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Your search keyword '"Hamid, Qutayba"' showing total 8 results
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8 results on '"Hamid, Qutayba"'

1. Epidemiological and Clinical Characteristics Associated with COVID-19 Severity Among Hospitalized Patients in the United Arab Emirates: A Retrospective Multicentre Study

Author

Al-Bluwi, Najlaa, Agha, Razan, Shukla, Ankita, Zeidan, Rouba Karen, AlZubaidi, Hamzah, Awad, Manal, Hussein, Amal, Abdelbagi, Muzan, AlSayed, Khaled, Alebaji, Mohamad B., Shaheen, Mahasin, Salameh, Laila, Mahboub, Bassam, Elkhodary, Hady, Bendardaf, Riyad, Mohammed, Ghada, Wardat, Dima, Al-Hano, Zahraa, Amara, Hajir I., Alhajjaj, Mohamed Saleh, Hamid, Qutayba, Halwani, Rabih, and Saddik, Basema

Published
2024
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2. Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Author

Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, and Lewthwaite, Hayley

Published
2024
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3. Association of specific ACE2 and TMPRSS2 variants with circulatory cytokines of COVID-19 Emirati patients

Author

Elemam, Noha M., primary, Bouzid, Amal, additional, Alsafar, Habiba, additional, Ahmed, Samrein BM, additional, Hafezi, Shirin, additional, Venkatachalam, Thenmozhi, additional, Eldohaji, Leen, additional, Al Hamidi, Tasneem, additional, Gerges, Peter Habib, additional, Halabi, Nour, additional, Hadj-Kacem, Hassen, additional, Talaat, Iman M., additional, Taneera, Jalal, additional, Sulaiman, Nabil, additional, Maghazachi, Azzam A., additional, Hamid, Qutayba, additional, Hamoudi, Rifat, additional, and Saber-Ayad, Maha, additional

Published
2024
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5. Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype.

Author

Ansari, Abdul Wahid, Jayakumar, Manju Nidagodu, Ahmad, Fareed, Venkatachalam, Thenmozhi, Salameh, Laila, Unnikannan, Hema, Raheed, Thesni, Mohammed, Abdul Khader, Mahboub, Bassam, Al-Ramadi, Basel K., Hamid, Qutayba, Steinhoff, Martin, and Hamoudi, Rifat

Subjects
MONONUCLEAR leukocytes, CELLULAR immunity, RESPIRATORY infections, LYMPHOPROLIFERATIVE disorders, MACROLIDE antibiotics
Abstract

Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the CD27 pathway in the pathophysiology of various T-lymphocyte-mediated inflammatory, autoimmune, and lymphoproliferative diseases, we examined the impact of AZM on CD27 regulation and potential consequences on CD4+ and CD8+ T-cell phenotypes. Using cellular immunology approaches on healthy donors' peripheral blood mononuclear cells, we demonstrate AZM-mediated downregulation of surface CD27 expression as well as its extracellular release as soluble CD27. Notably, AZM-exposed CD27high (hi) cells were defective in their ability to expand compared to CD27intermediate (Int) and CD27low (lo) subsets. The defective CD27hi subset expansion was found to be associated with impaired cell proliferation and cell division. At the molecular level, the CD27hi subset exhibited lower mTOR activity than other subsets. Functionally, AZM treatment resulted in marked depletion of helper CD4+ (Th1) and cytotoxic CD8+ T-lymphocyte (Tc1)-associated CXCR3+CD27hi effector cells and inhibition of inflammatory cytokine IFN-g production. These findings provide mechanistic insights on immunomodulatory features of AZM on T-lymphocyte by altering the CD27 pathway. From a clinical perspective, this study also sheds light on potential clinical benefits observed in patients on prophylactic AZM regimens against various respiratory diseases and opens avenues for future adjunct therapy against Th1- and Tc1-dominated inflammatory and autoimmune diseases. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Role of IL‐5 in asthma and airway remodelling.

