28 results on '"Hufnagel G"'
Search Results
2. The impact of differential pricing subject on consumer behavior.
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Chen, Jinsong, Zhang, Yuexin, and Wu, Yumin
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CONSUMER behavior ,PERCEPTION (Philosophy) ,PRICE regulation ,ARTIFICIAL intelligence ,PERCEIVED control (Psychology) ,CONSUMER complaints - Abstract
The escalating use of artificial intelligence in marketing significantly impacts all aspects of consumer life. This research, grounded in attribution theory and S–O-R theory, employs scenario-based experimental methods to simulate two distinct purchasing contexts. The aim is to investigate consumers' psychological and behavioral responses to AI-initiated pricing. Through SPSS analysis of variance and Bootstrap analysis, the mechanisms of influence of AI-initiated pricing on consumer behavior are tested, revealing the mediating variables of mind perception and consumer perceived ethicality, as well as the mediating variables of perceived enterprise control. Data were collected from Chinese customers to test the model of this study. A total of 841 valid questionnaires were analyzed using ANOVA and Bootstrap analysis with SPSS. The results show that: (1) Consumers exhibit higher repurchase and word-of-mouth recommendation behaviors and lower complaint and switching behaviors for AI-initiated pricing compared to marketers; (2) AI-initiated pricing leads to diminished mind perceptions and augmented ethical perceptions among consumers. Ethical perceptions serve as a complete mediator, while mind perceptions play a less significant mediating role; (3) Perceived enterprise control plays a moderating role in the impact of AI-initiated pricing on consumer behavior. That is, when consumers know that the enterprise can control pricing agents, AI-initiated pricing leads to lower repurchase and word-of-mouth recommendation behaviors, and higher instances of complaining and switching behaviors than humans. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Viral Myocarditis as a Factor Leading to the Development of Heart Failure Symptoms, Including the Role of Parvovirus B19 Infection—Systematic Review.
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Krych, Sebastian, Jęczmyk, Agata, Jurkiewicz, Michał, Żurek, Martyna, Jekiełek, Małgorzata, Kowalczyk, Paweł, Kramkowski, Karol, and Hrapkowicz, Tomasz
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HEART failure ,DILATED cardiomyopathy ,SYMPTOMS ,VIRUS diseases ,PROGNOSIS ,PARVOVIRUS B19 - Abstract
Myocarditis (MC) is defined as an immunological inflammatory reaction with various etiologies, clinical presentations and prognoses within the myocardium. Currently, parvovirus B19 (PVB19) has become the main factor leading to this disease, replacing the previously dominant viruses A and B. In the case of chronic heart failure with subsequent dilated cardiomyopathy, approximately 67% have a viral etiology, and most of them are the result of PVB19 infection. However, the analysis showed a correlation between PVB19 infection and the risk of developing inflammatory dilated cardiomyopathy (DCMi). PVB19 is detected in 23% of patients with DCMi. Chronic infection may also contribute to progressive left ventricular failure in patients with a history of MC. The above effect suggests the active replication of PVB19 only in heart biopsies with inflammation due to MC or DCMi. Moreover, the supply of IFN-β to suppress the active transcription of PVB19 accompanied by DCMi over a period of 6 months results in the normalization of NT-proBNP and an improvement in LVEF along with NYHA performance. The small number of reports on this topic and inaccuracies resulting from constantly conducted research and ongoing changes make it impossible to clearly answer the question of whether PVB19 is a factor inducing de novo MC and DCM or only accompanies the above conditions. However, large clinical cohort studies lead to the perception of PVB19 as a viral etiological agent capable of causing de novo MC together with DCMi. [ABSTRACT FROM AUTHOR]
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- 2024
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4. Baicalein suppresses Coxsackievirus B3 replication by inhibiting caspase-1 and viral protease 2A.
