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ABSTRACT Recently, optically pumped magnetometers (OPMs), which use the spin polarization of alkali metal atoms to measure magnetic fields, have attracted much attention. However, in order to realize high‐sensitivity biomagnetic field measurements using OPMs, it is necessary to reduce environmental magnetic noise and system noise. In this study, we investigate the effectiveness of the noise reduction of OPM signals when principal component analysis, independent component analysis, and empirical mode decomposition are used for signal processing. [ABSTRACT FROM AUTHOR]