64 results on '"García S."'
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2. “There is plenty of energy at the bottom”: A spectral conversion approach for upconversion-powered water-splitting PEC cell
- Author
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Méndez-Ramos, J., Borges, M.E., Torres-García, S., Medina-Alayón, M., Acosta-Mora, P., del-Castillo, J., Menéndez-Velázquez, A., García-Delgado, A.B., Mullins, C.B., and Esparza, P.
- Published
- 2025
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3. Constraint on the total width of the Higgs boson from Higgs boson and four-top-quark measurements in pp collisions at [formula omitted] = 13 TeV with the ATLAS detector
- Author
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Aad, G., Aakvaag, E., Abbott, B., Abdelhameed, S., Abeling, K., Abicht, N.J., Abidi, S.H., Aboelela, M., Aboulhorma, A., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Ackermann, A., Adam Bourdarios, C., Adamczyk, L., Addepalli, S.V., Addison, M.J., Adelman, J., Adiguzel, A., Adye, T., Affolder, A.A., Afik, Y., Agaras, M.N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Ahmadov, F., Ahmed, W.S., Ahuja, S., Ai, X., Aielli, G., Aikot, A., Ait Tamlihat, M., Aitbenchikh, B., Akbiyik, M., Åkesson, T.P.A., Akimov, A.V., Akiyama, D., Akolkar, N.N., Aktas, S., Al Khoury, K., Alberghi, G.L., Albert, J., Albicocco, P., Albouy, G.L., Alderweireldt, S., Alegria, Z.L., Aleksa, M., Aleksandrov, I.N., Alexa, C., Alexopoulos, T., Alfonsi, F., Algren, M., Alhroob, M., Ali, B., Ali, H.M.J., Ali, S., Alibocus, S.W., Aliev, M., Alimonti, G., Alkakhi, W., Allaire, C., Allbrooke, B.M.M., Allen, J.S., Allen, J.F., Allendes Flores, C.A., Allport, P.P., Aloisio, A., Alonso, F., Alpigiani, C., Alsolami, Z.M.K., Alvarez Estevez, M., Alvarez Fernandez, A., Alves Cardoso, M., Alviggi, M.G., Aly, M., Amaral Coutinho, Y., Ambler, A., Amelung, C., Amerl, M., Ames, C.G., Amidei, D., Amini, B., Amirie, K.J., Amor Dos Santos, S.P., Amos, K.R., Amperiadou, D., An, S., Ananiev, V., Anastopoulos, C., Andeen, T., Anders, J.K., Anderson, A.C., Andrean, S.Y., Andreazza, A., Angelidakis, S., Angerami, A., Anisenkov, A.V., Annovi, A., Antel, C., Antipov, E., Antonelli, M., Anulli, F., Aoki, M., Aoki, T., Aparo, M.A., Aperio Bella, L., Appelt, C., Apyan, A., Arbiol Val, S.J., Arcangeletti, C., Arce, A.T.H., Arguin, J-F., Argyropoulos, S., Arling, J.-H., Arnaez, O., Arnold, H., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N.A., Ashby Pickering, R.A., Assamagan, K., Astalos, R., Astrand, K.S.V., Atashi, S., Atkin, R.J., Atkinson, M., Atmani, H., Atmasiddha, P.A., Augsten, K., Auricchio, S., Auriol, A.D., Austrup, V.A., Avolio, G., Axiotis, K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Bachiu, A., Bachmann, E., Backman, F., Badea, A., Baer, T.M., Bagnaia, P., Bahmani, M., Bahner, D., Bai, K., Baines, J.T., Baines, L., Baker, O.K., Bakos, E., Bakshi Gupta, D., Balabram Filho, L.E., Balakrishnan, V., Balasubramanian, R., Baldin, E.M., Balek, P., Ballabene, E., Balli, F., Baltes, L.M., Balunas, W.K., Balz, J., Bamwidhi, I., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Bansal, S., Barak, L., Barakat, M., Barberio, E.L., Barberis, D., Barbero, M., Barel, M.Z., Barillari, T., Barisits, M-S., Barklow, T., Baron, P., Baron Moreno, D.A., Baroncelli, A., Barr, A.J., Barr, J.D., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barros Teixeira, M.G., Barsov, S., Bartels, F., Bartoldus, R., Barton, A.E., Bartos, P., Basan, A., Baselga, M., Bassalat, A., Basso, M.J., Bataju, S., Bate, R., Bates, R.L., Batlamous, S., Batool, B., Battaglia, M., Battulga, D., Bauce, M., Bauer, M., Bauer, P., Bazzano Hurrell, L.T., Beacham, J.B., Beau, T., Beaucamp, J.Y., Beauchemin, 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Clark, A., Clark, P.J., Clarke Hall, N., Clarry, C., Clavijo Columbie, J.M., Clawson, S.E., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Coelho Barrue, R.F., Coelho Lopes De Sa, R., Coelli, S., Colangeli, L.S., Cole, B., Collot, J., Conde Muiño, P., Connell, M.P., Connell, S.H., Conroy, E.I., Conventi, F., Cooke, H.G., Cooper-Sarkar, A.M., Corchia, F.A., Cordeiro Oudot Choi, A., Corpe, L.D., Corradi, M., Corriveau, F., Cortes-Gonzalez, A., Costa, M.J., Costanza, F., Costanzo, D., Cote, B.M., Couthures, J., Cowan, G., Cranmer, K., Cremer, L., Cremonini, D., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosby, J.E., Crosetti, G., Cueto, A., Cui, H., Cui, Z., Cunningham, W.R., Curcio, F., Curran, J.R., Czodrowski, P., Da Cunha Sargedas De Sousa, M.J., Da Fonseca Pinto, J.V., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dal Santo, D., Dallapiccola, C., Dam, M., D'amen, G., D'Amico, V., Damp, J., Dandoy, J.R., Dannheim, D., Danninger, 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Dimitriadi, C., Dimitrievska, A., Dingfelder, J., Dingley, T., Dinu, I-M., Dittmeier, S.J., Dittus, F., Divisek, M., Dixit, B., Djama, F., Djobava, T., Doglioni, C., Dohnalova, A., Dolejsi, J., Dolezal, Z., Domijan, K., Dona, K.M., Donadelli, M., Dong, B., Donini, J., D'Onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dos Santos Fernandes, N., Dougan, P., Dova, M.T., Doyle, A.T., Draguet, M.A., Drescher, M.P., Dreyer, E., Drivas-koulouris, I., Drnevich, M., Drozdova, M., Du, D., du Pree, T.A., Dubinin, F., Dubovsky, M., Duchovni, E., Duckeck, G., Ducu, O.A., Duda, D., Dudarev, A., Duden, E.R., D'uffizi, M., Duflot, L., Dührssen, M., Duminica, I., Dumitriu, A.E., Dunford, M., Dungs, S., Dunne, K., Duperrin, A., Duran Yildiz, H., Düren, M., Durglishvili, A., Duvnjak, D., Dwyer, B.L., Dyckes, G.I., Dyndal, M., Dziedzic, B.S., Earnshaw, Z.O., Eberwein, G.H., Eckerova, B., Eggebrecht, S., Egidio Purcino De Souza, E., Ehrke, L.F., Eigen, G., Einsweiler, K., Ekelof, T., Ekman, P.A., El 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Gurdasani, S.S., Gustavino, G., Gutierrez, P., Gutierrez