362 results on '"Duong J"'
Search Results
2. Validation of the clinical utility of MicroRNA as non-invasive biomarkers of cardiac allograft rejection monitoring: A prospective longitudinal multicenter study
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Coutance, G., primary, Racapé, M., additional, Baudry, G., additional, Lecuyer, L., additional, Roubille, F., additional, Blanchart, K., additional, Epailly, E., additional, Vermes, E., additional, Pattier, S., additional, Boignard, A., additional, Gay, A., additional, Jouven, X., additional, Duong, J.-P., additional, and Loupy, A., additional
- Published
- 2024
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3. Coproduction with peer support groups: A new approach to culturally responsive social services.
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Fang Q, Poon AWC, Fisher KR, Duong J, and Lee JS
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- Humans, Australia, Qualitative Research, Male, Female, Disabled Persons psychology, Cultural Competency, Trust, Adult, Cultural Diversity, Peer Group, Social Work, Self-Help Groups
- Abstract
The disparity of access to suitable social services for people from culturally diverse backgrounds is receiving increased attention. Coproduction between service users and providers has the potential as an approach to improve the cultural responsiveness of social services. What remains unknown is how social service organizations can facilitate and support coproduction with people from culturally diverse backgrounds. This article examines how three disability support organizations in Australia worked with peer support groups run by people with disability and their families from Chinese background to improve the organizations' service provision. We collected qualitative data through observations of activities in the groups and semistructured interviews with group members and organization staff. We found that organizing peer support groups facilitated knowledge exchange between people from culturally diverse backgrounds and organizations to inform practice development. Five contributors to the knowledge exchange were as follows: (1) assigning staff responsibility for exchange and trust with the group; (2) encouraging the group to challenge practice and cultural norms; (3) identifying and supporting the capacity of peer facilitators; (4) fostering trust within the group; and (5) collaborating with other organizations. Cultural responsiveness means incorporating people's cultural preferences in support provision and addressing the negative influences of cultural norms on people., (© 2024 The Authors. American Journal of Community Psychology published by Wiley Periodicals LLC on behalf of Society for Community Research and Action.)
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- 2024
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4. Pre-operative Embolization of a Cerebellar Hemangioblastoma Using Polyvinyl Alcohol (PVA) and Target Tetra 360 Detachable Coil.
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Wang AS, Murnin JC, Wiginton Iv J, Tchalukov K, Stout CE, Duong J, and Sweiss R
- Abstract
Due to its hypervascularity, hemangioblastoma, a rare primary central nervous system intracranial tumor, has been treated with pre-operative embolization prior to surgical resection. Here, we describe a case treated as such. A 37-year-old male presented with worsening chronic headache and right ear tinnitus was found to have a hypervascular, heterogeneous right cerebellar lesion suspicious for arteriovenous malformation or hemangioblastoma. He underwent polyvinyl alcohol (PVA) and Target Tetra 360 (Fremont, CA: Stryker Neurovascular) detachable coil embolization followed by complete tumor resection. Pathology was consistent with hemangioblastoma. He presented with complete resolution of his symptoms immediately post-operatively and at a two-week follow-up. Our case highlighted the importance of pre-operative embolization to help achieve complete tumor resection which is considered curative in the treatment of hypervascular hemangioblastoma. The Target Tetra 360 detachable coil embolization is another material that can be considered., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Wang et al.)
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- 2024
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5. An Algorithm for Treatment of Symptomatic Chronic Subdural Hematomas.
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Wang AS, Rahman R, Ueno A, Farr S, Duong J, and Miulli DE
- Abstract
Introduction: Although chronic subdural hematoma (CSDH) is a common neurosurgical disease, there is a lack of algorithms for the treatment of asymptomatic and symptomatic CSDH. The purpose of this article is to describe an algorithm developed using our institutional experience for the treatment of symptomatic CSDH that aims to decrease symptoms and/or hematoma size or to completely resolve both. Our algorithm for treatment of symptomatic CSDH includes subdural drain (SDD) placement via twist-drill craniostomy (TDC) as the first-line treatment, followed by supplemental tissue plasminogen activator (tPA) as second-line treatment, with possible middle meningeal artery embolization (MMAE), followed by craniotomy as the last therapeutic option. This study investigated the efficacy of our institution's algorithm in treating symptomatic CSDH., Methods: A retrospective study was conducted from 2019 to 2023 identifying patients with CSDH treated with TDC. Electronic medical records were used to gather patient demographics, clinical presentation, radiographic findings, treatment modalities, and clinical outcomes., Results: There were a total of 109 patients with 128 SDD placements. All 109 patients underwent TDC; among them, 37 patients received tPA instillation with three patients requiring craniotomy. Factors including age, gender, race, mechanism of injury, blood thinner usage, Glasgow Coma Scale (GCS), neurologic exam, thickness of CSDH, and midline shift were comparable for all patients regardless of treatment received. The mean number of neomembranes was higher in patients who eventually required craniotomy (4.5) compared to those treated with TDC only (1.8) and TDC+tPA (2.1) (p=0.0035). There was a greater mean hematoma drainage in patients who received tPA instillation without craniotomy (586.7 mL) than those treated with TDC only (293.0 mL) (p<0.0001). Clinical improvement was found in 52/72 patients (72.2%) treated with TDC only, 23/34 patients (67.6%) treated with TDC+tPA only, and 0/3 patients (0.0%) treated with TDC+tPA+craniotomy. Radiographic improvement in mean thickness of CSDH and midline shift, respectively, was found in patients treated with TDC only (p<0.0001; p<0.0001) and TDC+tPA (p<0.0001; p<0.0001) but not in TDC+tPA+craniotomy (p=0.1494; p=0.0762). There were also fewer neomembranes after TDC+tPA treatment only (2.1 vs. 0.5, p<0.0001). Seven patients were readmitted that did not follow the algorithm and only patients treated following the algorithm showed clinical and radiographic improvement., Conclusions: Using our institutional algorithm, our study demonstrates successful clinical outcomes in treating symptomatic CSDH and recurrent CSDH with minimally invasive therapeutic interventions including SDD via TDC and tPA, thereby minimizing the utilization of more invasive interventions including craniotomy., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Wang et al.)
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- 2024
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6. Making sense of the cancer journey: Pediatric cancer survivors' and their parents' autobiographical memories.
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Cho S, Wurz A, Henry B, Tran A, Duong J, Noel M, Neville A, Patton M, Russell KB, Giles J, Reynolds K, and Schulte F
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- Adolescent, Humans, Child, Middle Aged, Survivors, Parents, Caregivers, Cancer Survivors, Memory, Episodic, Neoplasms therapy
- Abstract
Purpose: Youth diagnosed with acute lymphoblastic leukemia (ALL) and their caregiver's experience a myriad of challenges in all domains of health that extend beyond treatment. Yet, little is known about how the cancer experience, and recollections associated with the experience, impact survivorship. We explored pediatric ALL survivors' and their caregivers' autobiographical memories of the cancer experience from diagnosis onwards., Methods: Survivors of ALL, and one of their caregivers, were recruited through a local clinic. Survivors and their caregivers completed a demographic survey and semi-structured, private, one-on-one interviews. Demographic information were analyzed using descriptive statistics. Interviews were transcribed verbatim and analyzed using reflexive thematic analysis at the level of the individual and dyad., Results: Insights from survivors (N = 19; M
age = 15.3 years) and their caregivers (n = 19; Mage = 45.4 years) were captured. Analyses generated two themes contingent on role (i.e., survivor or caregiver): (1) It is hard to recall my cancer experience and (2) We did as much as we could to manage our child's cancer experience and two unified themes (present in both survivors and their caregivers): (3) It took a village to get through the cancer experience and (4) The cancer diagnosis and experience has had a lasting impact., Conclusions: Findings highlight the varied and long-lasting ways cancer impacts survivors of pediatric ALL and their caregivers. Survivors had difficultly remembering their experience or felt that information was withheld and were acutely aware of their caregiver's distress. Caregivers were cautious and intentionally limited the information they shared., Implications for Cancer Survivors: Survivors desired to be included within, or told about, decisions related to their healthcare and were acutely aware of their caregiver's distress. Efforts should be made to communicate with survivors (from diagnosis onward) openly and to consider strategies to minimize the short- and long-term impacts of pediatric ALL among survivors and their caregivers., (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)- Published
- 2024
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7. 51 Prevalence of Clostridioides difficile in people with cystic fibrosis participating in the PROMISE Study before and after initiating elexacaftor/tezacaftor/ivacaftor.
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Gill, E., Duong, J., Pope, C., Hayden, H., Verster, A., Hoffman, L., Schwarzenberg, S., Heltshe, S., Solomon, G., Freedman, S., and Goss, C.
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- *
CLOSTRIDIOIDES difficile , *CYSTIC fibrosis - Published
- 2024
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8. Evaluating an Integrated Clinical Pharmacy Service in Ambulatory Clinics at Australia’s First Dedicated Cardiac Hospital
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Duong, J., Doody, H., Nguyen, G., Tran, M., and Khalil, V.
