85 results on '"Endocrine Disorders"'
Search Results
2. Central precocious puberty: assessment, diagnosis and decisions about treatment.
- Author
-
Mason, Leah and Daskas, Nikolaos
- Subjects
- *
PRECOCIOUS puberty , *SEX hormones , *PARENTS , *PSYCHOLOGICAL distress , *ADOLESCENT health , *MENTAL health , *ENDOCRINOLOGISTS , *INTRAMUSCULAR injections , *DECISION making in clinical medicine , *PEDIATRICS , *CHILD development , *SEXUAL cycle , *GONADOTROPIN releasing hormone , *HYPOTHALAMIC-pituitary-adrenal axis , *MEDICAL needs assessment , *ENDOCRINE diseases , *MEDICAL referrals , *DISEASE risk factors , *DISEASE complications , *ADOLESCENCE - Abstract
Why you should read this article: • To understand the long-term negative physical and psychosocial consequences of precocious puberty • To learn about central precocious puberty (CPP), the more prevalent form of precocious puberty • To familiarise yourself with the factors to consider when deciding whether to treat CPP. Precocious puberty is defined as the onset of puberty before the age of eight years in girls and before the age of nine years in boys. It is associated with negative physical health consequences in the long term and can also have negative psychosocial effects, particularly in adolescence. Central precocious puberty (CPP), which is caused by the early activation of the hypothalamic-pituitary-gonadal axis, is the more prevalent form of precocious puberty. This article explains CPP and its signs, assessment, diagnosis and treatment. It also discusses the factors to consider when deciding whether or not to treat it, stressing the importance of a shared decision-making process that children and parents should be involved in. Precocious puberty must be diagnosed and managed by specialists, but all children’s nurses need a broad understanding of the condition so that they can refer children as early as possible and reassure and advise families. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
3. Childhood craniopharyngioma: a retrospective study of children followed in Hôpital Universitaire de Bruxelles.
- Author
-
Magerman, Clémentine, Boros, Emese, Preziosi, Marco, Lhoir, Sophie, Gilis, Nathalie, De Witte, Olivier, Heinrichs, Claudine, Salmon, Isabelle, Fricx, Christophe, Vermeulen, Françoise, Lebrun, Laetitia, Brachet, Cécile, and Rodesch, Marine
- Subjects
CRANIOPHARYNGIOMA ,PITUITARY dwarfism ,CHILD patients ,INTRACRANIAL tumors ,SYMPTOMS ,TUMORS in children - Abstract
Introduction: Craniopharyngiomas (CPs) are benign brain tumors accounting for 5 - 11% of intracranial tumors in children. These tumors often recur and can cause severe morbidity. Postoperative radiotherapy efficiently controls and prevents progression and recurrence. Despite advancements in neurosurgery, endocrinological, visual, and neuropsychological complications are common and significantly lower the quality of life of patients. Methods: We performed a retrospective study, including all patients younger than sixteen diagnosed with CP between July 1989 and August 2022 and followed up in Hôpital Universitaire de Bruxelles. Results: Nineteen children with CP were included, with median age of 7 years at first symptoms and 7.5 at diagnosis. Common symptoms at diagnosis were increased intracranial pressure (63%), visual impairment (47%), growth failure (26%), polyuria/polydipsia (16%), and weight gain (10.5%). As clinical signs at diagnosis, growth failure was observed in 11/18 patients, starting with a median lag of 1 year and 4 months before diagnosis. On ophthalmological examination, 27% of patients had papillary edema and 79% had visual impairment. When visual disturbances were found, the average preoperative volume was higher (p=0.039). Only 6/19 patients had gross total surgical resection. After the first neurosurgery, 83% experienced tumor recurrence or progression at a median time of 22 months. Eleven patients (73%) underwent postsurgical radiotherapy. At diagnosis, growth hormone deficiency (GHD) was the most frequent endocrine deficit (8/17) and one year post surgery, AVP deficiency was the most frequent deficit (14/17). Obesity was present in 13% of patients at diagnosis, and in 40% six months after surgery. There was no significant change in body mass index over time (p=0.273) after the first six months post-surgery. Conclusion: CP is a challenging brain tumor that requires multimodal therapy and lifelong multidisciplinary follow-up including hormonal substitution therapy. Early recognition of symptoms is crucial for prompt surgical management. The management of long-term sequelae and morbidity are crucial parts of the clinical path of the patients. The results of this study highlight the fundamental importance of carrying out a complete assessment (ophthalmological, endocrinological, neurocognitive) at the time of diagnosis and during follow-up so that patients can benefit from the best possible care. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
4. Paediatric endocrine disorders as seen at the University of Benin Teaching Hospital over a ten-year period
- Author
-
Onyiriuka AN and Kouyaté M
- Subjects
endocrine disorders ,clinical pattern ,children ,hospital ,nigeria ,Medicine - Abstract
Background: In most developing countries, data on the prevalence and distribution of paediatric endocrine disorders is lacking. Objective: To describe the pattern of endocrine disorders seen in the Department of Child Health, University of Benin Teaching Hospital (UBTH), Benin City, Nigeria between 2004 to 2013. Methods: In this retrospective study, the case files of children seen in the paediatric endocrinemetabolic clinic and those admitted into the wards at the UBTH, Benin City from January, 2004 to December, 2013 were audited. Information obtained included age at presentation, gender, principal complaints, and final diagnosis. For those who were admitted, the outcome was noted. The hospital’s paediatric clinic register was examined to obtain the total number of new cases seen during the period under review. Results: A total of 13,735 new cases were seen in the Department of Child Health, UBTH during the ten-year period under review and 99 (0.72%) of these had endocrine disorders. The frequencies of the four leading groups of endocrine disorders seen were as follows: diabetes mellitus 17.2%; disorders of sex development 13.8%; disorders of the thyroid gland 12.1%; and disorders of energy balance 11.2%. Short stature was a rare presenting complaint. Conclusion: Diabetes mellitus and disorders involving sex development, thyroid gland, energy balance and pubertal development were the five leading groups of childhood endocrine disorders encountered in our clinical practice in UBTH.
- Published
- 2024
5. Multi-omics Investigations in Endocrine Systems and Their Clinical Implications
- Author
-
Peliciari-Garcia, Rodrigo Antonio, de Barros, Carolina Fonseca, Secio-Silva, Ayla, de Barros Peruchetti, Diogo, Romano, Renata Marino, Bargi-Souza, Paula, Crusio, Wim E., Series Editor, Dong, Haidong, Series Editor, Radeke, Heinfried H., Series Editor, Rezaei, Nima, Series Editor, Steinlein, Ortrud, Series Editor, Xiao, Junjie, Series Editor, and Verano-Braga, Thiago, editor
- Published
- 2024
- Full Text
- View/download PDF
6. Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center
- Author
-
Vassos Neocleous, Pavlos Fanis, Meropi Toumba, Nicos Skordis, and Leonidas A. Phylactou
- Subjects
ENDO-ERN ,Endocrine disorders ,CAH ,MEN2 ,RET ,MKRN3 ,Medicine - Abstract
Abstract The report covers the current and past activities of the department Molecular Genetics-Function and Therapy (MGFT) at the Cyprus Institute of Neurology and Genetics (CING), an affiliated Reference Center for the European Reference Network on Rare Endocrine Conditions (Endo-ERN). The presented data is the outcome of > 15 years long standing collaboration between MGFT and endocrine specialists from the local government hospitals and the private sector. Up-to-date > 2000 genetic tests have been performed for the diagnosis of inherited rare endocrine disorders. The major clinical entities included Congenital Adrenal Hyperplasia (CAH) due to pathogenic variants in CYP21A2 gene and Multiple Endocrine Neoplasia (MEN) type 2 due to pathogenic variants in the RET proto-oncogene. Other rare and novel pathogenic variants in ANOS1, WDR11, FGFR1, RNF216, and CHD7 genes were also found in patients with Congenital Hypogonadotropic Hypogonadism. Interestingly, a few patients with Disorders of Sexual Differentiation (DSD) shared rare pathogenic variants in the SRD5A2, HSD17B3 and HSD3B2 while patients with Glucose and Insulin Homeostasis carried theirs in GCK and HNF1A genes. Lastly, MGFT over the last few years has established an esteemed diagnostic and research program on premature puberty with emphasis on the implication of MKRN3 gene on the onset of the disease and the identification of other prognosis biomarkers. As an Endo-ERN member MGFT department belongs to this large European network and holds the same humanistic ideals which aim toward the improvements of health care for patients with rare endocrine conditions in respect to improved and faster diagnosis.
