkar RM, Tabacof L, Peña-Hernandez M, Kamath K, Mao T, Mccarthy D, Medzhitov R, van Dijk D, Krumholz HM, Guan L, Putrino D, and Iwasaki A

Abstract

Strong sex differences in the frequencies and manifestations of Long COVID (LC) have been reported with females significantly more likely than males to present with LC after acute SARS-CoV-2 infection 1-7 . However, whether immunological traits underlying LC differ between sexes, and whether such differences explain the differential manifestations of LC symptomology is currently unknown. Here, we performed sex-based multi-dimensional immune-endocrine profiling of 165 individuals 8 with and without LC in an exploratory, cross-sectional study to identify key immunological traits underlying biological sex differences in LC. We found that female and male participants with LC experienced different sets of symptoms, and distinct patterns of organ system involvement, with female participants suffering from a higher symptom burden. Machine learning approaches identified differential sets of immune features that characterized LC in females and males. Males with LC had decreased frequencies of monocyte and DC populations, elevated NK cells, and plasma cytokines including IL-8 and TGF-β-family members. Females with LC had increased frequencies of exhausted T cells, cytokine-secreting T cells, higher antibody reactivity to latent herpes viruses including EBV, HSV-2, and CMV, and lower testosterone levels than their control female counterparts. Testosterone levels were significantly associated with lower symptom burden in LC participants over sex designation. These findings suggest distinct immunological processes of LC in females and males and illuminate the crucial role of immune-endocrine dysregulation in sex-specific pathology.

Published
2024
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39. Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID.

Author

Grady CB, Bhattacharjee B, Silva J, Jaycox J, Lee LW, Monteiro VS, Sawano M, Massey D, Caraballo C, Gehlhausen JR, Tabachnikova A, Mao T, Lucas C, Peña-Hernandez MA, Xu L, Tzeng TJ, Takahashi T, Herrin J, Güthe DB, Akrami A, Assaf G, Davis H, Harris K, McCorkell L, Schulz WL, Grffin D, Wei H, Ring AM, Guan L, Cruz CD, Iwasaki A, and Krumholz HM

Abstract

Background: Long COVID contributes to the global burden of disease. Proposed root cause hypotheses include the persistence of SARS-CoV-2 viral reservoir, autoimmunity, and reactivation of latent herpesviruses. Patients have reported various changes in Long COVID symptoms after COVID-19 vaccinations, leaving uncertainty about whether vaccine-induced immune responses may alleviate or worsen disease pathology., Methods: In this prospective study, we evaluated changes in symptoms and immune responses after COVID-19 vaccination in 16 vaccine-naïve individuals with Long COVID. Surveys were administered before vaccination and then at 2, 6, and 12 weeks after receiving the first vaccine dose of the primary series. Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination., Results: Self-report at 12 weeks post-vaccination indicated 10 out of 16 participants had improved health, 3 had no change, 1 had worse health, and 2 reported marginal changes. Significant elevation in SARS-CoV-2-specific TCRs and Spike protein-specific IgG were observed 6 and 12 weeks after vaccination. No changes in reactivities were observed against herpes viruses and self-antigens. Within this dataset, higher baseline sIL-6R was associated with symptom improvement, and the two top features associated with non-improvement were high IFN-β and CNTF, among soluble analytes., Conclusions: Our study showed that in this small sample, vaccination improved the health or resulted in no change to the health of most participants, though few experienced worsening. Vaccination was associated with increased SARS-CoV-2 Spike protein-specific IgG and T cell expansion in most individuals with Long COVID. Symptom improvement was observed in those with baseline elevated sIL-6R, while elevated interferon and neuropeptide levels were associated with a lack of improvement.

Published
2024
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