5 results on '"Glover, N"'
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2. The Large Hadron–Electron Collider at the HL-LHC
- Author
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Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, Zurita, P, Agostini, P, Aksakal, H, Alekhin, S, Allport, P P, Andari, N, Andre, K D J, Angal-Kalinin, D, Antusch, S, Aperio Bella, L, Apolinario, L, Apsimon, R, Apyan, A, Arduini, G, Ari, V, Armbruster, A, Armesto, N, Auchmann, B, Aulenbacher, K, Azuelos, G, Backovic, S, Bailey, I, Bailey, S, Balli, F, Behera, S, Behnke, O, Ben-Zvi, I, Benedikt, M, Bernauer, J, Bertolucci, S, Biswal, S S, Blümlein, J, Bogacz, A, Bonvini, M, Boonekamp, M, Bordry, F, Boroun, G R, Bottura, L, Bousson, S, Bouzas, A O, Bracco, C, Bracinik, J, Britzger, D, Brodsky, S J, Bruni, C, Brüning, O, Burkhardt, H, Cakir, O, Calaga, R, Caldwell, A, Calıskan, A, Camarda, S, Catalan-Lasheras, N C, Cassou, K, Cepila, J, Cetinkaya, V, Chetvertkova, V, Cole, B, Coleppa, B, Cooper-Sarkar, A, Cormier, E, Cornell, A S, Corsini, R, Cruz-Alaniz, E, Currie, J, Curtin, D, D’Onofrio, M, Dainton, J, Daly, E, Das, A, Das, S P, Dassa, L, de Blas, J, Delle Rose, L, Denizli, H, Deshpande, K S, Douglas, D, Duarte, L, Dupraz, K, Dutta, S, Efremov, A V, Eichhorn, R, Eskola, K J, Ferreiro, E G, Fischer, O, Flores-Sánchez, O, Forte, S, Gaddi, A, Gao, J, Gehrmann, T, Gehrmann-De Ridder, A, Gerigk, F, Gilbert, A, Giuli, F, Glazov, A, Glover, N, Godbole, R M, Goddard, B, Gonçalves, V, Gonzalez-Sprinberg, G A, Goyal, A, Grames, J, Granados, E, Grassellino, A, Gunaydin, Y O, Guo, Y C, Guzey, V, Gwenlan, C, Hammad, A, Han, C C, Harland-Lang, L, Haug, F, Hautmann, F, Hayden, D, Hessler, J, Helenius, I, Henry, J, Hernandez-Sanchez, J, Hesari, H, Hobbs, T J, Hod, N, Hoffstaetter, G H, Holzer, B, Honorato, C G, Hounsell, B, Hu, N, Hug, F, Huss, A, Hutton, A, Islam, R, Iwamoto, S, Jana, S, Jansova, M, Jensen, E, Jones, T, Jowett, J M, Kaabi, W, Kado, M, Kalinin, D A, Karadeniz, H, Kawaguchi, S, Kaya, U, Khalek, R A, Khanpour, H, Kilic, A, Klein, M, Klein, U, Kluth, S, Köksal, M, Kocak, F, Korostelev, M, Kostka, P, Krelina, M, Kretzschmar, J, Kuday, S, Kulipanov, G, Kumar, M, Kuze, M, Lappi, T, Larios, F, Latina, A, Laycock, P, Lei, G, Levitchev, E, Levonian, S, Levy, A, Li, R, Li, X, Liang, H, Litvinenko, V, Liu, M, Liu, T, Liu, W, Liu, Y, Liuti, S, Lobodzinska, E, Longuevergne, D, Luo, X, Ma, W, Machado, M, Mandal, S, Mäntysaari, H, Marhauser, F, Marquet, C, Martens, A, Martin, R, Marzani, S, McFayden, J, Mcintosh, P, Mellado, B, Meot, F, Milanese, A, Milhano, J G, Militsyn, B, Mitra, M, Moch, S, Mohammadi Najafabadi, M, Mondal, S, Moretti, S, Morgan, T, Morreale, A, Nadolsky, P, Navarra, F, Nergiz, Z, Newman, P, Niehues, J, Nissen, E A, Nowakowski, M, Okada, N, Olivier, G, Olness, F, Olry, G, Osborne, J A, Ozansoy, A, Pan, R, Parker, B, Patra, M, Paukkunen, H, Peinaud, Y, Pellegrini, D, Perez-Segurana, G, Perini, D, Perrot, L, Pietralla, N, Pilicer, E, Pire, B, Pires, J, Placakyte, R, Poelker, M, Polifka, R, Polini, A, Poulose, P, Pownall, G, Pupkov, Y A, Queiroz, F S, Rabbertz, K, Radescu, V, Rahaman, R, Rai, S K, Raicevic, N, Ratoff, P, Rashed, A, Raut, D, Raychaudhuri, S, Repond, J, Rezaeian, A H, Rimmer, R, Rinolfi, L, Rojo, J, Rosado, A, Ruan, X, Russenschuck, S, Sahin, M, Salgado, C A, Sampayo, O A, Satendra, K, Satyanarayan, N, Schenke, B, Schirm, K, Schopper, H, Schott, M, Schulte, D, Schwanenberger, C, Sekine, T, Senol, A, Seryi, A, Setiniyaz, S, Shang, L, Shen, X, Shipman, N, Sinha, N, Slominski, W, Smith, S, Solans, C, Song, M, Spiesberger, H, Stanyard, J, Starostenko, A, Stasto, A, Stocchi, A, Strikman, M, Stuart, M J, Sultansoy, S, Sun, H, Sutton, M, Szymanowski, L, Tapan, I, Tapia-Takaki, D, Tanaka, M, Tang, Y, Tasci, A T, Ten-Kate, A T, Thonet, P, Tomas-Garcia, R, Tommasini, D, Trbojevic, D, Trott, M, Tsurin, I, Tudora, A, Turk Cakir, I, Tywoniuk, K, Vallerand, C, Valloni, A, Verney, D, Vilella, E, Walker, D, Wallon, S, Wang, B, Wang, K, Wang, X, Wang, Z S, Wei, H, Welsch, C, Willering, G, Williams, P H, Wollmann, D, Xiaohao, C, Xu, T, Yaguna, C E, Yamaguchi, Y, Yamazaki, Y, Yang, H, Yilmaz, A, Yock, P, Yue, C X, Zadeh, S G, Zenaiev, O, Zhang, C, Zhang, J, Zhang, R, Zhang, Z, Zhu, G, Zhu, S, Zimmermann, F, Zomer, F, Zurita, J, and Zurita, P
