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Salt mixing enables the transport of water between the inflow and outflow layers of estuarine circulation and therefore closes the circulation by driving a diahaline exchange flow. A recently derived universal law links the salt mixing inside an estuarine volume bounded by an isohaline surface to freshwater discharge: it states that on long-term average, the area-integrated mixing across the bounding isohaline is directly proportional to the freshwater discharge entering the estuary. However, even though numerous studies predict that periods of extreme discharge will become more frequent with climate change, the direct impact of such periods on estuarine mixing and circulation has yet to be investigated. Therefore, this numerical modeling study focuses on salinity mixing and diahaline exchange flows during a low-discharge and an extreme high-discharge period. To this end, we apply a realistic numerical setup of the Elbe estuary in northern Germany, using curvilinear coordinates that follow the navigational channel. This is the first time the direct relationship between diahaline exchange flow and salt mixing as well as the spatial distribution of the diahaline exchange flow is shown in a realistic tidal setup. The spatial distribution is highly correlated with the local mixing gradient for salinity, such that inflow occurs near the bottom at the upstream end of the isohaline. Meanwhile, outflow occurs near the surface at its downstream end. Last, increased vertical stratification occurs within the estuary during the high-discharge period, while estuarine-wide mixing strongly converges to the universal law for averaging periods of the discharge event time scale. Significance Statement: Inside estuaries, such as river mouths, terrestrial freshwater is mixed with salty ocean water. This is accompanied by an estuarine circulation with inflow of saltwater into the estuary and outflow of brackish water toward the ocean. Here, we aim to better understand how salt mixing and estuarine circulation in a tidal estuary react to periods of extreme freshwater discharge. We find that even during extremely high or low discharge, salt mixing follows the freshwater discharge on time scales as short as days, and that estuarine circulation patterns are largely explained by the local distribution of mixing. As extreme runoff events are likely to occur more often with climate change, these findings may help to understand the dynamics inside future estuaries. [ABSTRACT FROM AUTHOR]