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ObjectiveTo explore the compliance related factors of repeated screening for colorectal cancer in Jiading District, and to provide a scientific basis for the prevention and control of colorectal cancer.MethodsBased on the natural population cohort in Jiading District, and the screening situation in 2017‒2019 and 2020‒2022, the study subjects were divided into the groups of never participating in screening and participating in screening. Subjects in the participating group were further divided into participating in one round of screening or having repeated screening. SPSS 21.0 software was used to analyze the demographic characteristics of each group. χ2 test or Fisher precise probability test were used to conduct univariate analysis of the factors such as gender, age, education level, marital status, retirement status, and type of medical insurance. Factors with the significant difference (P

Chronic myelomonocytic leukemia (CMML) complicated with immune thrombocytopenia (ITP) is rare. This article reports the clinical data of a patient with CMML complicated with ITP treated with a combination of venetoclax, ripertamab (an anti-CD20 monoclonal antibody), and hetrombopag. The coexistence mechanism of CMML and ITP needs to be further clarified. Venetoclax combined with anti-CD20 monoclonal antibody and thrombopoietin receptor agonist may be an effective strategy for the treatment of this complication.

Objective: In order to predict and control the hot air drying process of Mango. Methods: Using fresh Mangifera indica Linn as experimental material, the effects were studied in different hot air temperatures (60, 65, 70 ℃) and different thickness of Mango slices (0.8, 1.0, 1.2 cm) on the drying curve, drying characteristic curve and effective moisture diffusion coefficient of Mango. Selecting six commonly used drying models suitable for fruits and vegetables for fitting, analysis, and validation, the most suitable model for Mango hot air drying was selected. Results: With the increase of temperature and the decrease of slice thickness, the drying rate of Mango slices was accelerated, resulting in shorter drying times. The effective diffusion coefficient of water increases with the increase of temperature and thickness, in the range of 1.401 39×10-10 to 3.655 46×10-10 m2/s. R2 of Logarithmic model was the largest, and X2 and RMSE were the smallest, which were 0.998 87, 0.000 124 779 and 0.001 37 respectively. Conclusion: The predicted values are basically consistent with the experimental values, accord with Mango hot air drying, it can better reflect the changing law of moisture content of Mango slices during drying.

Nocardia disease is an opportunistic infection, the occurrence is rare and mostly occurs in patients with immune deficiency. Even if the patient is immunocompetent, it can still be life-threatening. This case report describes a previously healthy 78-year-old male farmer with lung lesions discovered on a computerized tomography scan. Combined with the patient’s history of fever and the results of elevated laboratory markers associated with inflammation, the patient was diagnosed with a lung infection. After escalating empirical broad-spectrum antibiotics, antiviral and antifungal therapy, the patient continued to deteriorate to septic shock. In the meanwhile, the patient’s sputum was cultured repeatedly, and no obvious positive pathogenic bacteria were found. Considering the patient was elderly and that these lesions were solid with burr signs, as well as the progression after antimicrobial therapy cancer was considered in the differential diagnosis. Artificial intelligence (YITU, Hangzhou Yitu Medical Technology Limited Company) was also applied, and it also calculated that these lesions were cancerous. The patient received a puncture biopsy of the largest lung lesion. During the puncture pus was withdrawn from largest lung lesion. Culture and metagenome next-generation sequencing (mNGS) detection performed on pus indicated Nocardia otitidiscaviarum. The test report of the mNGS is also attached with a susceptibility report of commonly used clinical antibiotics to this Nocardia spp. Using this result, the patient’s disease was quickly controlled after selecting the targeted drug compound sulfamethoxazole and intravenous meropenem for treatment. In view of the high misdiagnosis rate and poor sensitivity of culture for Nocardia spp., this case emphasized mNGS playing a key role in the diagnosis and selection of effective antibiotics for the treatment of Nocardia spp. lung infections.