Zagazeta, L.F., Gutsche, M., Gutschow, C., Gwenlan, C., Gwilliam, C.B., Haaland, E.S., Haas, A., Habedank, M., Haber, C., Hadavand, H.K., Hadef, A., Hadzic, S., Hagan, A.I., Hahn, J.J., Haines, E.H., Haleem, M., Haley, J., Hallewell, G.D., Halser, L., Hamano, K., Hamer, M., Hampshire, E.J., Han, J., Han, L., Han, S., Han, Y.F., Hanagaki, K., Hance, M., Hangal, D.A., Hanif, H., Hank, M.D., Hansen, J.B., Hansen, P.H., Harada, D., Harenberg, T., Harkusha, S., Harris, M.L., Harris, Y.T., Harrison, J., Harrison, N.M., Harrison, P.F., Hartman, N.M., Hartmann, N.M., Hasan, R.Z., Hasegawa, Y., Haslbeck, F., Hassan, S., Hauser, R., Hawkes, C.M., Hawkings, R.J., Hayashi, Y., Hayden, D., Hayes, C., Hayes, R.L., Hays, C.P., Hays, J.M., Hayward, H.S., He, F., He, M., He, Y., Heatley, N.B., Hedberg, V., Heggelund, A.L., Hehir, N.D., Heidegger, C., Heidegger, K.K., Heilman, J., Heim, S., Heim, T., Heinlein, J.G., Heinrich, J.J., Heinrich, L., Hejbal, J., Held, A., Hellesund, S., Helling, C.M., Hellman, S., Henderson, R.C.W., Henkelmann, L., Henriques Correia, A.M., Herde, H., Hernández Jiménez, Y., Herrmann, L.M., Herrmann, T., Herten, G., Hertenberger, R., Hervas, L., Hesping, M.E., Hessey, N.P., Hessler, J., Hidaoui, M., Hidic, N., Hill, E., Hillier, S.J., Hinds, J.R., Hinterkeuser, F., Hirose, M., Hirose, S., Hirschbuehl, D., Hitchings, T.G., Hiti, B., Hobbs, J., Hobincu, R., Hod, N., Hodgkinson, M.C., Hodkinson, B.H., Hoecker, A., Hofer, D.D., Hofer, J., Holm, T., Holzbock, M., Hommels, L.B.A.H., Honan, B.P., Hong, J.J., Hong, J., Hong, T.M., Hooberman, B.H., Hopkins, W.H., Hoppesch, M.C., Horii, Y., Horstmann, M.E., Hou, S., Howard, A.S., Howarth, J., Hoya, J., Hrabovsky, M., Hrynevich, A., Hryn'ova, T., Hsu, P.J., Hsu, S.-C., Hsu, T., Hu, M., Hu, Q., Huang, S., Huang, X., Huang, Y., Huang, Z., Hubacek, Z., Huebner, M., Huegging, F., Huffman, T.B., Hufnagel Maranha De Faria, M., Hugli, C.A., Huhtinen, M., Huiberts, S.K., Hulsken, R., Huseynov, N., Huston, J., Huth, J., Hyneman, R., Iacobucci, G., Iakovidis, G., Iconomidou-Fayard, L., Iddon, J.P., Iengo, P., Iguchi, R., Iiyama, Y., Iizawa, T., Ikegami, Y., Ilic, N., Imam, H., Inacio Goncalves, G., Ingebretsen Carlson, T., Inglis, J.M., Introzzi, G., Iodice, M., Ippolito, V., Irwin, R.K., Ishino, M., Islam, W., Issever, C., Istin, S., Ito, H., Iuppa, R., Ivina, A., Izen, J.M., Izzo, V., Jacka, P., Jackson, P., Jagfeld, C.S., Jain, G., Jain, P., Jakobs, K., Jakoubek, T., Jamieson, J., Jang, W., Javurkova, M., Jawahar, P., Jeanty, L., Jejelava, J., Jenni, P., Jessiman, C.E., Jia, C., Jia, H., Jia, J., Jia, X., Jia, Z., Jiang, C., Jiggins, S., Jimenez Pena, J., Jin, S., Jinaru, A., Jinnouchi, O., Johansson, P., Johns, K.A., Johnson, J.W., Jolly, F.A., Jones, D.M., Jones, E., Jones, K.S., Jones, P., Jones, R.W.L., Jones, T.J., Joos, H.L., Joshi, R., Jovicevic, J., Ju, X., Junggeburth, J.J., Junkermann, T., Juste Rozas, A., Juzek, M.K., Kabana, S., 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- 2025
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4. Measurement of top-quark pair production in association with charm quarks in proton–proton collisions at [formula omitted] TeV with the ATLAS detector
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Aad, G., Aakvaag, E., Abbott, B., Abdelhameed, S., Abeling, K., Abicht, N.J., Abidi, S.H., Aboelela, M., Aboulhorma, A., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Ackermann, A., Adam Bourdarios, C., Adamczyk, L., Addepalli, S.V., Addison, M.J., Adelman, J., Adiguzel, A., Adye, T., Affolder, A.A., Afik, Y., Agaras, M.N., Aggarwal, A., Agheorghiesei, C., Ahmadov, F., Ahuja, S., Ai, X., Aielli, G., Aikot, A., Ait Tamlihat, M., Aitbenchikh, B., Akbiyik, M., Åkesson, T.P.A., Akimov, A.V., Akiyama, D., Akolkar, N.N., Aktas, S., Al Khoury, K., Alberghi, G.L., Albert, J., Albicocco, P., Albouy, G.L., Alderweireldt, S., Alegria, Z.L., Aleksa, M., Aleksandrov, I.N., Alexa, C., Alexopoulos, T., Alfonsi, F., Algren, M., Alhroob, M., Ali, B., Ali, H.M.J., Ali, S., Alibocus, S.W., Aliev, M., Alimonti, G., Alkakhi, W., Allaire, C., Allbrooke, B.M.M., Allen, J.S., Allen, J.F., Allendes Flores, C.A., Allport, P.P., Aloisio, A., Alonso, F., Alpigiani, C., Alsolami, Z.M.K., Alvarez Estevez, M., Alvarez Fernandez, A., Alves Cardoso, M., Alviggi, M.G., Aly, M., Amaral Coutinho, Y., Ambler, A., Amelung, C., Amerl, M., Ames, C.G., Amidei, D., Amini, B., Amirie, K.J., Amor Dos Santos, S.P., Amos, K.R., Amperiadou, D., An, S., Ananiev, V., Anastopoulos, C., Andeen, T., Anders, J.K., Anderson, A.C., Andrean, S.Y., Andreazza, A., Angelidakis, S., Angerami, A., Anisenkov, A.V., Annovi, A., Antel, C., Antipov, E., Antonelli, M., Anulli, F., Aoki, M., Aoki, T., Aparo, M.A., Aperio Bella, L., Appelt, C., Apyan, A., Arbiol Val, S.J., Arcangeletti, C., Arce, A.T.H., Arguin, J-F., Argyropoulos, S., Arling, J.-H., Arnaez, O., Arnold, H., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N.A., Ashby Pickering, R.A., Assamagan, K., Astalos, R., Astrand, K.S.V., Atashi, S., Atkin, R.J., Atmani, H., Atmasiddha, P.A., Augsten, K., Auriol, A.D., Austrup, V.A., Avolio, G., Axiotis, K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Bachiu, A., Bachmann, E., Badea, A., Baer, T.M., Bagnaia, 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- 2025
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5. Combination of searches for singly and doubly charged Higgs bosons produced via vector-boson fusion in proton–proton collisions at [formula omitted] TeV with the ATLAS detector
- Author