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- 2024
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9. Assessing the Frequency of Continuation of Beta Blocker Therapy Among Patients Admitted With Acute Decompensated Heart Failure—A Pilot Audit in a Multi-Centre Australian Hospital
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Khalil, V., Chew, D., Soldatos, G., Rivers, G., Duong, J., and Lu, P.
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- 2024
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10. LB994 Dermatology personal statement themes and match outcomes
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Bardhi, R., Bugosh, L., Al-Hadidi, M., Duong, J., Colbert, S., Jones, B., and Daveluy, S.
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- 2024
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11. Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science (DHREAMS)
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Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and National Institutes of Health (NIH)
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- 2024
12. Synthesis and Characterization of MOF-Derived Structures: Recent Advances and Future Perspectives.
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Payam AF, Khalil S, and Chakrabarti S
- Abstract
Due to their facile tunability, metal-organic frameworks (MOFs) are employed as precursors and templates to construct advanced functional materials with unique and desired chemical, physical, mechanical, and morphological properties. By tuning MOF precursor composition and manipulating conversion processes, various MOF-derived materials commonly known as MOF derivatives can be constructed. The possibility of controlled and predictable properties makes MOF derivatives a preferred choice for numerous advanced technological applications. The innovative synthetic designs besides the plethora of interdisciplinary characterization approaches applicable to MOF derivatives provide the opportunity to perform a myriad of experiments to explore the performance and offer key insight to develop the next generation of advanced materials. Though there are many published works of literature describing various synthesis and characterization techniques of MOF derivatives, it is still not clear how the synthesis mechanism works and what are the best techniques to characterize these materials to probe their properties accurately. In this review, the recent development in synthesis techniques and mechanisms for a variety of MOF derivates such as MOF-derived metal oxides, porous carbon, composites/hybrids, and sulfides is summarized. Furthermore, the details of characterization techniques and fundamental working principles are summarized to probe the structural, mechanical, physiochemical, electrochemical, and electronic properties of MOF and MOF derivatives. The future trends and some remaining challenges in the synthesis and characterization of MOF derivatives are also discussed., (© 2024 The Authors. Small published by Wiley‐VCH GmbH.)
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- 2024
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13. Composition and Conformation of Hetero- versus Homo-Fluorinated Triazolamers Influence their Activity on Islet Amyloid Polypeptide Aggregation.
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Laxio Arenas J, Lesma J, Ha-Duong T, Ranjan Sahoo B, Ramamoorthy A, Tonali N, Soulier JL, Halgand F, Giraud F, Crousse B, Kaffy J, and Ongeri S
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- Humans, Molecular Dynamics Simulation, Halogenation, Protein Aggregates, Islet Amyloid Polypeptide chemistry, Islet Amyloid Polypeptide metabolism, Triazoles chemistry
- Abstract
Novel fluorinated foldamers based on aminomethyl-1,4-triazolyl-difluoroacetic acid (1,4-Tz-CF
2 ) units were synthesized and their conformational behaviour was studied by NMR and molecular dynamics. Their activity on the aggregation of the human islet amyloid polypeptide (hIAPP) amyloid protein was evaluated by fluorescence spectroscopy and mass spectrometry. The fluorine labelling of these foldamers allowed the analysis of their interaction with the target protein. We demonstrated that the preferred extended conformation of homotriazolamers of 1,4-Tz-CF2 unit increases the aggregation of hIAPP, while the hairpin-like conformation of more flexible heterotriazolamers containing two 1,4-Tz-CF2 units mixed with natural amino acids from the hIAPP sequence reduces it, and more efficiently than the parent natural peptide. The longer heterotriazolamers having three 1,4-Tz-CF2 units adopting more folded hairpin-like and ladder-like structures similar to short multi-stranded β-sheets have no effect. This work demonstrates that a good balance between the structuring and flexibility of these foldamers is necessary to allow efficient interaction with the target protein., (© 2024 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.)- Published
- 2024
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14. Spacer rotation technique allows precise evaluation of gap balance in total knee arthroplasty.
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Matziolis G, Layher F, Vogt S, Bergner L, Wassilew G, and Kirschberg J
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- Humans, Rotation, Knee Prosthesis, Range of Motion, Articular, Knee Joint surgery, Knee Joint physiology, Knee Joint physiopathology, Biomechanical Phenomena, Observer Variation, Arthroplasty, Replacement, Knee methods, Cadaver
- Abstract
The symmetry of the flexion and extension gap influences the functional and long-term outcome after total knee arthroplasty (TKA). Most surgeons check it by applying varus and valgus stress using spacers. This technique has limited accuracy and could be easily extended by rotational movement of the spacer. The objective was to determine the detection threshold and interobserver reliability of this technique. In an in vitro setting with a human cadaveric knee, gap asymmetries were simulated by different medially and laterally applied forces. Using an optical measurement system, the pivot point of the spacer was calculated as a function of the gap symmetry in the first part of the experiment. In the second part, the detection threshold and interobserver reliability of 4 surgeons were determined. For this purpose, gap asymmetries were adjusted to between 0 and 120N in a blinded trial. With a symmetrical gap, the centre of rotation of the spacer was located in the centre of the tibia. With increasing gap asymmetry, the centre of rotation of the spacer shifted to the tight side. This shift was approximately linearly dependent on the force difference. A perfectly balanced gap was detected by the examiners in 50% of the cases. From a force difference of 40N, all examiners identified the gap asymmetry in all cases (ICC = 1.0). The method of spacer rotation described is suitable for reliably detecting gap differences at ≥ 40N, independently of the examiner., (© 2024. The Author(s).)
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- 2024
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15. Impact of a Genetic Diagnosis for a Child's Autism on Parental Perceptions.
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Wynn J, Karlsen A, Huber B, Levine A, Salem A, White LC, Luby M, Bezborodko E, Xiao S, Chung WK, Klitzman RL, and Appelbaum PS
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Genetic testing is recommended as part of an autism assessment, and most parents support genetic testing for their minor children. However, the impact on parents of receiving a monogenetic/ copy number variant diagnosis for autism in their child is not well understood. To explore this, we surveyed and interviewed parents of children in the SPARK study, a study of autism that includes genetic testing. Surveys were administered one month before and one and 12 months after parents received their child's genetic result. Interviews were conducted approximately one month after results disclosure. A genetic diagnosis (GD) for their child appeared to reduce parents' sense of self-blame and feelings of guilt, and this impact was relatively stable. The data also indicate a modest impact on parents' actions related to the condition, perceptions of themselves, and some aspects of life planning for their child, as measured by quantitative instruments at one month and 12 months after receipt of results. Other measures of parental identity and expectations for their child, in contrast, showed little change following receipt of genetic findings. Overall, parents who were told that no GD was identified showed minimal changes in their responses over time. These results suggest a discernable but relatively limited impact of genetic test results on parents of children with autism. These results should be reassuring to clinicians caring for children with autism and are consistent with studies in other areas of medicine that have suggested that genetic results tend to have fewer effects-negative or positive-than were anticipated., (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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- 2024
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16. Minimizing Interfacial Recombination in 1.8 eV Triple-Halide Perovskites for 27.5% Efficient All-Perovskite Tandems.
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Yang F, Tockhorn P, Musiienko A, Lang F, Menzel D, Macqueen R, Köhnen E, Xu K, Mariotti S, Mantione D, Merten L, Hinderhofer A, Li B, Wargulski DR, Harvey SP, Zhang J, Scheler F, Berwig S, Roß M, Thiesbrummel J, Al-Ashouri A, Brinkmann KO, Riedl T, Schreiber F, Abou-Ras D, Snaith H, Neher D, Korte L, Stolterfoht M, and Albrecht S
- Abstract
All-perovskite tandem solar cells show great potential to enable the highest performance at reasonable costs for a viable market entry in the near future. In particular, wide-bandgap (WBG) perovskites with higher open-circuit voltage (V
OC ) are essential to further improve the tandem solar cells' performance. Here, a new 1.8 eV bandgap triple-halide perovskite composition in conjunction with a piperazinium iodide (PI) surface treatment is developed. With structural analysis, it is found that the PI modifies the surface through a reduction of excess lead iodide in the perovskite and additionally penetrates the bulk. Constant light-induced magneto-transport measurements are applied to separately resolve charge carrier properties of electrons and holes. These measurements reveal a reduced deep trap state density, and improved steady-state carrier lifetime (factor 2.6) and diffusion lengths (factor 1.6). As a result, WBG PSCs achieve 1.36 V VOC , reaching 90% of the radiative limit. Combined with a 1.26 eV narrow bandgap (NBG) perovskite with a rubidium iodide additive, this enables a tandem cell with a certified scan efficiency of 27.5%., (© 2023 The Authors. Advanced Materials published by Wiley-VCH GmbH.)- Published
- 2024
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17. Oral N-acetylcysteine for Retinitis Pigmentosa (NAC Attack)
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National Eye Institute (NEI), Duke University, Emory University, Massachusetts Eye and Ear Infirmary, Mayo Clinic, Medical College of Wisconsin, Retina Foundation of the Southwest, Stanford University, University of California, Davis, University of Florida, University of Iowa, University of Miami, University of Michigan, University of Minnesota, University of Oklahoma, University of Southern California, University of Utah, University of Washington, University of Wisconsin, Madison, Vanderbilt University, Vitreo Retinal Associates, PA, University of Houston, Medical University of Graz, McGill University, Universität Tübingen, Centro Medico ABC, Radboud University Medical Center, University of Amsterdam, University Hospital, Basel, Switzerland, University College London Hospitals, Northwestern University, and University of Pennsylvania
- Published
- 2024
18. Impact of a poly(ethylene glycol) corona block on drug encapsulation during polymerization induced self-assembly.
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Li, Guanrui, Duclos, Cassie, and Ricarte, Ralm G.