- Published
- 2024
- Full Text
- View/download PDF
7. An observation into the conduction of nerve fibers and goniometry in women with hypothyroidism
- Author
-
Syed Madhar Shah K, Kavitha P, Shalini S, and Janardhanan S
- Subjects
hypothyroidism ,nerve conduction ,goniometry ,endocrine disorders ,Medicine - Abstract
Background: The thyroid hormone is so essential that it is involved in the functioning of all the body systems, especially in the development of the brain in fetal life. The World Health Organization has estimated that around 2 billion individuals are suffering from thyroid disorders. Hence, it is essential to identify and diagnose hypothyroid patients so that the treatment strategy can be started at the earliest. Aims and Objectives: The present study aimed to find out the peripheral nerve conduction velocity, range, and degree of movement of joints in newly diagnosed hypothyroid women and compare them with those of normal euthyroid women. Materials and Methods: The present study was a case–control study conducted from July 2015 to March 2016. A total of 50 cases of newly diagnosed hypothyroid women and 50 age-matched euthyroid women were part of the study after obtaining written and informed consent. Thyroid estimation was performed in the Clinical Biochemistry Department by the ELISA method, and nerve conduction studies were performed in the Neurology Department. Results: The age and height of the participants were not statistically significant. Weight and body mass index were significantly higher in the cases when compared to the control group. Sensory and motor conduction velocities of the right median nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the right ulnar nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the left median nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the left ulnar nerve are significantly less in these cases when compared to control group participants. The goniometric parameters (right and left sides) of the cases and control group participants were not significantly different. Conclusion: Hypothyroid women have a delay in peripheral nerve conduction velocities, including sensory and motor components, and the degree and range of movements of limb joints were not affected. A nerve conduction study may be utilized as a routine screening test for hypothyroid individuals so that hormone replacement therapy can be instituted at the earliest.
- Published
- 2024
- Full Text
- View/download PDF
8. An uncommon presentation of autoimmune polyglandular syndrome type 1 (APS‐1)—A case report.
- Author
-
Alrufaidi, Ali M., Alnashery, Mohammed Mosa, Alghanimi, Ageel Ahmad, Elmansor, Rash Elamin Ahmed, and Ghazy, Ramy Mohamed
- Subjects
- *
HYPOPARATHYROIDISM , *ADDISON'S disease , *SYNDROMES , *GENETIC testing , *REGULATOR genes , *INTRAVENOUS therapy , *MEDICAL screening - Abstract
Key Clinical Message: Autoimmune polyglandular syndrome type 1 (APS‐1) is a rare disorder defined by the presence of at least two of the following conditions: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism, and Addison's syndrome. Despite the lack of CMC and autoimmune history, APS‐1 can be diagnosed using genetic testing. We present the case of a 28‐year‐old female patient with a history of hypocalcemia due to hypoparathyroidism since the age of 2 years. She presented to the endocrine clinic with hypogonadism, primary amenorrhea, and primary ovarian insufficiency. Addison's disease was eventually diagnosed, despite a negative Synacthen test. The adrenal crisis required intravenous hydrocortisone therapy. No CMC was documented, and there was no family history of such conditions. The diagnosis of APS‐1 was confirmed by genetic testing, revealing homozygous pathogenic variants of the autoimmune regulator gene. Management included oral calcium and calcitriol and oral hydrocortisone and fludrocortisone for Addison's disease. Hormonal induction of secondary sexual characteristics was initiated. The patient received combined oral estrogen and progesterone pills. This case highlights the critical significance of early recognition, thorough evaluation, and tailored treatment for patients with APS‐1 to enhance their quality of life and mitigate potentially life‐threatening complications. This underscores the importance of screening for associated minor autoimmune diseases as part of a holistic approach to care. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field.
- Author
-
Olejarz, Michal, Szczepanek-Parulska, Ewelina, and Ruchala, Marek
- Subjects
ENDOCRINE diseases ,THYROID gland ,BLOOD lipoproteins ,THYROID diseases ,THYROID hormone receptors ,POLYCYSTIC ovary syndrome ,PARATHYROID glands - Abstract
Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Exploring the Connection between Hypothyroidism and Polycystic Ovary Syndrome: A Comprehensive Review.
- Author
-
Barman, Indrani, Sharma, Trishna, and Talukdar, Nayan
- Abstract
Hypothyroidism and Polycystic Ovary Syndrome (PCOS) constitute prevalent endocrine conditions that have serious effects on the health of women. Hormonal dysregulation, ovarian dysfunction, and polycystic ovarian morphology are hallmarks of PCOS, whereas insufficient thyroid hormone production causes hypothyroidism. This study explores the complex interactions between hypothyroidism and PCOS, highlighting the urgent need for a thorough understanding of their coexistence. It is crucial to understand that PCOS and hypothyroidism frequently co-occur since they both involve similar metabolic and hormonal dysregulations. The complex interrelationship between these illnesses is further highlighted by genetic predispositions and epigenetic changes. Clinical manifestations and reproductive issues in afflicted people are mostly influenced by hormonal imbalances, insulin resistance, and metabolic abnormalities. It is crucial to use a multidisciplinary approach to patient treatment, collaborating with endocrinologists, gynaecologists, primary care doctors, nutritionists, and mental health specialists. This comprehensive approach takes into account not only the hormonal and metabolic components of PCOS and hypothyroidism but also the psychological well-being of persons dealing with these conditions. The importance of understanding and treating the interaction between PCOS and hypothyroidism in clinical practice is emphasized in this study. Improved results and a higher quality of life for afflicted people can result from early diagnosis and suitable care techniques. Future research initiatives on genetic, epigenetic, and metabolic issues also show potential for improving therapeutic and diagnostic approaches, eventually improving patient care. This review provides a comprehensive understanding of the challenges linked to PCOS and hypothyroidism, emphasizing the importance of a comprehensive treatment plan for improved outcomes. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. Relationship between Blood Groups and the Risk of Covid-19 Infection; a Cohort Study.
- Author
-
Mahjoor, Mohamad, Askari, Abolfazl, Khaledi, Mansoor, Afkhami, Hamed, Sadeghi-Dehsahraei, Hamed, Arabpour, Javad, Fathi, Javad, Valizadeh, Amir, Amini, Mohammad Esmaeil, Esmkhani, Mohammad, Safarinia, Reza, and Mottaghiyan, Zahra
- Subjects
- *
BLOOD grouping & crossmatching , *BLOOD groups , *ABO blood group system , *COVID-19 , *RH factor , *BLOOD group antigens , *COHORT analysis - Abstract
Background: ABO blood types are not known to cause diseases directly, but they can be vulnerable and surrender to diseases and health problems. This study aimed to evaluate the susceptibility to COVID-19 in individuals with different blood groups at different ages. Methods: An electronic health record was used in this retrospective cohort study at Shahid Beheshti Hospital. We studied 858 patients who were referred to Shahid Beheshti Hospital, we identified 434 of them as COVID-19 patients using RT-PCR. An analysis of the electronic record involved collecting retrospective laboratory data and demographic information, including age, sex, and blood type. Next, we examined the differences between the ABO blood groups of COVID-19 patients and the control group (1991 case). We used SPSS26 for statistical computations. Data were scrutinizeed with the χ2 test. P < 0.05 was considered statistically outstanding. Results: Based on the distribution of ABO blood groups in 434 COVID-19 patients, it was revealed that 288 of them were male and 146 were female, and the majority of them were in their third decade of life. A total of 159 patients (36.6%) had type B blood, 116 had type A (26.7%), 109 had type O (25.1%), and 50 had type AB (11.5%). COVID-19 patients had a higher percentage of type B and AB blood than the control group Conclusion: Our study found that the frequency ratio of blood group B was remarkably higher in patients than in the control group, which indicates that the blood group B may play a pivotal role in COVID-19 disease. [ABSTRACT FROM AUTHOR]
- Published
- 2024
12. An observation into the conduction of nerve fibers and goniometry in women with hypothyroidism.
- Author
-
K., Syed Madhar Shah, Kavitha P., Shalini S., and Janardhanan S.
