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13 results on '"Hakeem A"'

4. Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Author

Ackerley, Cassie Grimsley, Graciaa, Daniel, Kelley, Colleen, Rouphael, Nadine, Curate-Ingram, Sharon, Korber, Bette, Wagh, Kshitij, Sane, Nandini, Grossman, Jennifer, Hasan, Sophie, Robinson, Michelle, Lucas, Jonathan, Gildea, Marianne, Babinec, Amber, Coomes, Bethany, Dumond, Julie, Beck, Justine, Chege, Wairimu, Han, Xue, Hanke, Jen, Karg, Carissa, Rinn, Laurie, Chicurel-Bayard, Miriam, Nagar, Shashikala, White, Hakeem, Cooley, W Scott, Broder, Gail, Hunt, Machel, Cummings, Vanessa, Donaty, Kristine, Randhawa, April, Fair, Ramey, Darden-Tabb, Noshima, Chaturvedi, Richa, Baden, Lindsey, Sherman, Amy, Gothing, Jon, Paz, Andres Avila, Klopfer, Julia, Powell, Megan, Piermattei, Anna, Heithoff, August, Weiner, Joshua A., Kovacikova, Gabriela, Axelrod, Katherine S., Zhang, Lu, Baral, Saman, Yates, Nicole, Chiong, Kelvin, Kuo, Irene, Jordan, Jeanne, Lintner, Madison, Langlands, Kayley, Saintilma, Bitana, Yellin, Hannah, Balachandran, Madhu, Magnus, Manya, Baumblatt, Jane, Tindale, India, Fortier, Samantha, Khodabakhshian, Aleen, Pierce, Nick, Gonzalez, Maricela, Mark, Lisa, Kuo, Melinda, Afemata, Ste'von, Edupuganti, Srilatha, Hurt, Christopher B, Stephenson, Kathryn E, Huang, Yunda, Paez, Carmen A, Yu, Chenchen, Yen, Catherine, Hanscom, Brett, He, Zonglin, Miner, Maurine D, Gamble, Theresa, Heptinstall, Jack, Seaton, Kelly E, Domin, Elizabeth, Lin, Bob C, McKee, Krisha, Doria-Rose, Nicole, Regenold, Stephanie, Spiegel, Hans, Anderson, Maija, McClosky, Nadia, Zhang, Lily, Piwowar-Manning, Estelle, Ackerman, Margaret E, Pensiero, Michael, Dye, Bonnie J, Landovitz, Raphael J, Mayer, Kenneth, Siegel, Marc, Sobieszczyk, Magdalena, Walsh, Stephen R, Gama, Lucio, Barouch, Dan H, Montefiori, David C, and Tomaras, Georgia D

Published
2025
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9. Triptycene based microporous hypercrosslinked polymer with amino functionality for selective CO2 capture.

Author

Ansari, Mosim, Helal, Aasif, Abdelnaby, Mahmoud Mohamed, Hakeem, Abbas Saeed, and Khan, Mohd Yusuf

Subjects
CARBON sequestration, POROUS polymers, ATMOSPHERIC carbon dioxide, PHYSISORPTION, ENVIRONMENTAL remediation
Abstract

The increasing CO2 concentration in the atmosphere contributes significantly to global warming, necessitating effective capture techniques. Though amine‐based solvents are commonly used, they have drawbacks like high energy consumption and corrosion. Physical adsorption using microporous sorbents with polar groups emerges as a promising alternative, offering high efficiency and selectivity for CO2 capture. This work presents the design of a new microporous hypercrosslinked polymer with amino groups derived from the 3D molecular building block triptycene (TBMP‐NH2), for CO2 capture applications. The triptycene unit in the polymer backbone provides high surface area, thermal stability, and microporosity. TBMP‐NH2 demonstrates excellent thermal stability (Td > 350°C), considerable microporosity, and a high BET‐specific surface area of 866 m2/g, making it a promising microporous adsorbent. It exhibits a high CO2 adsorption capacity of 1.86 mmol/g at 273 K and 1.23 mmol/g at 298 K, with a Qst value of 33.95 kJ/mol, indicating a physisorption mechanism where the micropore volume (Vmic = 0.359 cm3/g) plays a crucial role. TBMP‐NH2 displays good CO2/N2 and CO2/CH4 selectivity, outperforming several reported porous polymers. Owing to its high physiochemical and thermal properties, and efficient and selective CO2 capture ability, TBMP‐NH2 can be considered a promising material for CO2 capture and environmental remediation application. [ABSTRACT FROM AUTHOR]

Published
2025
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10. Mixed Bayesian Stackelberg Strategies for Robust Adversarial Classifiers.