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Aad, G., Aakvaag, E., Abbott, B., Abdelhameed, S., Abeling, K., Abicht, N.J., Abidi, S.H., Aboelela, M., Aboulhorma, A., Abramowicz, H., Abreu, H., Abulaiti, Y., Acharya, B.S., Ackermann, A., Adam Bourdarios, C., Adamczyk, L., Addepalli, S.V., Addison, M.J., Adelman, J., Adiguzel, A., Adye, T., Affolder, A.A., Afik, Y., Agaras, M.N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Ahmadov, F., Ahmed, W.S., Ahuja, S., Ai, X., Aielli, G., Aikot, A., Ait Tamlihat, M., Aitbenchikh, B., Akbiyik, M., Åkesson, T.P.A., Akimov, A.V., Akiyama, D., Akolkar, N.N., Aktas, S., Al Khoury, K., Alberghi, G.L., Albert, J., Albicocco, P., Albouy, G.L., Alderweireldt, S., Alegria, Z.L., Aleksa, M., Aleksandrov, I.N., Alexa, C., Alexopoulos, T., Alfonsi, F., Algren, M., Alhroob, M., Ali, B., Ali, H.M.J., Ali, S., Alibocus, S.W., Aliev, M., Alimonti, G., Alkakhi, W., Allaire, C., Allbrooke, B.M.M., Allen, J.S., Allen, J.F., Allendes Flores, C.A., Allport, P.P., Aloisio, A., Alonso, F., Alpigiani, C., Alsolami, Z.M.K., Alvarez Estevez, M., Alvarez Fernandez, A., Alves Cardoso, M., Alviggi, M.G., Aly, M., Amaral Coutinho, Y., Ambler, A., Amelung, C., Amerl, M., Ames, C.G., Amidei, D., Amini, B., Amirie, K.J., Amor Dos Santos, S.P., Amos, K.R., Amperiadou, D., An, S., Ananiev, V., Anastopoulos, C., Andeen, T., Anders, J.K., Anderson, A.C., Andrean, S.Y., Andreazza, A., Angelidakis, S., Angerami, A., Anisenkov, A.V., Annovi, A., Antel, C., Antipov, E., Antonelli, M., Anulli, F., Aoki, M., Aoki, T., Aparo, M.A., Aperio Bella, L., Appelt, C., Apyan, A., Arbiol Val, S.J., Arcangeletti, C., Arce, A.T.H., Arguin, J-F., Argyropoulos, S., Arling, J.-H., Arnaez, O., Arnold, H., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N.A., Ashby Pickering, R.A., Assamagan, K., Astalos, R., Astrand, K.S.V., Atashi, S., Atkin, R.J., Atkinson, M., Atmani, H., Atmasiddha, P.A., Augsten, K., Auricchio, S., Auriol, A.D., Austrup, V.A., Avolio, G., Axiotis, K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Bachiu, A., Bachmann, E., Backman, F., Badea, A., Baer, T.M., Bagnaia, P., Bahmani, M., Bahner, D., Bai, K., Baines, J.T., Baines, L., Baker, O.K., Bakos, E., Bakshi Gupta, D., Balabram Filho, L.E., Balakrishnan, V., Balasubramanian, R., Baldin, E.M., Balek, P., Ballabene, E., Balli, F., Baltes, L.M., Balunas, W.K., Balz, J., Bamwidhi, I., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Bansal, S., Barak, L., Barakat, M., Barberio, E.L., Barberis, D., Barbero, M., Barel, M.Z., Barillari, T., Barisits, M-S., Barklow, T., Baron, P., Baron Moreno, D.A., Baroncelli, A., Barr, A.J., Barr, J.D., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barros Teixeira, M.G., Barsov, S., Bartels, F., Bartoldus, R., Barton, A.E., Bartos, P., Basan, A., Baselga, M., Bassalat, A., Basso, M.J., Bataju, S., Bate, R., Bates, R.L., Batlamous, S., Batool, B., Battaglia, M., Battulga, D., Bauce, M., Bauer, M., Bauer, P., Bazzano Hurrell, L.T., Beacham, J.B., Beau, T., Beaucamp, J.Y., Beauchemin, 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Clark, A., Clark, P.J., Clarke Hall, N., Clarry, C., Clavijo Columbie, J.M., Clawson, S.E., Clement, C., Coadou, Y., Cobal, M., Coccaro, A., Coelho Barrue, R.F., Coelho Lopes De Sa, R., Coelli, S., Colangeli, L.S., Cole, B., Collot, J., Conde Muiño, P., Connell, M.P., Connell, S.H., Conroy, E.I., Conventi, F., Cooke, H.G., Cooper-Sarkar, A.M., Corchia, F.A., Cordeiro Oudot Choi, A., Corpe, L.D., Corradi, M., Corriveau, F., Cortes-Gonzalez, A., Costa, M.J., Costanza, F., Costanzo, D., Cote, B.M., Couthures, J., Cowan, G., Cranmer, K., Cremer, L., Cremonini, D., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosby, J.E., Crosetti, G., Cueto, A., Cui, H., Cui, Z., Cunningham, W.R., Curcio, F., Curran, J.R., Czodrowski, P., Da Cunha Sargedas De Sousa, M.J., Da Fonseca Pinto, J.V., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dal Santo, D., Dallapiccola, C., Dam, M., D'amen, G., D'Amico, V., Damp, J., Dandoy, J.R., Dannheim, D., Danninger, 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Stampekis, A., Stanecka, E., Stanek-Maslouska, W., Stange, M.V., Stanislaus, B., Stanitzki, M.M., Stapf, B., Starchenko, E.A., Stark, G.H., Stark, J., Staroba, P., Starovoitov, P., Stärz, S., Staszewski, R., Stavropoulos, G., Stefl, A., Steinberg, P., Stelzer, B., Stelzer, H.J., Stelzer-Chilton, O., Stenzel, H., Stevenson, T.J., Stewart, G.A., Stewart, J.R., Stockton, M.C., Stoicea, G., Stolarski, M., Stonjek, S., Straessner, A., Strandberg, J., Strandberg, S., Stratmann, M., Strauss, M., Strebler, T., Strizenec, P., Ströhmer, R., Strom, D.M., Stroynowski, R., Strubig, A., Stucci, S.A., Stugu, B., Stupak, J., Styles, N.A., Su, D., Su, S., Su, W., Su, X., Suchy, D., Sugizaki, K., Sulin, V.V., Sullivan, M.J., Sultan, D.M.S., Sultanaliyeva, L., Sultansoy, S., Sumida, T., Sun, S., Sunneborn Gudnadottir, O., Sur, N., Sutton, M.R., Suzuki, H., Svatos, M., Swiatlowski, M., Swirski, T., Sykora, I., Sykora, M., Sykora, T., Ta, D., Tackmann, K., Taffard, A., Tafirout, R., Tafoya Vargas, J.S., 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Zambito, S., Zamora Saa, J.A., Zang, J., Zanzi, D., Zaplatilek, O., Zeitnitz, C., Zeng, H., Zeng, J.C., Zenger, D.T., Jr, Zenin, O., Ženiš, T., Zenz, S., Zerradi, S., Zerwas, D., Zhai, M., Zhang, D.F., Zhang, J., Zhang, K., Zhang, L., Zhang, P., Zhang, R., Zhang, S., Zhang, T., Zhang, X., Zhang, Y., Zhang, Z., Zhao, H., Zhao, T., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, J., Zheng, K., Zheng, X., Zheng, Z., Zhong, D., Zhou, B., Zhou, H., Zhou, N., Zhou, Y., Zhu, C.G., Zhu, J., Zhu, X., Zhu, Y., Zhuang, X., Zhukov, K., Zimine, N.I., Zinsser, J., Ziolkowski, M., Živković, L., Zoccoli, A., Zoch, K., Zorbas, T.G., Zormpa, O., Zou, W., and Zwalinski, L.
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- 2025
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6. Humanización y calidad de vida profesional en el cuidado oncohematológico y radioterápico: un estudio descriptivo en un hospital universitario
- Author
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Gutiérrez Delgado, A., Gómez Martín, C.J., Martín-Arriscado Arroba, C., González Monterrubio, G., Pérez García, S., and Jariego Gómez, A.
- Abstract
Evaluar los niveles de humanización, calidad de vida profesional, resiliencia, habilidades comunicativas y uso del silencio entre los profesionales sanitarios en estas áreas.