- Subjects
- *
NEURAL conduction , *NERVE fibers , *NERVE conduction studies , *HORMONE therapy , *CARPAL tunnel syndrome , *MEDIAN nerve , *THYROID diseases - Abstract
Background: The thyroid hormone is so essential that it is involved in the functioning of all the body systems, especially in the development of the brain in fetal life. The World Health Organization has estimated that around 2 billion individuals are suffering from thyroid disorders. Hence, it is essential to identify and diagnose hypothyroid patients so that the treatment strategy can be started at the earliest. Aims and Objectives: The present study aimed to find out the peripheral nerve conduction velocity, range, and degree of movement of joints in newly diagnosed hypothyroid women and compare them with those of normal euthyroid women. Materials and Methods: The present study was a case--control study conducted from July 2015 to March 2016. A total of 50 cases of newly diagnosed hypothyroid women and 50 age-matched euthyroid women were part of the study after obtaining written and informed consent. Thyroid estimation was performed in the Clinical Biochemistry Department by the ELISA method, and nerve conduction studies were performed in the Neurology Department. Results: The age and height of the participants were not statistically significant. Weight and body mass index were significantly higher in the cases when compared to the control group. Sensory and motor conduction velocities of the right median nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the right ulnar nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the left median nerve are significantly less in these cases when compared to control group participants. Sensory and motor conduction velocities of the left ulnar nerve are significantly less in these cases when compared to control group participants. The goniometric parameters (right and left sides) of the cases and control group participants were not significantly different. Conclusion: Hypothyroid women have a delay in peripheral nerve conduction velocities, including sensory and motor components, and the degree and range of movements of limb joints were not affected. A nerve conduction study may be utilized as a routine screening test for hypothyroid individuals so that hormone replacement therapy can be instituted at the earliest. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
13. Journal of Medical Academics
- Subjects
adverse drug reaction ,acute coronary syndrome ,coronavirus ,epidemiology ,endocrine disorders ,anatomy ,Medicine - Published
- 2024
14. Suspected Acromegaly - Looking for Ectopic Hormone Production.
- Author
-
Orczyk, Jakub, Ołownia, Aleksandra, and Szafraniec-Porada, Aneta
- Abstract
Introduction: Acromegaly is a slow-progressing disease caused by excessive secretion of growth hormone, typically by pituitary adenomas. Ectopic tumors, such as those in the lungs or pancreas, are a rare cause. Acromegaly associated with ectopic GHRH secretion is more common in women. Case Report: The 48-year-old man underwent head contrast computed tomography (CT) and pituitary magnetic resonance imaging (MRI) due to persistent headaches, but no lesions were found. Outpatient tests showed elevated levels of growth hormone (GH) and insulin-like growth factor 1 (IGF-1). Physical examination revealed coarse facial features, enlarged hands and feet, hyperhidrosis, and snoring. During hospitalization, elevated levels of IGF-1 and serotonin were noted, along with paradoxical GH release during an oral glucose tolerance test and abnormal thyroid hormone levels. Chest X-ray showed opacity in the right lung. The patient, diagnosed with acromegaly, also had obesity, hypertension, left ventricular hypertrophy, impaired fasting glucose, and cholelithiasis. Treatment with liraglutide was initiated. Ectopic sites of GH secretion were investigated, revealing emphysematous bullae and nodules in the lungs, as well as suspicious findings in the anterior mediastinum. Subsequent hospitalization showed normal thyroid and gonadal function, and MRI showed no pituitary lesions. Conclusion: This case illustrates the difficulties in diagnosing acromegaly. Pituitary hyperplasia visualized on imaging studies does not always indicate pituitary acromegaly, as it could result from hypertrophy due to ectopic GHRH secretion. Although ectopic acromegaly is rare, it should always be considered in the differential diagnosis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
15. Occult endocrine disorders newly diagnosed in patients with post-COVID-19 symptoms
- Author
-
Yasuhiro Nakano, Naruhiko Sunada, Kazuki Tokumasu, Hiroyuki Honda, Yuki Otsuka, Yasue Sakurada, Yui Matsuda, Toru Hasegawa, Daisuke Omura, Kanako Ochi, Miho Yasuda, Hideharu Hagiya, Keigo Ueda, and Fumio Otsuka
- Subjects
Diabetes mellitus ,Endocrine disorders ,Long COVID ,Metabolic disorders ,Thyroid disease ,Medicine ,Science - Abstract
Abstract Determination of long COVID requires ruling out alternative diagnoses, but there has been no report on the features of alternative diagnoses. This study was a single-center retrospective study of outpatients who visited our clinic between February 2021 and June 2023 that was carried out to determine the characteristics of alternative diagnoses in patients with post-COVID-19 symptoms. In a total of 731 patients, 50 patients (6.8%) were newly diagnosed with 52 diseases requiring medical intervention, and 16 (32%) of those 50 patients (2.2% of the total) were considered to have priority for treatment of the newly diagnosed disorders over long COVID treatment. The proportion of patients with a new diagnosis increased with advance of age, with 15.7% of the patients aged 60 years or older having a new diagnosis. Endocrine and metabolic diseases and hematological and respiratory diseases were the most common, being detected in eight patients (16%) each. Although 35 of the 52 diseases (67%) were related to their symptoms, endocrine and metabolic diseases were the least associated with specific symptoms. Other disorders that require attention were found especially in elderly patients with symptomatic long COVID. Thus, appropriate assessment and differentiation from alternative diagnoses are necessary for managing long COVID.
- Published
- 2024
- Full Text
- View/download PDF
16. Effects of hormonal changes on the human voice: a review
- Author
-
Omayma Afsah
- Subjects
Voice ,Vocal fold ,Endocrine disorders ,Thyroid ,Pituitary ,Otorhinolaryngology ,RF1-547 - Abstract
Abstract The human voice is commonly affected by hormonal changes, both in physiological and pathological conditions. Voice changes were reported in a number of endocrine disorders, and dysphonia may be the initial sign of these disorders. A number of studies documented endocrine-related voice changes utilizing both subjective and objective voice assessment tools. The objective of the present review is to draw the phoniatrician’s attention to the wide variety of typical changes, as well as the potential for hormonal imbalances that may affect the voice, in order to identify them promptly and generate proper treatment and referrals.
- Published
- 2024
- Full Text
- View/download PDF
17. Diabetes-induced male infertility: potential mechanisms and treatment options
- Author
-
Runchun Huang, Jiawang Chen, Buyu Guo, Chenjun Jiang, and Weiming Sun
- Subjects
Diabetes ,Male infertility ,Hyperglycemia ,Oxidative stress ,Chronic inflammation ,Endocrine disorders ,Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Abstract Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive problems, especially infertility, shows a very similar trend to the incidence of diabetes within the same age range. In addition, a large number of previous in vivo and in vitro experiments have also suggested that the complex pathophysiological changes caused by diabetes may induce male infertility in multiple aspects, including hypothalamic-pituitary–gonadal axis dysfunction, spermatogenesis and maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on the above related mechanisms, a large number of studies have focused on the potential therapeutic association between diabetes progression and infertility in patients with diabetes and infertility, providing important clues for the treatment of this population. In this paper, we summarized the research results of the effects of diabetes on male reproductive function in recent 5 years, elaborated the potential pathophysiological mechanisms of male infertility induced by diabetes, and reviewed and prospected the therapeutic measures.