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Yanyan Dong, Enze Shao, Siwei Li, Ruiqi Wang, Dan Wang, Lixin Wang, Hong Yang, Yingxia He, Tian Luan, Yang Chen, Yao Wang, Lexun Lin, Yan Wang, Zhaohua Zhong, and Wenran Zhao
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CASPASES ,MYOCARDIUM ,ENTEROVIRUS diseases ,DILATED cardiomyopathy ,VIRAL proteins ,YOUNG adults - Abstract
Myocarditis is an inflammatory disease of the cardiac muscle and one of the primary causes of dilated cardiomyopathy. Group B coxsackievirus (CVB) is one of the leading causative pathogens of viral myocarditis, which primarily affects children and young adults. Due to the lack of vaccines, the development of antiviral medicines is crucial to controlling CVB infection and the progression of myocarditis. In this study, we investigated the antiviral effect of baicalein, a flavonoid extracted from Scutellaria baicaleinsis. Our results demonstrated that baicalein treatment significantly reduced cytopathic effect and increased cell viability in CVB3-infected cells. In addition, significant reductions in viral protein 3D, viral RNA, and viral particles were observed in CVB3-infected cells treated with baicalein. We found that baicalein exerted its inhibitory effect in the early stages of CVB3 infection. Baicalein also suppressed viral replication in the myocardium and effectively alleviated myocarditis induced by CVB3 infection. Our study revealed that baicalein exerts its antiviral effect by inhibiting the activity of caspase-1 and viral protease 2A. Taken together, our findings demonstrate that baicalein has antiviral activity against CVB3 infection and may serve as a potential therapeutic option for the myocarditis caused by enterovirus infection. [ABSTRACT FROM AUTHOR]
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- 2024
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5. Immunomodulating and Immunosuppressive Therapy for Virus-Negative Immune-Mediated Myocarditis.
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Frustaci, Andrea, Letizia, Claudio, Alfarano, Maria, Marchionni, Giulia, Verardo, Romina, and Chimenti, Cristina
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CARDIOMYOPATHIES ,CONNECTIVE tissue diseases ,HEART failure ,DRUG allergy ,SYMPTOMS - Abstract
Myocarditis is an inflammatory disease of the myocardium caused by infectious and noninfectious agents. Clinical manifestations range from mildly symptomatic forms to acute heart failure, cardiogenic shock, life-threatening arrhythmias and sudden death. Myocarditis is still a challenging diagnosis because of its wide variability in clinical presentation and unpredictable course. Moreover, a standardized, specific treatment in not yet available. Immunosuppressive treatment for virus-negative lymphocytic myocarditis is still controversial. Conversely, immunosuppression is well established in sarcoidosis, eosinophilic, giant-cell, drug hypersensitivity, and trauma-related myocarditis as well as lymphocytic myocarditis associated with connective tissue diseases or with the rejection of a transplanted heart. Recently, immunosuppressive therapy has been also recognized as an effective treatment in virus-negative inflammatory cardiomyopathy. The aim of this review is to underline the role of immunomodulating and immunosuppressive therapies in patients with immune-mediated myocarditis and illustrate the different treatment strategies depending on the etiology. An endomyocardial biopsy remains the gold standard for the diagnosis of myocarditis as well as for a tailored treatment. [ABSTRACT FROM AUTHOR]
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- 2024
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6. Sudden death of a 12-year-old boy with severe myocardial fibrosis due to inapparent chronic myocarditis.
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Madea, B., Duval, I., and Doberentz, E.
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Sudden death due to unknown cardiac disease in children is an unusual occurrence. An apparently healthy 12-year-old boy without any physical restrictions collapsed suddenly and died despite cardiopulmonary resuscitation. The main autopsy finding was extensive scarring of the myocardium, especially the interventricular septum. This extensive scarring was exceptional for the young age. Histologically, replacement-type fibrosis with patchy lymphomonocytic infiltrate and infiltration by macrophages were observed. The case was diagnosed as chronic myocarditis, which may have progressed to dilated cardiomyopathy with inflammation or inflammatory cardiomyopathy. [ABSTRACT FROM AUTHOR]
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- 2024
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7. Personalised pricing under the current European legal framework: a call for ethics, sustainability and responsibility in the age of artificial intelligence.
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van der Rest, Jean-Pierre and Heidary, Kimia
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PRICING ,ARTIFICIAL intelligence ,TOURISM - Abstract
As pricing in hospitality and tourism evolves due to the opportunities presented by artificial intelligence (AI), so do the concerns that come with technological advancements. There is a fine line between what is possible, what is profitable, and what is ethical, sustainable and responsible in the use of AI for pricing. This viewpoint article draws attention to the dark side of pricing, and presents a framework towards sustainable pricing, against the backdrop of the current European Union legal framework. The framework includes ethical guidelines, self-regulation, self-protection and technological regulation, which should be considered as a whole. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Major Group-B Enterovirus populations deleted in the noncoding 5' region of genomic RNA modulate activation of the type I interferon pathway in cardiomyocytes and induce myocarditis.
