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The Dalaku'an mafic–ultramafic intrusion, located in the western segment of the East Kunlun, presents conducive conditions for the magmatic Cu-Ni sulfide deposits. According to the detailed petrographic observation, the amphiboles within distinct rock types were analyzed by EPMA analysis. The crystallization conditions, such as temperature, pressure, oxygen fugacity, and water content of the magma, were calculated to explore the genesis of the intrusion. The amphiboles were divided into three types: Amp-I, characterized by low silicon content but enrichment of aluminum, titanium, and alkali, predominantly comprising Tschermakitic hornblende and Magnesio-hornblende with mantle-derived traits; Amp-II, exhibiting elevated silicon content but diminished levels of aluminum, titanium, and alkali, primarily constituted of Magnesio-hornblende; whereas Amp-III manifests as Actinolitic hornblende, indicative of crustal origins. The calculated temperatures of amphiboles ranged between Amp-I (955–880) °C, Amp-II (852–774) °C, and Amp-III (761–760) °C; the pressures ranged between Amp-I (454–274) MPa, Amp-II (194–93) MPa, and Amp-III (101–84) MPa; the oxygen fugacities (△NNO) ranged between Amp-I (0.93–2.17), Amp-II (1.55–2.52), and Amp-III (1.89); and the water contents (H2Omelt) ranged from (6.69–8.67) to (5.90–7.32). The magma experienced multiple stages of crystallization and underwent complex magma evolution at different depths. The high oxygen fugacity and water content could be attributed to the subduction of the oceanic crust. The magma source of the Dalaku'an intrusion was metasomatized by fluids from subducting plates, thereby originating within a post-collision extension. [ABSTRACT FROM AUTHOR]

Carbon-supported non-precious metal catalysts with highly exposed active sites have great potential for applications in the hydrogenation reduction of nitro compounds. Herein, a strategy for the preparation of carbon-supported Mo-based catalysts (Mo@C/MC) is proposed. Protein–Mo ion networks are first coated on the surface of microsphere carbons (MC). The coated MC employed as a precursor is then pyrolyzed to produce carbon-supported Mo-based catalysts. Notably, neither pore-forming agents nor post-treatment is required in the preparation of the catalyst. The active sites tend to disperse uniformly on the surface of the carbon matrix, facilitating the exposure of the active sites of the catalyst. The as-prepared catalyst Mo@C/MC shows high conversion (>99%) and selectivity (>98%) for the hydrogenation of nitro compounds under mild reaction conditions (100 °C, 5 bar H2). [ABSTRACT FROM AUTHOR]

Herein, two sulfhydryl‐functionalized polymers, namely, EDT‐HCPS and TMPMP‐HCPS, were synthesized according to the Friedel‐Craft s alkylation and nucleophilic substitution, and they were used to adsorb Pd2+ and Ag+ from aqueous solution. The Friedel‐Crafts alkylation offered the polymers with hyper‐cross‐linking frameworks composed of plentiful rigid methylene. The nucleophilic substitution brought abundant functional SH groups (the sulfur contents were 12.6 and 9.4 wt%, respectively) to the polymers. The adsorption results showed that the capacities of Pd2+ and Ag+ on EDT‐HCPS were larger than TMPMP‐HCPS, and the higher quantities of functional SH groups and the porosity played a beneficial role. The equilibrium data can be characterized by the Langmuir model, and the maximum capacities of Pd2+ and Ag+ on EDT‐HCPS at 308 K were predicted to be 383.92 and 212.93 mg g−1, respectively. The produced polymers represented superior adsorption selectivity, reproducibility, and reusability, demonstrating their excellent performance for the adsorption of Pd2+ and Ag+, and analysis of the adsorption mechanism demonstrated that the SH groups played a major role due to the strong chemical complexation of the functional SH with Pd2+/Ag+. [ABSTRACT FROM AUTHOR]