- Published
- 2024
- Full Text
- View/download PDF
18. Probiotics ameliorate endocrine disorders via modulating inflammatory pathways: a systematic review.
- Author
-
Nemati, Marzieh, Ebrahimi, Bahareh, and Montazeri-Najafabady, Nima
- Abstract
Probiotics has offered a new prospect to treat and manage a variety of endocrine disorders such as obesity, diabetes, non- alcoholic fatty liver disease and metabolic syndrome. The precise mechanisms by which probiotics exert their beneficial effects on endocrine disorders and its associated problems are still indecisive. It seems that regulating the immune system and suppressing pro-inflammatory pathways like tumor necrosis factor-α and interleukin-6 or triggering anti-inflammatory pathways like interleukin-4 and 10 may be one of the potential mechanisms in the managing of endocrine disorders. In this systematic review, we hypothesized that various probiotic strains (Lactobacillus, Biofidiobacteria, Streptococcus, Entrococcus, Clostridium, and Bacillus) alone or in combination with each other could manage endocrine disorders via modulating inflammatory pathways such as suppressing pro-inflammatory cytokines (IL-6, IL-12, TNF-α, TNF-β, NFκB, and MCP-1), stimulating anti-inflammatory cytokines (IL-4,IL-6, IL-22, IL-23, IL-33, and TGF-β) and maintaining other factors like C-reactive protein, Toll like receptors, LPS, and NK cells. Data source this search was performed in PubMed and Scopus. Both human and animal studies were included. Among more than 15,000 papers, 25 studies were identified as eligible for more assessments. Quality assessment of the studies was cheeked by two researchers independently by title and abstract screening, then article which have inclusion criteria were included, and data retrieved from the included full text studies as the authors had originally reported. Results specified that Lactobacillus has been the most widely used probiotic as well as which one exhibiting the extend of the therapeutic effects on endocrine disorders, especially obesity by modulating immune responses. Also, most studies have revealed that probiotics through suppressing pro-inflammatory pathways specially via reducing levels TNF-α cytokine exhibited protective or beneficial effects on endocrine diseases particularly obesity as well as through decreasing level of IL-6 induced therapeutic effects in diabetes. This systematic review suggests that probiotics could ameliorate endocrine disorders via their immunomodulatory effects. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
19. Occult endocrine disorders newly diagnosed in patients with post-COVID-19 symptoms.
- Author
-
Nakano, Yasuhiro, Sunada, Naruhiko, Tokumasu, Kazuki, Honda, Hiroyuki, Otsuka, Yuki, Sakurada, Yasue, Matsuda, Yui, Hasegawa, Toru, Omura, Daisuke, Ochi, Kanako, Yasuda, Miho, Hagiya, Hideharu, Ueda, Keigo, and Otsuka, Fumio
- Subjects
- *
ENDOCRINE diseases , *POST-acute COVID-19 syndrome , *COVID-19 pandemic , *BLOOD diseases , *OLDER patients , *CLINICS - Abstract
Determination of long COVID requires ruling out alternative diagnoses, but there has been no report on the features of alternative diagnoses. This study was a single-center retrospective study of outpatients who visited our clinic between February 2021 and June 2023 that was carried out to determine the characteristics of alternative diagnoses in patients with post-COVID-19 symptoms. In a total of 731 patients, 50 patients (6.8%) were newly diagnosed with 52 diseases requiring medical intervention, and 16 (32%) of those 50 patients (2.2% of the total) were considered to have priority for treatment of the newly diagnosed disorders over long COVID treatment. The proportion of patients with a new diagnosis increased with advance of age, with 15.7% of the patients aged 60 years or older having a new diagnosis. Endocrine and metabolic diseases and hematological and respiratory diseases were the most common, being detected in eight patients (16%) each. Although 35 of the 52 diseases (67%) were related to their symptoms, endocrine and metabolic diseases were the least associated with specific symptoms. Other disorders that require attention were found especially in elderly patients with symptomatic long COVID. Thus, appropriate assessment and differentiation from alternative diagnoses are necessary for managing long COVID. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
20. PCOS and vitamin D: a clinical appraisal.
- Author
-
Sparic, Radmila, Andjic, Mladen, Vergara, Daniele, Morciano, Andrea, D'Oria, Ottavia, Baldini, Giorgio Maria, Malvasi, Antonio, and Tinelli, Andrea
- Subjects
- *
VITAMIN D , *POLYCYSTIC ovary syndrome , *ENDOCRINE diseases , *METABOLIC disorders , *METABOLIC syndrome , *INSULIN resistance - Abstract
Purpose: Polycystic ovary syndrome (PCOS) is the most common endocrine-reproductive disease linked not just to infertility but also to serious comorbidities. There is a reported association between low vitamin D levels and multiple health conditions including PCOS. This narrative review aims to analyze the role of vitamin D in PCOS development, use of the vitamin D in the treatment of PCOS, and the molecular basis of these observations. Methods: A Medline and PubMed research was performed, during the years 1990–2023, using a combination of keywords on such topic. According to the author's evaluation and target, papers were identified and included for a narrative review. Results: There are associations between lower levels of vitamin D and PCOS, as well as with insulin resistance, metabolic syndrome, hyperandrogenemia, metabolic and endocrine disorders as well as the onset of oxidative stress and pro-inflammatory milieu, in PCOS women. Conclusion: Vitamin D has a role in pathologic changes linked to PCOS. Molecular and clinical investigations which give new information about the role of vitamin D in the development of PCOS and related endocrine and metabolic disturbance are further needed. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
21. Pollution and endometriosis: A deep dive into the environmental impacts on women's health.
- Author
-
Vallée, Alexandre, Ceccaldi, Pierre‐François, Carbonnel, Marie, Feki, Anis, and Ayoubi, Jean‐Marc
- Subjects
- *
ENDOMETRIOSIS , *WOMEN'S health , *POLLUTION , *WATER pollution , *WASTE management - Abstract
Background: The interaction between pollution and endometriosis is a pressing issue that demands immediate attention. The impact of pollution, particularly air and water pollution, or occupational hazards, on hormonal disruption and the initiation of endometriosis remains a major issue. Objectives: This narrative review aims to delve into the intricate connection between pollution and endometriosis, shedding light on how environmental factors contribute to the onset and severity of this disease and, thus, the possible public health policy implications. Discussion: Endocrine‐disrupting chemicals (EDCs) in pollutants dysregulate the hormonal balance, contributing to the progression of this major gynaecological disorder. Air pollution, specifically PM2.5 and PAHs, has been associated with an increased risk of endometriosis by enhancing chronic inflammation, oxidative stress, and hormonal imbalances. Chemical contaminants in water and work exposures, including heavy metals, dioxins, and PCBs, disrupt the hormonal regulation and potentially contribute to endometriosis. Mitigating the environmental impact of pollution is required to safeguard women's reproductive health. This requires a comprehensive approach involving stringent environmental regulations, sustainable practices, responsible waste management, research and innovation, public awareness, and collaboration among stakeholders. Conclusion: Public health policies have a major role in addressing the interaction between pollution and endometriosis in a long‐term commitment. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
22. Knowledge of osteoporosis prevention among people with endocrine disorders: A cross-sectional study.
- Author
-
Yaqiong Tan, Bihua Luo, and Zhifeng Sheng
- Subjects
- *
OSTEOPOROSIS prevention , *HEALTH literacy , *RISK assessment , *CROSS-sectional method , *RESEARCH funding , *SEX distribution , *MULTIPLE regression analysis , *KRUSKAL-Wallis Test , *DESCRIPTIVE statistics , *MANN Whitney U Test , *ENDOCRINE diseases , *OSTEOPOROSIS , *COMPARATIVE studies , *HEALTH education , *DATA analysis software , *EDUCATIONAL attainment , *COMORBIDITY , *DISEASE risk factors , *DISEASE complications - Abstract
People with endocrine disorders are at an increased risk of osteoporosis, yet their knowledge of osteoporosis prevention is rarely studied. This study aimed to assess the knowledge related to osteoporosis prevention and its associated factors among people with endocrine disorders in China. A cross-sectional study was conducted in a Chinese hospital's Department of Metabolism and Endocrinology. A total of 562 people with endocrine disorders completed the Chinese version of the Osteoporosis Prevention and Awareness Tool to assess their knowledge of osteoporosis prevention. Results showed that participants had a mean knowledge of 59.36 ± 23.90 out of 100, with only 52.1% scoring above 60 points. Being female, having higher education, with comorbidities, with a recent osteoporosis diagnosis, and having received health education related to osteoporosis prevention were associated with higher knowledge of osteoporosis prevention. Our study indicates that more efforts are needed to improve the knowledge related to osteoporosis prevention among people with endocrine disorders. This may be realized by strengthening and expanding diverse education, focusing on males and those with lower education and without comorbidities. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
23. 肌少症与睡眠障碍关系研究.