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Callon, Domitille, Glenet, Marie, Lebreil, Anne-Laure, Heng, Laetitia, Bouland, Nicole, Fichel, Caroline, Fornes, Paul, Andreoletti, Laurent, and Berri, Fatma
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TYPE I interferons ,INTERFERONS ,MYOCARDITIS ,RNA ,VIRAL genomes ,HEART cells ,HAIRPIN (Genetics) - Abstract
Major 5'-terminally deleted (5'TD) RNA forms of group-B coxsackievirus (CVB-5'TD) has been associated with myocarditis in both mice and humans. Although it is known that interferon-β (IFN-β) signaling is critical for an efficient innate immune response against CVB-induced myocarditis, the link between CVB-5'TD RNA forms and type I IFN signaling in cardiomyocytes remains to be explored. In a mouse model of CVB3/28-induced myocarditis, major early-emerging forms of CVB-5'TD RNA have been characterized as replicative viral populations that impair IFN-β production in the heart. Synthetic CVB3/28 RNA forms mimicking each of these major 5'TD virus populations were transfected in mice and have been shown to modulate innate immune responses in the heart and to induce myocarditis in mice. Remarkably, transfection of synthetic viral RNA with deletions in the secondary structures of the 5'-terminal CVB3 RNA domain I, modifying stem-loops "b", "c" or "d", were found to impair IFN-β production in human cardiomyocytes. In addition, the activation of innate immune response by Poly(I:C), was found to restore IFN-β production and to reduce the burden of CVB-5'TD RNA-forms in cardiac tissues, thereby reducing the mortality rate of infected mice. Overall, our results indicate that major early-emerging CVB3 populations deleted in the domain I of genomic RNA, in the 5' noncoding region, modulate the activation of the type I IFN pathway in cardiomyocytes and induce myocarditis in mice. These findings shed new light on the role of replicative CVB-5'TD RNA forms as key pathophysiological factors in CVB-induced human myocarditis. Author summary: Myocarditis is an inflammatory disease of the heart. Viruses or post-viral immune mediated response are the main causes of myocarditis. Human group B enteroviruses, specifically Coxsackievirus B3 (CVB3), are common infectious causes of acute myocarditis in the young. Early emergence and maintenance of major 5'terminally deleted RNA forms of CVB have been associated with acute and chronic myocarditis in both mice and humans. To achieve viral genome maintenance in the cardiac cells, viruses could modulate innate immunity activation. Here, we report on major early-emerging CVB3 populations deleted in the 5'non-coding region of viral genomic RNA that modulate the activation of the type I interferon pathway in cardiomyocytes and cause myocarditis in mice. Activating the innate immune sensors after CVB3 infection protects mice from CVB3-induced myocarditis and shall promote further studies in immunotherapies in viral acute and chronic myocarditis. [ABSTRACT FROM AUTHOR]
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- 2024
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9. The Epidemiology of COVID-19 Vaccine-Induced Myocarditis.
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Costa, Christos and Moniati, Foteini
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- 2024
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10. Clinical Application of Extracorporeal Membrane Oxygenation in the Treatment of Fulminant Myocarditis.
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Zhijun Fan, Junlin Wen, Binfei Li, and Xiaozu Liao
- Abstract
Fulminant myocarditis (FM) is a rare but serious clinical syndrome which can be characterized by the rapid deterioration of cardiac function, with cardiogenic shock (CS) and arrhythmic electrical storms being common presentations, often requiring adjunctive support with mechanical circulatory devices. With the development of mechanical circulatory support (MCS) devices, there are now more and more studies investigating the application of MCS in FM patients, and the use of extracorporeal membrane oxygenation (ECMO) to treat FM has shown good survival rates. This review elucidates the treatment of FM, and the application and clinical outcomes associated with ECMO intervention. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Does culture matter? Corporate reputation and sustainable satisfaction in the Chinese and German banking sector.
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Damberg, Svenja, Liu, Yide, and Ringle, Christian M.