Abstract Spinal cord injury (SCI) leads to massive cell death, disruption, and demyelination of axons, resulting in permanent motor and sensory dysfunctions. Stem cell transplantation is a promising therapy for SCI. However, owing to the poor microenvironment that develops following SCI, the bioactivities of these grafted stem cells are limited. Cell implantation combined with biomaterial therapies is widely studied for the development of tissue engineering technology. Herein, an insulin‐like growth factor‐1 (IGF‐1)‐bioactive supramolecular nanofiber hydrogel (IGF‐1 gel) is synthesized that can activate IGF‐1 downstream signaling, prevent the apoptosis of neural stem cells (NSCs), improve their proliferation, and induce their differentiation into neurons and oligodendrocytes. Moreover, implantation of NSCs carried out with IGF‐1 gels promotes neurite outgrowth and myelin sheath regeneration at lesion sites following SCI. In addition, IGF‐1 gels can enrich extracellular vesicles (EVs) derived from NSCs or from nerve cells differentiated from these NSCs via miRNAs related to axonal regeneration and remyelination, even in an inflammatory environment. These EVs are taken up by autologous endogenous NSCs and regulate their differentiation. This study provides adequate evidence that combined treatment with NSCs and IGF‐1 gels is a potential therapeutic strategy for treating SCI.

To enhance the effectiveness and teaching quality of ideological and political education in colleges and universities, this study used a questionnaire survey method to collect data for teachers and students of X University. The collected data were validated and analyzed through structural equation modeling and Pearson’s correlation coefficient to ensure accuracy. The study constructed a multiple linear regression model of ideological and political education and estimated the model parameters with robustness. In particular, tutor involvement was introduced as a mediating variable to explore its mediating role between students’ personalized learning characteristics and the practical effects of ideological and political education. It was found that students’ customized learning characteristics had a significant positive impact on the functional quality of ideological and political education, with a standardized coefficient of more than 0.92. The mediating effect value of tutor involvement was 0.064, accounting for 0.703 of the total effect. Ideological and political education in colleges and universities should focus on the learning needs of students and broaden their knowledge horizons through the active participation of teachers, to effectively enhance the practical effect of ideological and political education.

In the era of the digital economy, the continuous development of digital technology has had profound effects across various industries. The 20th National Congress report of the Party also emphasizes the need to “promote digitalization in education.” This paper aims to explore new approaches to teaching design in the context of digitization, addressing the needs and challenges of modern society. Starting from the issues encountered in the professional teaching process, it analyzes students’ psychology, the trends in different specialized directions, and industry demands such as visual communication design, product design, environmental design, and digital media art. Leveraging digital empowerment, the paper proposes several innovative teaching approaches, including interdisciplinary teaching, project-driven teaching, integrated teaching, and collaborative teaching. The exploration of these teaching design strategies aims to break down disciplinary barriers, providing a broader space for the art and design discipline. The goal is to cultivate professionals better suited to the demands of social development, contributing to the field of education.

Building Information Modelling(BIM) is the foundation of digital transformation in architecture, engineering, and construction(AEC)industry. BIM is the holistic process of creating and managing information for a built asset. A traditional CAD and 3D modelling technology is widely used in university’s architecture and landscape courses teaching today. Every single detail of traditional course education does not match the internationally market and BIM technology which is more common and popular today. Using BIM technology in university to teach architecture and landscape design will make changes to design education, and will improve the education practice in Environmental Design system. This article will introduce more detail about BIM technology, and how it changes and affects traditional architecture & landscape teaching, how this technology merged with professions, and how this technology brings comprehensive learning ways and new insight for students in their future career life.

The late third-millennium BC Longshan period was a crucial time for state formation in central China. During these centuries, long-distance networks expanded and shared material culture and then cultural practices spread across wider areas precipitating social and ideological developments that presaged the rise of states and cities on the Central Plain. In this research, the authors use multiple (strontium, oxygen and carbon) isotope analyses from the dental enamel of 67 individuals buried at the Xiajin cemetery, Shanxi Province. The results indicate significant long-distance migration among females during the Longshan period, which the authors interpret as evidence of exogamous marriage for political alliance-building--a phenomenon found more widely across Eurasia at the start of the Bronze Age. Keywords: central China, Neolithic, Bronze Age, Taosi culture, burial, isotopic analysis, migration, exogamy, Introduction The Longshan period (c. 2500-1900 BC) was a crucial time for state formation in central China. During this period, inter-regional networks developed rapidly, transmitting shared material forms and cultural [...]