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Abstract The concept of the Human Digital Twin (HDT) has recently emerged as a new research area within the domain of digital twin technology. HDT refers to the replica of a physical-world human in the digital world. Currently, research on HDT is still in its early stages, with a lack of comprehensive and in-depth analysis from the perspectives of universal frameworks, core technologies, and applications. Therefore, this paper conducts an extensive literature review on HDT research, analyzing the underlying technologies and establishing typical frameworks in which the core HDT functions or components are organized. Based on the findings from the aforementioned work, the paper proposes a generic architecture for the HDT system and describes the core function blocks and corresponding technologies. Subsequently, the paper presents the state of the art of HDT technologies and their applications in the healthcare, industry, and daily life domains. Finally, the paper discusses various issues related to the development of HDT and points out the trends and challenges of future HDT research and development.

Abstract BackgroundParkinson disease (PD) is reported to be among the most prevalent neurodegenerative diseases globally, presenting ongoing challenges and increasing burden on health care systems. In an effort to support patients with PD, their carers, and the wider health care sector to manage this incurable condition, the focus has begun to shift away from traditional treatments. One of the most contemporary treatments includes prescribing assistive technologies (ATs), which are viewed as a way to promote independent living and deliver remote care. However, the uptake of these ATs is varied, with some users not ready or willing to accept all forms of AT and others only willing to adopt low-technology solutions. Consequently, to manage both the demands on resources and the efficiency with which ATs are deployed, new approaches are needed to automatically assess or predict a user’s likelihood to accept and adopt a particular AT before it is prescribed. Classification algorithms can be used to automatically consider the range of factors impacting AT adoption likelihood, thereby potentially supporting more effective AT allocation. From a computational perspective, different classification algorithms and selection criteria offer various opportunities and challenges to address this need. ObjectiveThis paper presents a novel hybrid multicriteria decision-making approach to support classifier selection in technology adoption processes involving patients with PD. MethodsFirst, the intuitionistic fuzzy analytic hierarchy process (IF-AHP) was implemented to calculate the relative priorities of criteria and subcriteria considering experts’ knowledge and uncertainty. Second, the intuitionistic fuzzy decision-making trial and evaluation laboratory (IF-DEMATEL) was applied to evaluate the cause-effect relationships among criteria/subcriteria. Finally, the combined compromise solution (CoCoSo) was used to rank the candidate classifiers based on their capability to model the technology adoption. ResultsWe conducted a study involving a mobile smartphone solution to validate the proposed methodology. Structure (F5) was identified as the factor with the highest relative priority (overall weight=0.214), while adaptability (F4) (D-R=1.234) was found to be the most influencing aspect when selecting classifiers for technology adoption in patients with PD. In this case, the most appropriate algorithm for supporting technology adoption in patients with PD was the A3 - J48 decision tree (M3 ConclusionsThe IF-AHP-IF-DEMATEL-CoCoSo approach helped to identify classification algorithms that do not just discriminate between good and bad adopters of assistive technologies within the Parkinson population but also consider technology-specific features like design, quality, and compatibility that make these classifiers easily implementable by clinicians in the health care system.

Heterogeneous cross-project defect prediction (HCPDP) aims to predict defects in new software projects using defect data from previous software projects where the source and target projects have some different metrics. Most existing methods only find linear relationships in the software defect datasets. Additionally, these methods use multiple defect datasets from different projects as source datasets. In this paper, we propose a novel method called heterogeneous cross-project defect prediction using encoder networks and transfer learning (ENTL). ENTL uses encoder networks to extract the important features from source and target datasets. Also, to minimize the negative transfer during transfer learning, we used an augmented dataset that contains pseudo-labels and the source dataset. Additionally, we have used a single dataset to train the model. To evaluate the performance of the ENTL approach, 16 datasets from four publicly available software defect projects were used. Furthermore, we compared the proposed method with four HCPDP methods namely EGW, HDP_KS, CTKCCA and EMKCA, and one WPDP method from existing literature. The proposed method on average outperforms the baseline methods in terms of PD, PF, F1-score, G-mean and AUC.