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BANK management ,BANKING industry ,CORPORATE image ,SATISFACTION ,INTERNATIONAL banking industry ,SCIENTIFIC knowledge - Abstract
Corporate reputation is important for all types of banks across the world, despite these countries differing culturally. Building on an extended corporate reputation model, we identify the key drivers of customer-based reputation and sustainable customer satisfaction in two culturally different countries, namely China and Germany. We also consider two reputation dimensions—perceived competence and likeability—and their effects on the target construct. Empirical data from 625 German and 734 Chinese commercial bank customers allow us to estimate the corporate reputation model with the partial least squares structural equation modeling (PLS-SEM) method, and by substantiating the relationships by means of a necessary condition analysis (NCA) and a predictive power analysis. By comparing the two countries' results, we identify their cultural differences. Overall, we confirm the model's relevance for the two cultures, finding that banks' perceived attractiveness is the most important driver of both cultures' customer-perceived bank reputation. By means of an importance-performance map analysis, we identify a large overlap between the two cultures' set of important constructs, likeability's much greater importance in Germany, and the perceived quality construct's relevance in both countries. We contribute to research and scientific knowledge about corporate reputation models by identifying the similarities in and differences between two countries' markets with respect to the banking sector, all of which have implications for international banks' management. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Mt10 Vaccine Protects Diversity Outbred Mice from CVB3 Infection by Producing Virus-Specific Neutralizing Antibodies and Diverse Antibody Isotypes.
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Rasquinha, Mahima T., Mone, Kiruthiga, Sur, Meghna, Lasrado, Ninaad, Massilamany, Chandirasegaran, Kachman, Stephen D., Steffen, David, and Reddy, Jay
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FOOT & mouth disease ,HUMAN genetic variation ,IMMUNOGLOBULINS ,VIRAL proteins ,VIRAL vaccines ,MICE - Abstract
Group B coxsackieviruses (CVBs) cause a wide range of diseases in humans, but no vaccines are currently available to prevent these infections. Previously, we had demonstrated that a live attenuated CVB3 vaccine virus, Mutant 10 (Mt10), offers protection against multiple CVB serotypes as evaluated in various inbred mouse strains; however, the applicability of these findings to the outbred human population remains uncertain. To address this issue, we used Diversity Outbred (DO) mice, whose genome is derived from eight inbred mouse strains that may capture the level of genetic diversity of the outbred human population. To determine the efficacy of the Mt10 vaccine, we established the CVB3 infection model in the DO mice. We noted that CVB3 infection resulted mainly in pancreatitis, although viral RNA was detected in both the pancreas and heart. Histologically, the pancreatic lesions comprised of necrosis, post-necrotic atrophy, and lymphocyte infiltration. In evaluating the efficacy of the Mt10 vaccine, both male and female DO mice were completely protected in challenge studies with CVB3, and viral RNA was not detected in the heart or pancreas. Likewise, vaccine recipients of both sexes showed significant levels of virus-neutralizing antibodies. Furthermore, by using the CVB3 viral protein 1, virus-reactive antibodies were found to be diverse in the order of IgG2c, followed by IgG2a, IgG2b/IgG3, and IgG1. Together, the data suggest that the Mt10 vaccine virus can offer protection against CVB infections that may have translational significance. [ABSTRACT FROM AUTHOR]
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- 2024
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13. Exploring the Impact of Coconut Peat and Vermiculite on the Rhizosphere Microbiome of Pre-Basic Seed Potatoes under Soilless Cultivation Conditions.
