1. Inflammatory Markers and Measures of Cardiovascular Autonomic Neuropathy in Type 1 Diabetes
- Author
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Lynn Ang, Sejal Gunaratnam, Yiyuan Huang, Brendan R. Dillon, Catherine L. Martin, Aaron Burant, Jacob Reiss, Pennelope Blakely, Alexi Vasbinder, Lili Zhao, Kara Mizokami‐Stout, Yaling Tang, Eva L. Feldman, Alessandro Doria, Cathie Spino, Mousumi Banerjee, Salim S. Hayek, and Rodica Pop‐Busui
- Subjects
biomarkers ,cardiovascular autonomic neuropathy ,cardiovascular autonomic reflex tests ,heart rate variability ,inflammation ,soluble urokinase plasminogen activator receptor ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Cardiovascular autonomic neuropathy (CAN) and inflammation predict more severe outcomes in type 1 diabetes (T1D). However, the link between CAN and inflammation in T1D remains unclear. We examined associations between CAN measures and inflammatory biomarkers in individuals with T1D. Methods and Results In a cross‐sectional study, we measured cardiovascular autonomic reflex tests and heart rate variability (established CAN measures) and a panel of 39 inflammatory biomarkers, including soluble urokinase plasminogen activator receptor (suPAR), in T1D participants of the TINSAL‐T1DN (Targeting Inflammation with Salsalate in Individuals with T1D Neuropathy) trial (n=57, discovery), and the PERL (Preventing Early Renal Loss in Diabetes) trial (n=468, validation). Amongst 39 inflammatory biomarkers measured in TINSAL‐T1DN, suPAR levels had the strongest negative correlations with CAN measures: expiration/inspiration (r=−0.48), Valsalva (r=−0.28), 30:15 (r=−0.37), SD of the normal RR interval (r=−0.37), and root mean square of differences of successive RR intervals (r=−0.31) (all P
- Published
- 2025
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