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Objective: To discuss the effects of physical exercise (PE) on adolescent short video addiction (SVA) and analyze the mediating effects of self-control (SC) and the moderating effects of the cumulative ecological risk (CER), aiming to provide theoretical support for PE relative to adolescent SVA, investigate the underlying mechanisms of the effects of PE. Methods: The Physical Activity Rating Scale-3, Problematic TikTok Use Scale, Self-Control Scale, and Cumulative Ecological Risk Scale were used to survey 756 adolescents in Chongqing and Chengdu, China. SPSS was used to construct a research model by conducting reliability, confirmatory factor, common method bias, and AMOS analyses. Results: PE was significantly and negatively related to adolescent SVA (β = −0.30, p

This article deeply integrates the characteristics of the China financial market under the background of the spread of the global new coronavirus pneumonia epidemic and integrates the multi-sector DSGE model including heterogeneous residents, manufacturers, banks, and macro-prudential supervision, and then numerically simulates the impact of technology and financial shocks on major economic indicators. Macroprudential capital regulation can help stabilize large economic waves, increase labour supply in the economic system, and restrain excessive transmission of systemic risks in the financial system. Meanwhile, the leverage ratio of banks will also change correspondingly with the price fluctuations of the real estate market. The relevant decision-making departments of the central government and the financial supervision departments coordinated in many ways to find the optimal internal balance point and increase the combined effect of effectively deflating systemic risks. [ABSTRACT FROM AUTHOR]

The analysis of biogenetic data makes an important contribution to the understanding of disease mechanisms and the diagnosis of rare diseases. In this analysis, the selection of significant features affecting the disease provides an effective basis for subsequent disease judgment and treatment direction. However, this is not a simple task as biogenetic data have challenges such as ultra‐high dimensionality of potential features, imbalance of response variables, and genetic associations. This study focuses on the group structure in feature screening with biogenetic data. Specifically, group structure exists for biogenetic data, so we need to analyze the entire genome rather than individual strongly correlated genes. This study proposes a group feature screening method that considers group correlations using adjusted Pearson's cardinality statistic to address this issue. The method can be applied to both continuous and discrete covariates. The performance of the proposed method is illustrated by simulation studies, where the proposed method performs well with imbalanced data and multicategorical responses. In the application of lung cancer diagnosis, the proposed method for imbalanced data categorization is impressive, and the dimension reduction using linear discriminant is still good. [ABSTRACT FROM AUTHOR]

Seroepidemiological characteristics of human papillomavirus (HPV) in community residents reflect natural infection and can guide the reform of vaccination programs. A population‐based serological survey was conducted in Guangdong Province. Serum anti‐HPV IgG antibody levels were determined by an ELISA. Neutralizing antibodies against HPV6, 11, 16, and 18 were detected via a pseudovirus‐based neutralization assay (PBNA). A total of 5122 serum samples were collected from community residents, including 1989 males and 3133 females, in three cities of Guangdong Province. The rate of HPV IgG antibody positivity in females was 5.39% (95% CI: 4.6–6.2), which was greater than that in males (2.36%; 95% CI: 1.7–3.1). HPV IgG antibodies were more frequently detected in females aged 51–60 years (11.30%; 95% CI: 7.6–16.0), whereas in males, the detection increased with age and reached 4.94% (95% CI: 2.8–6.9) in the group aged ≥71 years. The seropositivity of neutralizing antibodies against HPV6 and 11 was greater than that against HPV16 and 18. The serum neutralizing antibody titers in individuals who received three doses of a vaccine were 7‐ to 12‐fold greater than those in individuals who did not receive the vaccine. The neutralizing antibody titers slightly decreased within 40 months and ranged from 0.038 to 0.057 log ED50 per month. A moderate consistency between the HPV ELISA and PBNA results was observed (Kappa score = 0.49, r = 0.249, 0.635, 0.382, and 0.466 for HPV6, 11, 16, and 18, respectively). The HPV seropositivity rate among healthy residents of Guangdong Province was found to be low among children and adolescents and to increase with age. The serum neutralizing antibody titers were significantly greater in the vaccine group than that in the control group, and this difference persisted over time, which indicated promising protection against HPV infection. [ABSTRACT FROM AUTHOR]

