1. Cognitive Dysfunction in Non-CNS Metastatic Cancer: Comparing Brain Metastasis, Non-CNS Metastasis, and Healthy Controls.
- Author
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Collette C, Willhelm G, Del Bene VA, Aita SL, Marotta D, Myers T, Anderson J, Gammon M, Gerstenecker A, Nabors LB, Fiveash J, and Triebel KL
- Subjects
- Humans, Male, Female, Middle Aged, Cross-Sectional Studies, Prospective Studies, Case-Control Studies, Aged, Adult, Executive Function, Brain Neoplasms secondary, Brain Neoplasms psychology, Cognitive Dysfunction etiology, Neuropsychological Tests
- Abstract
Limited research has compared cognition of people with non-central nervous system metastatic cancer (NCM) vs. metastatic brain cancer (BM). This prospective cross-sectional study was comprised 37 healthy controls (HC), 40 NCM, and 61 BM completing 10 neuropsychological tests. The NCM performed below HCs on processing speed and executive functioning tasks, while the BM group demonstrated lower performance across tests. Tasks of processing speed, verbal fluency, and verbal memory differentiated the clinical groups (BM < NCM). Nearly 20% of the NCM group was impaired on at least three neuropsychological tests whereas approximately 40% of the BM group demonstrated the same level of impairment.
- Published
- 2024
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