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The article discusses the use of [15O]H2O PET/CT myocardial perfusion imaging to diagnose coronary artery disease, with a case study of a 74-year-old male who presented with symptoms of peripheral edema and orthopnea. While the patient's myocardial perfusion was normal, the imaging revealed subsegmental perfusion defects in the lower and middle lobes of the right lung, leading to a suspicion of pulmonary embolisms. The study highlights the importance of recognizing perfusion defects during PET/CT imaging as potential indicators of pulmonary embolism, even though PET/CT is not a primary diagnostic tool for this condition. [Extracted from the article]