The SARS-CoV-2 Omicron variant sparked the largest wave of infections worldwide. Mainland China eased its strict COVID-19 measures in late 2022 and experienced two nationwide Omicron waves in 2023. Here, we investigated lineage distribution and virus evolution in Guangdong, China, 2022-2023 by comparing 5813 local viral genomes with the datasets from other regions of China and worldwide. Additionally, we conducted three large-scale serological surveys involving 1696 participants to measure their immune response to the BA.5 and XBB.1.9 before and after the corresponding waves. Our findings revealed the Omicron variants, mainly the BA.5.2.48 lineage, causing infections in over 90% of individuals across different age groups within a month. This rapid spread led to the establishment of widespread immunity, limiting the virus's ability to further adaptive mutation and dissemination. While similar immune responses to BA.5 were observed across all age groups after the initial wave, children aged 3 to 11 developed a stronger cross immune response to the XBB.1.9 strain, possibly explaining their lower infection rates in the following XBB.1 wave. Reinfection with Omicron XBB.1 variant triggered a more potent neutralizing immune response among older adults. These findings highlight the impact of age-specific immune responses on viral spread in potential future waves. Release of the zero-COVID policy in China in late 2022 led to two large Omicron-driven waves of infection in 2023. Here, the authors analyze virus genomes and serology data from before and after the two waves and describe changes in virus lineage distribution and age-specific antibody responses. [ABSTRACT FROM AUTHOR]

Sequence recommendation is a prominent research area within recommender systems, focused on predicting items that users may be interested in by modeling their historical interaction sequences. However, due to data sparsity, user interaction sequences in sequence recommendation are typically short. A common approach to address this issue is filling sequences with zero values, significantly reducing the effective utilization of input space. Furthermore, traditional sequence recommendation methods based on self-attention mechanisms exhibit quadratic complexity with respect to sequence length. These issues affect the performance of recommendation algorithms. To tackle these challenges, we propose a multi-task sequence recommendation model, Blin, which integrates bidirectional KL divergence and linear attention. Blin abandons the conventional zero-padding strategy, opting instead for random repeat padding to enhance sequence data. Additionally, bidirectional KL divergence loss is introduced as an auxiliary task to regularize the probability distributions obtained from different sequence representations. To improve the computational efficiency compared to traditional attention mechanisms, a linear attention mechanism is employed during sequence encoding, significantly reducing the computational complexity while preserving the learning capacity of traditional attention. Experimental results on multiple public datasets demonstrate the effectiveness of the proposed model. [ABSTRACT FROM AUTHOR]

Mutations in the C-terminal of KIF1A (Kinesin family member 1A) may lead to amyotrophic lateral sclerosis (ALS) through unknown mechanisms that are not yet understood. Using iPSC reprogramming technology and motor neuron differentiation techniques, we generated iPSCs from a healthy donor and two ALS patients with KIF1A mutations (R1457Q and P1688L) and differentiated them into spinal motor neurons (iPSC-MN) to investigate KIF1A-related ALS pathology. Our in vitro iPSC-iMN model faithfully recapitulated specific aspects of the disease, such as neurite fragmentation. Through this model, we observed that these mutations led to KIF1A aggregation at the proximal axon of motor neurons and abnormal accumulation of its transport cargo, LAMP1, resulting in autophagy dysfunction and cell death. RNAseq analysis also indicated that the functions of the extracellular matrix, structure, and cell adhesion were significantly disturbed. Notably, using rapamycin during motor neuron differentiation can effectively prevent motor neuron death. [ABSTRACT FROM AUTHOR]

Background: We present a case of a 29-year-old male patient without immunodeficiency who suffered from rapid osteonecrosis and tooth exfoliation resulting from herpes zoster (HZ) infection in the left maxillary branch of the trigeminal nerve. Various complications associated with shingles infections have been reported, cases of osteonecrosis and tooth exfoliation due to HZ infection among young people without immunodeficiency are rare. In this case, we focus on the particular manifestation of HZ infection. Case presentation: The patient presented with clusters of erythema and papules, along with non-hemorrhagic blisters on the left face and the loss of the left upper incisor. All lesions were localized to the left side of the face without exceeding the midline. After receiving antibacterial and antiviral treatment, successful control over the infection was achieved; however, he experienced the loss of all upper teeth on the left side except for the first and second upper left molars. Conclusion: This case highlights that rapid osteonecrosis and tooth exfoliation may occur among young individuals without immunodeficiency after HZ infection. HZ infection of the face should be taken very seriously to obtain prompt treatment to prevent the rare complications of bone necrosis and tooth loss as much as possible. [ABSTRACT FROM AUTHOR]

