Search

Salah satu faktor yang sangat penting untuk diperhatikan dalam perencanaan perkerasan landasan pacu bandar udara adalah daya dukung tanah dasar yang baik. Daya dukung tanah dasar pada perkerasan struktur landasan pacu menggunakan parameter berupa nilai CBR. Dalam menentukan daya dukung tanah dasar ini, salah satu metode pengujian yang banyak digunakan yaitu dengan metode pengujian CBR lapangan. Metode ini dipilih karena memiliki tingkat keakuratan yang lebih tinggi dibandingkan metode yang lain. Tujuan penelitian adalah untuk menentukan dan menganalisis nilai CBR tanah dasar pada pembangunan landasan pacu Bandar Udara Siboru melalui pengujian CBR lapangan. Dalam penelitian diambil sampel sepanjang 500 m dengan jumlah titik pengujian sebanyak 10 titik. Metode pengujian yang digunakan mengacu pada ASTM D4229 – 09 dan SNI 1738:2011. Dari hasil penelitian di peroleh nilai CBR tanah dasar terendah sebesar 12,02% dan nilai CBR tertinggi sebesar 24,40%. Kesimpulan yang diperoleh dari hasil analisis dan evaluasi nilai CBR bahwa tanah dasar memiliki kategori high (A) dengan interval nilai CBR ≥ 13% pada 8 titik pengujian dan kategori medium (B) dengan interval nilai CBR 8% < CBR < 13% pada 2 titik pengujian.

Gojek is one of the most popular ride-hailing companies in Indonesia. It has recently started innovations in developing its loyalty program; therefore, analyzing its impact on customer satisfaction and loyalty is an area that has the scope and need for research. This study aims to determine whether Gojek’s loyalty program, GoClub, influences the loyalty of its customers. For this study, online questionnaires were used with 555 respondents. The data were then processed using partial least squares structural equation modeling. Interviews with 20 respondents were also conducted to understand in detail the reasons for the rejection of the hypotheses. The results of the data analysis showed that the customers’ perceived quality of information, service, system, and value of the Gojek app significantly affected their level of satisfaction in using the GoClub loyalty program. This study also found that customers’ attitudes, subjective norms, and perceived behavioral control also influenced their loyalty to Gojek app. Furthermore, no relation was found between customers’ satisfaction in using the GoClub loyalty program and their loyalty to the Gojek application where millennial loyalty on certain app in Indonesia is very low. The findings of this study can help ride-hailing companies understand the factors that increase customers’ loyalty to such companies.

The concept of man in Islam centres on the belief that man is the most noble creation, endowed with freedom of will and the ability to develop morally and intellectually. Hasan Hanafi, a Muslim theologian, developed a liberation hermeneutic that criticises classical Islamic theology and contributes to understanding human nature from an Islamic perspective. This research seeks to understand how Islam views human nature based on Hasan Hanafi's Islamic theology and the relationship between the paradigm shift from theocentrism to anthropocentrism that affects human life. The research method applied was a descriptive qualitative with a literature study approach. The results demonstrated that Hasan Hanafi's work reflects a critical and transformative approach to Islamic theology, focusing on the practical realities and challenges facing Muslim societies. He advocates a shift from a theocentric theological paradigm to an anthropocentric one, which emphasises humans' centrality in addressing the world's problems. This reconstruction emphasises human self-reliance and makes Islamic theology the foundation of spiritual and practical values. Theocentric approaches emphasise divinity, ignoring human needs, while anthropocentric ones place humans at the centre, potentially endangering the environment. Balancing these approaches will likely serve to promote shared prosperity and environmental sustainability, forming meaningful social relationships. [ABSTRACT FROM AUTHOR]

