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Adaptive capacity was recognized as one of the critical components of vulnerability assessment in 2001 by the Intergovernmental Panel on Climate Change. Adaptive capacity extends beyond the mere accumulation of resources to encompass the willingness and ability to transform available resources into adaptive actions. In this context, adaptive capacity denotes the ability of social-ecological systems to adjust to the negative effects of environmental change or recovery from it. Hence, enhancing adaptive capacity enriches the ability to cope with a wider spectrum and greater magnitude of climate impacts. Based on the literature review and content analysis, this study explores the foundational concepts of adaptive capacity and further assesses the evolving focus on concept, scale, geographical emphasis, dimensions, and indicators through a systematic review. The findings underscore that adaptive capacity constitutes a multidimensional and interdisciplinary research domain characterized by a range of dimensions and indicators, and diverse methods and techniques at various geographic scales. The study found that adaptive capacity research has predominantly centered on asset-based analyses within the Sustainable Livelihoods Framework in the earlier stage. However, since the past decade, the focus has shifted to indicators like agency, technology, innovation, governance, knowledge, information, and infrastructure, besides climate variability and socio-economic and cultural diversity. It is suggested that to bridge the gap between adaptive capacity and actual adaptation action, policy interventions need to be targeted. The study concludes that, despite abundant research and available literature on climate change and adaptation, there is still a lack of context-specific understanding, particularly from an insider's perspective in South Asia. [ABSTRACT FROM AUTHOR]

As a part of our ongoing search for bioactive constituents of Artemisia capillaris, we isolated 4-O-caffeoyl-2-C-methyl-d-threonic acid (PPT-14). This is a rare caffeic acid ester derivative that is reported here for the first time in the Artemisia species, which is the third occurrence in any plant species worldwide. In this study, we evaluated the anti-diabetic potential of PPT-14 using in vitro and in silico approaches. PPT-14 demonstrated significant inhibitory activity against two crucial enzymes linked to diabetes progression and complications: protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR). These had IC50 values of 64.92 and 19.50 µM, respectively. Additionally, PPT-14 exhibited free radical scavenging activity with 2,2-diphenyl-2-picrylhydrazyl (IC50 14.46 µM). Molecular docking and 200 ns molecular dynamics simulations confirmed that there were stable binding interactions with the key residues of PTP1B and AR, highlighting strong affinity and dynamic stability. Pharmacokinetic analyses revealed favorable water solubility, adherence to Lipinski's Rule of Five, and minimal interactions with cytochrome P450 enzymes, indicating the drug-like potential of PPT-14. Toxicity studies confirmed its safety profile, showing no genotoxicity, hepatotoxicity, or significant toxicity risks, with an acceptable oral LD50 value of 2.984 mol/kg. These findings suggest that PPT-14 could be a promising multitarget lead compound for ameliorating diabetes and its associated complications. [ABSTRACT FROM AUTHOR]