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Yan, Kan, Ma, Yanni, Bao, Songming, Li, Wandi, Wang, Yunjiao, Sun, Chao, Lu, Xin, and Ran, Juan
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SEED potatoes ,VERMICULITE ,POTATO seeds ,POTATOES ,PEAT ,COCONUT ,HYDROPONICS ,PLANT growing media - Abstract
Soilless cultivation of potatoes often utilizes organic coconut peat and inorganic vermiculite as growing substrates. The unique microbial communities and physicochemical characteristics inherent to each substrate significantly influence the microecological environment crucial for potato growth and breeding. This study analyzed environmental factors within each substrate and employed Illumina sequencing alongside bioinformatics tools to examine microbial community structures, their correlation with environmental factors, core microbial functions, and the dynamics of microbial networks across various samples. These included pure coconut peat (CP1) and pure vermiculite (V1), substrates mixed with organic fertilizer for three days (CP2 and V2), and three combinations cultivated with potatoes for 50 days (CP3, V3, and CV3—a 1:1 mix of coconut peat and vermiculite with organic fertilizer). Vermiculite naturally hosts a more diverse microbial community. After mixing with fertilizer and composting for 3 days, and 50 days of potato cultivation, fungal diversity decreased in both substrates. Coconut peat maintains higher bacterial diversity and richness compared to vermiculite, harboring more beneficial bacteria and fungi, resulting in a more complex microbial network. However, vermiculite shows lower bacterial diversity and richness, with an accumulation of pathogenic microorganisms. Among the 11 environmental factors tested, water-soluble nitrogen (WSN), total nitrogen (TN), available potassium (AK), total organic carbon (TOC) and air-filled porosity (AFP) were significantly associated with microbial succession in the substrate.The nutritional type composition and interaction patterns of indigenous microorganisms differ between vermiculite and coconut peat. Adding abundant nutrients significantly affects the stability and interaction of the entire microbial community, even post-potato cultivation. When using vermiculite for soilless cultivation, precise control and adjustment of nutrient addition quantity and frequency are essential. [ABSTRACT FROM AUTHOR]
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- 2024
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14. Interferon-stimulated gene PVRL4 broadly suppresses viral entry by inhibiting viral-cellular membrane fusion.
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Cai, Qiaomei, Sun, Nina, Zhang, Yurui, Wang, Jingfeng, Pan, Chaohu, Chen, Yu, Li, Lili, Li, Xiaorong, Liu, Wancheng, Aliyari, Saba R., Yang, Heng, and Cheng, Genhong
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SARS-CoV-2 ,MEMBRANE fusion ,VIRUS diseases ,TYPE I interferons ,INTERFERON receptors - Abstract
Background: Viral infection elicits the type I interferon (IFN-I) response in host cells and subsequently inhibits viral infection through inducing hundreds of IFN-stimulated genes (ISGs) that counteract many steps in the virus life cycle. However, most of ISGs have unclear functions and mechanisms in viral infection. Thus, more work is required to elucidate the role and mechanisms of individual ISGs against different types of viruses. Results: Herein, we demonstrate that poliovirus receptor-like protein4 (PVRL4) is an ISG strongly induced by IFN-I stimulation and various viral infections. Overexpression of PVRL4 protein broadly restricts growth of enveloped RNA and DNA viruses, including vesicular stomatitis virus (VSV), herpes simplex virus 1 (HSV-1), influenza A virus (IAV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whereas deletion of PVRL4 in host cells increases viral infections. Mechanistically, it suppresses viral entry by blocking viral-cellular membrane fusion through inhibiting endosomal acidification. The vivo studies demonstrate that Pvrl4-deficient mice were more susceptible to the infection of VSV and IAV. Conclusion: Overall, our studies not only identify PVRL4 as an intrinsic broad-spectrum antiviral ISG, but also provide a candidate host-directed target for antiviral therapy against various viruses including SARS-CoV-2 and its variants in the future. [ABSTRACT FROM AUTHOR]
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- 2024
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15. Persistent peritonitis in peritoneal dialysis: a comphrenesive review of recurrent, relapsing, refractory, and repeat peritonitis.
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Wang, Aaron H., Sawyer, Kelsey, and Shah, Ankur D.
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Peritonitis is a major cause of morbidity and technique failure in patients receiving peritoneal dialysis. Complicated peritonitis that manifests as multiple or unresolving episodes is classified as refractory, recurrent, relapsing, or repeat peritonitis, and often possesses higher risk of technique failure and mortality as well as lower complete cure rates than primary or uncomplicated episodes. While these peritonitis subtypes affect a considerable portion of PD patients, details regarding their epidemiology, pathogenesis, diagnosis, clinical sequelae, and management have not yet been fully elucidated. Improved clinical awareness and understanding of complicated peritonitis subtypes is crucial to ensure optimal management for these patients; thus, we consolidate and report the pertinent findings of recent literature on these four entities. [ABSTRACT FROM AUTHOR]
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- 2024
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16. A consumer perspective of AI certification – the current certification landscape, consumer approval and directions for future research.