- Author
-
刘震超, 王妍之, 刘光, 王碧颖, and 宋梅
- Abstract
Sarcopenia is a disease mainly characterized by a decrease in skeletal muscle mass and muscle strength in the elderly population and chronic disease patients. Its main pathogenic factors include endocrine metabolic disorders, insufficient physical activity, chronic inflammation, etc. Recently, the impact of sleep disorders on sarcopenia has begun to receive attention, more studies have shown a correlation between sleep disorders and sarcopenia. Sleep disorders can lead to circadian disorders and thus affect the secretion of hormones such as insulin and sex hormones, as well as promote the secretion of pro-inflammatory inflammatory factors, all of which can lead to abnormal synthesis and breakdown of skeletal muscle proteins and may cause the development of sarcopenia. Therefore, exploring the relationship between the two and targeting sleep disorders may be effective in the prevention and treatment of sarcopenia and is a potential treatment strategy to intervene in the development of sarcopenia. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
24. Effects of hormonal changes on the human voice: a review.
- Author
-
Afsah, Omayma
- Subjects
HORMONE metabolism ,ENDOCRINE diseases ,POLYCYSTIC ovary syndrome ,HUMAN voice ,VOCAL cords ,MEDICAL referrals ,SEX hormones ,VOICE disorders - Abstract
The human voice is commonly affected by hormonal changes, both in physiological and pathological conditions. Voice changes were reported in a number of endocrine disorders, and dysphonia may be the initial sign of these disorders. A number of studies documented endocrine-related voice changes utilizing both subjective and objective voice assessment tools. The objective of the present review is to draw the phoniatrician's attention to the wide variety of typical changes, as well as the potential for hormonal imbalances that may affect the voice, in order to identify them promptly and generate proper treatment and referrals. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
25. Diabetes-induced male infertility: potential mechanisms and treatment options.
- Author
-
Huang, Runchun, Chen, Jiawang, Guo, Buyu, Jiang, Chenjun, and Sun, Weiming
- Subjects
- *
MALE infertility , *LEYDIG cells , *HYPOTHALAMIC-pituitary-gonadal axis , *IMPOTENCE , *ETIOLOGY of diabetes , *INFERTILITY - Abstract
Male infertility is a physiological phenomenon in which a man is unable to impregnate a fertile woman during a 12-month period of continuous, unprotected sexual intercourse. A growing body of clinical and epidemiological evidence indicates that the increasing incidence of male reproductive problems, especially infertility, shows a very similar trend to the incidence of diabetes within the same age range. In addition, a large number of previous in vivo and in vitro experiments have also suggested that the complex pathophysiological changes caused by diabetes may induce male infertility in multiple aspects, including hypothalamic-pituitary–gonadal axis dysfunction, spermatogenesis and maturation disorders, testicular interstitial cell damage erectile dysfunction. Based on the above related mechanisms, a large number of studies have focused on the potential therapeutic association between diabetes progression and infertility in patients with diabetes and infertility, providing important clues for the treatment of this population. In this paper, we summarized the research results of the effects of diabetes on male reproductive function in recent 5 years, elaborated the potential pathophysiological mechanisms of male infertility induced by diabetes, and reviewed and prospected the therapeutic measures. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
26. Microbiota Implications in Endocrine-Related Diseases: From Development to Novel Therapeutic Approaches.
- Author
-
Clemente-Suárez, Vicente Javier, Redondo-Flórez, Laura, Rubio-Zarapuz, Alejandro, Martín-Rodríguez, Alexandra, and Tornero-Aguilera, José Francisco
- Subjects
THERAPEUTICS ,HUMAN microbiota ,FECAL microbiota transplantation ,HORMONE regulation ,ENDOCRINE system - Abstract
This comprehensive review article delves into the critical role of the human microbiota in the development and management of endocrine-related diseases. We explore the complex interactions between the microbiota and the endocrine system, emphasizing the implications of microbiota dysbiosis for the onset and progression of various endocrine disorders. The review aims to synthesize current knowledge, highlighting recent advancements and the potential of novel therapeutic approaches targeting microbiota-endocrine interactions. Key topics include the impact of microbiota on hormone regulation, its role in endocrine pathologies, and the promising avenues of microbiota modulation through diet, probiotics, prebiotics, and fecal microbiota transplantation. We underscore the importance of this research in advancing personalized medicine, offering insights for more tailored and effective treatments for endocrine-related diseases. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
27. An uncommon presentation of autoimmune polyglandular syndrome type 1 (APS‐1)—A case report
- Author
-
Ali M. Alrufaidi, Mohammed Mosa Alnashery, Ageel Ahmad Alghanimi, Rash Elamin Ahmed Elmansor, and Ramy Mohamed Ghazy
- Subjects
AIRE gene mutation ,autoimmune diseases ,endocrine disorders ,hormonal replacement therapy ,polyglandular autoimmune syndrome type 1 ,primary ovarian insufficiency ,Medicine ,Medicine (General) ,R5-920 - Abstract
Key Clinical Message Autoimmune polyglandular syndrome type 1 (APS‐1) is a rare disorder defined by the presence of at least two of the following conditions: chronic mucocutaneous candidiasis (CMC), chronic hypoparathyroidism, and Addison's syndrome. Despite the lack of CMC and autoimmune history, APS‐1 can be diagnosed using genetic testing. We present the case of a 28‐year‐old female patient with a history of hypocalcemia due to hypoparathyroidism since the age of 2 years. She presented to the endocrine clinic with hypogonadism, primary amenorrhea, and primary ovarian insufficiency. Addison's disease was eventually diagnosed, despite a negative Synacthen test. The adrenal crisis required intravenous hydrocortisone therapy. No CMC was documented, and there was no family history of such conditions. The diagnosis of APS‐1 was confirmed by genetic testing, revealing homozygous pathogenic variants of the autoimmune regulator gene. Management included oral calcium and calcitriol and oral hydrocortisone and fludrocortisone for Addison's disease. Hormonal induction of secondary sexual characteristics was initiated. The patient received combined oral estrogen and progesterone pills. This case highlights the critical significance of early recognition, thorough evaluation, and tailored treatment for patients with APS‐1 to enhance their quality of life and mitigate potentially life‐threatening complications. This underscores the importance of screening for associated minor autoimmune diseases as part of a holistic approach to care.
- Published
- 2024
- Full Text
- View/download PDF
28. Childhood craniopharyngioma: a retrospective study of children followed in Hôpital Universitaire de Bruxelles
- Author
-
Clémentine Magerman, Emese Boros, Marco Preziosi, Sophie Lhoir, Nathalie Gilis, Olivier De Witte, Claudine Heinrichs, Isabelle Salmon, Christophe Fricx, Françoise Vermeulen, Laetitia Lebrun, Cécile Brachet, and Marine Rodesch
- Subjects
childhood craniopharyngioma ,neurosurgery ,radiotherapy ,hypothalamic obesity ,endocrine disorders ,visual disorders ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
IntroductionCraniopharyngiomas (CPs) are benign brain tumors accounting for 5 - 11% of intracranial tumors in children. These tumors often recur and can cause severe morbidity. Postoperative radiotherapy efficiently controls and prevents progression and recurrence. Despite advancements in neurosurgery, endocrinological, visual, and neuropsychological complications are common and significantly lower the quality of life of patients.MethodsWe performed a retrospective study, including all patients younger than sixteen diagnosed with CP between July 1989 and August 2022 and followed up in Hôpital Universitaire de Bruxelles.ResultsNineteen children with CP were included, with median age of 7 years at first symptoms and 7.5 at diagnosis. Common symptoms at diagnosis were increased intracranial pressure (63%), visual impairment (47%), growth failure (26%), polyuria/polydipsia (16%), and weight gain (10.5%). As clinical signs at diagnosis, growth failure was observed in 11/18 patients, starting with a median lag of 1 year and 4 months before diagnosis. On ophthalmological examination, 27% of patients had papillary edema and 79% had visual impairment. When visual disturbances were found, the average preoperative volume was higher (p=0.039). Only 6/19 patients had gross total surgical resection. After the first neurosurgery, 83% experienced tumor recurrence or progression at a median time of 22 months. Eleven patients (73%) underwent postsurgical radiotherapy. At diagnosis, growth hormone deficiency (GHD) was the most frequent endocrine deficit (8/17) and one year post surgery, AVP deficiency was the most frequent deficit (14/17). Obesity was present in 13% of patients at diagnosis, and in 40% six months after surgery. There was no significant change in body mass index over time (p=0.273) after the first six months post-surgery.ConclusionCP is a challenging brain tumor that requires multimodal therapy and lifelong multidisciplinary follow-up including hormonal substitution therapy. Early recognition of symptoms is crucial for prompt surgical management. The management of long-term sequelae and morbidity are crucial parts of the clinical path of the patients. The results of this study highlight the fundamental importance of carrying out a complete assessment (ophthalmological, endocrinological, neurocognitive) at the time of diagnosis and during follow-up so that patients can benefit from the best possible care.