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- 2025
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7. Modelling Legal Enforcement with UFO-L: A Case from Swedish Healthcare
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Lindeberg, Jöran, Johannesson, Paul, Perjons, Erik, Henkel, Martin, Lappalainen, Katarina Fast, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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8. Safety Assurances in Autonomous Vessels
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Sreedharan, Sreekant, Ramachandran, Muthu, Røsæg, Erik, Rokseth, Børge, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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9. An LLM Assistant for Characterizing Conceptual Modeling Research Contributions
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Liddle, Stephen W., Mayr, Heinrich C., Pastor, Oscar, Storey, Veda C., Thalheim, Bernhard, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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10. AI-Assisted Analytics – An Automated Approach to Data Visualization
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Alves, Alberto, Moura Pires, João, Santos, Maribel Yasmina, Almeida, Andreia, León, Ana, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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11. Combining Natural Language Generation and Graph Algorithms to Explain Causal Maps Through Meaningful Paragraphs
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Gandee, Tyler J., Giabbanelli, Philippe J., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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12. The eu-FAIRnews: A Preliminary Exploration of Bridging Disinformation and Digital Justice Through FAIR Data Practices in Online News Sources
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Calò, Antonella, Colella, Davide Damiano, Longo, Marco, Tarantino, Priamo, Longo, Antonella, Zappatore, Marco, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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13. Evaluating a Framework of Conceptual Modelling Research
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Panach, Jose Ignacio, Pastor, Óscar, Liddle, Stephen W., Storey, Veda C., Mayr, Heinrich C., Thalheim, Bernhard, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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14. Towards Leveraging Gamified Code-Testing for Effective Model Validation
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Cammaerts, Felix, Snoeck, Monique, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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15. Resignifying Compliance Between Ontologies and Epistemologies of Law (Invited Paper)
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Buffa, Matteo, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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16. Extending Goal Models with Execution Orders: An Investigation of the Impact on Comprehensibility
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Raja, Jeshwitha Jesus, Raju, Akhila Vissom, Brings, Jennifer, Daun, Marian, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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17. Integrative Ontology of Bipolar Disorder (OBD): Advancing Bipolar Disorder Research Through an Interoperable Ontological Framework
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Tian, Yujia, He, Yongqun, Richesson, Rachel, Mclnnis, Melvin, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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18. Enhancing Vaxign-DL for Vaccine Candidate Prediction with Added ESM-Generated Features
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Chen, Yichao, Zhang, Yuhan, He, Yongqun, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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19. How Does UML Look and Sound? Using AI to Interpret UML Diagrams Through Multimodal Evidence
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Gavric, Aleksandar, Bork, Dominik, Proper, Henderik A., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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20. Can Large Language Models Learn Conceptual Modeling by Looking at Slide Decks and Pass Graduate Examinations? An Empirical Study
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Flandre, Noé Y., Giabbanelli, Philippe J., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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21. On the Expressiveness of Petri Nets for Modeling Biological Processes: The Case for mRNA Translation and Protein Synthesis
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Costa Neto, Luis Henrique, Lifschitz, S., Baião, F., Catanho, M., de Miranda, A. B., Haeusler, E. H., Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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22. Conceptual Modeling for Polygenic Risk Score Research: Improving Domain Understanding and Clinical Utility
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Martínez-Minguet, Diana, Pastor, Óscar, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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23. Conceptual Modeling for Public AI Systems
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Ju, Seonghwan, Ko, Seoltae, Lim, Andrew, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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24. Effects of Perceived Ease of Use and Perceived Usefulness of Technology Acceptance Model on Intention to Continue Using Generative AI: Focusing on the Mediating Effect of Satisfaction and Moderating Effect of Innovation Resistance
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Jeong, Sarang, Kim, Sihoo, Lee, Seunghee, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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25. Self-explanatory Retrieval-Augmented Generation for SDG Evidence Identification
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Garigliotti, Darío, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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26. Empirical Study on the Use of Artificial General Intelligence Healthcare in the Elderly (Invited Paper)
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Seo, Seungho, Jung, Jintaek, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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27. A Methodological Framework for Designing Human-Centered Artificial Intelligence Services
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Le Dinh, Thang, Le, Tran Duc, Ralyté, Jolita, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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28. An MLOps Framework to Data-Driven Modelling of Digital Twins with an Application to Virtual Test Rigs
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Kruschinski, Denis, Ngassam, Dylan Tchawou, Durak, Umut, Hartmann, Sven, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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29. GRASPER: Leveraging Knowledge Graphs for Predictive Supply Chain Analytics
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Janzen, Sabine, Stein, Hannah, Baer, Sebastian, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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30. Beyond One-Fits-All: A Case Study Approach to AI System Design Methods
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Janzen, Sabine, Stein, Hannah, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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31. Empirical Case Study of AI Service and Application for People with Disabilities (Invited Paper)
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Lee, Jaehwan, Jung, Jintaek, Goos, Gerhard, Series Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Saeki, Motoshi, editor, Wong, Leah, editor, Araujo, João, editor, Ayora, Clara, editor, Bernasconi, Anna, editor, Buffa, Matteo, editor, Castano, Silvana, editor, Fettke, Peter, editor, Fill, Hans-Georg, editor, García S., Alberto, editor, Goulão, Miguel, editor, Griffo, Cristine, editor, Jung, Jin-Taek, editor, Köpke, Julius, editor, Marín, Beatriz, editor, Montanelli, Stefano, editor, Rohrer, Edelweis, editor, and Román, José F. Reyes, editor
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- 2025
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32. Advances in Conceptual Modeling - ER 2024 Workshops, AISA, CMLS, EmpER, QUAMES, JUSMOD, LLM4Modeling, Pittsburgh, PA, USA, October 28-31, 2024, Proceedings
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Motoshi Saeki, Leah Wong, João Araújo 0001, Clara Ayora, Anna Bernasconi 0002, Matteo Buffa, Silvana Castano, Peter Fettke, Hans-Georg Fill, Alberto García S., Miguel Goulão, Cristine Griffo, Jin-Taek Jung, Julius Köpke, Beatriz Marín, Stefano Montanelli, Edelweis Rohrer, and José F. Reyes Román
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- 2025
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33. A bioinspired and environmentally sustainable polyphenol-based water adhesive.
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López-Moral A, Bolaños-Cardet J, Alibés R, Busqué F, Yuste VJ, Ruiz-Molina D, and Suárez-García S
- Abstract
Most commercial adhesives currently available pose significant environmental concerns due to the presence of contaminants such as volatile organic compounds (VOCs). To address this challenge, much research is being focused on developing water-based adhesives. Herein, we demonstrate that polymerisation of a natural polyphenolic compound (pyrogallol) with an amino-based ligand (tris(2-aminoethyl) amine) in water allowed for the development of a novel bioinspired water-based adhesive without involving VOCs. The reaction conditions were meticulously optimised by adjusting the reaction time, ratio, drying methodology and curing temperature, to produce a functional adhesive applicable across a broad spectrum of materials. Adhesion tests demonstrated competitive and outstanding performance on aluminium, followed by wood (oak and pine) and plastics (polypropylene, polycarbonate, and polymethylmethacrylate). Notably, the adhesive outperformed one of the most commercially used adhesives on pine and oak, highlighting its competitive advantage., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
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- 2025
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34. Influence of patient characteristics and discharge destination on circulatory system diseases readmissions among older heart failure patients.
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Esteban-Fernández A, Anguita-Sánchez M, Rosillo N, Bernal-Sobrino JL, Prado ND, Fernández-Pérez C, Navarro-Ceballos C, Corredera-García S, Fernández-Rozas I, and Elola-Somoza FJ
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- Humans, Female, Male, Retrospective Studies, Aged, Aged, 80 and over, Spain epidemiology, Risk Factors, Comorbidity, Patient Readmission statistics & numerical data, Heart Failure epidemiology, Heart Failure therapy, Patient Discharge statistics & numerical data, Nursing Homes statistics & numerical data
- Abstract
Introduction: Heart failure (HF) prevalence is rising, particularly among older people, constituting a significant cause of hospitalization. Discharge destinations, including nursing homes (NH), play a crucial role in post-hospitalization outcomes but remain underexplored., Methods: A retrospective study utilizing the Spanish National Health System's Minimum Basic Data Set identified older HF patients (≥75 years) discharged from acute hospitals between 2016 and 2019. Patient demographics, comorbidities, and discharge destinations were analyzed. Predictors of 30-day readmissions for circulatory system diseases and NH admission were assessed using multilevel logistic regression models., Results: Of 157,330 index episodes, 2.8 % were discharged to NH, more frequently in females. Thirty-day readmission incidence was 9.3 %, with HF exacerbations accounting for 80.6 % of cases. Predictors of 30-day readmission included renal failure (OR: 1.38), severe hematological disorders (OR: 1.30), and history of coronary revascularization surgery (OR: 1.23), while discharge to NH lowered the risk (OR: 0.70). Admission to NH was associated with neurological diseases (OR: 3.27), cardiogenic shock (OR: 3.19), stroke (OR: 2.68), advanced cancer (OR: 2.51), with higher likelihood among females (OR: 1.23). After propensity score-matched analysis, patients discharged to NH had significantly lower 30-day readmission rates than those discharged home (6.4 % vs. 28.9 %, adjusted OR: 0.169)., Conclusion: Discharge to NH is infrequent but associated with lower readmission risk for older HF patients. Female gender, specific comorbidities, and acute conditions influence NH admission. Enhanced collaboration between HF units and NH is crucial for optimizing post-hospitalization outcomes. Further research and policy initiatives are needed to improve care coordination and reduce HF readmissions., Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Spanish Society of Cardiology reports administrative support was provided by Spanish Society of Cardiology. This study was carried out thanks to an unconditional grant from Menarini (SEC RECALCAR project). Menarini has not participated in any part of elaborating on and submitting the article. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
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- 2025
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35. [Evaluation of the management of Clostridioides difficile infection as a risk factor for recurrence. A retrospective observational study].
