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The life stories of older adults encapsulate an array of personal experiences that reflect their care needs. However, due to inherent fuzzy features, fragmented natures, repetition, and redundancies, the practical application of the life story approach poses challenges for caregivers in acquiring and comprehending these narratives. Addressing this challenge, our study introduces a novel approach called Life Story Hierarchies with Graph-Enhanced Event Feature Refinement (LSH-GEFR). LSH-GEFR constructs a bilayer graph. Firstly, the event element map leverages intricate relationships between event elements to extract environmental features, providing a detailed context for understanding each event element. Secondly, the event map explores the complex web of relationships between the events themselves, allowing LSH-GEFR to generate a comprehensive understanding of each event and enhance its representation. Subsequently, we conducted experiments on different datasets and found that, in comparison with four advanced event tree generation methods, the proposed LSH-GEFR method outperformed them in terms of path coherence, branch reasonableness, and overall readability when generating life story hierarchies. Over 84.91% of the structured life narratives achieved readability, marking a 5.96% increase over the best-performing approach at the baseline.

A notable feature of volcanic activity in the Halmahera arc since the Middle Miocene is that eruptions have occurred episodically from south to north, rather than simultaneously. However, the dynamic cause of the volcanic age disparity between the northern and southern regions remains unresolved. To investigate this, thermal simulation methods were employed to calculate the temperature structures of the subducted slab and mantle wedge under varying movement rates of subduction and overriding plates. Simulation results indicate that arc magmatism is favored at lower subduction rates or higher overriding plate movement rates. During the Middle Miocene, the northward drift of the Australian plate propelled the Obi microplate southward via left-lateral strike-slip faults, accelerating its movement rate. In contrast, the movement rate of the Halmahera microplate in the north remained lower, unaffected by the Australian plate. The accelerated movement of the Obi microplate resulted in the rapid generation of a higher temperature zone, facilitating arc volcanism on Obi Island in the late Middle Miocene. Meanwhile, the lower movement rate of the Halmahera microplate delayed the formation of a favorable high-temperature zone for arc volcanism, leading to the emergence of volcanism on Halmahera Island in the late Pliocene. [ABSTRACT FROM AUTHOR]

Aquaculture originates from ancient Chinese wisdom, and is considered the most efficient food-producing industry. About 70 years ago, New China proposed an industrial approach to fish production and made a policy decision to begin modern aquaculture development. As one of lucky persons since the early 1980s, I have committed my scholarly career to the studies on genetics and breeding biotechnology of polyploid gibel carp (Carassius gibelio). Here, several significant recent innovations, such as the proposition of the amphitriploid concept, the association of ploidy changes with reproduction transition, the finding of a unique ameiofusiongenesis mode, the establishment of a controllable fertility approach, the creation of intermuscular bonefree mutants, as well as the recreation of desirable goldfish, are introduced and emphasized from an active participant of these innovations. Additionally, some modern innovations and contributions are also highlighted in other aspects of aquaculture including feed development, disease control, facilities and equipment upgrading, as well as paradigm and mode changes. This comprehensive synthesis of ancient Chinese wisdom and modern innovations seeks to provide valuable insights into the field from a historical basis. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study is to analyze the factors affecting college students' subjective well-being and the relationship between research achievement motivation, self-efficacy and emotional well-being among college students. Design/Methodology/Approach: 1,082 students were selected from 10 universities in Guangxi Province using a convenience sampling method. Questionnaires were administered based on achievement motivation, self-efficacy and subjective well-being scales. The data were analyzed using SPSS 24.0 and AMOS 22.0. Findings: College students' achievement motivation has a significant positive effect on emotional well-being. Self-efficacy acts as a mediator in the relationship between achievement motivation and subjective well-being. Conclusion: Achievement motivation can stimulate positive actions and efforts in college students enabling them to face challenges and difficulties more confidently. Approving activities and increased confidence enhance students' self-efficacy improving their subjective well-being. Research Limitations The interpretation of study results and inferences is constrained in sampling because of the time and expertise of the researchers. Practical Implications: It is possible to effectively improve college students' subjective well-being by focusing on the development of achievement motivation, self-efficacy and social support. Contribution to the Literature: This study further clarifies the influence of achievement motivation on subjective well-being and the mechanism of self-efficacy which is a supplement to the current research in this field at the same time. It also helps to enrich and perfect the research on achievement motivation, self-efficacy and subjective well-being of college students. [ABSTRACT FROM AUTHOR]