Polymer-based membrane separation technology is gaining popularity due to its cost-effectiveness and operational simplicity. Cellulose acetate (CA) stands out as an attractive biobased polymer for membrane applications due to its remarkable mechanical properties and ease of manufacturing. To improve the selectivity of CA-based membranes for carbon dioxide (CO2) separation, the incorporation of polyethylene glycol methyl ether acrylate (PEGMEA), known for its CO2 absorption properties, has emerged as a promising approach for creating high-performance membrane materials with low operating pressure. This study provides insight into the production of PEGMEA-grafted CA membranes via gamma radiation and their performance for CO2/CH4 gas separation. CO2 permeation of the obtained CA-PEGMEA membranes was successfully improved and achieved the desired selectivity for CO2/CH4 separation. A comprehensive study of the membrane properties was conducted, encompassing structural characterization, surface analysis, permeability, selectivity, thermal analysis, and crystallinity, which are essential for understanding and assessing the membrane's performance. This work emphasizes gamma radiation graft polymerization and shows its applicability for high-performance gas separation membrane materials. [ABSTRACT FROM AUTHOR]

Inflammations have been linked to tumours, suggesting a potential association between NLRP1 and cancer. Nevertheless, a systematic assessment of NLRP1's role across various cancer types currently absent. A comprehensive bioinformatic analysis was conducted to determine whether NLRP1 exhibits prognostic relevance linked to immune metabolism across various cancers. The study leveraged data from the TCGA and GTEx databases to explore the clinical significance, metabolic features, and immunological characteristics of NLRP1, employing various tools such as R, GEPIA, STRING and TISIDB. NLRP1 exhibited differential expression patterns across various cancers, with elevated expression correlating with a more favourable prognosis in lung adenocarcinoma (LUAD) and pancreatic adenocarcinoma (PAAD). Downregulation of NLRP1 reduced tumour metabolic activity in LUAD. Moreover, the mutational signature of NLRP1 was linked to a favourable prognosis. Interestingly, high NLRP1 expression inversely correlated with tumour stemness while positively correlating with tumour immune infiltration in various cancers including LUAD and PAAD. Through extensive big data analysis, we delved into the role of NLRP1 across various tumour types, constructing a comprehensive role map of its involvement in pan‐cancer scenarios. Our findings highlight the potential of NLRP1 as a promising therapeutic target specifically in LUAD and PAAD. [ABSTRACT FROM AUTHOR]

Recent research has uncovered a surprisingly high occurrence of aberrant expression and mutations in the genes that encode subunits of the SWI/SNF chromatin-remodeling complexes (SCRC). Nevertheless, the carcinogenic effects of aberrant expression and mutations in SWI/SNF genes have only been acknowledged in recent times, resulting in a comparatively limited understanding of these modifications. In this study, we comprehensively analyzed the expression difference, somatic mutation, potential biological pathways, stromal or immune cell infiltration, and drug sensitivity of SCRC-related genes (SCRGs) in pan-cancer. Furthermore, the evolutionary trend, prognostic signature, and immunotherapy response of SCRGs in kidney renal clear cell carcinoma (KIRC) were also evaluated. The expression of SCRGs was changed in 13 out of 14 tumor types, strongly linked to prognosis, and mutated in 30.9% of tumor patients. SCRGs were also closely associated with immune-related pathways and tumor metastasis pathways. The expression of SCRGs was positively associated with the immune score or stromal score but negatively correlated with Tumor purity. Three potential drugs (FK866, Ispinesib mesylate, and WZ3105) were identified to target the SCRGs. In KIRC, scRNA-seq analysis showed that the enrichment of SCRC and the communication frequency with immune cells were significantly declined during tumor cell progression. A prognostic signature was constructed in KIRC and was effective in predicting the prognosis for KIRC. Aberrant expression of eleven prognostic genes identified from the KIRC prognostic signature and the cytotoxicity of FK866 and Ispinesib mesylate to KIRC were verified by qRT-PCR and CCK-8 assay, respectively. Our study identified SCRGs as potential biomarker and therapeutic targets, providing new insights into SCRC for tumor-targeted therapy. [ABSTRACT FROM AUTHOR]

