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Objective: Pseudoexfoliation (PEX) syndrome is a systemic condition associated with age, and its exact cause remains elusive. Inflammatory processes heighten the risk of PEX development. This study marks the first attempt to jointly investigate the Systemic Inflammatory Response Index (SIRI) and Pan-Immune Inflammation Value (PIV) biomarkers in PEX patients. Materials and Methods: A total of 84 patients and 71 healthy controls underwent examination. Ratios of neutrophils to lymphocytes (NLR) and platelets to lymphocytes (PLR), along with the Systemic Inflammation Index (SII), SIRI, and PIV values, were computed as indicators linked to the inflammatory cascade. Results: The study encompassed 155 subjects, including 71 healthy controls averaging 73.8±7.7 years and 84 PEX patients averaging 71.3±8.9 years. Statistically significant differences in neutrophil and lymphocyte levels were evident between the groups (p<0.05). A notable statistical distinction was observed in the NLR, PLR, derived Neutrophil to Lymphocyte Ratio (dNLR), SII, SIRI, and PIV indices when comparing the groups (p<0.05). However, hemoglobin, platelet, mean platelet volume (MPV), white blood cell (WBC), and C-reactive protein (CRP) values did not show significant differences between the groups (p>0.05). Conclusion: This study highlights that SIRI and PIV could provide insights into the relationship between PEX and inflammation, offering a glimpse into the potential systemic implications of PEX-related inflammation. [ABSTRACT FROM AUTHOR]