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- 2024
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19. Enhanced charge transport of wide-bandgap perovskite solar cells enabled by crown ether-mediated crystal modulation.
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Zhong, Han, Liu, Xuanling, Wang, Xuanyu, Yang, Jianfei, Zhang, Ziling, Li, Jinxian, Liu, Jianbo, Shen, Heping, and Lin, Hong
- Abstract
Further improving the performance of wide-bandgap perovskite solar cells has attracted significant attention due to its crucial role in further lifting the power conversion efficiency (PCE) of perovskite-based tandem solar cells. The majority of the efforts have focused on reducing the loss of open-circuit voltage (V
oc ), while little attention has been paid to improving the fill factor (FF). Herein, we employ a crown ether to manipulate the crystallization process of wide-bandgap perovskites. The strong affinity of crown ether with the metal cations suppresses the fast precipitation of cesium salts and delays the crystallization process during the deposition of the perovskite, leading to large grains and elimination of lateral grain boundaries. Moreover, the perovskite film treated with the crown ether exhibits a pronounced orientation of (110), leading to high conductivity and mobility. The improved charge transport properties within the perovskite significantly increase the FF of the as-prepared perovskite solar cell by an absolute value of 3%. In combination with the passivation of uncoordinated Pb2+ defects, the champion wide-bandgap (1.68 eV) solar cell with an n–i–p architecture shows a high FF of 83%, a Voc of 1.21 V, and a PCE of 20.6%. Meanwhile, the long-term stability of the devices is enhanced, with the unencapsulated devices retaining 99.6% of their initial PCE after 1080 hours of storage in air. This work presents a new strategy to further improve the performance of wide-bandgap perovskites and perovskite-based tandem devices. [ABSTRACT FROM AUTHOR]- Published
- 2024
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20. Surface defect induced polarization manipulation in Cu2SnS3 for boosting electrochemical CO2 reduction.
- Author
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Haihua Wang, Ning Wen, Yupeng Li, Xiuling Jiao, Yuguo Xia, and Dairong Chen
- Abstract
Controlling the electrocatalyst's surface polarization is crucial for the interfacial CO
2 electrolysis that takes place. Here, we propose an efficient way to increase the electrochemical reduction of CO2 to formate by controlling the Cu2 SnS3 surface polarization. This results in a formate partial current density of 408.3 mA cm−2 at an applied bias of −1.2 V vs. RHE and a faradaic efficiency of 91.7%. More specifically, the concentration of sulfur vacancies is controlled to alter the surface polarization of Cu2 SnS3 . Theoretical computations and experimental characterization studies emphasize the importance of sulfur vacancies in controlling Cu2 SnS3 's surface polarization. Additionally, the altered CO2 evolution pathway is explained by the local charge redistribution caused by sulfur vacancies, and the lower Gibbs free energy for the formation of intermediate *OCHO, which guarantees its high selectivity toward formate, is explained by the coordination structural changes of the Cu and Sn atoms involved in deficient Cu2 SnS3 . This study presents a practical approach to surface polarization regulation-based CO2 -to-formate electrocatalyst design. [ABSTRACT FROM AUTHOR]- Published
- 2024
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21. Clinical characteristics, treatment, and outcomes for elderly patients in a dedicated Covid-19 ward at a primary health care facility in western Norway: a retrospective observational study.
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Kittang, Bård Reiakvam, Øien, Ane Tveiten, Engtrø, Einar, Skjellanger, Marian, and Krüger, Kjell
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HOME care services ,HEALTH facilities ,NURSING home patients ,COVID-19 ,ADVANCE directives (Medical care) - Abstract
Background: The coronavirus pandemic has hit the oldest and frailest individuals hard, particularly patients and residents in nursing homes. In March 2020, we established a Covid-19 ward at a nursing home in Bergen, western Norway for elderly patients with Sars-CoV-2 infection and in the need of treatment and care in a primary health care facility. The aims of this study were to describe the organization of the ward, the clinical outcomes of infection, treatment, mortality rates in the population, the level of advanced care planning, and end-of-life care for those who died. Methods: We present patient characteristics, outcomes, vaccination status, treatment, decisions regarding treatment intensity upon clinical deterioration, and mortality for the patients in the ward. Clinical factors possibly related to a fatal outcome were analysed with chi square test (categorical variables) or t-test (continuous variables). Results: 257 patients were included from March 2020 to April 2022. Fifty-nine patients (23.0%) developed respiratory failure. Ten patients (3.9%) were admitted to hospital. Advance care planning was undertaken for 245 (95.3%) of the patients. 30-day mortality rate decreased from 42 to 4% during the study period. Of the 29 (11.3%) patients who died, all were well alleviated in the terminal phase, and 26 (89.7%) of them had a Clinical Frailty Scale (CFS) value ≥ 7. A high score for CFS, respiratory failure and respiratory co-infection were significantly associated with Covid-19 related death within 30 days. Conclusions: Covid-19-related mortality markedly decreased during the study period, and a high score for CFS was related to a fatal outcome. Thorough planning of treatment intensity upon deterioration, low hospitalization rates, and good relief for those who died suggest that dedicated Covid-19 wards in nursing homes can provide good treatment for the patients and relieve other nursing homes and specialist health care services. [ABSTRACT FROM AUTHOR]
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- 2024
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22. Understanding mediated sports consumption by Irish children: a qualitative study exploring their exposure and understanding of gambling marketing, risks and harms.
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Kitchin, Paul James, McEvoy, Erin, Kerr, Aphra, and O'Brennan, John
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Background: Gambling marketing communications create a public health risk by increasing the normalisation of gambling in sports. In a context where broad level studies report significant underage gambling, currently no evidence exists on how these communications are received by children in the Republic of Ireland (hereafter Ireland) and Northern Ireland. To build this evidence base and provide granular detail below broad level data, this study explored the sport consumption habits and views of Irish children (aged 14–17 years) on their exposure, awareness and perceptions of the relationship between sport and gambling. Methods: Drawing on a constructivist approach to data collection, 6 face-to-face focus groups were staged with a total of 51 youth sport consumers from both sides of the border region on the island of Ireland. Results: Four main themes were established. First, mediated sport consumption was predominantly via mobile social media. Second, we found that their exposure to gambling marketing was high and while frequently seen through social media channels it was also prevalent in peer-to-peer conversations and on the main street. Third, we found mixed responses on their perceptions about gambling and sport. While many felt that sport and gambling were a good fit, they were aware of the financial risks involved. Few children understood the wider social risks with gambling harm. Fourth, children were sceptical of claims made in gambling communications. These findings highlight concerns about how exposure to gambling marketing is impacting children’s views on sport and on gambling. These views need to be taken into consideration when broadcasters and sport organizations are entering into commercial associations. Conclusions: Gambling marketing is noticed by children watching mass and social media, and in the towns in the border regions of the island of Ireland. Our study provides children’s viewpoints on this topic which complements the larger quantitative studies in Ireland and Northern Ireland that highlight the growing prevalence of children and gambling. This study not only extends the literature on the exposure, awareness and perceptions of children on the island of Ireland but provides crucial evidence to public health advocates in this region demonstrating the pervasiveness of gambling communications in and around children’s spaces. [ABSTRACT FROM AUTHOR]
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- 2024
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23. Polyamine Derived Photosensitizer: A Novel Approach for Photodynamic Therapy of Cancer.
