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The article discusses the importance of biodiversity and conservation in large river basins, specifically focusing on the Mississippi and Yangtze River basins. It highlights the threats that these river systems face, such as over-exploitation, pollution, and climate change. The article also presents research findings from the Mississippi-Yangtze River Basin Symposium, which include topics such as non-native fish monitoring, habitat and biodiversity under human stressors, and restoration and management strategies. The authors emphasize the need for international collaborations to promote the conservation of aquatic ecosystems in large river basins. [Extracted from the article]