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Blösser, Myrthe and Weihrauch, Andrea
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SOCIAL marketing ,SOCIAL media in marketing ,ARTIFICIAL intelligence ,CONSUMERS ,CONSUMER preferences ,TRUST - Abstract
Purpose: In spite of the merits of artificial intelligence (AI) in marketing and social media, harm to consumers has prompted calls for AI auditing/certification. Understanding consumers' approval of AI certification entities is vital for its effectiveness and companies' choice of certification. This study aims to generate important insights into the consumer perspective of AI certifications and stimulate future research. Design/methodology/approach: A literature and status-quo-driven search of the AI certification landscape identifies entities and related concepts. This study empirically explores consumer approval of the most discussed entities in four AI decision domains using an online experiment and outline a research agenda for AI certification in marketing/social media. Findings: Trust in AI certification is complex. The empirical findings show that consumers seem to approve more of non-profit entities than for-profit entities, with the government approving the most. Research limitations/implications: The introduction of AI certification to marketing/social media contributes to work on consumer trust and AI acceptance and structures AI certification research from outside marketing to facilitate future research on AI certification for marketing/social media scholars. Practical implications: For businesses, the authors provide a first insight into consumer preferences for AI-certifying entities, guiding the choice of which entity to use. For policymakers, this work guides their ongoing discussion on "who should certify AI" from a consumer perspective. Originality/value: To the best of the authors' knowledge, this work is the first to introduce the topic of AI certification to the marketing/social media literature, provide a novel guideline to scholars and offer the first set of empirical studies examining consumer approval of AI certifications. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Addressing Cultural Stigma: Endometriosis Diagnosis in the Arab World.
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Al Shukri, Maryam and Almarzooqi, Maryam
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ENDOMETRIOSIS ,SOCIAL stigma ,DELAYED diagnosis ,QUALITY of life - Abstract
Copyright of Gulf Education & Social Policy Review is the property of Knowledge E DMCC and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2024
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18. Fibrinolytic Platelet Decoys Reduce Cancer Metastasis by Dissociating Circulating Tumor Cell Clusters.
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Schnoor B, Morris K, Kottana RK, Muldoon R, Barron J, and Papa AL
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During metastasis, circulating tumor cells (CTCs) can travel in the bloodstream as individual cells or clusters, associated with fibrin and platelets. Clusters have a higher metastatic potential due to their increased ability to withstand shear stress and arrest in small vessels. Moreover, CTC-platelet interaction protects CTCs from shear stress and immune detection. The objective of this project is to develop a fibrinolytic platelet system to leverage platelet-CTC interactions and dissociate CTC clusters. For this approach, tissue plasminogen activator (tPA) is loaded onto two modified platelet systems: platelet Decoys and lyophilized platelets. The activities of the systems are characterized using a Förster Resonance Energy Transfer-based assay and an angiogenic assay. Furthermore, the ability of the system to dissociate cancer cell clusters in vitro is assessed using light transmission aggregometry. The data demonstrates that the fibrinolytic platelets can maintain tPA activity, interact with CTCs, and dissociate cancer cell clusters. Finally, fibrinolytic platelets are assessed in vivo, demonstrating a decreased tumor load and increased survival with tPA-Decoy treatment, which is selected as the optimal treatment based on favorable in vitro results and in vivo trials. Therefore, this fibrinolytic platelet approach is a promising method for leveraging platelet-CTC interactions to disperse CTC clusters and reduce metastasis., (© 2024 Wiley‐VCH GmbH.)
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- 2024
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19. A 3-month-old neonatal rhesus macaque HFMD model caused by coxsackievirus B1 infection and viral tissue tropism.