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Deng, Hao, Xie, Ke, Hu, Liling, Liu, Xiaowen, Li, Qingyun, Xie, Donghui, Xiang, Fengyi, Liu, Wei, Zheng, Weihong, Xiao, Shuzhang, Zheng, Jun, and Tan, Xiao
- Subjects
PHOTODYNAMIC therapy ,CANCER cell proliferation ,PANCREATIC cancer ,CANCER treatment ,PHOTOSENSITIZERS - Abstract
Polyamines play a pivotal role in cancer cell proliferation. The excessive polyamine requirement of these malignancies is satisfied through heightened biosynthesis and augmented extracellular uptake via the polyamine transport system (PTS) present on the cell membrane. Meanwhile, photodynamic therapy (PDT) emerges as an effective anti-cancer treatment devoid of drug resistance. Recognizing these intricacies, our study devised a novel polyamine-derived photosensitizer (PS) for targeted photodynamic treatment, focusing predominantly on pancreatic cancer cells. We synthesized and evaluated novel spermine-derived fluorescent probes (N2) and PS (N3), exhibiting selectivity towards pancreatic cancer cells via PTS. N3 showed minimal dark toxicity but significant phototoxicity upon irradiation, effectively causing cell death in vitro. A significant reduction in tumor volume was observed post-treatment with no pronounced dark toxicity using the pancreatic cancer CDX mouse model, affirming the therapeutic potential of N3. Overall, our findings introduce a promising new strategy for cancer treatment, highlighting the potential of polyamine-derived PSs in PDT. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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24. Vertical maximal functions on manifolds with ends.
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Sharma, Himani and Sikora, Adam
- Abstract
We consider the setting of manifolds with ends which are obtained by compact perturbation (gluing) of ends of the form R n i × M i . We investigate the family of vertical resolvent { t ∇ (1 + t Δ) - m } t > 0 , where m ≥ 1 . We show that the family is uniformly continuous on all L p for 1 ≤ p ≤ min i n i . Interestingly, this is a closed-end condition in the considered setting. We prove that the corresponding maximal function is bounded in the same range except that it is only weak-type (1, 1) for p = 1 . The Fefferman-Stein vector-valued maximal function is again of weak-type (1, 1) but bounded if and only if 1 < p < min i n i , and not at p = min i n i . [ABSTRACT FROM AUTHOR]
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- 2024
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25. Over 29%-efficient, stable n–i–p monolithic perovskite/silicon tandem solar cells based on double-sided poly-Si/SiO2 passivating contact silicon cells.
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Duan, Leiping, Phang, Sieu Pheng, Yan, Di, Stuckelberger, Josua, Walter, Daniel, Hou, Yihui, Wang, Wei, Chang, Nathan, Bui, Anh Dinh, Mayon, Azul Osorio, Chang, Lichun, Kang, Di, Duong, The, Basnet, Rabin, Nguyen, Hieu, White, Thomas, Bullock, James, Weber, Klaus, MacDonald, Daniel, and Catchpole, Kylie
- Abstract
Perovskite/silicon (Si) tandem solar cells (TSCs) continue to rapidly advance. The majority of the monolithic perovskite/Si TSCs have been built on heterojunction (HJT) Si solar cells, which have seen limited industrial uptake due to manufacturing cost and concern over the viability of metal electrodes and transparent conductive oxides (TCOs) incorporating expensive elements. In this work, we demonstrate that high efficiencies of perovskite/Si TSCs can be achieved with Si bottom cells based on a double-side poly-Si/Si dioxide (SiO
2 ) passivating contact (poly-Si cell) without silver or TCOs, fabricated using mass-production techniques. Meanwhile, a novel low-absorption, dopant-free bilayer-structured hole transport layer (HTL) composed of ultra-thin poly(N,N′-bis-4-butylphenyl-N,N′-bisphenyl)benzidine (Poly-TPD) and 2,2′,7,7′-tetra(N,N-di-p-tolyl)amino-9,9-spirobifluorene (Spiro-TTB) double layers was developed for the perovskite top cell, which passivates the perovskite surface and enhances the near-interface conductivity, thus increasing the open-circuit voltage and fill factor. A power conversion efficiency of more than 29% was achieved, the highest for a perovskite/Si TSC based on poly-Si bottom cells and/or n–i–p perovskite top cells reported to date. Moreover, the tandem cells exhibit exceptional thermal and light stability, retaining their original output without loss after undergoing 1750 hours of light–dark cycles. Under continuous one-sun illumination and a bias near the maximum power point at 55 ± 5 °C, the tandem devices maintained 93% and 89% of their initial PCE after 500 hours and 1782 hours, respectively. These results pave the way for large-scale manufacturing of industrially viable perovskite/Si TSCs in the near future. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
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26. Recent advances in upgrading CO2 to C3+ products via electrochemical and complementary engineering.
- Author
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Zhong, Xian, Peng, Hong-Jie, Xia, Chuan, and Liu, Xinyan
- Abstract
Upgrading CO
2 to various carbon-containing products through renewable electrochemical routes offers a promising solution to achieve a "Net Zero" and circular economy. Multicarbon C3+ products are especially energy-rich and economically valuable. However, due to the diverse possibilities of C–C coupling and the complexities of reaction pathways, the efficient and selective electrochemical reduction of CO2 to C3+ products remains a tremendous challenge. Summarizing the latest advances in generating C3+ products from CO2 , this review focuses on both key material development and process design in electrochemical and complementary engineering approaches. For the methodologies involving only electrochemical reactions, we categorize them based on the catalysts adopted, summarizing the specific design strategies and mechanistic understandings of copper and non-copper catalysts, respectively. To further improve the efficiency of C3+ synthesis, the concept of "electrochemical + X" is introduced. "X" herein refers to a complementary sector to direct CO2 electrolysis, encompassing the homogeneous non-electrocatalytic reactions in a one-pot electrochemical process and the sequential thermochemical or biological processes after electrochemical CO2 conversion. Lastly, we discuss the challenges of pure electrochemical as well as "electrochemical + X" approaches and outline promising future directions. We believe that this review contains a comprehensive summary of the means to optimize for C3+ compounds, and can motivate researchers to develop innovative strategies to further enhance C3+ production efficiency, paving the way towards the ultimate renewable-driven chemical industries. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
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27. Increased resting lactate levels and reduced carbohydrate intake cause νLa.max underestimation by reducing net lactate accumulation—A pilot study in young adults.
- Author
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Pohl, Alexander, Schünemann, Frederik, Schaaf, Kirill, Yang, Woo‐Hwi, Heck, Hermann, Heine, Oliver, Jacko, Daniel, and Gehlert, Sebastian
- Subjects
YOUNG adults ,CARBOHYDRATES ,LACTATES ,LACTATION ,PILOT projects - Abstract
Modulation of testing conditions such as resting lactate (Larest) levels or carbohydrate intake may affect the calculation of the maximal glycolytic rate (νLa.max). To evaluate the impact of elevated Larest as well as reduced and increased carbohydrate availability on νLa.max in running sprints (RST), twenty‐one participants completed five 15‐s RST tests on a running track under five different conditions: (I). baseline: Larest ≤1.5 mmol·L−1; (II). Lactate+: Larest ≥2.5 mmol·L−1; (III). CHO−: carbohydrate intake: ≤ 1 g·kg−1 BW d−1 for 3 days; (IV). CHO+: carbohydrate intake: ≥ 9 g·kg−1 BW d−1 for one day; and (V). acuteCHO: 500 mL glucose containing beverage consumed before RST. νLa.max was significantly reduced in lactate+ and CHO− conditions compared to the baseline RST, due to a reduction in the arithmetic mean delta (∆) between Lapeak and Larest lactate concentration (Lapeak, mmol · L−1). AcuteCHO led to an increase in Larest compared to baseline, CHO− and CHO+ with a high interindividual variability but did not significantly reduce νLa.max. Therefore, avoiding low carbohydrate nutrition before νLa.max testing, along with carefully adjusting Larest to below ≤1.5 mmol·L‐1, is crucial to prevent the unintentional underestimation of νLa.max. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
28. A new gap balancing technique with functional alignment in total knee arthroplasty using the MAKO robotic arm system: a preliminary study.
- Author
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Tsai, Hung-Kang, Bao, Zhengyuan, Wu, Dengxian, Han, Jing, Jiang, Qing, and Xu, Zhihong
- Subjects
TOTAL knee replacement ,PATIENT satisfaction ,LIKERT scale ,RANGE of motion of joints ,TREATMENT effectiveness - Abstract
Background: Gap tension is an important factor influencing the clinical outcomes of total knee arthroplasty (TKA). Traditional mechanical alignment (MA) places importance on neutral alignment and often requires additional soft tissue releases, which may be related to patient dissatisfaction. Conversely, the functional alignment requires less soft tissue release to achieve gap balance. Conventional gap tension instruments present several shortcomings in practice. The aim of this study is to introduce a new gap balancing technique with FA using the modified spacer-based gap tool and the MAKO robotic arm system. Methods: A total of 22 consecutive patients underwent primary TKA using the MAKO robotic arm system. The gap tension was assessed and adjusted with the modified spacer-based gap tool during the operation. Patient satisfaction was evaluated post-operatively with a 5-point Likert scale. Clinical outcomes including lower limb alignment, Knee Society Score (KSS) and Western Ontario and McMaster Universities Arthritis Index (WOMAC) were recorded before surgery, 3 months and 1 year after surgery. Results: The range of motion (ROM) was significantly increased (p < 0.001) and no patients presented flexion contracture after the surgery. KSS and WOMAC score were significantly improved at 3 months and 1 year follow-up (p < 0.001 for all). During the surgery, the adjusted tibial cut showed more varus than planned and the adjusted femoral cut presented more external rotation than planned (p < 0.05 for both). The final hip-knee-ankle angle (HKA) was also more varus than planned (p < 0.05). Conclusions: This kind of spacer-based gap balancing technique accompanied with the MAKO robotic arm system could promise controlled lower limb alignment and improved functional outcomes after TKA. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
29. Complex isomerism influencing the textural properties of organometallic [Cu(salen)] porous polymers: paramagnetic solid-state NMR characterization and heterogeneous catalysis.