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Barbero Allende JM, Ureña I, Cañivano L, García S, Paz C, Olmo-Ruiloba A, Jauregi K, Coronado S, López Requejo L, Porcel L, Perea V, Irigoyen M, Cano J, García A, León E, Fernández-Domingo N, Lanchares P, Lino B, Ortolá M, Lizasoain A, Sánchez V, Arévalo-Cañas C, and Arévalo-Serrano J
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- Humans, Retrospective Studies, Male, Female, Risk Factors, Aged, Middle Aged, Aged, 80 and over, Proton Pump Inhibitors therapeutic use, Vancomycin therapeutic use, Metronidazole therapeutic use, Adult, Clostridium Infections drug therapy, Recurrence, Anti-Bacterial Agents therapeutic use
- Abstract
Objective: One of the main problems with Clostridioides difficile infection (CDI) is its tendency to recur. The objective of the study is to analyze which factors in the clinical management of CDI favor recurrence., Methods: This is a retrospective study conducted at the Hospital Universitario Príncipe de Asturias on cases of CDI between January 2021 and June 2023. Demographic variables, comorbidities, risk factors for recurrence, and treatments used for CDI were recorded. Non-optimal clinical management was defined as: not discontinuing treatment with proton pump inhibitors (PPIs) if the patient was on them, not discontinuing concomitant antibiotic treatments if the patient was on these, the use of metronidazole monotherapy in any case, or the use of standard-dose vancomycin if there were risk factors for recurrence., Results: A total of 327 cases were found in 256 patients. 69 patients died within 8 weeks after the episode (26.9%). Among the remaining 258 episodes, there were 68 recurrences (26.3%). Of these 68 recurrences, 63 cases received nonoptimal treatment (93.2%), compared to 112/190 (58.9%) among those who did not recur. In the multivariate analysis adjusted for confounding factors, patients who received optimal treatment had an 89% lower risk of recurrence compared to those who did not receive it (OR 0.1; p < 0.001)., Conclusions: Reducing the use of PPIs and antibiotics and prioritizing more effective treatments against CDI could improve the recurrence rates of this infection., (©The Author 2024. Published by Sociedad Española de Quimioterapia. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)(https://creativecommons.org/licenses/by-nc/4.0/).)
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- 2025
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36. Fear and attitudes toward death in nursing students: A longitudinal study.
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Maestro-González A, Zuazua-Rico D, Villalgordo-García S, Mosteiro-Díaz MP, and Sánchez-Zaballos M
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- Humans, Longitudinal Studies, Female, Male, Surveys and Questionnaires, Spain, Adult, Attitude of Health Personnel, Education, Nursing, Baccalaureate methods, Young Adult, Students, Nursing psychology, Students, Nursing statistics & numerical data, Fear psychology, Attitude to Death, Terminal Care psychology
- Abstract
Background: Nurses are the most involved healthcare professionals in end-of-life care. Although scientific evidence has demonstrated the effectiveness of specific education in this aspect, the optimal timing of its delivery has not been identified., Aim: To determine the characteristics of fear of death and attitudes toward end-of-life care among nursing students during academic education., Design: This longitudinal observational study was conducted between October 2019 and June 2023., Participants: A total of 486 questionnaires were administered to nursing students from two Spanish faculties., Methods: A data collection sheet was developed to track various sociodemographic variables, which was distributed along with the Collett-Lester Fear of Death Scale and the Frommelt Attitude Toward Care of the Dying scale., Results: In the Frommelt Attitude Toward Care of the Dying scale, the lowest score for Factor I was observed in the third year (F(3,228) = 153.5, p < 0.001) and for Factor II in the second year (χ2(3) = 186.45, p < 0.001). The best attitude was demonstrated in the final academic year, with statistically significant differences. On the Collett-Lester Fear of Death Scale, the highest fear, both in the overall score and in all four factors, was noted in the first year and the lowest in the final year. We found a significant effect of time on the total score (F(3,300) = 7.43, p < 0.001), with differences observed between the first and other years (p < 0.001). The same pattern was found in Factor 3, fear of the death of others (F(3,300) = 18.7, p < 0.001), and in Factor 4, fear of dying of others., Conclusions: It is suggested that education be provided on fear of death in the first year, person- and family-centered care in the second year, and end-of-life care in the third year, with interventions lasting more than two months., Competing Interests: Declaration of competing interest None., (Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
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- 2025
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37. Longitudinal Analysis of the Transition Between Multimorbidity and Mortality Patterns from a Syndemic Perspective.
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Mino-León D, Salinas-Escudero G, Sánchez-García S, Rojas-Huerta AV, and Reyes-Morales H
- Abstract
Background: Longitudinal analysis of multimorbidity (MM) from a holistic approach to the aging population is necessary to guide medical care., Aims: To estimate the probability of transition between different MM patterns and the "death" stage and to characterize the socioeconomic, health, behavioral, and functional dimensions of MM patterns from a syndemic perspective., Methods: A cohort of 7,120 people ≥50 from the Mexican Health and Aging Study and mortality data at 11 and 17 years of follow-up were analyzed using the latent class approach. MM was defined as the coexistence of two or more chronic diseases (CDs). Socioeconomic, health, behavioral, and functional indicators were registered. Descriptive analysis, latent class analysis, and Markov chain models were carried out., Results: The model included three latent classes: "healthy" (low probability of CD); "multi-organic" (high probability of hypertension, arthritis, diabetes mellitus, lung disease, and myocardial infarction); and "sensitive-emotional, mental, neurological" (high probability of chronic pain, depression, and cognitive impairment). At the first follow-up, people in the "multi-organic" class were more likely to move on to death, and at the second follow-up, they were in the "sensitive-emotional, mental, neurological" class. In addition, the characteristic profiles of the indicators for each latent class were identified., Conclusions: The probabilities of transition between the three classes of MM and death, as well as the socioeconomic, behavioral, and functional dimensions in those over 50 years of age, revealed, from a syndemic perspective, the variability in the likelihood of progressing toward an unfavorable outcome., Competing Interests: Conflict of Interest The authors declared no conflicts of interest., (Copyright © 2025 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved.)
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- 2025
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38. The Brussels consensus for non-invasive ICP monitoring when invasive systems are not available in the care of TBI patients (the B-ICONIC consensus, recommendations, and management algorithm).
