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Com o presente trabalho pretende-se investigar as diretrizes constitucionais e normativas acerca da competência e políticas públicas em matéria de meio ambiente com foco em um modelo sistêmico. Dessa forma, visa-se responder ao problema de pesquisa: quais as contribuições que uma teoria sistêmica das políticas públicas pode contribuir na concretização do direito fundamental ao meio ambiente? Para tanto utilizou-se do método de abordagem dedutivo, método de procedimento adotou-se o monográfico e, as técnicas de pesquisa resumem-se a consulta a livros, artigos, periódicos, teses, dissertações, dentre outros meios. Considerando que a pesquisa encontra-se em andamento, os resultados preliminares são no sentido de que é fundamental uma observação sistêmica das políticas públicas utilizando referenciais não apenas jurídicos, mas também sociais e políticos.

Background and purposeImage-guided adapted brachytherapy (IGABT) is superior to other radiotherapy techniques in the treatment of locally advanced cervical cancer (LACC). We aimed to investigate the benefit of interstitial needles (IN) for a combined intracavitary/interstitial (IC/IS) approach using IGABT over the intracavitary approach (IC) alone in patients with LACC after concomitant external beam radiotherapy (EBRT) and chemotherapy.Materials and methodsWe included consecutive patients with LACC who were treated with IC/IS IGABT after radiochemotherapy (RCT) in our retrospective, observational study. Dosimetric gain and sparing of organs at risk (OAR) were investigated by comparing the IC/IS IGABT plan with a simulated plan without needle use (IC IGABT plan) and the impact of other clinical factors on the benefit of IC/IS IGABT.ResultsNinety-nine patients were analyzed, with a mean EBRT dose of 45.5 ± 1.7 Gy; 97 patients received concurrent chemotherapy. A significant increase in median D90% High Risk Clinical target volume (HR-CTV) was found for IC/IS (82.8 Gy) vs IC (76.2 Gy) (p < 10-4). A significant decrease of the delivered dose for all OAR was found for IC/IS vs IC for median D2cc to the bladder (77.2 Gy), rectum (68 Gy), sigmoid (53.2 Gy), and small bowel (47 Gy) (all p < 10-4).ConclusionHR-CTV coverage was higher with IC/IS IGABT than with IC IGABT, with lower doses to the OAR in patients managed for LACC after RCT. Interstitial brachytherapy in the management of LACC after radiotherapy provides better coverage of the target volumes, this could contribute to better local control and improved survival of patients.

Company is a group of people who are members of an organization working to achieve certain goals. One of the most basic company goals is to obtain maximum profit from the business activities carried out by the company. Establishing a company aims not only to gain maximum profit, but also to increase the prosperity of parties related to the company's business activities, such as shareholders so that the firm value has a rise. This research used quantitative data method. The results found that Working Capital Management has a positive and significant effect on Firm Value while Leverage has no significant effect on Firm Value. In addition, Working Capital Management and Leverage simultaneously have no significant effect on Firm Value. Firm value could be used as the basis for making investment decisions because the aspect measures the ability of the company's assets to generate a return on investment made in the company's asset instruments. [ABSTRACT FROM AUTHOR]