- Author
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Šorm, David, Blahut, Jan, Bashta, Bogdana, Císařová, Ivana, Vrbková, Eva, Vyskočilová, Eliška, and Sedláček, Jan
- Subjects
POROUS polymers ,HETEROGENEOUS catalysis ,POLYMER networks ,ISOMERISM ,ORGANOMETALLIC polymers ,COPPER ,HETEROGENEOUS catalysts ,COORDINATION polymers - Abstract
Although organometallic porous polymer networks are recognized as promising heterogeneous catalysts, the relationship between ligand/monomer geometry and network parameters is usually not well understood due to the lack of atom-resolved characterization methods for the amorphous network matrix. In this work, a series of copper(II) salen-type metal complexes was synthesized, using trans- and cis-1,2-diaminocyclohexane segments, and thoroughly characterized by single-crystal X-ray diffraction and solution- and solid-state NMR spectroscopy. Terminal ethynyl groups of the complexes were then transformed into polyacetylene chains by coordination chain-growth homopolymerization, resulting in highly porous (458–655 m
2 g−1 ) organometallic polymer networks with a copper(II) ion content of about 12 wt%. The presence of paramagnetic copper(II) moieties in these complexes and respective polymer networks required the application of tailored NMR techniques, which together with X-ray crystallography and DFT calculations of the paramagnetic NMR shifts made it possible to investigate the differences in the complex geometry in liquid, powder and crystalline form and compare it with the complex geometry in polymer networks. All prepared organometallic polymer networks were also tested as heterogeneous catalysts for styrene oxidation with uncommonly high substrate conversions and compared with their low-molecular-weight analogues. The high reusability of such heterogeneous polymer-based catalysts was also proven. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
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30. High responsivity and stability of MSM structured MoS2 photodetectors by remote hydrogen plasma treatment and alternating growth of Al2O3/HfO2 passivation layers.
- Author
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Li, Yulin, Tian, Yajun, Bao, Lingjie, Cheng, Haoran, and Cheng, Qijin
- Abstract
Molybdenum disulfide (MoS
2 ) is a representative material of transition metal dichalcogenides with a wide range of potential practical applications. However, the low responsivity and relatively short lifespan of MoS2 photodetectors restrict their further development. To enhance the performance of MoS2 photodetectors, we propose a strategy involving defect introduction and surface passivation. Sulphur vacancy defects are introduced in MoS2 through remote hydrogen plasma treatment and surface passivation of MoS2 is achieved by alternating growth of Al2 O3 /HfO2 passivation layers. The obtained MoS2 photodetector features a high responsivity of 567 A W−1 , a specific detectivity of 1.12 × 1010 jones, and a response time of 10.51/15.78 s at a bias of −5 V. Moreover, the obtained MoS2 photodetector maintains excellent stability. It is demonstrated that, after 2 months of placement in an atmospheric environment, the responsivity and the specific detectivity are maintained at approximately 95% of the fresh device, while the response time slightly increases. Finally, the underlying physical mechanism based on the energy band diagram has been proposed to interpret the obtained experimental results. The simple and efficient method proposed in this study for improving the performance of the MoS2 photodetector can open up new avenues for research in MoS2 -based photoelectric devices. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
31. Robotic arthroplasty software training improves understanding of total knee arthroplasty alignment and balancing principles: a randomized controlled trial.
- Author
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Saad, Ahmed, Bleibleh, S., Kayani, B., Plastow, R., Ollivier, M., Davis, Ed, and Sharma, A.
- Abstract
Understanding alignment and gap balancing in Total Knee Arthroplasty (TKA) can be challenging for trainee and experienced orthopedic surgeons. Traditional learning methods may not effectively translate to real-life scenarios. The advent of advanced technologies like robotic surgery and navigation systems has revolutionized intraoperative understanding of gap balancing techniques. This trial aims to investigate the effectiveness of robotic TKA planning software in educating trainees about alignment and ligament balancing. We hypothesize that a single session with the software will significantly enhance trainees' understanding of these techniques. This UK-based single-center, two-arm, group parallel randomized controlled trial was conducted during a national robotic arthroplasty symposium. It aims to evaluate the effect of robotic knee arthroplasty software training on understanding TKA alignment and gap balancing principles using Multiple Choice Questions (MCQs). The MCQ test was crafted based on established guidelines from a different institution with expert consensus in the field. Our study revealed that baseline knowledge of gap balancing and alignment principles was generally low among all participants. However, the intervention group, which received comprehensive robotic software training, demonstrated a significant improvement in their MCQ scores compared to the control group, which did not undergo the training. In conclusion, our study demonstrates that robotic arthroplasty software training significantly improves the understanding of TKA alignment and balancing principles among orthopedic trainees. Level of Evidence II. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
32. Electrocatalytic CO2 Reduction to Alcohols: Progress and Perspectives.
- Author
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Long, Ying, Chen, Zhijie, Wu, Lan, Liu, Xiaoqing, Hou, Ya‐Nan, Vernuccio, Sergio, Wei, Wei, Wong, Wai‐Yeung, and Ni, Bing‐Jie
- Subjects
CARBON dioxide reduction ,CARBON offsetting ,ELECTROCATALYSTS ,ELECTROLYTIC cells ,CARBON dioxide - Abstract
Utilizing renewable electricity for the electrocatalytic conversion of CO2 into alcohols represents a promising avenue for generating value‐added fuels and achieving carbon neutrality. Recently, there has been growing scientific interest in achieving high‐efficiency conversion of CO2 to alcohols, with significant advancements made in mechanism understanding, reactor design, catalyst development, and more. Herein, a thorough examination of the latest advances in electrocatalytic CO2 reduction reaction (CO2RR) to alcohols is provided. General mechanisms and pathways of electrocatalytic conversion of CO2‐to‐alcohols are systematically illustrated. Subsequently, electrolyzer configurations, electrolytes, and electrocatalysts employed in CO2RR are summarized. After that, critical operating parameters (e.g., reaction pressure, temperature, and pH) that would significantly influence the CO2RR process are also analyzed. Finally, the review addresses challenges and offers perspectives in this field to guide future studies aimed at advancing CO2‐to‐alcohols conversion technologies. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
33. Gastric Carcinogenesis and Potential Role of the Transient Receptor Potential Vanilloid 1 (TRPV1) Receptor: An Observational Histopathological Study.
- Author
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Groen, Sylvester R., Keszthelyi, Daniel, Szallasi, Arpad, van Veghel, Jara A., Alleleyn, Annick M. E., Csekő, Kata, Helyes, Zsuzsanna, Samarska, Iryna, Grabsch, Heike I., Masclee, Ad A. M., and Weerts, Zsa Zsa R. M.
- Subjects
TRPV cation channels ,ATROPHIC gastritis ,PRECANCEROUS conditions ,HELICOBACTER pylori ,INTESTINAL cancer ,GASTRIC mucosa - Abstract
The potential role of the transient receptor potential Vanilloid 1 (TRPV1) non-selective cation channel in gastric carcinogenesis remains unclear. The main objective of this study was to evaluate TRPV1 expression in gastric cancer (GC) and precursor lesions compared with controls. Patient inclusion was based on a retrospective review of pathology records. Patients were subdivided into five groups: Helicobacter pylori (H. pylori)-associated gastritis with gastric intestinal metaplasia (GIM) (n = 12), chronic atrophic gastritis (CAG) with GIM (n = 13), H. pylori-associated gastritis without GIM (n = 19), GC (n = 6) and controls (n = 5). TRPV1 expression was determined with immunohistochemistry and was significantly higher in patients with H. pylori-associated gastritis compared with controls (p = 0.002). TRPV1 expression was even higher in the presence of GIM compared with patients without GIM and controls (p < 0.001). There was a complete loss of TRPV1 expression in patients with GC. TRPV1 expression seems to contribute to gastric-mucosal inflammation and precursors of GC, which significantly increases in cancer precursor lesions but is completely lost in GC. These findings suggest TRPV1 expression to be a potential marker for precancerous conditions and a target for individualized treatment. Longitudinal studies are necessary to further address the role of TRPV1 in gastric carcinogenesis. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
