Berenguer, Juan, Calvo-Alcántara, María J, Alvaro-Meca, Alejandro, Estévez, José C, Basanta, Miguel, Ruiz, Sergio, Matáix, Ángel L, Bienzóbas, César, Cosano, Lourdes, Silva, Aura P, Salas, Pilar, Gullón, Pedro, Franco, Manuel, Arribas, José R, Molero, José M, and Hernán, Miguel A
Background Our objective was to assess the health impact of coronavirus disease 2019 (COVID-19) during 2020–2022 in the Madrid region. Methods We included all individuals registered in the Madrid Health System Registry as of 31 December 2019, and followed them until 31 December 2022. Using a unique personal identifier, we linked the databases of primary care, hospitals, pharmacies, certified laboratories performing diagnostic tests, vaccines, and mortality. Results Of 6 833 423 individuals, 21.4% had a confirmed COVID-19 diagnosis, and 1.5% had a COVID-19 hospitalization (primary diagnosis). Thirty-day mortality was 1.6% for confirmed COVID-19 (from 11.4% in first semester 2020 to 0.4% in first semester 2022). Thirty-day mortality was 10.8% for COVID-19 hospitalizations (from 14.0% in first semester 2020 to 6.0% in second semester 2022). There were 24 073 deaths within 30 days of a confirmed COVID-19 diagnosis. Advanced age, male sex, higher socioeconomic deprivation, and comorbidities were associated with higher mortality. Conclusions By linking administrative and clinical databases, we characterized the burden of the COVID-19 pandemic in Madrid over 3 years. Our analysis proposes a high-level framework for comparisons of the burden of COVID-19 across areas worldwide. [ABSTRACT FROM AUTHOR]