Purpose: Medulloblastoma is the most common childhood malignant brain tumor and is a leading cause of cancer-related death in children. Recent transcriptional studies have shown that medulloblastomas comprise at least four molecular subgroups, each with distinct demographics, genetics, and clinical outcomes. Medulloblastoma subtyping has become critical for subgroup-specific therapies. The use of gene expression assays to determine the molecular subgroup of clinical specimens is a long-awaited application of molecular biology for this pediatric cancer. Methods: In the current study, we established a medulloblastoma transcriptome database of 460 samples retrieved from three published datasets (GSE21140, GSE37382, and GSE37418). With this database, we identified a 23-gene signature that is significantly associated with the medulloblastoma subgroups and achieved a classification accuracy of 95.2%. Results: The 23-gene signature was further validated in a long-term cohort of 142 Chinese medulloblastoma patients. The 23-gene signature classified 21 patients as WNT (15%), 41 as SHH (29%), 16 as Group 3 (11%), and 64 as Group 4 (45%). For patients of WNT, SHH, Group 3, and Group 4, 5-year overall-survival rate reached 80%, 62%, 27%, and 47%, respectively (p < 0.0001), meanwhile 5-year progression-free survival reached 80%, 52%, 27%, and 45%, respectively (p < 0.0001). Besides, SHH/TP53-mutant tumors were associated with worse prognosis compared with SHH/TP53 wild-type tumors and other subgroups. We demonstrated that subgroup assignments by the 23-gene signature and Northcott's NanoString assay were highly comparable with a concordance rate of 96.4%. Conclusions: In conclusion, we present a novel gene signature that is capable of accurately and reliably assigning FFPE medulloblastoma samples to their molecular subgroup, which may serve as an auxiliary tool for medulloblastoma subtyping in the clinic. Future incorporation of this gene signature into prospective clinical trials is warranted to further evaluate its clinical. [ABSTRACT FROM AUTHOR]

The non‐noble‐metal catalysed‐multicomponent reactions between flue gas CO2 and cheap industrial raw stocks into high value‐added fine chemicals is a promising manner for the ideal CO2 utilization route. To achieve this, the key fundamental challenge is the rational development of highly efficient and facile reaction pathway while establishing compatible catalytic system. Herein, through the stepwise solvent‐assisted linker installation, post‐synthetic fluorination and metalation, we report the construction of a series of perfluoroalkyl‐decorated noble‐metal‐free metal–organic frameworks (MOFs) PCN‐(BPY‐CuI)‐(TPDC‐Fx) [BPY=2,2′‐bipyridine‐5,5′‐dicarboxylate, TPDC‐NH2=2′‐amino‐[1,1′:4′,1′′‐terphenyl]‐4,4′′‐dicarboxylic acid] that can catalyze the one‐pot four‐component reaction between alkyne, aldehyde, amine and flue gas CO2 for the preparation of 2‐oxazolidinones. Such assembly endows the MOFs with superhydrophobic microenvironment, superior water resistance and highly stable catalytic site, leading to 21 times higher turnover numbers than that of homogeneous counterparts. Mechanism investigation implied that the substrates can be efficiently enriched by the MOF wall and then the adsorbed amine species act as an extrinsic binding site towards dilute CO2 through their strong preferential formation to carbamate acid. Moreover, density functional theory calculations suggest the tetrahedral geometry of Cu in MOF offers special resistance towards amine poisoning, thus maintaining its high efficiency during the catalytic process. [ABSTRACT FROM AUTHOR]

The non‐noble‐metal catalysed‐multicomponent reactions between flue gas CO2 and cheap industrial raw stocks into high value‐added fine chemicals is a promising manner for the ideal CO2 utilization route. To achieve this, the key fundamental challenge is the rational development of highly efficient and facile reaction pathway while establishing compatible catalytic system. Herein, through the stepwise solvent‐assisted linker installation, post‐synthetic fluorination and metalation, we report the construction of a series of perfluoroalkyl‐decorated noble‐metal‐free metal–organic frameworks (MOFs) PCN‐(BPY‐CuI)‐(TPDC‐Fx) [BPY=2,2′‐bipyridine‐5,5′‐dicarboxylate, TPDC‐NH2=2′‐amino‐[1,1′:4′,1′′‐terphenyl]‐4,4′′‐dicarboxylic acid] that can catalyze the one‐pot four‐component reaction between alkyne, aldehyde, amine and flue gas CO2 for the preparation of 2‐oxazolidinones. Such assembly endows the MOFs with superhydrophobic microenvironment, superior water resistance and highly stable catalytic site, leading to 21 times higher turnover numbers than that of homogeneous counterparts. Mechanism investigation implied that the substrates can be efficiently enriched by the MOF wall and then the adsorbed amine species act as an extrinsic binding site towards dilute CO2 through their strong preferential formation to carbamate acid. Moreover, density functional theory calculations suggest the tetrahedral geometry of Cu in MOF offers special resistance towards amine poisoning, thus maintaining its high efficiency during the catalytic process. [ABSTRACT FROM AUTHOR]