34. Area and Device Count Efficient Binary Logic Circuits using Anti‐Ambipolar Switch Devices.
- Author
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Jun, Jae Hyeon, Lee, Yongsu, Lee, Hae‐Won, Kim, Minjae, Hwang, Hyeon Jun, and Lee, Byoung Hun
- Subjects
LOGIC circuits ,TRANSISTOR circuits ,HETEROJUNCTIONS ,THIOPHENES ,ZINC oxide ,COMPLEMENTARY metal oxide semiconductors - Abstract
The unique characteristics of an anti‐ambipolar switch (AAS) device exhibit Λ‐shaped transfer responses (namely delta conductance) and present unique opportunities to overcome the limit of silicon‐based, complementary metal‐oxide‐semiconductor (CMOS) logic circuits. It is crucial because a device that only turns on under a certain bias range can be utilized to simplify the logic circuit and reduce the device count and circuit area required to perform logic functions. In this study, a physically scalable AAS device is investigated using ZnO and dinaphtho[2,3‐b:2′,3′‐f]thieno[3,2‐b]thiophene as heterojunction structures to reduce the operating voltage and enhance the peak current and peak‐to‐valley ratio of the AAS device. Moreover, novel logic circuits for AND, OR, XOR, DEMUX, and half‐adder functions are demonstrated using AAS devices. AAS device‐based logic circuits exhibit power‐efficiency characteristics (≈49 times lower than that of the 90‐nm silicon‐based CMOS inverter) and reduce the transistor count and the circuit area by ≈67% and ≈70%, respectively. These results indicate that the use of AAS device‐based logic circuits can be a promising approach to overcome the physical scaling limit of current CMOS technology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
35. Room temperature chiral magnetoresistance in a chiral-perovskite-based perpendicular spin valve.
- Author
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Kang, Min-Gu, Hwang, In-Kook, Kyung, Hee-Chang, Kang, Jaimin, Han, Donghyeon, Lee, Soogil, Kwon, Junyoung, Lee, Kyung-Jin, Yeom, Jihyeon, and Park, Byong-Guk
- Subjects
SPIN valves ,FERROMAGNETIC materials ,PEROVSKITE ,MAGNETIC fields ,LOW temperatures - Abstract
Chirality-induced spin selectivity (CISS) allows for the generation of spin currents without the need for ferromagnets or external magnetic fields, enabling innovative spintronic device designs. One example is a chiral spin valve composed of ferromagnetic and chiral materials, in which the resistance depends on both the magnetization direction of the ferromagnet and the chirality of the chiral material. So far, chiral spin valves have predominately employed chiral organic molecules, which have limited device applications. Chiral perovskites, which combine the properties of inorganic perovskites with chiral organic molecules, provide an excellent platform for exploring CISS-based devices. However, previous chiral perovskite-based spin valves exhibited magnetoresistance (MR) only at low temperatures. Here, we report room temperature MR in a chiral spin valve consisting of chiral perovskites/AlOx/perpendicular ferromagnet structures. It is observed that the chiral MR increases with rising temperature, suggesting the crucial role of phonon-induced enhancement of spin–orbit coupling in CISS in our device. Furthermore, we enhanced the chiral MR by introducing chiral molecules with amplified chirality. This highlights the potential of chirality engineering to improve CISS and the associated chiral MR, thereby opening possibilities for chiral spin valves tailored for cutting-edge spintronic applications. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
36. Research progress on two-dimensional indium selenide crystals and optoelectronic devices.
- Author
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Zheng, Dan, Chen, Peng, Liu, Yi, Li, Xing, Liu, Kejing, Yin, Zi'ang, Frisenda, Riccardo, Zhao, Qinghua, and Wang, Tao
- Abstract
Two-dimensional (2D) materials, with unique electronic properties, superior optoelectronic properties, and dangling-bond-free surfaces, have attracted significant attention and experienced rapid development both in fundamental science and for practical applications. Amid the plethora of 2D materials, indium selenide (InSe) has emerged as a promising candidate for future high-mobility optoelectronic devices. Nobel Prize laureate Andre Geim even describes it as "the 'golden middle' between silicon and graphene". Over the past decade, remarkable findings and progress have been made in the fabrication of 2D InSe crystals and their application in devices, motivating us to delve deeply into these forefront developments. In this review, the physical properties such as the crystalline structure, band structure, and photoluminescence characteristics are discussed first. Then, the advancements in terms of synthesis techniques, characteristics and synthesis schemes in the fabrication of 2D InSe are summarized. Subsequently, the mechanisms of optimized strategies and recent progress in field effect transistors (FETs) as well as photodetectors based on this material are summarized, also highlighting the promising applications of 2D InSe in sensors and memory. Finally, an outlook, challenges and potential future research directions in the fabrication of 2D InSe and its devices are presented, such as large-scale fabrication without defect to integrate more devices, a variety of physical and chemical properties are regulated by doping or modification to broaden applications, improving the contact interface between the 2D materials and each layer of the stacking hetero interface to enhance the performance of devices, and designing multifunctional devices for future advanced optoelectronic devices as well as sensors, flexible, and wearable/portable electronic devices. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
37. Manipulation of Cs0.1FA0.9PbI3 crystallization behavior towards efficient carbon-based printable mesoscopic perovskite solar cells.
- Author
-
Wang, Jinjiang, Wang, Dongjie, Zhang, Yang, Chen, Yiwen, Huang, Tianhuan, Zhu, Wending, Zhang, Zheling, Huang, Yu, Xiong, Jian, Xiang, Dinghan, and Zhang, Jian
- Abstract
Carbon-based printable mesoscopic perovskite solar cells (MPSCs) have attracted significant attention due to their excellent stability and low manufacturing cost. However, the filling and crystallization behavior of perovskite are difficult to finely manipulate due to the confined space of triple-mesoporous layers. Herein, an innovative approach is first proposed to effectively manipulate the crystallization behavior of Cs
0.1 FA0.9 PbI3 perovskite in triple-mesoporous layers by introducing propylamine hydrochloride (PACl). Under the manipulation of PACl, the nucleation density of perovskite crystals was significantly increased, the crystallization rate was delayed, thus the compact filling and preferred crystal orientation growth of the perovskite were realized. Simultaneously, ammonium ions (NH3 + ) and chloride ions (Cl− ) of PACl compensate for ionic vacancies in the perovskite through hydrogen bonds and ionic bonds, thus passivating defects. Consequently, MPSCs with PACl achieved a champion power conversion efficiency of 18.06%, and the open circuit voltage of MPSCs increased from 0.940 V to 0.991 V. The work developed a simple method based on alkylamine hydrochloride to finely manipulate the crystallization of the CsFA-based perovskite. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
38. SOLAMEN syndrome with cardiovascular damage.
- Author
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Zhao, Xiong, Yue, Xiaojie, Yuan, Shifan, Dai, Yefeng, and Gu, Hao
- Subjects
LYMPHATIC abnormalities ,ARTERIOVENOUS malformation ,NUCLEOTIDE sequencing ,GENETIC disorder diagnosis ,LIPOMATOSIS ,CEREBRAL arteriovenous malformations - Abstract
SOLAMEN syndrome is a rare, recently recognized congenital syndrome that is characterized by progressive and hypertrophic diseases involving multiple systems, including segmental overgrowth, lipomatosis, arteriovenous malformation (AVM) and epidermal nevus. According to literatures, SOLAMEN syndrome is caused by heterozygous PTEN mutation. Phenotypic overlap complicates the clinical identification of diseases associated with PTEN heterozygous mutations, making the diagnosis of SOLAMEN more challenging. In addition, SOLAMEN often presents with segmental tissue overgrowth and vascular malformations, increasing the possibility of misdiagnosis as klipple-trenaunay syndrome or Parks-Weber syndrome. Here, we present a case of a child presenting with macrocephaly, patchy lymphatic malformation on the right chest, marked subcutaneous varicosities and capillaries involving the whole body, overgrowth of the left lower limb, a liner epidermal nevus on the middle of the right lower limb, and a large AVM on the right cranial thoracic entrance. Based on the typical phenotypes, the child was diagnosed as SOLAMEN syndrome. detailed clinical, imaging and genetic diagnoses of SOLAMEN syndrome was rendered. Next-generation sequencing (NGS) data revealed that except for a germline PTEN mutation, a PDGFRB variant was also identified. A subsequent echocardiographic examination detected potential cardiac defects. We suggested that given the progressive nature of AVM and the potential severity of cardiac damage, regular echocardiographic evaluation, imaging follow-up and appropriate interventional therapy for AVM are recommended. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
