1. Type 2 diabetes mellitus remission in sleeve gastrectomy patients: Role of enteroendocrine response and serum citrulline and I-FABP levels.
- Author
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Aydin MA, Aykal G, Gunduz UR, Dincer A, Turker A, Turkoglu F, and Guler M
- Subjects
- Humans, Female, Male, Prospective Studies, Adult, Middle Aged, Weight Loss physiology, Obesity, Morbid surgery, Obesity, Morbid blood, Remission Induction, Case-Control Studies, Blood Glucose analysis, Blood Glucose metabolism, Fatty Acid-Binding Proteins, Diabetes Mellitus, Type 2 blood, Gastrectomy methods, Citrulline blood
- Abstract
Introduction: This prospective cohort study examines the relationship between post-sleeve gastrectomy (SG) weight loss and serum citrulline, I-FABP levels, and the I-FABP/citrulline ratio in obese patients, alongside the correlation with type 2 diabetes mellitus (T2DM) remission., Methods: 88 participants were enrolled, including 48 undergoing SG and 21 with T2DM. 40 healthy individuals served as controls. Preoperative and 1-year postoperative assessments included citrulline, I-FABP, glucose, insulin, HbA1c, and C peptide levels., Results: Significant weight loss and T2DM remission (11/21) were observed post-SG. Preoperatively, patients had low citrulline and high I-FABP levels, which normalized postoperatively. A positive correlation was found between the I-FABP/citrulline ratio and weight, BMI, glucose, insulin, and C peptide levels., Conclusion: SG not only induces enterocyte dysfunction and mass recovery but also may facilitate T2DM remission and alleviate obesity-related effects on the enteroendocrine system. These findings highlight the potential beneficial effects of SG on enteroendocrine function in obese patients., Competing Interests: Declaration of competing interest All of the authors reported no biomedical financial interests or potential conflicts of interest., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
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