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The use of observational studies for causal inference is a necessity, as randomized trials are not always available or possible to carry out. To reduce sources of bias present in "classical" observational studies, the target trial framework has been proposed. First one defines the following components of the pragmatic clinical trial (the target trial) would answer our research question: eligibility criteria, treatment strategies, assignment, follow-up, outcomes, causal contrast, and statistical analysis plan. Then, these components are modified based on available observational data, and used to emulate the target trial as closely as possible. This leads to observational studies that are generally less biased and with more reliable results. Nonetheless, it is important to consider the limitations of this framework given it is still an observational study and not a randomized experiment. [ABSTRACT FROM AUTHOR]