- Abstract
The Large Hadron–Electron Collider (LHeC) is designed to move the field of deep inelastic scattering (DIS) to the energy and intensity frontier of particle physics. Exploiting energy-recovery technology, it collides a novel, intense electron beam with a proton or ion beam from the High-Luminosity Large Hadron Collider (HL-LHC). The accelerator and interaction region are designed for concurrent electron–proton and proton–proton operations. This report represents an update to the LHeC’s conceptual design report (CDR), published in 2012. It comprises new results on the parton structure of the proton and heavier nuclei, QCD dynamics, and electroweak and top-quark physics. It is shown how the LHeC will open a new chapter of nuclear particle physics by extending the accessible kinematic range of lepton–nucleus scattering by several orders of magnitude. Due to its enhanced luminosity and large energy and the cleanliness of the final hadronic states, the LHeC has a strong Higgs physics programme and its own discovery potential for new physics. Building on the 2012 CDR, this report contains a detailed updated design for the energy-recovery electron linac (ERL), including a new lattice, magnet and superconducting radio-frequency technology, and further components. Challenges of energy recovery are described, and the lower-energy, high-current, three-turn ERL facility, PERLE at Orsay, is presented, which uses the LHeC characteristics serving as a development facility for the design and operation of the LHeC. An updated detector design is presented corresponding to the acceptance, resolution, and calibration goals that arise from the Higgs and parton-density-function physics programmes. This paper also presents novel results for the Future Circular Collider in electron–hadron (FCC-eh) mode, which utilises the same ERL technology to further extend the reach of DIS to even higher centre-of-mass energies.
- Published
- 2024
3. Impact of occupational stress on healthcare workers' family members before and during COVID-19: A systematic review.
- Author
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Tekin S, Nicholls H, Lamb D, Glover N, and Billings J
- Subjects
- Humans, Mental Health, Quality of Life psychology, SARS-CoV-2, Pandemics, COVID-19 psychology, COVID-19 epidemiology, Health Personnel psychology, Family psychology, Occupational Stress psychology, Adaptation, Psychological
- Abstract
We aimed to explore the experiences, needs, and mental health impact of family members of healthcare workers (HCWs) before and during the COVID-19 pandemic. Eleven quantitative and nine qualitative studies were included in this review. Based on the narrative synthesis, we identified five outcomes: 'Mental health outcomes', 'Family relationships, 'Coping skills and resilience', 'Quality of life and social life', and 'Practical outcomes'. Our findings indicated that there was a high risk to the mental health and well-being of families of healthcare workers both before and during the pandemic. However, with the COVID-19 pandemic, some experiences and mental health issues of families were worsened. There was also a negative association between working long hours/shift work and family relationships/communication, family social life, and joint activities, and family members taking on more domestic responsibilities. Families tended to use both positive and negative coping strategies to deal with their loved one's job stress. Organisations and support services working with people in health care work should consider widening support to families where possible. With this understanding, HCWs and their families could be supported more effectively in clinical and organisational settings. Trial registration: Systematic Review Registration Number: CRD42022310729. https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022310729., Competing Interests: NO authors have competing interests., (Copyright: © 2024 Tekin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
- Published
- 2024
- Full Text
- View/download PDF
4. Biological variability hampers the use of skeletal staining methods in zebrafish embryo developmental toxicity assays.