- Published
- 2024
- Full Text
- View/download PDF
29. Lipoprotein alterations in endocrine disorders - a review of the recent developments in the field
- Author
-
Michal Olejarz, Ewelina Szczepanek-Parulska, and Marek Ruchala
- Subjects
endocrine disorders ,lipoproteins ,HDL-cholesterol ,LDL-cholesterol ,triglycerides ,lipoprotein (a) ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Abstract
Dyslipidemia is one of the most common disorders worldwide, which, if left untreated, results in a multitude of complications. Thus proper diagnostics, which includes identifying of secondary causes of dyslipidemia is crucial. Endocrine disorders are an important cause of secondary dyslipidemia. This paper aims to review the publications on lipoprotein alterations in endocrine disorders from the past two years and provide an overview of the recent discoveries in this dynamically developing and large field. Significant changes in lipoprotein serum concentrations are present in most endocrinological diseases and can be modified with proper treatment. Some lipoproteins have also been proposed as markers in some endocrine diseases, e.g., thyroid carcinoma. From the scope of endocrine disorders, the largest number of studies explored the lipoprotein changes in polycystic ovary syndrome and in women during the menopausal and peri-menopausal period. Even though the association of thyroid disorders with dyslipidemia is already well studied, new research has delivered some exciting findings about lipoprotein alterations in euthyroid patients with either positive antithyroid peroxidase antibodies or reduced sensitivity to thyroid hormones. The problem of the adverse metabolic profile, including dyslipidemia in hypoprolactinemia has been recognized. Moreover, this review describes other significant discoveries encompassing lipoprotein alterations in disorders of the adrenals, thyroid, parathyroid glands, pituitary, and gonads. The up-to-date knowledge of the influence of endocrine disorders and hormonal changes on serum lipoproteins is prudent as it can significantly impact therapeutic decisions.
- Published
- 2024
- Full Text
- View/download PDF
30. Association of polycystic ovary syndrome with atopic dermatitis: a case control study
- Author
-
Kim, Iris H., Andrade, Luis F., Haq, Zaim, Abdi, Parsa, Diaz, Michael J., and Bray, Fleta N.
- Published
- 2024
- Full Text
- View/download PDF
31. Dyslipidaemia in endocrine disorders
- Author
-
Kalyani Sridharan and Sanjay Kalra
- Subjects
Lipid disorders ,Endocrine disorders ,dyslipidemia ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Lipid disorders are common in several endocrine conditions. Diabetes mellitus, hypothyroidism and Cushing's syndrome are the common endocrine disorders with dyslipidemia. Dyslipidemia has a significant impact on endocrine and metabolic health and the risk of atherosclerotic cardiovascular disease. In most cases of dyslipidemia, the suspicion of endocrine diseases must be based on clinical symptoms and signs. Optimal management of the dyslipidemia requires treatment of the underlying endocrine condition. Lipid lowering therapy is a useful adjunct or a requirement in many cases. The Indian guidelines provide a pragmatic and practical approach to the management of lipid disorders in endocrine disease, as well as endocrine vigilance with lipid therapy.
- Published
- 2024
- Full Text
- View/download PDF
32. Editorial: Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants
- Author
-
Dipak Kumar Sahoo, Luna Samanta, Kavindra Kumar Kesari, and Sutapa Mukherjee
- Subjects
endocrine disorders ,oxidative stress ,redox imbalance/homeostasis ,hormone receptors ,mitochondrial dysfunction ,antioxidants ,Diseases of the endocrine glands. Clinical endocrinology ,RC648-665 - Published
- 2024
- Full Text
- View/download PDF
33. Editorial: Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants.
- Author
-
Sahoo, Dipak Kumar, Samanta, Luna, Kesari, Kavindra Kumar, and Mukherjee, Sutapa
- Subjects
OXIDATIVE stress ,SPERMATOZOA ,ANTIOXIDANTS ,ENDOMETRIOSIS ,OXIDANT status ,VITAMIN E ,STEROID receptors ,CAROTENOIDS - Abstract
This document is an editorial published in Frontiers in Endocrinology titled "Hormonal imbalance-associated oxidative stress and protective benefits of nutritional antioxidants." The editorial discusses the complex relationship between hormonal conditions, redox state, and oxidative stress (OS) in various biological processes. It highlights the potential of plant-based compounds and nutritional antioxidants in combating OS and addressing disorders associated with hormonal dysregulation. The editorial also explores the effects of antioxidants on thyroid pathologies, male fertility, and the reproductive tract following mating. The use of antioxidant supplements as adjunctive modalities in therapeutic interventions is also mentioned. [Extracted from the article]
- Published
- 2024
- Full Text
- View/download PDF
34. Role of Mediterranean diet in endocrine diseases: a joint overview by the endocrinologist and the nutritionist
- Author
-
Barrea, L., Verde, L., Annunziata, G., Camajani, E., Caprio, M., Sojat, A. S., Marina, L. V., Guarnotta, V., Colao, A., and Muscogiuri, G.
- Published
- 2024
- Full Text
- View/download PDF
35. Slipped capital femoral epiphysis in an adult patient after surgery for pituitary tumor.
- Author
-
Liu, Hanwen, Hu, Hao, Ge, Jianhua, and Tan, Meiyun
- Published
- 2024
- Full Text
- View/download PDF
36. Tiny pills, big impacts: A systematic review on the endocrine disrupting effects of paediatric pharmaceuticals.
- Author
-
Tourvieilhe L, Salvo F, Bréant V, Kassai B, and Portefaix A
- Abstract
Endocrine disrupting chemicals (EDCs) may impact children's health, with medicines as a possible exposure source. Objective: to assess the potential impact of substances in paediatric medications and essential oils on children as EDC. It is a systematic review of five databases including Medline following the PECOT approach. The review focused on publications about children exposed to medication (active ingredients or excipients of interest) and having developed clinical signs of endocrine dysfunction. Out of 946 studies identified, 28 studies were included. They revealed that parabens, lavender essential oils and anti-epileptics are the most identified pharmaceutical products. The reported outcomes relate to puberty, thyroid disorders, obesity and growth. The evidence indicates potential risks, but the overall quality of available data is limited. This systematic review exposes a lack of robust evidence linking paediatric medication exposure to EDC, predominantly relying on case reports. It cautions about potential conflicts of interest., Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
37. Endocrine Disorders in Children with Primary Mitochondrial Diseases: Single-Center Experience.
- Author
-
Papatya Çakır ED, Ersıoy M, Çakır Biçer N, and Gedikbaşı A
- Abstract
Objective: Endocrine abnormalities may represent the only clinical manifestation of primary mitochondrial disorders. This study aimed to evaluate the endocrinological characteristics of mitochondrial disease in our cohort., Methods: A total of twenty-six pediatric patients diagnosed with mitochondrial disease were categorized on the basis of their specific genetic abnormalities. The auxologic data, pubertal development, and, based on their clinical symptoms, hormonal profiles were obtained., Results: Twelve of the cohort of 26 patients (46%) were female. In 15 of the patients (57.6%), their mitochondrial disease (MD) was caused by nuclear DNA mutations (nDNA group). Four patients had Leigh syndrome, 2 patients had LHON syndrome, 2 patients had MELAS, and 1 patient had KSS clinical phenotype. The median age at diagnosis was 2.91 (0.59-16.8) years, and the median age at first endocrinologic evaluation was 4.62 (1.26-18) years. The mean height SDS was -1.34 ± 2.12, and the mean BMI SDS was -0.82 ± 1.96 for all patients. Of the 26 patients, 6 (23%) had a range of hormonal deficits. Ovarian insufficiency, central adrenal insufficiency, central hypothyroidism, diabetes mellitus, and critical illness-related adrenal insufficiency were all observed. Three of the patients were initially monitored in the endocrine clinic for hormone deficiencies but it was later determined that the hormonal abnormalities were caused by underlying mitochondrial disease., Conclusion: Individuals diagnosed with mitochondrial disease, particularly those with specific genetic abnormalities, are considered a high-risk group for developing hormonal deficits. Endocrine diseases could be one of the primary mitochondrial disorders' early warning symptoms.
