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This dataset comprises a comprehensive collection of tweets pertaining to Assets of Cultural Interest along the French Way in Castilla y León, spanning from January 1, 2009, to March 24, 2023. Assembled with the aid of the twarc2 Python package and academic access credentials, the dataset provides raw, unprocessed data for each cultural landmark, featuring a wide array of fields including text, date, language as identified by Twitter, author, number of retweets, and more., The authors would like to acknowledge the support and funding from the Spanish Ministry of Science and Innovation through its networks of excellence HAR2017-90883-REDC and RED2018-102518-T, and the project PID2020118906GB-I00, as well as from the Regional Government of Castilla y León - Department of Education (BDNS 425389), and the FWO-WOG (W001220N). Additionally, this work has been partially funded by the European Social Fund, through the predoctoral contract awarded to Silvia Díaz de la Fuente by the Department of Education of the Regional Government of Castilla y León. We acknowledge Santander Supercomputacion support group at the University of Cantabria who provided access to the supercomputer Altamira Supercomputer at the Institute of Physics of Cantabria (IFCA-CSIC), member of the Spanish Supercomputing Network, for performing processing work.

Curcumin is a natural molecule widely tested in preclinical and clinical studies due to its antioxidant and anti-inflammatory activity. Nevertheless, its high hydrophobicity and low bioavailability limit in vivo applications. To overcome curcumin´s drawbacks, small extracellular vesicles (sEVs) have emerged as potential drug delivery systems due to their non-immunogenicity, nanometric size and amphiphilic composition. This work presents curcumin cargo into milk sEV structure and further in vitro and in vivo evaluation as a therapeutic nanoplatform. The encapsulation of curcumin into sEV was performed by two methodologies under physiological conditions: a passive incorporation and active cargo employing saponin. Loaded sEVs (sEVCurPas and sEVCurAc) were fully characterized by physicochemical techniques, confirming that neither methodology affects the morphology or size of the nanoparticles (sEV: 113.3±5.1 nm, sEVCurPas: 127.0±4.5 nm and sEVCurAc: 98.5±3.6 nm). Through the active approach with saponin (sEVCurAc), a three-fold higher cargo was obtained (433.5 µg/mL) in comparison with the passive approach (129.1 µg/mL). These sEVCurAc were further evaluated in vitro by metabolic activity assay (MTT), confocal microscopy, and flow cytometry, showing a higher cytotoxic effect in the tumoral cells RAW264.7 and HepG2 than in primary hepatocytes, specially at high doses of sEVCurAc (4%, 15% and 30% of viability). In vivo evaluation in an experimental model of liver fibrosis confirmed sEVCurAc therapeutic effects, leading to a significant decrease of serum markers of liver damage (ALT) (557 U/L to 338 U/L with sEVCurAc therapy) and a tendency towards decreased liver fibrogenesis and extracellular matrix (ECM) deposition., Depto. de Inmunología, Oftalmología y ORL, Fac. de Medicina, TRUE, pub

Agradecimientos y financiación: El presente estudio se pudo llevar a cabo gracias a la ayuda a la investigación concedida por la Cátedra Real Madrid- Universidad Europea de Madrid en su convocatoria 2010 Referencias bibliográficas: • Baker, J., Coté, J. y Abernethy, B. (2003). Sport specific practice and the development of expert decision making in team ball sports. Journal of Applied Sport Psychology, 15, 12-25 • Cianciolo, A.T., Matthew, C., Sternberg, R.J., y Wagner, R.K. (2006). Tacit knowledge, practical intelligence and expertise. En K.A. Ericsson, N. Charness, P.J. Feltovich, y R.R. Hoffman (Eds.), The Cambridge Handbook of Expertise and Expert Performance (pp. 613-632). Cambridge: Cambridge University Press. • De la Vega, R., Del Valle, S., Maldonado, A. y Moreno, A. (2008a). Una nueva herramienta para la comprensión táctica del fútbol. Revista Internacional de Medicina y Ciencias de la Actividad Física y el Deporte, 8, 30, 130-145. • De la Vega, R., Del Valle, S., Maldonado, A. y Moreno, A. (2008b). Pensamiento y Acción en el Deporte. Sevilla: Wanceulen. Drasgow, F. (2003). Intelligence and the workplace. En W. Borman, D. Ilgen y R. Klimoski (eds.), Handbook of Psychology, 12 (pp.107-129). New York: John Wiley. • Elferink-Gemser, M.T., Visscher, C., Richard, H., y Lemmink, K.A. P.M. (2005). Development of the tactical skills inventory for sports. Perceptual and Motor Skills, 99, 3, 883-895. • Fradua, L. (1997). La visión de juego en el futbolista. Barcelona: Editorial Paidotribo. • Furnham, A. (2005). Gender and personality differences in self and other ratings of business intelligence. British Journal of Management, 16(2), 91-103. • García, V. (2009). Inteligencia contextual, competencia decisional, inteligencia emocional y habilidades de afrontamiento en deportistas de diferente nivel de pericia. Tesis doctoral inédita, Universidad de Castilla – La Mancha, Toledo. • García, V., Ruiz, L.M. y Graupera, J.L. (2009). Perfiles decisionales de jugadores y jugad, Para los entrenadores la inteligencia en el juego es uno de los intangibles que predicen el éxito en la competición. De ahí que el objetivo de este estudio fuera analizar la percepción que jugadores de fútbol de diferente nivel de pericia tenían de su inteligencia para el juego. Se aplicó el Cuestionario de Inteligencia Contextual en el Deporte (ICD) que evalúa tres dimensiones: Inteligencia Anticipatoria, Inteligencia Táctica e Inteligencia Competitiva. En este estudio participaron 690 jugadores de fútbol de diferente nivel competitivo. Los resultados mostraron que a medida que aumentaba el nivel competitivo se incrementaba la percepción de los jugadores sobre su inteligencia contextual. Este estudio confirma el papel que para los jugadores posee el sentirse competentes para solucionar los problemas tácticos de su deporte y que este sentimiento aumenta con su nivel de competencia., Coaches consider that game intelligence is one of the main elements that can predict success in competition. The objective of this study was to analize the perceptions that soccer players of different level of expertise had about their intelligence in the field. The Contextual Intelligence Questionnaire (ICD) was applied to a sample of spanish soccer players. This instrument evaluate three dimensions: Anticipatory intelligence, Tactical Intelligence and Competitive Intelligence. Six hundred and ninety of spanish soccer players of different level of expertise, participated in this study. Results showed that this self-perception increased with the level of players. This study confirmed the relevance of feeling able of solving tactical problems in the game, and how this feeling increase with the level of expertise., Depto. de Didáctica de las Lenguas, Artes y Educación Física, Fac. de Educación, TRUE, pub