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Robba C, Picetti E, Vásquez-García S, Abulhasan YB, Ain A, Adeleye AO, Aries M, Brasil S, Badenes R, Bertuccio A, Bouzat P, Bustamante L, Calabro' L, Njimi H, Cardim D, Citerio G, Czosnyka M, Geeraerts T, Godoy DA, Hirzallah MI, Devi BI, Jibaja M, Lochner P, Mijangos Méndez JC, Meyfroidt G, Munusamy T, Portilla JP, Prabhakar H, Rasulo F, Sánchez Parra DM, Sarwal A, Shrestha GS, Shukla DP, Sung G, Tirsit A, Vásquez F, Videtta W, Wang YL, Paiva WS, Taccone FS, and Rubiano AM
- Abstract
Background: Invasive systems are commonly used for monitoring intracranial pressure (ICP) in traumatic brain injury (TBI) and are considered the gold standard. The availability of invasive ICP monitoring is heterogeneous, and in low- and middle-income settings, these systems are not routinely employed due to high cost or limited accessibility. The aim of this consensus was to develop recommendations to guide monitoring and ICP-driven therapies in TBI using non-invasive ICP (nICP) systems., Methods: A panel of 41 experts, that regularly use nICP systems for guiding TBI care, was established. Three scoping and four systematic reviews with meta-analysis were performed summarizing the current global-literature evidence. A modified Delphi method was applied for the development of recommendations. An in-person meeting with group discussions and voting was conducted. Strong recommendations were defined for an agreement of at least 85%. Weak recommendations were defined for an agreement of 75-85%., Results: A total of 34 recommendations were provided (32 Strong, 2 Weak) divided into three domains: general consideration for nICP use, management of ICP using nICP methods and thresholds of nICP tools for escalating/de-escalating treatment. We developed four clinical algorithms for escalating treatment and heatmaps for de-escalating treatment., Conclusions: Using a mixed-method approach involving literature review and an in-person consensus by experts, a set of recommendations designed to assist clinicians managing TBI patients using nICP systems plus clinical assessment, in the presence or absence of brain imaging, were built. Further clinical studies are required to validate the potential use of these recommendations in the daily clinical practice., Competing Interests: Declarations. Conflicts of interest: SB-DC serves as a scientific advisor for brain4care.CR received fees as speaker from Edwards, and Integra. GC received consulting fees from Integra and Neuroptics., (© 2025. Springer-Verlag GmbH Germany, part of Springer Nature.)
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- 2025
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39. ST-elevation myocardial infarction incidence in a high-risk seismic zone.
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Ortega-Hernández JA, González-Pacheco H, Gopar-Nieto R, Sierra-Lara-Martínez D, Araiza-Garaygordobil D, Mendoza-García S, Castillo AA, López Villaseñor LG, Neri-Bale RR, Adib-Gracia AE, and Arias-Mendoza A
- Abstract
Introduction: Earthquakes are unpredictable natural events that can elicit acute physiological responses, potentially triggering cardiovascular events. This study investigates the association between seismic activity and ST-elevation myocardial infarction (STEMI) admissions in a tertiary care hospital in an earthquake-prone region over 19 years., Methods: We analyzed STEMI admissions at a tertiary center in Mexico City from October 2005 to August 2024. Earthquakes with a magnitude ≥6.0 and geographic relevance to Mexico were identified using the USGS database. Admission rates were compared for ±7 days surrounding each earthquake and control periods derived from the same date in the previous year, adjusted for overlaps and seismic events. Poisson regression analyses were used to compare admission rates., Results: Among 9611 STEMI patients, 904 admissions occurred near earthquake periods, with 863 during controls. Post-earthquake admissions rose significantly on the day earthquake (day 0) with an incidence rate ratio (IRR) = 1.49 (95 % CI 1.17-1.89, P = 0.001), and in the post-quake (+1 to +7 days) IRR = 1.19 (95 % CI 1.03-1.36, P = 0.015) compared to the pre-quake (-7 to -1 days) period. Notably, admissions on days +1 and + 2 (IRR = 1.54 [95 % CI 1.11-2.14] and 1.58 [95 % CI 1.07-2.34]) showed a significant increase compared to controls. Elevated systolic blood pressure was observed post-quake, while demographics, severity, and mortality showed no significant differences., Conclusions: Our findings suggest a significant association between earthquake events and increased STEMI admissions within the days following an earthquake in a high-seismic area. Compared to pre-earthquake and control periods, the observed rise in post-earthquake admissions indicates that seismic stress may contribute to STEMI events., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025. Published by Elsevier Inc.)
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- 2025
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40. Emergency Healthcare Utilization and Unmet Care Needs in Chemsex Users: A Cross-Sectional Survey among Sexual Minority Men.
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Gonzalez-Recio P, Moreno-García S, Donat M, Palma D, Guerras JM, and Belza MJ
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Chemsex entails potential risks that may lead to medical emergencies. This cross-sectional study analyzed data from an anonymous, self-administered online survey on substance use among 1,203 sexual minority men (SMM) who engage in chemsex in Spain. The study aimed to determine the proportion of chemsex users that have sought emergency care following a session, identify their reasons for consultation, examine associated sociodemographic factors, and assess the proportion who felt they should have sought emergency care but did not. Frequencies of emergency consultations following chemsex sessions and episodes where participants felt they should have sought care but did not were calculated. Associations between seeking emergency care and sociodemographic and substance use factors were analyzed using Poisson regressions. Reasons for consultation were categorized based on responses to an open-ended question. 15.4% (95%CI:12.9-17.8) of chemsex users sought emergency care to request HIV post-exposure prophylaxis (PEP), and 4.0% (95%CI: 2.9-5.1) for other reasons. However, 21.8% (95%CI:19.3-24.2) did not seek care despite feeling they should have. The most common reasons for consultation were overdose symptoms, STI symptoms, and trauma. Living in smaller towns was associated with 2.4 times lower likelihood of visiting emergency services (95% CI:1.2-5.0). Injection substance use and mephedrone use were associated with 2.7 (95%CI:1.2-5.9) and 2.3 (95%CI:1.0-5.2) times higher likelihood of seeking care, respectively. Emergency visits for reasons other than requesting PEP were infrequent among chemsex users; however, a notable percentage felt they should have sought care but did not. Risk reduction strategies should prioritize addressing injection use and mephedrone consumption., Competing Interests: Declarations. Conflict of Interest: Authors declare no conflicts of interest. This study was funded by the Delegación del Gobierno para el Plan Nacional sobre Drogas (Spanish Ministry of Health) (2019I017). The Delegación del Gobierno para el Plan Nacional sobre Drogas had no further role in study design; in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the paper for publication., (© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2025
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41. Chemerin is a new sex-specific target in aortic stenosis concomitant with diabetes regulated by the aldosterone/mineralocorticoid receptor axis.
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Goñi-Olóriz M, Garaikoetxea Zubillaga M, San Ildefonso-García S, Fernández-Celis A, Castillo P, Navarro A, Álvarez V, Sádaba R, Jover E, Martín-Núñez E, and López-Andrés N
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Diabetes mellitus (DM) increases the risk of aortic stenosis (AS) and worsens its pathophysiology in a sex-specific manner. Aldosterone/mineralocorticoid receptor (Aldo/MR) pathway participates in early stages of AS and in other diabetic-related cardiovascular complications. We aim to identify new sex-specific Aldo/MR targets in AS complicated with DM. We performed discovery studies using Olink Proteomics® technology in 87 AS patient-derived aortic valves (AVs) (N=28 and N=19 non-diabetic and diabetic men; N=32 and N=8 non-diabetic and diabetic women, respectively) and human cytokine array (N=24 AVs/sex/condition). Both approaches revealed chemerin as a target differentially upregulated in AVs from male diabetic patients, further validated in a cohort of stenotic AVs (N=283, 27.6% DM, 59.4% men). Valvular chemerin levels directly correlated with VIC activation, MR, inflammation, angiogenesis and calcification markers exclusively in diabetic men. In vitro , Aldo (10
-8 M) treatment exclusively increased chemerin levels in valve interstitial cells (VICs) from male DM patients. Aldo also upregulated inflammatory, angiogenic and osteogenic markers in DM and non-DM donors' VICs, which were prevented by MR antagonism. Increased glucose levels in cell media upregulated chemerin in VICs from male diabetic patients. Overall, RARRES2 -knockdown in male diabetic VICs resulted in downregulation of inflammatory, angiogenic and osteogenic markers and blocked Aldo-induced responses in high glucose conditions. These data suggest the Aldo/MR pathway selectively increases chemerin in VICs from diabetic men, promoting inflammation, angiogenesis and calcification associated to AS progression.- Published
- 2025
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42. Therapeutic drug monitoring-guided high-dose isavuconazole therapy for invasive pulmonary aspergillosis in a patient on extracorporeal membrane oxygenation support.