- Published
- 2024
- Full Text
- View/download PDF
38. Atypical Presentation and Successful Management of Combined Hyperthyroidism and Adrenal Insufficiency in a Young Male.
- Author
-
Khalil Z, Hussein RE, and Al-Abbedien EZ
- Abstract
This case report details the unusual presentation and successful management of a 25-year-old male diagnosed with both hyperthyroidism and adrenal insufficiency. The patient initially presented with symptoms of fatigue, weight loss, and palpitations, with no significant past medical history. Further evaluation revealed elevated thyroid hormone levels and decreased cortisol levels, confirming the diagnosis of concurrent hyperthyroidism and adrenal insufficiency. The complexity of managing these coexisting endocrine disorders required a multidisciplinary approach. Techniques utilized included detailed hormonal assays, imaging studies, and dynamic endocrine testing. The therapeutic regimen involved the administration of antithyroid medications, beta-blockers for symptom control, and glucocorticoid replacement therapy. This report underscores the importance of considering multiple endocrine disorders in patients with nonspecific systemic symptoms and highlights the need for individualized treatment plans to address the unique challenges presented by such comorbidities., Competing Interests: Human subjects: Consent was obtained or waived by all participants in this study. Institutional Review Board of October 6th University issued approval 2024-0274. This study was conducted in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The study protocol was reviewed and approved by the Institutional Review Board (IRB) of October 6th University (IRB Protocol No. 2024-0274). Written informed consent was obtained from the patient for the publication of this case report and any accompanying images. All procedures performed were in compliance with relevant laws and institutional guidelines. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Khalil et al.)
- Published
- 2024
- Full Text
- View/download PDF
39. Dysphagia as a Manifestation of Endocrine and Metabolic Disorders.
- Author
-
Santa Maria C and O'Dell K
- Subjects
- Humans, Malnutrition etiology, Malnutrition complications, Deglutition physiology, Deglutition Disorders etiology, Deglutition Disorders diagnosis, Endocrine System Diseases complications, Metabolic Diseases complications
- Abstract
Dysphagia is a common manifestation of endocrine and metabolic diseases. Swallowing is a complex neuromuscular process, with an interplay of sensory and motor function, that has voluntary and involuntary control. Disruptions in any of these processes can cause significant dysphagia. Endocrine disorders and metabolic derangements are systemic conditions that affect multiple organ systems. They contribute to the development of neuropathies, myopathies, and motility disorders that lead to swallowing difficulty. Malnutrition and critical illness can lead to deconditioning and atrophy which can cause dysphagia, which in turn can lead to further malnutrition and deconditioning., Competing Interests: Disclosure The authors have no relevant disclosures., (Copyright © 2024 Elsevier Inc. All rights reserved.)
- Published
- 2024
- Full Text
- View/download PDF
40. The Role of Laser and Microwave in Treatment of Endocrine Disorders: A Systematic Review.
- Author
-
Noghabaei G, Ahmadzadeh A, Pouran F, Mahdavian A, Rezaei M, Razzaghi M, Mansouri V, and Maleki F
- Abstract
Introduction: The treatment of endocrine problems like thyroid disease, diabetes mellitus (DM), and polycystic ovary syndrome (PCOS) faces significant challenges so that medical professionals worldwide try to find a new therapeutic approach. However, along with common treatments which include medications, hormone replacement therapy, and surgery; there is a growing interest in alternative therapies like laser therapy, which offers a non-invasive and unique technique for treating endocrine disorders alone or in combination with traditional methods. The main goal of this review was to do a systematic review on the role of the laser and Microwave in the treatment endocrine disorders. Methods: In the present systematic review, the most important databases, including PubMed, Scopus and Google Scholar, were searched for the studies examining the effect of lasers on the treatment of endocrine problems by using appropriate keywords and specific strategies from 1995 to 2023. All the studies that were not about lasers and endocrine were excluded. Results: Based on 51 reviewed studies, lasers and radiofrequency ablation such as RFA are effective in the treatment of thyroid diseases, hyperparathyroidism, pancreatic disorders, and sexual dysfunctions. Laser-induced interstitial thermal therapy (LITT) and microwave ablation (MWA) are genuine minimally invasive methods for the treatment of benign nodules, adenomas, and tumor ablation including pancreatic carcinomas and adrenal tumors. Intravenous laser blood irradiation (ILBI) which uses red, UV, and blue light could be effective in treating various metabolic disorders, such as DM. Conclusion: Laser as a cutting-edge and minimally invasive approach could treat various endocrine disorders. It has a great potential to treat and regulate hormonal imbalances, decrease inflammation, and relieve symptoms of various ailments, such as endocrine disorders., Competing Interests: There are no competing interests., (Copyright © 2024 J Lasers Med Sci.)
- Published
- 2024
- Full Text
- View/download PDF
41. Editorial: Machine learning-assisted diagnosis and treatment of endocrinerelated diseases.
- Author
-
Heng Zhang, Kahlert, Ulf D., and Wenjie Shi
- Subjects
THERAPEUTICS ,DIAGNOSIS ,ARTIFICIAL intelligence ,MACHINE learning ,MACHINERY - Published
- 2024
- Full Text
- View/download PDF
42. Research on Endocrine Disorders Discussed by Researchers at General Hospital of Central Theater Command (The association between serum soluble a-Klotho and thyroid profile among adults from NHANES 2007-2012).
- Published
- 2024
43. Study Findings from Zhejiang University Advance Knowledge in Endocrine Disorders (Blood glucose control among type 2 diabetic farmers in Chinese resettlement areas: a mixed methods study).
- Published
- 2024
44. Study Findings on Endocrine Disorders Detailed by Researchers at Women's Hospital School of Medicine Zhejiang University (Association between maternal age and sex-based neonatal free triiodothyronine levels).
- Abstract
A study conducted by researchers at Women's Hospital School of Medicine Zhejiang University explores the association between maternal age and neonatal free triiodothyronine (fT3) levels. The study, which included 203 healthy women with term singleton pregnancies, found that there were no significant differences in thyroid hormone levels between male and female births. However, the study did find an inverse association between maternal age and cord blood levels of fT3 in euthyroid pregnant women, suggesting that maternal aging may impact offspring thyroid function. Further research is needed to fully understand the implications of these findings. [Extracted from the article]
- Published
- 2024
45. A Comprehensive Review of the Role of Biomarkers in the Early Detection of Endocrine Disorders in Critical Illnesses.
- Author
-
Deulkar P, Singam A, and Jain A
- Abstract
Endocrine disorders pose significant challenges in the management of critically ill patients, contributing to morbidity and mortality in intensive care settings. Timely detection of these disorders is essential to optimizing patient outcomes. Biomarkers, as measurable indicators of biological processes or disease states, play a crucial role in the early identification and monitoring of endocrine dysfunction. This comprehensive review examines the role of biomarkers in the early detection of endocrine disorders in critical illnesses. We provide an overview of common endocrine disorders encountered in the intensive care unit (ICU) and discuss the impact of endocrine dysregulation on patient outcomes. Additionally, we classify biomarkers and explore their significance in diagnosing and monitoring endocrine disorders, including thyroid dysfunction, adrenal insufficiency, and hypopituitarism. Furthermore, we discuss the clinical applications of biomarkers, including their utility in guiding therapeutic interventions, monitoring disease progression, and predicting outcomes in critical illnesses. Emerging trends and future directions in biomarker research are also highlighted, emphasizing the need for continued investigation into novel biomarkers and technological advancements. Finally, we underscore the potential of biomarkers to revolutionize the early detection and management of endocrine disorders in critical illnesses, ultimately improving patient care and outcomes in the ICU., Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work., (Copyright © 2024, Deulkar et al.)
- Published
- 2024
- Full Text
- View/download PDF
46. Exploring the Impact of Subclinical Hypothyroidism on Hyperpigmentation: A Rare Presentation in a 42-Year-Old Woman.
- Author
-
Smith B, Abramowitz C, Silkov A, and Kay M
- Abstract
Hyperpigmentation of the skin can occur due to internal and external causes. This case highlights an unusual presentation of generalized acute hyperpigmentation associated with subclinical hypothyroidism in a 42-year-old Indian American woman. After unsuccessful trials of various topical agents, the patient exhibited significant improvement in hyperpigmentation after levothyroxine treatment. Improvements included lightening in the bilateral antecubital fossa, axillae, and neck regions. This case underscores the importance of considering thyroid dysfunction as a potential factor that may contribute to atypical pigmentation disorders., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Smith et al.)