- Author
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Hoyberghs J, Ball J, Trznadel M, Beekhuijzen M, Burbank M, Wilhelmi P, Muriana A, Powles-Glover N, Letamendia A, and Van Cruchten S
- Subjects
- Animals, Staining and Labeling, Bone and Bones drug effects, Bone and Bones abnormalities, Embryonic Development drug effects, Fluoresceins toxicity, Anthraquinones toxicity, Zebrafish embryology, Teratogens toxicity, Embryo, Nonmammalian drug effects, Toxicity Tests methods
- Abstract
Zebrafish embryo assays are used by pharmaceutical and chemical companies as new approach methodologies (NAMs) in developmental toxicity screening. Despite an overall high concordance of zebrafish embryo assays with in vivo mammalian studies, false negative and false positive results have been reported. False negative results in risk assessment models are of particular concern for human safety, as developmental anomalies may be missed. Interestingly, for several chemicals and drugs that were reported to be false negative in zebrafish, skeletal findings were noted in the in vivo studies. As the number of skeletal endpoints assessed in zebrafish is very limited compared to the in vivo mammalian studies, the aim of this study was to investigate whether the sensitivity could be increased by including a skeletal staining method. Three staining methods were tested on zebrafish embryos that were exposed to four teratogens that caused skeletal anomalies in rats and/or rabbits and were false negative in zebrafish embryo assays. These methods included a fixed alizarin red-alcian blue staining, a calcein staining, and a live alizarin red staining. The results showed a high variability in staining intensity of larvae exposed to mammalian skeletal teratogens, as well as variability between control larvae originating from the same clutch of zebrafish. Hence, biological variability in (onset of) bone development in zebrafish hampers the detection of (subtle) treatment-related bone effects that are not picked-up by gross morphology. In conclusion, the used skeletal staining methods did not increase the sensitivity of zebrafish embryo developmental toxicity assays., Competing Interests: Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Steven Van Cruchten reports financial support was provided by University of Antwerp. Jonathan Ball reports financial support and equipment, drugs, or supplies were provided by University of Exeter. Steven Van Cruchten is Associate Editor for Reproductive Toxicology and Guest Editor for the Special Issue on NAMs for DART testing If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
5. DrosOMA: the Drosophila Orthologous Matrix browser.
- Author
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Thiébaut A, Altenhoff AM, Campli G, Glover N, Dessimoz C, and Waterhouse RM
- Subjects
- Animals, Comparative Genomic Hybridization, Databases, Factual, Genomics, Drosophila genetics, Evolution, Molecular
- Abstract
Background: Comparative genomic analyses to delineate gene evolutionary histories inform the understanding of organismal biology by characterising gene and gene family origins, trajectories, and dynamics, as well as enabling the tracing of speciation, duplication, and loss events, and facilitating the transfer of gene functional information across species. Genomic data are available for an increasing number of species from the genus Drosophila, however, a dedicated resource exploiting these data to provide the research community with browsable results from genus-wide orthology delineation has been lacking., Methods: Using the OMA Orthologous Matrix orthology inference approach and browser deployment framework, we catalogued orthologues across a selected set of Drosophila species with high-quality annotated genomes. We developed and deployed a dedicated instance of the OMA browser to facilitate intuitive exploration, visualisation, and downloading of the genus-wide orthology delineation results., Results: DrosOMA - the Drosophila Orthologous Matrix browser, accessible from https://drosoma.dcsr.unil.ch/ - presents the results of orthology delineation for 36 drosophilids from across the genus and four outgroup dipterans. It enables querying and browsing of the orthology data through a feature-rich web interface, with gene-view, orthologous group-view, and genome-view pages, including comprehensive gene name and identifier cross-references together with available functional annotations and protein domain architectures, as well as tools to visualise local and global synteny conservation., Conclusions: The DrosOMA browser demonstrates the deployability of the OMA browser framework for building user-friendly orthology databases with dense sampling of a selected taxonomic group. It provides the Drosophila research community with a tailored resource of browsable results from genus-wide orthology delineation., Competing Interests: No competing interests were disclosed., (Copyright: © 2024 Thiébaut A et al.)
- Published
- 2024
- Full Text
- View/download PDF
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