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Pau-Parra A, Sosa Garay M, Doménech Moral L, Díez Poch M, Martínez Pla M, Gallart E, Vima Bofarull J, Nuvials X, García-García S, Doménech Vila JM, Planas Viñuales L, Cruz López I, Lalueza Broto P, Gorgas Torner MQ, Ferrer R, and Riera J
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We review the case of a 58-year-old female on extracorporeal membrane oxygenation (ECMO) support diagnosed with invasive pulmonary aspergillosis (IPA). Intravenous isavuconazole was started, requiring dose escalation to achieve isavuconazole trough concentration (ISA-Cmin) within the therapeutic range (2.5-5.0 μg/mL). For more than 4 months, she maintained a dose of 200 mg q12h, with a median ISA-Cmin of 3.4 (interquartile range [IQR]: 3.1-4.9) µg/mL. Throughout this interval, 17 assessments of ISA-Cmin were performed (weekly). Of these, 82% (14/17) were within the therapeutic range, with an intra-individual variability of 36.8%. Although no signs of hepatotoxicity were observed, she experienced short-term gastrointestinal adverse events related to potential isavuconazole over-exposure (ISA-Cmin > 5.0 μg/mL). ECMO circuit changes did not appear to affect ISA-Cmin. She was not obese (IMC ≈ 25 kg/m
2 ) and did not require other extracorporeal therapy, but hypoalbuminemia may have contributed to an increase in unbound isavuconazole fraction and consequently its clearance.- Published
- 2025
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43. [Clinical characteristics and pharmacological treatment of patients with heart failure in a primary health care cohort].
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Giner-Sorian M, Monfà R, Vives R, Fernández-García S, Vallano A, and Morros R
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Objective: To characterise patients with heart failure (HF) in Primary Health Care (PHC) and describe their socio-demographic and clinical characteristics and pharmacological treatment., Design: Descriptive cohort study. SITE: Information System for the Development of Research in Primary Care (SIDIAP), which captures information from the electronic health records of PHC of the Catalan Institute of Health (approximately 80% of the Catalan population)., Participants: Adults with an active diagnosis of HF between 2018 and 2022., Main Measurements: Sociodemographic and anthropometric variables, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA), laboratory data, comorbidities, exposure to drugs for HF and other pathologies., Results: 75,769 individuals were included; 22.7% with HF with reduced LVEF (HFrEF), 26.2% with preserved LVEF (HfpEF) and 51.2% with non-specific HF. The HfrEF group consisted mostly of men (59.5%), with a mean age of 74.8 years, and the others of women (58.8% and 54.6%, aged 78.7 and 80.6 years, respectively). LVEF was recorded in 20.3% and NYHA in 43.9% of patients. In terms of treatment, 75.3% of people with HfrEF were receiving renin-angiotensin system (RAS) drugs, 75.9% beta-blockers, 42.1% mineralocorticoid receptor antagonists, 33.6% sodium-glucose cotransporter type 2 inhibitors and 62.8% diuretics. 63% with HfpEF were receiving RAS and 68% diuretics. 61.8% with unspecified HF were receiving RAS and 67.5% diuretics., Conclusions: We analysed the population with HF in PHC in Catalonia. We highlight a low registry of cardiac function, LVEF and NYHA. The frequency of drug use for HF was different between populations and differed from the recommendations., (Copyright © 2024 The Author(s). Publicado por Elsevier España S.L.U. All rights reserved.)
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- 2025
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44. miRNAs in umbilical Wharton's jelly in neonates with different birth weights: A pilot study.
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García-Muro C, Toledo-Gotor C, Pasamón-García S, de Pablo-de Las Heras M, Esteban-Zubero E, Ruiz Del Prado MY, and Domínguez-Garrido E
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- Humans, Infant, Newborn, Pilot Projects, Female, Wharton Jelly metabolism, Adult, Male, Infant, Small for Gestational Age, Pregnancy, Gestational Age, Gene Expression Profiling methods, MicroRNAs genetics, MicroRNAs metabolism, Birth Weight genetics, Umbilical Cord metabolism
- Abstract
Background: Birth weight is a critical indicator of perinatal health. miRNAs are small non-coding RNA molecules, ranging from 18 to 25 nucleotides in length, that regulate gene expression. Specific miRNAs have been implicated in metabolic pathways influencing fetal growth, and their dysregulation may contribute to variations in birth weight. Our objective was to isolate amplifiable miRNAs from umbilical cord tissue and compare their expression across three patient groups., Methods: The study sample comprised 23 patients: 8 small for gestational age (SGA), 10 large for gestational age (LGA), and 5 appropriate for gestational age (AGA). Umbilical cord tissue samples were collected immediately after childbirth, stored, and subsequently processed. The miRNA expression profile of these samples was analyzed using high-throughput sequencing, and the results were evaluated through bioinformatic analysis., Results: We identified significant differences in the expression levels of 6 miRNAs. miR-324-3p was downregulated in SGA compared to both AGA and LGA groups. Conversely, miR-337-3p was upregulated in LGA compared to both SGA and AGA. miR-760 was downregulated in LGA relative to SGA and AGA, while miR-4707-3p, miR-548a-3p, and miR-6733-5p were upregulated in both SGA and LGA compared to AGA. Most of these miRNAs appear to be associated with the transforming growth factor-beta signaling pathway., Conclusions: This exploratory study suggests that miRNA expression in umbilical cord tissue is associated with birth weight. Notably, the downregulation of miR-324-3p in SGA newborns indicates that its decreased expression may be related to SGA conditions., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024. Published by Elsevier B.V.)
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- 2025
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45. Nursing Skills in the Care of Patients With Respiratory Stomas in Hospitals With and Without Advanced Practice Tracheostomy Service.
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Martínez B, López M, Juana S, Jiménez JM, Alcoceba I, and García S
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Aims: To identify whether there are differences in knowledge regarding the management of patients with respiratory stomas among nurses working in hospitals with an advanced practice tracheostomy service compared to those without it., Design: Descriptive, cross-sectional, comparative, analytical survey study., Method: The study was conducted from January to March 2023 in four tertiary care hospitals, two of which have an advanced practice tracheostomy service. A self-administered questionnaire was designed, consisting of 16 questions about nurses' specialised training in caring for tracheostomy patients. The study adhered to the STROBE checklist. Statistical analyses were performed using SPSS (24.0) from IBM., Results: Nurses in hospitals with a dedicated tracheostomy service obtained a higher mean score (7.1/10) and demonstrated greater anxiety when managing patients with stomas (p < 0.001), as well as an increased willingness to undergo specific training (p = 0.017) to reduce their lack of self-confidence., Conclusions: A higher level of anxiety in the management of tracheostomised patients and a greater interest in receiving specific training have been observed among nurses in hospitals with advanced practice services (APTS), despite having greater training. Therefore, institutions should commit to incorporating advanced practice nurses and continuing education in the approach to ostomies among their professionals., Implications for the Profession And/or Patient Care: Implementing ongoing training programmes and specific tracheostomy services or units in hospitals would enable nurses to provide high-quality care for patients with respiratory stomas., Reporting Method: The study adhered to the STROBE checklist., Patient or Public Contribution: Neither patients nor the public were involved in the design or conduct of this research. Nurses participated exclusively in data collection., (© 2025 John Wiley & Sons Ltd.)
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- 2025
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46. Spiers Memorial Lecture: How to do impactful research in artificial intelligence for chemistry and materials science.