- Published
- 2024
- Full Text
- View/download PDF
47. Rare Presentation of Thyrotoxicosis Defying Methimazole Treatment: A Case Series.
- Author
-
Renzu M, Mehta V, Qazi A, Satei AM, and Taha W
- Abstract
Thyrotoxicosis, also known as hyperthyroidism, is a condition characterized by the excessive production of thyroid hormones by the thyroid gland. Besides Graves' disease, other common causes of thyrotoxicosis include toxic multinodular goiter, toxic adenoma, and subacute thyroiditis. The treatment of thyrotoxicosis depends on the underlying cause and may include medications (e.g., antithyroid drugs, beta-blockers), radioactive iodine therapy, or surgical removal of the thyroid gland (thyroidectomy). In this report, we present two instances of thyrotoxicosis where conventional high doses of antithyroid treatment failed to control the condition effectively. This failure prompted the exploration of alternative therapeutic interventions. These cases highlight the intricacies involved in managing thyrotoxic crises that do not respond to methimazole (MMI), emphasizing the necessity for innovative approaches such as plasmapheresis and thyroidectomy. Understanding such scenarios is vital for enhancing the care provided to patients encountering resistance to standard treatments. The distinct clinical pathways and treatment strategies adopted in these cases offer valuable insights into this disease management, particularly concerning resistance to MMI., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Renzu et al.)
- Published
- 2024
- Full Text
- View/download PDF
48. Genetic diagnosis of endocrine disorders in Cyprus through the Cyprus Institute of Neurology and Genetics: an ENDO-ERN Reference Center.
- Author
-
Neocleous V, Fanis P, Toumba M, Skordis N, and Phylactou LA
- Subjects
- Humans, Cyprus, Genetic Testing, Ubiquitin-Protein Ligases, Steroid 21-Hydroxylase genetics, Membrane Proteins genetics, 3-Oxo-5-alpha-Steroid 4-Dehydrogenase, Multiple Endocrine Neoplasia Type 2a diagnosis, Multiple Endocrine Neoplasia Type 2a genetics, Endocrine System Diseases diagnosis, Endocrine System Diseases genetics, Adrenal Hyperplasia, Congenital diagnosis, Adrenal Hyperplasia, Congenital genetics
- Abstract
The report covers the current and past activities of the department Molecular Genetics-Function and Therapy (MGFT) at the Cyprus Institute of Neurology and Genetics (CING), an affiliated Reference Center for the European Reference Network on Rare Endocrine Conditions (Endo-ERN).The presented data is the outcome of > 15 years long standing collaboration between MGFT and endocrine specialists from the local government hospitals and the private sector. Up-to-date > 2000 genetic tests have been performed for the diagnosis of inherited rare endocrine disorders. The major clinical entities included Congenital Adrenal Hyperplasia (CAH) due to pathogenic variants in CYP21A2 gene and Multiple Endocrine Neoplasia (MEN) type 2 due to pathogenic variants in the RET proto-oncogene. Other rare and novel pathogenic variants in ANOS1, WDR11, FGFR1, RNF216, and CHD7 genes were also found in patients with Congenital Hypogonadotropic Hypogonadism. Interestingly, a few patients with Disorders of Sexual Differentiation (DSD) shared rare pathogenic variants in the SRD5A2, HSD17B3 and HSD3B2 while patients with Glucose and Insulin Homeostasis carried theirs in GCK and HNF1A genes. Lastly, MGFT over the last few years has established an esteemed diagnostic and research program on premature puberty with emphasis on the implication of MKRN3 gene on the onset of the disease and the identification of other prognosis biomarkers.As an Endo-ERN member MGFT department belongs to this large European network and holds the same humanistic ideals which aim toward the improvements of health care for patients with rare endocrine conditions in respect to improved and faster diagnosis., (© 2024. The Author(s).)
- Published
- 2024
- Full Text
- View/download PDF
49. Thyroid Troubles: A Case of Hypothyroidism-Associated Recurrent Massive Pleural Effusion.
- Author
-
Ansari FA, Ibrahim S, Abo Baker A, Aftab M, and March C
- Abstract
Pleural effusions can be secondary to several different etiologies. Sometimes, they can be related to hypothyroidism. We present a case of massive pleural effusion resulting from hypothyroidism. A 75-year-old male with a history of liver cirrhosis, hypothyroidism, and medication non-adherence presented to the emergency department (ED) with shortness of breath and altered mental status. Physical exam and chest imaging were consistent with right-sided pleural effusion. Effusion was exudative. Multiple recurrences complicated the hospitalization despite thoracentesis and pleurodesis. Labs revealed hypothyroidism, and finally, the patient was started on hormone replacement, resulting in the resolution of the effusion. Pleural effusion is a rare manifestation of hypothyroidism, thought to be mediated by vascular endothelial factors. Pleural fluid analysis shows both exudative and transudative patterns. Hormonal replacement is the mainstay of treatment. Clinicians need to be aware of the rare etiologies of pleural effusion. Depending on the patient's presentation, due work-up should be done to ensure a timely diagnosis and management., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Ansari et al.)
- Published
- 2024
- Full Text
- View/download PDF
50. Oncological and endocrinological outcomes for children and adolescents with testicular and ovarian sex cord-stromal tumors. Results of the TGM13 National Registry.
- Author
-
Fuentes C, Ouldbey Y, Orbach D, Sudour-Bonnange H, Verité C, Rome A, Dumesnil C, Thebaud E, Hameury F, Dijoud F, Chabaud S, Cote MD, Fresneau B, and Faure-Conter C
- Subjects
- Child, Male, Humans, Female, Adolescent, Registries, Ribonuclease III, DEAD-box RNA Helicases, Gynecomastia, Ovarian Neoplasms surgery, Ovarian Neoplasms diagnosis, Sex Cord-Gonadal Stromal Tumors metabolism, Sex Cord-Gonadal Stromal Tumors pathology, Sertoli-Leydig Cell Tumor
- Abstract
Rationale: Sex cord-stromal tumors (SCST) are hormonally active and rare. The aim was to describe their endocrinological presentation and outcomes., Method: Patients (< 19 years) registered in the TGM13 registry between 2014 and 2021 for SCST were selected., Results: Sixty-three ovarian SCST (juvenile granulosa tumor (JGT) n = 34, Sertoli-Leydig cell tumor (SLCT) n = 17, other SCST n = 12) were included. Median age was 13.1 years (0.4-17.4). Germline DICER1 pathogenic variant was present in 9/17 SLCT. Sixty-one were FIGO stage I (IC n = 14). Adjuvant chemotherapy was administered for 15. Seven had recurrence (FIGO IA n = 3, IX n = 2, III n = 2), leading to one death. With a median follow-up of 42 months (2.5-92), the 3-year progression-free survival (PFS) was 89% (95% CI 76%-95%). Median age was 6.4 years (0.1-12.9) among the 15 testicular SCST (Leydig cell tumor n = 6, JGT n = 5, Sertoli cell tumor n = 3, mixed SCST n = 1). Tumor-nodes-metastases (TNM) stage was pSI in 14. Eight underwent a tumorectomy, 7 an orchiectomy. None experienced recurrence. Endocrinological data were reviewed for 41 patients (18 prepubescent). Endocrine symptoms were present at diagnosis in 29/34 females and 2/7 males (gynecomastia). After a median follow-up of 11 months, 15 patients had persistent endocrine abnormalities: gynecomastia/breast growth (2 males, 1 prepubescent female), precocious/advanced puberty (4 prepubescent females), and hirsutism/menstruation disorders/voice hoarseness/hot flashes (8 pubescent females). The mean height at the last follow-up was within normal ranges (+0.3 standard deviation)., Conclusions: SCSTs have a favorable prognosis. Tumorectomy appears safe with testicular primary. Endocrinological disorders, common at diagnosis, may persist warranting endocrinological follow-up., (© 2024 Wiley Periodicals LLC.)
- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.