In Southeast Asia, emerging subduction zones often appear to begin at the corners of small oceanic basins, which have a triangular‐indenter continent–ocean boundary geometry. To investigate the influence of a triangular corner on subduction initiation, we performed a series of three‐dimensional numerical simulations with varying corner angles and base lengths. The results show that the apex of the corner constitutes the initial location of subduction, irrespective of the angle or the extent of the corner. Smaller angle corners are more likely to facilitate subduction initiation. At the same time, wide acute angle corners are difficult to form. Our findings suggest that triangular corner structures may facilitate subduction initiation in smaller basins; however, the role such corners in subduction initiation is limited in larger basins. Our results emphasize the importance of accounting for the three‐dimensional geometry of a subduction zone when examining its subduction dynamics and geological features. Plain Language Summary: In Southeast Asia, new subduction zones near small ocean areas and near locations prone to subduction have a unique and common feature—subduction starts at triangular corner–shaped continent–ocean boundaries. To fully understand how these triangular corner shapes affect the initiation of subduction, we employed advanced computer simulations. We varied the angles and lengths of the corners in our models. We discovered that, no matter the size of the corner, subduction began at the apex of the corner. Interestingly, smaller corners are especially good at initiating subduction. However, forming a wide corner with small angles in nature appears to be very difficult. This study indicates that the corner shape helps subduction start in small ocean areas but is not as important in larger ocean areas. This insight helps us better understand how subduction works in different locations on the Earth. Key Points: In small ocean basins subduction initiates at the apex of the corner, regardless of its size or angle at the cornerThe smaller the angle of the corner in the oceanic basin, the more likely subduction is to initiateAn angle at the corner greater than 120° is less likely to lead to the subduction initiation [ABSTRACT FROM AUTHOR]

Abstract Oxygen is essential for aerobic organisms, but little is known about its role in antiviral immunity. Here, we report that during responses to viral infection, hypoxic conditions repress antiviral-responsive genes independently of HIF signaling. EGLN1 is identified as a key mediator of the oxygen enhancement of antiviral innate immune responses. Under sufficient oxygen conditions, EGLN1 retains its prolyl hydroxylase activity to catalyze the hydroxylation of IRF3 at proline 10. This modification enhances IRF3 phosphorylation, dimerization and nuclear translocation, leading to subsequent IRF3 activation. Furthermore, mice and zebrafish with Egln1 deletion, treatment with the EGLN inhibitor FG4592, or mice carrying an Irf3 P10A mutation are more susceptible to viral infections. These findings not only reveal a direct link between oxygen and antiviral responses, but also provide insight into the mechanisms by which oxygen regulates innate immunity.

In mammals, NLRX1 is a unique member of the nucleotide-binding domain and leucine-rich repeat (NLR) family showing an ability to negatively regulate IFN antiviral immunity. Intron-containing genes, including NLRX1, have more than one transcript due to alternative splicing; however, little is known about the function of its splicing variants. Here, we identified a transcript variant of NLRX1 in zebrafish (Danio rerio), termed NLRX1-tv4, as a negative regulator of fish IFN response. Zebrafish NLRX1-tv4 was slightly induced by viral infection, with an expression pattern similar to the full-length NLRX1. Despite the lack of an N-terminal domain that exists in the full-length NLRX1, overexpression of NLRX1-tv4 still impaired fish IFN antiviral response and promoted viral replication in fish cells, similar to the full-length NLRX1. Mechanistically, NLRX1-tv4 targeted STING for proteasome-dependent protein degradation by recruiting an E3 ubiquitin ligase RNF5 to drive the K48-linked ubiquitination, eventually downregulating the IFN antiviral response. Mapping of NLRX1-tv4 domains showed that its N-terminal and C-terminal regions exhibited a similar potential to inhibit STING-mediated IFN antiviral response. Our findings reveal that like the full-length NLRX1, zebrafish NLRX-tv4 functions as an inhibitor to shape fish IFN antiviral response. IMPORTANCE In this study, we demonstrate that a transcript variant of zebrafish NLRX1, termed NLRX1-tv4, downregulates fish IFN response and promotes virus replication by targeting STING for protein degradation and impairing the interaction of STING and TBK1 and that its N- and C-terminus exhibit a similar inhibitory potential. Our results are helpful in clarifying the current contradictory understanding of structure and function of vertebrate NLRX1s. [ABSTRACT FROM AUTHOR]

Summary: The development of CRISPR-Cas9 technology introduces an efficient tool for precise engineering of fish genomes. With a short reproduction cycle, zebrafish infection mode can be referenced as antiviral breeding researches in aquaculture fish. Previously we identified a crucian carp-specific gene ftrca1 as an inhibitor of interferon response in vitro. Here, we demonstrate that genome editing of zebrafish ftr42, a homolog of ftrca1, generates a zebrafish mutant (ftr42lof/lof) with an improved resistance to SVCV infection. Zebrafish ftr42 acts as a virus-induced E3 ligase and downregulates IFN antiviral response by facilitating TBK1 protein degradation and also IRF7 mRNA decay. Genome editing results in loss of function of zebrafish ftr42, which enables zebrafish to have enhanced interferon response, thus improving zebrafish survival against virus infection. Our results suggest that fine-tuning fish IFN innate immunity through genome editing of negative regulators can genetically improve viral resistance in fish.