39. Field deployment of Wolbachia-infected Aedes aegypti using uncrewed aerial vehicle.
- Author
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Lin, Ya-Hsun, Joubert, Dirk Albert, Kaeser, Sebastian, Dowd, Cameron, Germann, Jurg, Khalid, Anam, Denton, Jai Andrew, Retski, Kate, Tavui, Aminiasi, Simmons, Cameron Paul, O'Neill, Scott Leslie, and Gilles, Jeremie Roger Lionel
- Subjects
AEDES aegypti ,HUMIDITY control ,FIELD research ,MOSQUITOES ,TEMPERATURE control ,MOSQUITO control ,DENGUE - Abstract
Over the past 50 years, there has been a marked increase in diseases like dengue fever, chikungunya, and Zika. The World Mosquito Program (WMP) has developed an approach that, instead of attempting to eliminate vector species, introduces Wolbachia into native Aedes aegypti populations through the release of Wolbachia-infected mosquitoes. Using this approach, a randomized controlled study recently demonstrated a 77% reduction in dengue across a treatment area within Yogyakarta, Indonesia. Existing release methods use the ground-based release of mosquito eggs or adults that are labor-intensive, are logistically challenging to scale up, and can be restrictive in areas where staff safety is a concern. To overcome these limitations, we developed a fully automated mosquito dosing release system that released smaller cohorts of mosquitoes over a wide area and integrated it into an uncrewed aerial vehicle. We established the effectiveness of this system using an aerial mark, release, and recapture approach. We then demonstrated that using only the aerial release method, we can establish Wolbachia infection in a naive Ae. aegypti population. In both cases, the use of aerial releases demonstrated comparable outcomes to ground-based releases without the required labor or risk. These two trials demonstrated the feasibility of using an aerial release approach for large-scale mosquito releases. Editor's summary: The World Mosquito Program recently developed a technique to control dengue transmission by releasing Wolbachia-infected Aedes aegypti mosquitoes. Wolbachia bacteria act as a virus-blocking agent and are maternally transmitted to the local mosquito populations. However, scaling ground-based releases to large geographic areas poses a challenge. To address this, Lin et al. developed an automated mosquito dosing release system and incorporated it into an uncrewed aerial vehicle (UAV). This system, which includes temperature and humidity control, is designed to release 150 mosquitos per dose. Two successful field trials in Fiji demonstrated that the UAV-based release achieved similar uniformity to ground release methods and successfully established Wolbachia infections in the native population over a 2-km
2 area. —Melisa Yashinski [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
- View/download PDF
40. Recent Advances in Self-Powered Wearable Flexible Sensors for Human Gaits Analysis.
- Author
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Hu, Xiaohe, Ma, Zhiqiang, Zhao, Fuqun, and Guo, Sheng
- Subjects
HUMAN mechanics ,FLEXIBLE electronics ,WEARABLE technology ,ROBOTICS ,GAIT in humans ,ALGORITHMS - Abstract
The rapid progress of flexible electronics has met the growing need for detecting human movement information in exoskeleton auxiliary equipment. This study provides a review of recent advancements in the design and fabrication of flexible electronics used for human motion detection. Firstly, a comprehensive introduction is provided on various self-powered wearable flexible sensors employed in detecting human movement information. Subsequently, the algorithms utilized to provide feedback on human movement are presented, followed by a thorough discussion of their methods and effectiveness. Finally, the review concludes with perspectives on the current challenges and opportunities in implementing self-powered wearable flexible sensors in exoskeleton technology. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
41. Understanding the factors related to how East and Southeast Asian immigrant youth and families access mental health and substance use services: A scoping review.
- Author
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Gao, Chloe, Cho, Lianne L., Dhillon, Avneet, Kim, Soyeon, McGrail, Kimberlyn, Law, Michael R., Sunderji, Nadiya, and Barbic, Skye
- Subjects
SOUTHEAST Asians ,IMMIGRANT children ,ECOLOGICAL systems theory ,IMMIGRANT families - Abstract
The objective of the review is to identify factors related to how East and Southeast Asian immigrant youth aged 12–24 and their families access mental health and substance use (MHSU) services. To address how East and Southeast Asian youth and their families access mental health and substance use services, a scoping review was conducted to identify studies in these databases: PubMed, MEDLINE (Ovid), EMBASE (Ovid), PsychINFO, CINAHL, and Sociology Collection. Qualitative content analysis was used to deductively identify themes and was guided by Bronfenbrenner's Ecological Systems Theory, the process-person-context-time (PPCT) model, and the five dimensions of care accessibility (approachability, acceptability, availability and accommodation, appropriateness, affordability). Seventy-three studies met the inclusion criteria. The dimensions of healthcare accessibility shaped the following themes: 1) Acceptability; 2) Appropriateness; 3) Approachability; 4) Availability and Accommodation. Bronfenbrenner's Ecological Systems Theory and the PPCT model informed the development of the following themes: 1) Immediate Environment/Proximal Processes (Familial Factors, Relationships with Peers; 2) Context (School-Based Services/Community Resources, Discrimination, Prevention, Virtual Care); 3) Person (Engagement in Services/Treatment/Research, Self-management); 4) Time (Immigration Status). The study suggests that there is a growing body of research (21 studies) focused on identifying acceptability factors, including Asian cultural values and the model minority stereotype impacting how East and Southeast Asian immigrant youth access MHSU services. This review also highlighted familial factors (16 studies), including family conflict, lack of MHSU literacy, reliance on family as support, and family-based interventions, as factors affecting how East and Southeast Asian immigrant youth access MHSU care. However, the study also highlighted a dearth of research examining how East and Southeast Asian youth with diverse identities access MHSU services. This review emphasizes the factors related to the access to MHSU services by East and Southeast Asian immigrant youth and families while providing insights that will improve cultural safety. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
42. A flexible precontact CNT-Al2O3 fiber sensor resistant to extreme temperatures.
- Author
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Pan, Xinghai, Zhou, Zisong, Liu, Yanling, Xiao, Yuhang, Lin, Sen, Pu, Wei, and Wang, Haolun
- Published
- 2024
- Full Text
- View/download PDF
43. Urchin-like hierarchical spheres of FeSe2 embedded in a TiN/C composite covered by CNTs as anodes for sodium-ion storage.
- Author
-
Wang, Ling, Hu, Miaoling, Lin, Changzheng, and Yan, Wei
- Subjects
SODIUM ions ,TITANIUM nitride ,ANODES ,ELECTRIC conductivity ,SPHERES ,CARBON nanotubes - Abstract
Transition-metal selenides are considered promising anode materials for sodium-ion batteries due to their high theoretical capacity based on multielectron conversion reactions. However, their low intrinsic electrical conductivity and severe volume variations result in poor cycling performance and rate capability. Herein, a composite material of urchin-like hierarchical spheres in which FeSe
2 embedded in TiN/C covered by in situ grown carbon nanotubes (denoted as FeSe2 @TiN/C@CNTs) was designed and fabricated using a facile sol–gel, carbonization, and selenization process. The carbon matrix can disperse FeSe2 to prevent serious agglomeration, while TiN and CNTs could enhance the electrical conductivity of the composites. Additionally, TiN, carbon, and CNTs can buffer volume expansion during the charge/discharge process. Benefiting from the synergistic effects of FeSe2 , carbon, TiN, and CNTs, the hybrid urchin-like FeSe2 @TiN/C@CNTs spheres exhibit excellent cycling stability and ultrafast pseudocapacitive sodium-ion storage capability. The FeSe2 @TiN/C@CNTs electrode delivers reversible capacity of 343.5 mA h g−1 at 200 mA g−1 for 1000 cycles, and a rate capability of 262.5 mA h g−1 at a high current density of 2 A g−1 . Supported by the detailed kinetic analysis, the superior sodium-ion storage performance is attributed to the fast charge transfer rate and pseudocapacitive sodium-ion storage mechanism. Therefore, this work is expected to provide valuable insights for the rational design of metal-based compounds towards advanced metal-ion storage materials. [ABSTRACT FROM AUTHOR]- Published
- 2024
- Full Text
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44. Bridging barriers: advances and challenges in modeling biological barriers and measuring barrier integrity in organ-on-chip systems.
- Author
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Ugodnikov, Alisa, Persson, Henrik, and Simmons, Craig A.
- Subjects
MICROPHYSIOLOGICAL systems ,BIOLOGICAL models ,BLOOD-brain barrier ,HOMEOSTASIS ,EXTRACELLULAR matrix ,CELL culture ,PHYSIOLOGY ,BRIDGES - Abstract
Biological barriers such as the blood–brain barrier, skin, and intestinal mucosal barrier play key roles in homeostasis, disease physiology, and drug delivery – as such, it is important to create representative in vitro models to improve understanding of barrier biology and serve as tools for therapeutic development. Microfluidic cell culture and organ-on-a-chip (OOC) systems enable barrier modelling with greater physiological fidelity than conventional platforms by mimicking key environmental aspects such as fluid shear, accurate microscale dimensions, mechanical cues, extracellular matrix, and geometrically defined co-culture. As the prevalence of barrier-on-chip models increases, so does the importance of tools that can accurately assess barrier integrity and function without disturbing the carefully engineered microenvironment. In this review, we first provide a background on biological barriers and the physiological features that are emulated through in vitro barrier models. Then, we outline molecular permeability and electrical sensing barrier integrity assessment methods, and the related challenges specific to barrier-on-chip implementation. Finally, we discuss future directions in the field, as well important priorities to consider such as fabrication costs, standardization, and bridging gaps between disciplines and stakeholders. [ABSTRACT FROM AUTHOR]
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- 2024
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45. Ultra-large dipole moment organic cations derived 3D/2D p–n heterojunction for high-efficiency carbon-based perovskite solar cells.