The absorption of atmospheric carbon dioxide (CO2) in the Southern Ocean represents a critical component of the global oceanic carbon budget. Previous assessments of air‐sea carbon flux variations and long‐term trends in polar regions during winter have faced limitations due to scarce field data and the lack of ocean color satellite imagery, causing uncertainties in estimating CO2 flux estimation. This study utilized the Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation satellite to construct a continuous 16‐year (2006–2021) time series of sea surface partial pressure of CO2 (pCO2) in the Southern Ocean. Our findings revealed that the polar region in South Ocean acts as a carbon sink in winter, with CO2 flux of ∼30 TgC in high‐latitude areas (South of 50°S). This work highlights the efficacy of active remote sensing for monitoring sea surface pCO2 and contributes insights into the dynamic carbonate systems of the Southern Ocean. Plain Language Summary: Climate change data from recent decades have consistently shown an increase in atmospheric CO2 concentration. The Southern Ocean, a major carbon sink, is critical in this regard. However, limitations in ocean color remote sensing and infrequent sampling hinder a complete understanding of carbon uptake in high‐latitude regions during winter. Previous reconstructions inadequately considered the biological effect on the air‐sea CO2 exchange process in winter. This study used observations from an active remote sensing satellite to represent the biological effects of CO2 and construct a long‐term time series of sea surface CO2 level for the Southern Ocean. Additionally, the study reassessed the CO2 uptake capacity of the Southern Ocean in winter. These findings suggest that previous estimates may underestimate the CO2 uptake capacity in the high‐latitude regions during winter, potentially due to underestimations of biological effects. This research underscores the value of active remote sensing for obtaining critical biogeochemical parameters in high‐latitude oceans, providing an essential tool for monitoring carbonate systems. Key Points: A new method was proposed to reconstruct pressure of CO2 (pCO2) using CALIPSO‐derived bbp dataA 16‐year Cloud‐Aerosol Lidar and Infrared Pathfinder Satellite Observation observation‐based pCO2 product was constructedThe CO2 uptake capacity in the Southern Ocean during winter was estimated [ABSTRACT FROM AUTHOR]

Simple Summary: This study investigates the potential of small extracellular vesicles (sEVs) as vehicles for delivering therapeutic agents, with a focus on the p53 tumor suppressor gene. Fusion with CD63 or ARRDC1 was found to facilitate the overexpression and proper localization of p53 and significantly increase the yield and loading efficiency of sEVs with p53 mRNA and proteins. Moreover, the functional assessment of these engineered sEVs on H1299 cells demonstrated an enhanced anti-tumor effect, particularly with ARP-sEVs, suggesting a superior inhibition of cell proliferation and promotion of apoptosis. These results are expected to be informative in the application of EV therapy. Small extracellular vesicles (sEVs) have emerged as promising therapeutic agents and drug delivery vehicles. Targeted modification of sEVs and their contents using genetic modification strategies is one of the most popular methods. This study investigated the effects of p53 fusion with arrestin domain-containing protein 1 (ARRDC1) and CD63 on the generation of sEVs, p53 loading efficiency, and therapeutic efficacy. Overexpression of either ARRDC1–p53 (ARP) or CD63–p53 (CDP) significantly elevated p53 mRNA and protein levels. The incorporation of ARRDC1 and CD63 significantly enhanced HEK293T-sEV biogenesis, evidenced by significant increases in sEV-associated proteins TSG101 and LAMP1, resulting in a boost in sEV production. Importantly, fusion with ARRDC1 or CD63 substantially increased the efficiency of loading both p53 fusion proteins and its mRNA into sEVs. sEVs equipped with ARP or CDP significantly enhanced the enrichment of p53 fusion proteins and mRNA in p53-null H1299 cells, resulting in a marked increase in apoptosis and a reduction in cell proliferation, with ARP-sEVs demonstrating greater effectiveness than CDP-sEVs. These findings underscore the enhanced functionality of ARRDC1- and CD63-modified sEVs, emphasizing the potential of genetic modifications in sEV-based therapies for targeted cancer treatment. [ABSTRACT FROM AUTHOR]