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As topological charge constitutes an infinite‐dimensional Hilbert space, vortex beam has numerous applications in optical communications and other fields where signal capacity is a vital requirement. Multifunctional vortex beams, showing up to different controllable responses subjected to separate combinations of polarization states, have significantly exhibited improved capacity of signal transport. Relying on prior physical knowledge, complex requirement brings tremendous challenge to the design of multifunctional vortex beams. Here, a deep‐learning‐based platform for designing metasurfaces is proposed, which can intelligently generate predesigned multifunctional vortex beams. Employing the proposed strategy, the demonstrations of bifunctional and trifunctional vortex beams are consistent with the design targets. Three samples are fabricated and measured by a Michelson interferometer. Clear observed interference patterns revealed the topological nature of the generated vortex beams, unambiguously justifying the design platform. This intelligent design strategy, which may inspire new ideas in other scientific fields, lays a solid foundation for the high‐performance application of multifunctional vortex beams. This work fully exploits the potential of vortex beams for large‐scale dense data communication and quantum optics with high quantum numbers, which may further promote the development of the integrated photonic chip. [ABSTRACT FROM AUTHOR]

Abstract: The M1/M2 phenotypic shift of microglia after spinal cord injury plays an important role in the regulation of neuroinflammation during the secondary injury phase of spinal cord injury. Regulation of shifting microglia polarization from M1 (neurotoxic and proinflammatory type) to M2 (neuroprotective and anti-inflammatory type) after spinal cord injury appears to be crucial. Tryptanthrin possesses an anti-inflammatory biological function. However, its roles and the underlying molecular mechanisms in spinal cord injury remain unknown. In this study, we found that tryptanthrin inhibited microglia-derived inflammation by promoting polarization to the M2 phenotype in vitro. Tryptanthrin promoted M2 polarization through inactivating the cGAS/STING/NF-κB pathway. Additionally, we found that targeting the cGAS/STING/NF-κB pathway with tryptanthrin shifted microglia from the M1 to M2 phenotype after spinal cord injury, inhibited neuronal loss, and promoted tissue repair and functional recovery in a mouse model of spinal cord injury. Finally, using a conditional co-culture system, we found that microglia treated with tryptanthrin suppressed endoplasmic reticulum stress-related neuronal apoptosis. Taken together, these results suggest that by targeting the cGAS/STING/NF-κB axis, tryptanthrin attenuates microglia-derived neuroinflammation and promotes functional recovery after spinal cord injury through shifting microglia polarization to the M2 phenotype., (Copyright © 2025 Copyright: © 2025 Neural Regeneration Research.)