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Suqin D, Yongjie L, Wei Z, Ming Z, Yanyan L, Yuan Z, Weihua J, Quan L, Mingxue L, Wenting S, Lixiong C, Hongjie X, Jie T, Jingshan H, Zijun D, Fengmei Y, Shaohui M, and Zhanlong H
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- Animals, Antibodies, Viral blood, Antibodies, Neutralizing blood, Antibodies, Neutralizing immunology, Animals, Newborn, Cytokines metabolism, Macaca mulatta, Hand, Foot and Mouth Disease virology, Hand, Foot and Mouth Disease pathology, Disease Models, Animal, Viral Tropism, Viral Load, Enterovirus B, Human physiology, Enterovirus B, Human pathogenicity
- Abstract
Coxsackievirus B1 (CVB1), an enterovirus with multiple clinical presentations, has been associated with potential long-term consequences, including hand, foot, and mouth disease (HFMD), in some patients. However, the related animal models, transmission dynamics, and long-term tissue tropism of CVB1 have not been systematically characterized. In this study, we established a model of CVB1 respiratory infection in rhesus macaques and evaluated the clinical symptoms, viral load, and immune levels during the acute phase (0-14 days) and long-term recovery phase (15-30 days). We also investigated the distribution, viral clearance, and pathology during the long-term recovery period using 35 postmortem rhesus macaque tissue samples collected at 30 days postinfection (d.p.i.). The results showed that the infected rhesus macaques were susceptible to CVB1 and exhibited HFMD symptoms, viral clearance, altered cytokine levels, and the presence of neutralizing antibodies. Autopsy revealed positive viral loads in the heart, spleen, pancreas, soft palate, and olfactory bulb tissues. HE staining demonstrated pathological damage to the liver, spleen, lung, soft palate, and tracheal epithelium. At 30 d.p.i., viral antigens were detected in visceral, immune, respiratory, and muscle tissues but not in intestinal or neural tissues. Brain tissue examination revealed viral meningitis-like changes, and CVB1 antigen expression was detected in occipital, pontine, cerebellar, and spinal cord tissues at 30 d.p.i. This study provides the first insights into CVB1 pathogenesis in a nonhuman primate model of HFMD and confirms that CVB1 exhibits tissue tropism following long-term infection., (© 2024 The Author(s). Journal of Medical Virology published by Wiley Periodicals LLC.)
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- 2024
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20. Chinese Society of Cardiology guidelines on the diagnosis and treatment of adult fulminant myocarditis.
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Jiang J, Shu H, Wang DW, Hui R, Li C, Ran X, Wang H, Zhang J, Nie S, Cui G, Xiang D, Shao Q, Xu S, Zhou N, Li Y, Gao W, Chen Y, Bian Y, Wang G, Xia L, Wang Y, Zhao C, Zhang Z, Zhao Y, Wang J, Chen S, Jiang H, Chen J, Du X, Chen M, Sun Y, Li S, Ding H, Ma X, Zeng H, Lin L, Zhou S, Ma L, Tao L, Chen J, Zhou Y, and Guo X
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- Humans, China, Adult, Cardiology methods, Cardiology standards, Prognosis, Societies, Medical, Myocarditis diagnosis, Myocarditis therapy
- Abstract
Fulminant myocarditis is an acute diffuse inflammatory disease of myocardium. It is characterized by acute onset, rapid progress and high risk of death. Its pathogenesis involves excessive immune activation of the innate immune system and formation of inflammatory storm. According to China's practical experience, the adoption of the "life support-based comprehensive treatment regimen" (with mechanical circulation support and immunomodulation therapy as the core) can significantly improve the survival rate and long-term prognosis. Special emphasis is placed on very early identification,very early diagnosis,very early prediction and very early treatment., (© 2024. Science China Press.)