- Author
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Lin, Yu, Tang, Jiawei, Yan, Haocong, Lin, Jiaru, Wang, Wenran, Zhang, Shengsen, Rao, Huashang, Pan, Zhenxiao, and Zhong, Xinhua
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- 2024
- Full Text
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46. Facilitators and Barriers to the Implementation of a Digital Pain Assessment Tool in Pediatric Oncology Practice: A Qualitative Evaluation of a Quality Improvement Project.
- Author
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Hamilton, Rachel, Nguyen, Cynthia, Mills, Denise, Stinson, Jennifer N., and Jibb, Lindsey A.
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HEALTH services accessibility ,DIGITAL technology ,MOBILE apps ,PAIN measurement ,HUMAN services programs ,RESEARCH funding ,QUALITATIVE research ,QUESTIONNAIRES ,INTERVIEWING ,PEDIATRIC oncology nursing ,DESCRIPTIVE statistics ,SOUND recordings ,THEMATIC analysis ,RESEARCH methodology ,CONCEPTUAL structures ,NURSES' attitudes ,QUALITY assurance - Abstract
Background: Most children and adolescents with cancer experience acute pain, and many experience longer-lasting chronic pain, negatively impacting health-related quality of life and resulting in long-term morbidity. Digital apps can aid in enhancing pain assessment and management by offering children and adolescents with cancer an accessible tool to describe their pain as a multifaceted biopsychosocial construct. Pain Squad is a useable, acceptable, and psychometrically sound multidimensional cancer pain assessment app for children and adolescents with cancer. This project aimed to evaluate the capacity to implement Pain Squad into routine pediatric oncology practice. Method: Nurse champions were asked to prescribe the Pain Squad app to patients over a 6-month implementation period. After the implementation period, we conducted audiorecorded, semistructured interviews with nurse champions to investigate the facilitators and barriers related to nurses' experiences with implementing Pain Squad. Results: The facilitators and barriers to Pain Squad implementation were organized into four overarching Consolidated Framework for Implementation Research (CFIR)-related themes: (a) characteristics of the Pain Squad app; (b) clinic setting and its context; (c) nurse implementation champions; and (d) the process of implementing Pain Squad into clinical practice. Conclusions: Interviewed nurses believed Pain Squad had the potential to improve child cancer pain care, but barriers to everyday use were evident, described in relation to the internal setting, especially the lack of compatibility between app prescription and current nurse workflows. The use of CFIR to map identified implementation facilitators and barriers can formally support the recognition of factors that may boost the chances of successful uptake. [ABSTRACT FROM AUTHOR]
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- 2024
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47. NMR Investigation on Ion Selectivity of 18-Crown-6 Ether.
- Author
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Huimin Liu, Sun, Jian, Liu, Yanfang, and Yan, Shihai
- Abstract
The ion selectivity of 18-crown-6 (18C6) ether has been investigated by DFT method. The following conclusions are drawn with the analyses about the geometrical structure, the binding energy, the natural bond orbital charge population, the infrared spectra, and the spin-spin coupling constant. First of all, the ion selectivity of 18C6 attributes primarily to the valence state, the periodic number, and the volume of the cation. Secondly, for the cation encapsulated complex of the same main group, the variation of distance between two para-oxygen atoms in the complex and in 18C6 (ΔR
OO ) is proportionate to the binding energy of cation and 18C6. Then, the cation, bearing most of the electropositive charges, is encapsulated in the center of six electronegative oxygen atoms. Fourthly, the value of spin-spin coupling constant of cation and peripheral oxygen atom (1 J(M, O)) mainly dominated by the Fermi-contact term. The swing of cation along the para-position oxygen atoms is typical and can be taken as a characteristic for ion recognition. [ABSTRACT FROM AUTHOR]- Published
- 2024
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48. Biomarkers in bronchiectasis.
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Johnson, Emma, Long, Merete B., and Chalmers, James D.
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BIOMARKERS ,BRONCHIECTASIS ,MUCOCILIARY system ,INDIVIDUALIZED medicine ,BIOLOGY ,PROGNOSIS - Abstract
Bronchiectasis is a heterogeneous disease with multiple aetiologies and diverse clinical features. There is a general consensus that optimal treatment requires precision medicine approaches focused on specific treatable disease characteristics, known as treatable traits. Identifying subtypes of conditions with distinct underlying biology (endotypes) depends on the identification of biomarkers that are associated with disease features, prognosis or treatment response and which can be applied in clinical practice. Bronchiectasis is a disease characterised by inflammation, infection, structural lung damage and impaired mucociliary clearance. Increasingly there are available methods to measure each of these components of the disease, revealing heterogeneous inflammatory profiles, microbiota, radiology and mucus and epithelial biology in patients with bronchiectasis. Using emerging biomarkers and omics technologies to guide treatment in bronchiectasis is a promising field of research. Here we review the most recent data on biomarkers in bronchiectasis. [ABSTRACT FROM AUTHOR]
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- 2024
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49. Optical study on a heavy-duty natural gas dual-fuel engine applying POMDME as pilot fuel.
- Author
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Mühlthaler, Markus, Prager, Maximilian, and Jaensch, Malte
- Abstract
In this study, a fully optically accessible single-cylinder research engine is the basis for the visualization and generation of extensive knowledge about the in-cylinder processes of mixture formation, ignition, and combustion of alternative fuels for the dual-fuel combustion process. POMDME substitutes the fossil pilot fuel as a drop-in, non-sooting alternative to widely eliminate the NOx-PM tradeoff. Furthermore, an optimized ignition behavior, increased degrees of freedom in combustion phasing, and the pilot's energy content are expected. The flame luminosity transmitted via an optical piston was split in the optical path to record the natural flame luminosity simultaneously with an RGB high-speed camera. The second channel consisted of OH chemiluminescence recording, isolated by a bandpass filter via an intensified monochrome high-speed camera. To investigate the combustion process spectrally, spatially, and temporally resolved in more detail, selected operating points were re-recorded via a high-speed imaging spectrograph. POMDME is benchmarked against regular diesel oil, according to EN590. Synthetic natural gas is applied as the primary gaseous fuel. Experimental sweeps along the overall pilot's energy content (2%, 5%, 10%), injection pressure (500–1600 bar), and start of energizing (5–55 CAD bFTDC) are carried out. The given conditions result in decreased liquid-penetration length between 25% and 30% for the oxygenate, larger for earlier SOE and higher dilution. The lift-off length is nearer the liquid penetration length, increasing for higher rail pressures. The light-based ignition delay for EN590 is enlarged by 0.8 CAD after adding methane, while the oxygenate is not visibly retarded. Without methane, the oxygenate preceded EN590 by 0.6 CAD. The temporal and spatial position and extent of premixed, diffusive, and OH*, change significantly. RCCI operation at practically relevant 18.4 bar IMEP is demonstrated, highlighting the influence of the start of energizing variation with 51% decreased burn duration in the first half of combustion. [ABSTRACT FROM AUTHOR]
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- 2024
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50. Machine learning assisted prediction of land surface temperature (LST) based on major air pollutants over the Annamayya District of India.
- Author
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Mogaraju, Jagadish Kumar
- Subjects
RANDOM forest algorithms ,GEOGRAPHIC information systems ,CARBON monoxide ,LAND surface temperature ,AEROSOLS - Abstract
Re mote sensing (RS), Geographic information systems (GIS), and Machine learning can be integrated to predict land surface temperatures (LST) based on the data related to carbon monoxide (CO), Formaldehyde (HCHO), Nitrogen dioxide (NO2), Sulphur dioxide (SO2), absorbing aerosol index (AAI), and Aerosol optical depth (AOD). In this study, LST was predicted using machine learning classifiers, i.e., Extra trees classifier (ET), Logistic regressors (LR), and Random Forests (RF). The accuracy of the LR classifier (0.89 or 89%) is higher than ET (82%) and RF (82%) classifiers. Evaluation metrics for each classifier are presented in the form of accuracy, Area under the curve (AUC), Recall, Precision, F1 score, Kappa, and MCC (Matthew's correlation coefficient). Based on the relative performance of the ML classifiers, it was concluded that the LR classifier performed better. Geographic information systems and RS tools were used to extract the data across spatial and temporal scales (2019 to 2022). In order to evaluate the model graphically, ROC (Receiver operating characteristic) curve, Confusion matrix, Validation curve, Classification report, Feature importance plot, and t-SNE (t-distributed stochastic neighbour embedding) plot were used. On validation of each ML classifier, it was observed that the RF classifier returned model complexity due to limited data availability and other factors yet to be studied post data availability. Sentinel-5-P and MODIS data are used in this study. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
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