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BackgroundGestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between the Triglyceride Glucose (TyG) index and GDM and explore its clinical significance.MethodsA retrospective cohort study included 631 singleton pregnant women. The study collected data on the TyG index, glucose levels, and clinical outcomes from all participants. Research objectives were validated using logistic regression analysis and Receiver Operating Characteristic curves.ResultsWe found an independent correlation between TyG index and increased risk of GDM, with an odds ratio (OR) of 3.11 (95% confidence interval (CI): 2.09-4.63, P

Background: Gestational diabetes mellitus (GDM) is a common metabolic disorder with important health implications for both mother and offspring. This study aims to assess the relationship between the Triglyceride Glucose (TyG) index and GDM and explore its clinical significance. Methods: A retrospective cohort study included 631 singleton pregnant women. The study collected data on the TyG index, glucose levels, and clinical outcomes from all participants. Research objectives were validated using logistic regression analysis and Receiver Operating Characteristic curves. Results: We found an independent correlation between TyG index and increased risk of GDM, with an odds ratio (OR) of 3.11 (95% confidence interval (CI): 2.09-4.63, P<0.001). The spline model revealed a linear association between TyG index and GDM in early pregnancy (non-linear P=0.748), and the risk of GDM increased with the increase of TyG index. In addition, we found that TyG has high diagnostic performance in predicting GDM, with an AUC value of 0.668. Combined with Age, it can improve predictive performance, with an AUC value of 0.684. Compared to the lower quartile of the TyG index, women in the higher quartile have a higher incidence of premature birth, hypertensive disorders of pregnancy, and intrahepatic cholestasis of pregnancy (ICP). In the GDM group, the TyG index was negatively correlated with 25 (OH) D and TBIL, and positively correlated with FBG, TG, and TC. Conclusions: The TyG index is strongly linked to the development of GDM and is an independent risk factor for predicting it. Monitoring TyG levels in early pregnancy is valuable for identifying women at high risk for GDM. [ABSTRACT FROM AUTHOR]

A Gram-stain-positive, aerobic and non-motile actinobacterium, designated strain MR15.9 T , was isolated from sediment collected from a mangrove ecosystem in Semarang city, Indonesia. Strain MR15.9 T grew at 4-37 °C (optimum 30 °C), pH 6.0-11.0 (optimum 7.0-8.0), with 0-10% (w/v) NaCl (optimum 0-3%). The genome of strain MR15.9 T was 3.67 Mbp with 71.7 mol% G+C content. Phylogenetic analysis based on 16S rRNA gene sequence and genome sequence directed that strain MR15.9 T formed a well-supported clade with Tersicoccus solisilvae CGMCC 1.15480 T and Tersicoccus phoenicis 1P05MA T and shared the highest similarity to T. solisilvae CGMCC 1.15480 T (98.9% sequence similarity) and T. phoenicis 1P05MA T (98.6% sequence similarity). However, the comparative genome analysis between strain MR15.9 T and T. solisilvae CGMCC 1.15480 T gave average nt identity value of 85.2% and digital DNA-DNA hybridization value of 29.0%, which were below the statistical threshold for the delineation of the species. Chemotaxonomic data showed that the major fatty acids were anteiso-C 15:0 , anteiso-C 17:0 and iso-C 16:0 . The polar lipids consisted of diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, two unidentified glycolipids and two unidentified phospholipids. MK-8(H 2 ) and MK-9(H 2 ) were noted as the predominant respiratory quinones in this strain. The results of polyphasic characterization indicated that strain MR15.9 T represents a novel species of the genus Tersicoccus . The name Tersicoccus mangrovi sp. nov. is proposed, with the type strain MR15.9 T (=MCCC 1K08875 T =KCTC 59105 T ).