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Pan-Immune-Inflammation Value (PIV) has recently received more attention as a novel indicator of inflammation. We aimed to evaluate the association between PIV and prognosis in septic patients. Data were extracted from the Medical Information Mart for Intensive Care IV database. The primary and secondary outcomes were 28-day and 90-day mortality. The association between PIV and outcomes was assessed by Kaplan–Meier curves, Cox regression analysis, restricted cubic spline curves and subgroup analysis. A total of 11,331 septic patients were included. Kaplan–Meier curves showed that septic patients with higher PIV had lower 28-day survival rate. In multivariable Cox regression analysis, log2-PIV was positively associated with the risk of 28-day mortality [HR (95% CI) 1.06 (1.03, 1.09), P < 0.001]. The relationship between log2-PIV and 28-day mortality was non-linear with a predicted inflection point at 8. To the right of the inflection point, high log2-PIV was associated with an increased 28-day mortality risk [HR (95% CI) 1.13 (1.09, 1.18), P < 0.001]. However, to the left of this point, this association was non-significant [HR (95% CI) 1.01 (0.94, 1.08), P = 0.791]. Similar results were found for 90-day mortality. Our study showed a non-linear relationship between PIV and 28-day and 90-day mortality risk in septic patients. [ABSTRACT FROM AUTHOR]

Background: Gut microbiota are closely related to the development and regulation of the host immune system by regulating the maturation of immune cells and the resistance to pathogens, which affects the host immunity. Early use of antibiotics disrupts the homeostasis of gut microbiota and increases the risk of asthma. Gut microbiota actively interact with the host immune system via the gut‐lung axis, a bidirectional communication pathway between the gut and lung. The manipulation of gut microbiota through probiotics, helminth therapy, and fecal microbiota transplantation (FMT) to combat asthma has become a hot research topic. Body: This review mainly describes the current immune pathogenesis of asthma, gut microbiota and the role of the gut‐lung axis in asthma. Moreover, the potential of manipulating the gut microbiota and its metabolites as a treatment strategy for asthma has been discussed. Conclusion: The gut‐lung axis has a bidirectional effect on asthma. Gut microecology imbalance contributes to asthma through bacterial structural components and metabolites. Asthma, in turn, can also cause intestinal damage through inflammation throughout the body. The manipulation of gut microbiota through probiotics, helminth therapy, and FMT can inform the treatment strategies for asthma by regulating the maturation of immune cells and the resistance to pathogens. [ABSTRACT FROM AUTHOR]

Joint effects of winds and tides on near-inertial internal waves (NIWs) are numerically investigated via a series of three-dimensional quasi-realistic simulations in the northern South China Sea (NSCS). Model results demonstrate that in the presence of wind-induced NIWs, more tidal energy is transferred to NIWs, while in the presence of tide-induced NIWs, the extreme wind (cyclone) would inject less near-inertial kinetic energy (NIKE). The interaction between wind-induced and tide-induced NIWs produces total NIKE more (or less) than a linear superposition of that generated by wind and tide forcing alone at different sites in the NSCS. Specifically, near the Luzon Strait, both tides and winds make positive contributions to the local near-inertial energy input, resulting in more than 30% enhancement of total NIKE (>0.5 kJ m−2). However, in some deep-water regions along the cyclone paths, energy is transferred from cyclones to NIWs and also from NIWs to internal tides. Due to this "energy pipeline" effect, tide- and wind-induced NIWs contribute to weakening of total NIKE (∼0.3 kJ m−2 or 30%). Additionally, sensitivity experiments with varying initial tidal phases indicate that the interaction between wind-induced NIKE and tide-induced NIKE is robust in most of the model domain (over 80%) under different phase alignments between wind- and tide-induced NIWs. From the perspective of cyclones, tide-induced NIKE is comparable to wind-induced NIKE in the Luzon Strait before the arrival of cyclones, while tide-induced NIKE is two orders of magnitude smaller than wind-induced NIKE in most of the NSCS after the arrival of cyclones. Overall, our results highlight the joint effects of wind and tide forcing on the local NIW dynamics in the NSCS. Significance Statement: Near-inertial internal waves (NIWs) are ubiquitous phenomena in stratified water, which can significantly influence the ocean mixing, especially across the thermocline. NIWs are generated mainly by wind forcing near the sea surface, but also by internal tide breaking in the ocean interior. Hence, a question that arises is whether winds or tides play dominant roles in generating NIWs. In fact, due to the interaction between wind- and tide-induced NIWs, the total near-inertial kinetic energy (NIKE) is not merely a linear superposition of that generated by winds and tides forcing alone. By carrying out numerical experiments, we find that extreme winds can help to transfer more energy from tides to NIWs, while tides would suppress energy transferring from winds to NIWs. As a result, this fact is crucial in accurately reproducing NIW dynamics in a targeted region, thereby determining redistribution of local ocean mixing intensity. [ABSTRACT FROM AUTHOR]