Author

AbuJabal, Rola, Ramakrishnan, Rakhee K., Bajbouj, Khuloud, and Hamid, Qutayba

Subjects
ASTHMATICS, DRUG target, TISSUE remodeling, BIOTHERAPY, THERAPEUTICS
Abstract

Asthma is a common and burdensome chronic inflammatory airway disease that affects both children and adults. One of the main concerns with asthma is the manifestation of irreversible tissue remodelling of the airways due to the chronic inflammatory environment that eventually disrupts the whole structure of the airways. Most people with troublesome asthma are treated with inhaled corticosteroids. However, the development of steroid resistance is a commonly encountered issue, necessitating other treatment options for these patients. Biological therapies are a promising therapeutic approach for people with steroid‐resistant asthma. Interleukin 5 is recently gaining a lot of attention as a biological target relevant to the tissue remodelling process. Since IL‐5‐neutralizing monoclonal antibodies (mepolizumab, reslizumab and benralizumab) are currently available for clinical use, this review aims to revisit the role of IL‐5 in asthma pathogenesis at large and airway remodelling in particular, in addition to exploring its role as a target for biological treatments. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Airway tree caliber heterogeneity and airflow obstruction among older adults

Author

Vameghestahbanati, Motahareh, primary, Kingdom, Leina, additional, Hoffman, Eric A., additional, Kirby, Miranda, additional, Allen, Norrina B., additional, Angelini, Elsa, additional, Bertoni, Alain, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Jacobs, David R., additional, Laine, Andrew, additional, Maltais, François, additional, Michos, Erin D., additional, Sack, Coralynn, additional, Sin, Don, additional, Watson, Karol E., additional, Wysoczanksi, Artur, additional, Couper, David, additional, Cooper, Christopher, additional, Han, MeiLan, additional, Woodruff, Prescott, additional, Tan, Wan C., additional, Bourbeau, Jean, additional, Barr, R. Graham, additional, and Smith, Benjamin M., additional

Published
2024
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8. Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing

Author

Ekström, Magnus, primary, Li, Pei Zhi, additional, Lewthwaite, Hayley, additional, Bourbeau, Jean, additional, Tan, Wan C., additional, Schiöler, Linus, additional, Brotto, Andrew, additional, Stickland, Michael K., additional, Jensen, Dennis, additional, FitzGerald, J. Mark, additional, Sin, Don D., additional, Marciniuk, Darcy D., additional, O’Donnell, Denis E., additional, Hernandez, Paul, additional, Chapman, Kenneth R., additional, Walker, Brandie, additional, Aaron, Shawn, additional, Maltais, François, additional, Samet, Jonathon, additional, Puhan, Milo, additional, Hamid, Qutayba, additional, Hogg, James C., additional, Doiron, Dany, additional, Mancino, Palmina, additional, Baglole, Carolyn, additional, Fortier, Yvan, additional, Yang, Julia, additional, Road, Jeremy, additional, Comeau, Joe, additional, Png, Adrian, additional, Johnson, Kyle, additional, Coxson, Harvey, additional, Leipsic, Jonathon, additional, Hague, Cameron, additional, Kirby, Miranda, additional, Sadatsafavi, Mohsen, additional, To, Teresa, additional, Gershon, Andrea, additional, Song, Zhi, additional, Benedetti, Andrea, additional, Lo, Christine, additional, Cheng, Sarah, additional, Un, Elena, additional, Fung, Cynthia, additional, Wang, Wen Tiang, additional, Zheng, Liyun, additional, Faroon, Faize, additional, Radivojevic, Olga, additional, Chung, Sally, additional, Zou, Carl, additional, Baril, Jacinthe, additional, Labonte, Laura, additional, McClean, Patricia, additional, Audisho, Nadeen, additional, Dumonceaux, Curtis, additional, Machado, Lisette, additional, Fulton, Scott, additional, Osterling, Kristen, additional, Wigerius, Denise, additional, Vandemheen, Kathy, additional, Pratt, Gay, additional, Bergeron, Amanda, additional, McNeil, Matthew, additional, Whelan, Kate, additional, Brouillard, Cynthia, additional, Clemens, Ron, additional, Baran, Janet, additional, and Leuschen, Candice, additional

Published
2024
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