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Cheng AH, Ser CT, Skreta M, Guzmán-Cordero A, Thiede L, Burger A, Aldossary A, Leong SX, Pablo-García S, Strieth-Kalthoff F, and Aspuru-Guzik A
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Machine learning has been pervasively touching many fields of science. Chemistry and materials science are no exception. While machine learning has been making a great impact, it is still not reaching its full potential or maturity. In this perspective, we first outline current applications across a diversity of problems in chemistry. Then, we discuss how machine learning researchers view and approach problems in the field. Finally, we provide our considerations for maximizing impact when researching machine learning for chemistry.
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- 2025
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47. Sex Differences in Aortic Valve Inflammation and Remodeling in Chronic Severe Aortic Regurgitation.
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Tiraplegui C, Garaikoetxea Zubillaga M, Sádaba A, San Ildefonso-García S, Goñi-Olóriz M, Fernández-Celis A, Martin-Nuñez E, Álvarez V, Sádaba R, Anand V, Jover E, Navarro A, and López-Andrés N
- Abstract
Background: Aortic regurgitation (AR) is more prevalent in male, although cellular and molecular mechanisms underlying the sex differences in prevalence and pathophysiology are unknown. Objectives: This study evaluates the impact of sex on aortic valve (AV) inflammation and remodeling as well as the cellular differences in valvular interstitial cells (VICs) and valvular endothelial cells (VECs) in patients with AR. Methods: A total of 144 patients (27.5% female) with severe chronic AR were included. AVs were analyzed by imaging, histological and molecular biology techniques (ELISA, RT-PCR). VICs and VECs isolated from patients with AR were characterized and further treated with transforming growth factor (TGF)-β. Results: Anatomically, male had smaller index aortic dimensions and greater AV thickness. Proteome profiler analyzes in AVs (n=40/sex) evidenced higher expression of inflammatory markers in male and that was further validated (interleukins, chemokines). Histological composition showed higher expression of inflammatory mediators and collagen thick fibers in AVs from male. Male VICs and VECs secreted higher levels of inflammatory markers than female cells. Interestingly, male VICs produced higher amounts of collagen type I and lower fibronectin and aggrecan, whereas male VECs secreted lower decorin. TGF-β exclusively enhanced inflammation in male VICs, and decorin and aggrecan in female VICs. Conclusion: Compared to male, AVs from female were thinner, less inflamed and fibrotic. VIC seem to be the key cell type responsible for the sex-differences. Valvular inflammation associated with an active remodeling process could be a key pathophysiological process involved in AR.
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- 2025
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48. Appropriateness of urine culture requests in primary care in Spain: A cross-sectional descriptive study.
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Fernández-García S, Monfà R, Jiménez CM, Giner-Soriano M, Gómez F, and Moragas A
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Objective: Studies evaluating urine culture requests in our country have highlighted a high rate of requests that fall outside the indications specified in clinical guidelines. We evaluated the current degree of inadequacy in the request of urine cultures and how this influences the therapeutic decisions of general practitioners., Design: Cross-sectional descriptive study., Setting: Three primary care centres in Tarragona area., Participants: Urine culture requests from the adult population≥18 years old, received at the Microbiology Service of the reference hospital in 2022. All requests were made in primary care settings., Main Measures: The collected variables included sociodemographic data, urinary tract infection (UTI) symptoms at the time of the urine culture request, comorbidities, reason for the request (including diagnosis), type of urine culture, therapeutic approach before and after receiving the result, and the urine culture result., Results: A total of 461 urine cultures were reviewed: 152 men (mean age 64.1 years) and 309 women (mean age 57 years). Of the urine cultures analyzed, 17.4% were for cystitis (22% in women), 2.4% for pyelonephritis, 1.3% for complicated UTIs, and 1.5% for asymptomatic bacteriuria. In 10.6%, they were for recurrent UTIs; in 9.6%, post-treatment. In 55.5% of cases, general practitioners continued without antibiotic treatment, regardless of urine culture results. The reason to request was unknown in 18.9%. Antibiotic changes occurred in 5.6%., Conclusions: There is still a high rate of urine culture over-requesting in primary care, with 20% of cultures being ordered for otherwise uncomplicated UTIs. While the methodology of the project does not allow for causal analysis, it provides a detailed description of clinical practices in primary care., (Copyright © 2024 The Authors. Publicado por Elsevier España S.L.U. All rights reserved.)
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- 2025
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49. Effect of Mediterranean Diet in Combination with Isokinetic Exercise Therapy on Body Composition and Cytokine Profile in Patients with Metabolic Syndrome.
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Suárez-Cuenca JA, Díaz-Jiménez DE, Pineda-Juárez JA, Mendoza-Mota AG, Valencia-Aldana OD, Núñez-Angeles S, Vera-Gómez E, Hernández-Patricio A, Loeza-Magaña P, Lara-Vargas JA, Arteaga-Martínez JR, Garduño-Pérez ÁA, Montoya-Ramírez J, Díaz-Aranda MA, Chaparro-Hernández RC, Melchor-López A, García S, Gutiérrez-Salinas J, and Mondragón-Terán P
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- Humans, Middle Aged, Male, Adult, Female, Aged, Young Adult, Interleukin-10 blood, Adolescent, Resistin blood, Adiponectin blood, Insulin Resistance, Metabolic Syndrome therapy, Metabolic Syndrome diet therapy, Diet, Mediterranean, Body Composition, Cytokines blood, Exercise Therapy methods
- Abstract
Background: Metabolic syndrome (MS) is a combination of comorbidities that increase pro-inflammatory cytokines (PIC) production, with subsequent body composition (BC) abnormalities and high cardiovascular risk. Treatment with diet and exercise has been suggested as possible non-pharmacological adjuvant treatment., Objective: To determine changes in BC and PIC in patients with MS after a Mediterranean-type diet (MedDiet) and/or isokinetic exercise (IE)., Methods: A controlled randomized clinical trial was conducted at a third-level hospital in Mexico City. Intervention groups: G1: MedDiet + IE; G2: IE; G3: MedDiet; G4: control. Anthropometry, BC, and PIC were collected from the baseline and at 12 weeks post-intervention. MedDiet was estimated from a 24-h recall record. IE consisted of a standard high-intensity anaerobic exercise program., Results: Forty-two patients with MS aged 18-65 years old were included. The most frequent comorbidities were obesity, insulin resistance, and dyslipidemia. After 6 months of intervention, a significant reduction of resistin was observed within the IE group and MedDiet + IE, whereas the former group also showed an increase in adiponectin. Interventions of MedDiet and MedDiet + IE showed a decrease in IL-10. Regarding BC, all groups increased the resistance values in relation to the baseline but were lower than the control group., Conclusions: The results suggest that MedDiet and IE have a selective impact on pro-inflammatory mediators, while the combination of MedDiet and IE may induce only minor changes in BC.
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- 2025
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50. [Humanization and professional quality of life in oncohematology and radiotherapy care: A descriptive study in a university hospital].
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Gutiérrez Delgado A, Gómez Martín CJ, Martín-Arriscado Arroba C, González Monterrubio G, Pérez García S, and Jariego Gómez A
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Objective: To evaluate levels of humanization, professional quality of life, resilience, communication skills, and the use of silence among healthcare professionals in these areas., Methods: Observational, cross-sectional, and descriptive study conducted in a referral hospital. Data were collected from 152 healthcare professionals through questionnaires assessing professional quality of life (ProQOL), resilience (CD-RISC), humanization (HUMAS), communication skills (EHC-PS), and the use of silence (Q-SPS)., Results: The median age of the professionals was 42 years. They showed moderate levels of compassion satisfaction and resilience (means=23.47 and 29.96) but low levels of humanization (mean=66.09). Emotional exhaustion was significant among physicians (mean=19.19, P=.022), while radiotherapy technicians excelled in empathy (mean=27.33). Significant correlations were observed between compassion satisfaction and optimism (Rho=0.2017, P=.0127), and between productive silence and communication skills (Rho=0.3131, P=.0001)., Conclusions: Strengthening emotional and communication competencies is essential. Interventions should focus on reducing compassion fatigue and enhancing the well-being of healthcare professionals, improving care quality for oncohematology and radiotherapy patients., (Copyright © 2024 FECA. Publicado por Elsevier España, S.L.U. All rights reserved.)
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- 2025
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