Several indigenous swamp fish species have been successfully domesticated and cultivated by fish farmers in Sumatera, Indonesia. However, the hatching phase in hatcheries commonly encounters fungal infections attributed to Saprolegnia sp. This study investigates the efficacy of betel leaf extract in protecting the eggs of kissing gourami and climbing perch from saprolegniasis. Mimicking natural infection conditions, all eggs were exposed to 5 artificially infected eggs per tank. Prior to infection, the water was treated with betel leaf extract at various concentrations. Results indicate that betel leaf extract significantly protects the eggs from this fungal infection. For the climbing perch, the optimal dosage was determined to be 300 mg L-1, resulting in a hatching rate of 90% and a prevalence rate of 10%. For the kissing gourami, the optimal dosage was found to be 120 mg L-1, resulting in a hatching rate of 86.66% and a prevalence rate of 13.34%. [ABSTRACT FROM AUTHOR]

The progression of acute myeloid leukemia (AML) is influenced by the immune microenvironment in the bone marrow and dysregulated intracellular competing endogenous RNA (ceRNA) networks. Our study utilized data from UCSC Xena, The Cancer Genome Atlas Program, the Gene Expression Omnibus, and the Immunology Database and Analysis Portal. Using Cox regression analysis, we identified an immune-related prognostic signature. Genomic analysis of prognostic messenger RNA (mRNA) was conducted through Gene Set Cancer Analysis (GSCA), and a prognostic ceRNA network was constructed using the Encyclopedia of RNA Interactomes. Correlations between signature mRNAs and immune cell infiltration, checkpoints, and drug sensitivity were assessed using R software, gene expression profiling interactive analysis (GEPIA), and CellMiner, respectively. Adhering to the ceRNA hypothesis, we established a potential long noncoding RNA (lncRNA)/microRNA (miRNA)/mRNA regulatory axis. Our findings pinpointed 9 immune-related prognostic mRNAs (KIR2DL1, CSRP1, APOBEC3G, CKLF, PLXNC1, PNOC, ANGPT1, IL1R2, and IL3RA). GSCA analysis revealed the impact of copy number variations and methylation on AML. The ceRNA network comprised 14 prognostic differentially expressed lncRNAs (DE-lncRNAs), 6 prognostic DE-miRNAs, and 3 prognostic immune-related DE-mRNAs. Correlation analyses linked these mRNAs' expression to 22 immune cell types and 6 immune checkpoints, with potential sensitivity to 27 antitumor drugs. Finally, we identified a potential LINC00963/hsa-miR-431-5p/CSRP1 axis. This study offers innovative insights for AML diagnosis and treatment through a novel immune-related signature and ceRNA axis. Identified novel biomarkers, including 2 mRNAs (CKLF, PNOC), 1 miRNA (hsa-miR-323a-3p), and 10 lncRNAs (SNHG25, LINC01857, AL390728.6, AC127024.5, Z83843.1, AP002884.1, AC007038.1, AC112512, AC020659.1, AC005921.3) present promising candidates as potential targets for precision medicine, contributing to the ongoing advancements in the field. [ABSTRACT FROM AUTHOR]

This study aims to determine the influence of the work environment and career development on Organizational Citizenship Behavior (OCB) through work motivation as an intervening variable at Percetakan Menara Kudus. The study uses quantitative methods with the object of research at Percetakan Menara Kudus. The research sample consisted of 103 respondents using a purposive sampling technique with the criteria of employees who have worked for at least one year at Percetakan Menara Kudus. The data analysis method used was Partial Least Square (PLS), operated using the SmartPLS version 3.0 program. The study results show that the work environment and career development each positively and significantly affect work motivation. The work environment and career development do not affect OCB. Another result of this research is that work motivation positively and significantly affects OCB. Apart from that, research also shows that work motivation can be an intervening variable in the work environment and for career development on OCB as well. [ABSTRACT FROM AUTHOR]