Author

Quadri, Hakeem

Abstract

Deep neural networks (DNNs) have achieved state-of-the-art performance in classification tasks; however, they are susceptible to small perturbations that are seemingly imperceptible to the human eye but are enough to fool the network into misclassifying images. To develop more robust DNNs against adversarial attacks, research methods have focused on exploring the interaction between a machine learning classifier and a single adversary. However, these methods do not adequately model the real-world scenarios in which these classifiers are deployed. In this research paper, we address this gap and propose an adversarial learning algorithm with multiple adversaries using Bayesian Stackelberg games to model the interaction between the learner and multiple adversaries. We conclude that the nested Bayesian Stackelberg method is a useful strategy for developing adversarial learning algorithms to improve the robustness of DNNs. This strategy can serve as a benchmark in future defense attempts to create DNNs that resist adversarial attacks. [ABSTRACT FROM AUTHOR]

Published
2025
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11. Safety, tolerability, pharmacokinetics, and neutralisation activities of the anti-HIV-1 monoclonal antibody PGT121.414.LS administered alone and in combination with VRC07-523LS in adults without HIV in the USA (HVTN 136/HPTN 092): a first-in-human, open-label, randomised controlled phase 1 trial

Author

Edupuganti, Srilatha, Hurt, Christopher B, Stephenson, Kathryn E, Huang, Yunda, Paez, Carmen A, Yu, Chenchen, Yen, Catherine, Hanscom, Brett, He, Zonglin, Miner, Maurine D, Gamble, Theresa, Heptinstall, Jack, Seaton, Kelly E, Domin, Elizabeth, Lin, Bob C, McKee, Krisha, Doria-Rose, Nicole, Regenold, Stephanie, Spiegel, Hans, Anderson, Maija, McClosky, Nadia, Zhang, Lily, Piwowar-Manning, Estelle, Ackerman, Margaret E, Pensiero, Michael, Dye, Bonnie J, Landovitz, Raphael J, Mayer, Kenneth, Siegel, Marc, Sobieszczyk, Magdalena, Walsh, Stephen R, Gama, Lucio, Barouch, Dan H, Montefiori, David C, Tomaras, Georgia D, Ackerley, Cassie Grimsley, Graciaa, Daniel, Kelley, Colleen, Rouphael, Nadine, Curate-Ingram, Sharon, Korber, Bette, Wagh, Kshitij, Sane, Nandini, Grossman, Jennifer, Hasan, Sophie, Robinson, Michelle, Lucas, Jonathan, Gildea, Marianne, Babinec, Amber, Coomes, Bethany, Dumond, Julie, Beck, Justine, Chege, Wairimu, Han, Xue, Hanke, Jen, Karg, Carissa, Rinn, Laurie, Chicurel-Bayard, Miriam, Nagar, Shashikala, White, Hakeem, Cooley, W Scott, Broder, Gail, Hunt, Machel, Cummings, Vanessa, Donaty, Kristine, Randhawa, April, Fair, Ramey, Darden-Tabb, Noshima, Chaturvedi, Richa, Baden, Lindsey, Sherman, Amy, Gothing, Jon, Paz, Andres Avila, Klopfer, Julia, Powell, Megan, Piermattei, Anna, Heithoff, August, Weiner, Joshua A., Kovacikova, Gabriela, Axelrod, Katherine S., Zhang, Lu, Baral, Saman, Yates, Nicole, Chiong, Kelvin, Kuo, Irene, Jordan, Jeanne, Lintner, Madison, Langlands, Kayley, Saintilma, Bitana, Yellin, Hannah, Balachandran, Madhu, Magnus, Manya, Baumblatt, Jane, Tindale, India, Fortier, Samantha, Khodabakhshian, Aleen, Pierce, Nick, Gonzalez, Maricela, Mark, Lisa, Kuo, Melinda, and Afemata, Ste'von

Abstract

Multiple broadly neutralising monoclonal antibodies (mAbs) are in development for HIV-1 prevention. The aim of this trial was to test the PGT121.414.LS and VRC07-523LS mAbs for safety and pharmacokinetics in adults.

Published
2025
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13. Right Ventricular Injury Definition and Management in Veno-Venous Extracorporeal Membrane Oxygenation

Author

Dugar, Siddharth Pawan, Sato, Ryota, Charlton, Matthew, Hasegawa, Daisuke, Antonini, Marta Velia, Nasa, Prashant, Yusuff, Hakeem, Schultz, Marcus J., Harnegie, Mary Pat, Ramanathan, Kollengode, Shekar, Kiran, Schmidt, Matthieu, Zochios, Vasileios, and Duggal, Abhijit

Abstract

Right ventricular injury (RVI) in respiratory failure receiving veno-venous extracorporeal membrane oxygenation (VV ECMO) is associated with significant mortality. A scoping review is necessary to map the current literature and guide future research regarding the definition and management of RVI in patients receiving VV ECMO. We searched for relevant publications on RVI in patients receiving VV ECMO in Medline, EMBASE, and Web of Science. Of 1,868 citations screened, 30 studies reported on RVI (inclusive of right ventricular dilation, right ventricular dysfunction, and right ventricular failure) during VV ECMO. Twenty-three studies reported on the definition of RVI including echocardiographic indices of RV function and dimensions, whereas 13 studies reported on the management of RVI, including veno-pulmonary (VP) ECMO, veno-arterial (VA) ECMO, positive inotropic agents, pulmonary vasodilators, ultra-lung-protective ventilation (Ultra-LPV), and optimization of positive end-expiratory pressure (PEEP). The definitions of RVI in patients receiving VV ECMO used in the literature are heterogeneous. Despite the high incidence of RVI during VV ECMO support and its strong association with mortality, studies investigating therapeutic strategies for RVI are also lacking. To fill the existing knowledge gaps, a consensus on the definition of RVI and research investigating RV-targeted therapies during VV ECMO is urgently warranted.

Published
2025
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