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- 2024
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21. Lagrangian dynamics of the spring zooplankton community in a large river
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Hromova, Yuliia, Brauns, Mario, and Kamjunke, Norbert
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- 2024
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22. Mechanical convergence in mixed populations of mammalian epithelial cells
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Gauquelin, Estelle, Kuromiya, Keisuke, Namba, Toshinori, Ikawa, Keisuke, Fujita, Yasuyuki, Ishihara, Shuji, and Sugimura, Kaoru
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- 2024
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23. Entfremdung und Illusion : Soziales Handeln in der Moderne
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Horst Pöttker and Horst Pöttker
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- 2024
24. The Rose and Mackay Textbook of Autoimmune Diseases
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M. Eric Gershwin, George C. Tsokos, Betty Diamond, M. Eric Gershwin, George C. Tsokos, and Betty Diamond
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The Rose-Mackay Textbook of Autoimmune Diseases, Seventh Edition is a comprehensive reference that emphasizes the'3 P's'of 21st Century medicine: precision, prediction, and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ('omics') coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. This new edition continues its success with 75% of the content revised, updated, or completely new. This edition is a valuable resource to clinicians involved in the diagnosis and treatment of autoimmune disease, as well as to scientists who want to follow developments in the field.Provides new research on autoimmune diseases, their diagnosis, prevention, and therapyCovers a complete range of all common, rare and new autoimmune diseases, including cancer and COVIDExtensively revised with 75% new material based on autoimmunity, developments in the different diagnosis and therapies for these autoimmune diseases, and a completely updated description of the different diseasesSupplemented with a website that hosts a Podcast per chapter
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- 2024
25. Neurotransmitters and Toxicology
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Kevin Woodward, Tim Marrs, Kevin Woodward, and Tim Marrs
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- Toxicology, Neurotoxicology
- Abstract
Neurotransmitters are usually considered to be endogenous substances that are released from neurons, act on receptor sites that are typically present on membranes of postsynaptic cells and produce a functional change in the properties of the target cell. They are essential features of the nervous systems of all animals, and numerous chemicals can act as neurotransmitters either intentionally (e.g. pesticides) or unintentionally (neurotoxins). The most common forms of neurotoxicity are the death of neurons, degeneration of axons, damage to glial cells and interference with the axonal membrane or neurotransmission. Important neurotoxins are found among pesticides, metals, solvents, natural substances, and industrial chemicals. Environmental chemicals may also contribute to the pathology of neurodevelopmental, neuropsychiatric, and neurodegenerative disorders. Neurotransmitters and Toxicology will be particularly appealing to toxicologists interested in neurotoxicology in various sub-disciplines, as well as neuro-chemists interested in pathology and disease mechanisms associated with neurotoxicants.
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- 2024
26. Bioremediation of Emerging Contaminants From Soils : Soil Health Conservation for Improved Ecology and Food Security
- Author
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Prasann Kumar, Veena Chaudhary, Eric D. van Hullebusch, Rosa Busquets, Arun Lal Srivastav, Prasann Kumar, Veena Chaudhary, Eric D. van Hullebusch, Rosa Busquets, and Arun Lal Srivastav
- Abstract
Bioremediation of Emerging Contaminants from Soils: Soil Health Conservation Along with Food Security deals with current challenges of sustainable soil health using eco-friendly approaches. This book provides ways of reducing the chemicals burden on the soil by maintaining balance in terms of society, environment and economy, which are considered basic pillars of sustainability. Designed to highlight soil health best practices for both environmental and agricultural sustainability, these approaches are also considered important for improving global food security by ensuring safe growing conditions for crops for food and feed. Presented in two parts, the book first highlights emerging contaminants and their sources. The second part explores a variety of steps and tools for addressing contaminated soils including bio- and phytoremediation options. Case studies in each part provide real-world insights for practical application. This book will be unique in the specified area of sustainability using the principles of bioremediation. Moreover, scientists, researchers, and policymakers will receive insights to develop and explore innovate approaches to achieve sustainable development goals. Contains the latest practical and theoretical aspects of the soil health crisis and its management Presents collective information to ensure the remediation of soil from emerging contaminants Serves as baseline information for environmental issues in agriculture along with their alternative eco-friendly solutions
- Published
- 2024
27. Exploring the Financial Landscape in the Digital Age : Proceedings of the International Conference on Financial Management and the Digital Economy (ICFMDE 2023), Kuala Lumpur, Malaysia, 15–17 December 2023
- Author
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Thomas Andreas Maurer and Thomas Andreas Maurer
- Abstract
The Proceedings of the International Conference on Financial Management and the Digital Economy (ICFMDE 2023) offers an overview of research and insights into how financial management is evolving in the digital age.The book covers a broad spectrum from examining cryptocurrency trends to exploring fintech advancements. Topics also extend to digital transformation strategies, practical applications of blockchain technology, and the profound impact of digital innovations on financial markets. Through rigorous research and analysis, the proceedings offer valuable insights into the future trajectory of the global economy.Written for scholars, researchers, and industry professionals in finance, economics, and digital innovation, this collection provides valuable insights into the rapidly changing field of financial management. Readers will gain deep perspectives on how digitalization is reshaping financial landscapes worldwide.
- Published
- 2024
28. Max Webers Staatstheorie im Kontext seines Werkes.
- Author
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Michael Zängle and Michael Zängle
- Published
- 2024
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