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Background: Insulin resistance (IR) is a major health concern associated with various diseases, and prolonged QT interval can potentially lead to life-threatening arrhythmias and death. There are conflicting views on the relationship between IR and QT interval. This meta-analysis aims to comprehensively investigate the association between IR and QT interval., Methods: An extensive search in databases PubMed, Scopus, Cochrane Library, Embase, and Web of Science up to October 2024 was conducted. Cohort studies which reported means and standard deviations for the QTc interval across the case and control groups with and without insulin resistance based on HOMA-IR were eligible for inclusion. Research with partial or inaccessible primary data, those involving participants with pre-existing cardiac conditions, and those with ambiguous results were excluded. The evaluation of study quality utilized the Newcastle-Ottawa Scale. A random-effects model was applied for the meta-analysis, and Egger's test was used to assess publication bias. GRADEproGDT was used to evaluate the certainty of the evidence., Results: Five studies, encompassing 603 participants, met the inclusion criteria. A significant positive association was observed between IR and QT interval (Weighted Mean Difference [WMD] = 12.38, 95% Confidence Interval [CI]: 5.51, 19.25). All included studies demonstrated high methodological quality. Assessment for publication bias revealed no significant findings (p-value for Egger's test = 0.39). The quality of evidence for the main outcome was moderate. Subgroup analyses revealed a significant link between IR and QT interval in studies from Turkey and India, with samples over fifty, and involving adults., Conclusions: This meta-analysis highlights that IR is linked to an elevated risk of QT prolongation. Early identification of IR is crucial to mitigate the risk of QT prolongation and subsequent arrhythmias, thus emphasizing the importance of early intervention to prevent adverse cardiac outcomes and sudden cardiac death. Caution is needed when interpreting our results due to study heterogeneity, certainty of evidence, and sensitivity analysis findings. More rigorous research on this subject is required., Competing Interests: Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests., (© 2025. The Author(s).)

The first step to reducing the growing burden of cardiovascular disease (CVD) is to find modifiable risk factors with the highest burden in each population. Urban and rural citizens may have different priorities in this regard. This study aimed to compare the 10-year incidence probability of CVD events and its associated risk factors between rural and urban areas in Iran. Data was extracted from two big cohorts, Fasa Adults Cohort Study (FACS) and Shiraz Heart Study (SHS), with participation of over 12,000 general population. Linear regression models were used to test the difference in CVD risk between two populations. Totally, 6,258 FACS and 6,101 SHS participants entered the study. Urban participants had a significantly higher mean ASCVD score (4.43% vs. 5.51%, p-value < 0.001). Also, they significantly showed higher body mass index, waist circumference, cholesterol level, fasting blood glucose level, systolic blood pressure, educational attainment, and occupational status. However, the prevalence of smoking was higher in rural areas. Notably, socioeconomic parameters including marital, occupational, and educational statuses seem to have strong impact on cardiovascular risk factors. After adjustment for all confounders, living in the urban areas seemed to be associated with higher atherosclerotic CVD risk (β = 0.78, 95%CI: [0.69-1.05]), which was consistent across both sexes. Given the higher risk of cardiovascular events in urban areas and different profiles of risk factors between these two regions, preventive strategies should be precisely and separately designed for each population by the health authorities and policymakers in order to reduce the CVD toll efficiently., Competing Interests: Declarations. Ethics: The present study was conducted considering the Helsinki Declaration and approved by the Ethical Committee of Shiraz University of Medical Sciences (ethical code: IR.SUMS.REC.1400.413). All of the participants were aware of the aims, benefits, and risks of the study by a written informed consent. Competing interests: The authors declare no competing interests., (© 2024. The Author(s).)