The non‐noble‐metal catalysed‐multicomponent reactions between flue gas CO2 and cheap industrial raw stocks into high value‐added fine chemicals is a promising manner for the ideal CO2 utilization route. To achieve this, the key fundamental challenge is the rational development of highly efficient and facile reaction pathway while establishing compatible catalytic system. Herein, through the stepwise solvent‐assisted linker installation, post‐synthetic fluorination and metalation, we report the construction of a series of perfluoroalkyl‐decorated noble‐metal‐free metal–organic frameworks (MOFs) PCN‐(BPY‐CuI)‐(TPDC‐Fx) [BPY=2,2′‐bipyridine‐5,5′‐dicarboxylate, TPDC‐NH2=2′‐amino‐[1,1′:4′,1′′‐terphenyl]‐4,4′′‐dicarboxylic acid] that can catalyze the one‐pot four‐component reaction between alkyne, aldehyde, amine and flue gas CO2 for the preparation of 2‐oxazolidinones. Such assembly endows the MOFs with superhydrophobic microenvironment, superior water resistance and highly stable catalytic site, leading to 21 times higher turnover numbers than that of homogeneous counterparts. Mechanism investigation implied that the substrates can be efficiently enriched by the MOF wall and then the adsorbed amine species act as an extrinsic binding site towards dilute CO2 through their strong preferential formation to carbamate acid. Moreover, density functional theory calculations suggest the tetrahedral geometry of Cu in MOF offers special resistance towards amine poisoning, thus maintaining its high efficiency during the catalytic process. [ABSTRACT FROM AUTHOR]

The non‐noble‐metal catalysed‐multicomponent reactions between flue gas CO2 and cheap industrial raw stocks into high value‐added fine chemicals is a promising manner for the ideal CO2 utilization route. To achieve this, the key fundamental challenge is the rational development of highly efficient and facile reaction pathway while establishing compatible catalytic system. Herein, through the stepwise solvent‐assisted linker installation, post‐synthetic fluorination and metalation, we report the construction of a series of perfluoroalkyl‐decorated noble‐metal‐free metal–organic frameworks (MOFs) PCN‐(BPY‐CuI)‐(TPDC‐Fx) [BPY=2,2′‐bipyridine‐5,5′‐dicarboxylate, TPDC‐NH2=2′‐amino‐[1,1′:4′,1′′‐terphenyl]‐4,4′′‐dicarboxylic acid] that can catalyze the one‐pot four‐component reaction between alkyne, aldehyde, amine and flue gas CO2 for the preparation of 2‐oxazolidinones. Such assembly endows the MOFs with superhydrophobic microenvironment, superior water resistance and highly stable catalytic site, leading to 21 times higher turnover numbers than that of homogeneous counterparts. Mechanism investigation implied that the substrates can be efficiently enriched by the MOF wall and then the adsorbed amine species act as an extrinsic binding site towards dilute CO2 through their strong preferential formation to carbamate acid. Moreover, density functional theory calculations suggest the tetrahedral geometry of Cu in MOF offers special resistance towards amine poisoning, thus maintaining its high efficiency during the catalytic process. [ABSTRACT FROM AUTHOR]

The non-noble-metal catalysed-multicomponent reactions between flue gas CO 2 and cheap industrial raw stocks into high value-added fine chemicals is a promising manner for the ideal CO 2 utilization route. To achieve this, the key fundamental challenge is the rational development of highly efficient and facile reaction pathway while establishing compatible catalytic system. Herein, through the stepwise solvent-assisted linker installation, post-synthetic fluorination and metalation, we report the construction of a series of perfluoroalkyl-decorated noble-metal-free metal-organic frameworks (MOFs) PCN-(BPY-CuI)-(TPDC-F x ) [BPY=2,2'-bipyridine-5,5'-dicarboxylate, TPDC-NH 2 =2'-amino-[1,1':4',1''-terphenyl]-4,4''-dicarboxylic acid] that can catalyze the one-pot four-component reaction between alkyne, aldehyde, amine and flue gas CO 2 for the preparation of 2-oxazolidinones. Such assembly endows the MOFs with superhydrophobic microenvironment, superior water resistance and highly stable catalytic site, leading to 21 times higher turnover numbers than that of homogeneous counterparts. Mechanism investigation implied that the substrates can be efficiently enriched by the MOF wall and then the adsorbed amine species act as an extrinsic binding site towards dilute CO 2 through their strong preferential formation to carbamate acid. Moreover, density functional theory calculations suggest the tetrahedral geometry of Cu in MOF offers special resistance towards amine poisoning, thus maintaining its high efficiency during the catalytic process., (© 2023 Wiley-VCH GmbH.)