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Abstract Background Trabectedin in combination with pegylated liposomal doxorubicin (PLD) is approved for the treatment of patients with platinum-sensitive relapsed ovarian cancer. Nevertheless, there is currently limited information regarding this treatment in elderly patients with ovarian cancer in a real-world setting. Methods This observational and multicentric study retrospectively evaluated trabectedin plus PLD in a real-world setting treatment of elderly patients diagnosed with platinum-sensitive relapsed ovarian cancer, treated according to the Summary of Product Characteristics (SmPC) from 15 GEICO-associated hospitals. Patients ≥ 70 years old at the time of treatment initiation and platinum-free intervals ≥ 6 months were considered eligible. Results Forty-three patients with a median age of 74.0 years were treated between January 1st, 2015, and December 31st, 2019 in 15 Spanish centers. Four patients achieved complete response (9.3%), 14 (32.6%) partial response, and 13 (30.2%) stable disease as the best radiological response. In the analysis of biological overall response according to CA125 serum levels (i.e., Rustin criteria), 14 responded to the treatment (32.6%), 11 responded and normalized (25.6%), three patients stabilized (7.0%) and three progressed (7.0%). Median progression-free survival (PFS) and overall survival (OS) in the study population were 7.7 and 19.5 months, respectively. The most common grade 3/4 adverse events were neutropenia (n = 8, 18.7%) and asthenia (n = 5, 11.6%). Conclusions This analysis demonstrated that trabectedin combined with PLD is a feasible and effective treatment in elderly patients with platinum-sensitive relapsed ovarian cancer, showing an acceptable safety profile, which is crucial in the palliative treatment of these patients.

The present study aims to determine the mediating effect that authentic coach leadership has on the interaction between coach competence and athletes' perceived support for basic psychological needs (BPN). A cross-sectional study was conducted with 115 team sports players (17.96 ±2.85 years of age; 8.18 ±4.67 years of experience) using the Basic Psychological Needs Support, Perceived Authentic Leadership, and Athletes' Perceptions of Coach Competence questionnaires. Correlation and mediation analyses (Coach Competence → Authentic Leadership → BPN Support) were performed. The results show a positive and significant indirect effect (ƥ = 0.288; 95% CI = 0.167, 0.415) of authentic leadership on the direct interaction between coach competence and BPN support (ƥ = 0.277; p < 0.01), increasing the total model effect (ƥ = 0.555; p < 0.01) to aid athletes' perceived BPN support when their coaches are competent and authentic leaders. In conclusion, it is not enough to be a well-prepared coach, he/she must also have the ability to lead, motivate and make decisions taking care of his/her interrelationships with athletes and promoting the satisfaction of basic psychological needs.

Abstract Background Self‐medication is a fairly common practice among medical doctors. Although frequently seen in clinical practice, there are few published studies that describe the process of self‐treatment in dermatology, being even lower in number those that evaluate this circumstance among health professionals. Objectives To know the prevalence of self‐medication among medical professionals in our centre, to assess the need for preventive and training actions that help to avoid the misuse of dermatological treatments. Methods Descriptive cross‐sectional study based on the responses of non‐dermatologist medical professionals at the University Hospital of Pontevedra (Spain). Data were collected through a self‐administered, anonymous and voluntary online questionnaire. Results The questionnaire was completed by 283 physicians (50.63% participation rate, 62.90% females). Up to 77.39% of the physicians carried out self‐treatment for any pathology, and 55.12% for dermatological problems. The mean age of the doctors who practiced self‐treatment was significantly higher. The most used drugs were corticosteroids as topical treatment and antihistamines as systemic therapy. Irritant or allergic contact dermatitis was the most frequent pathology considered suitable for self‐medication (18.02%), followed by fungal infections (16.86%). After self‐treatment, the 7.5% needed to be seen by a dermatologist. A large group of 69.23% stated that they would recommend the treatment carried out to someone suffering from a similar process. Conclusions The prevalence of self‐treatment for skin diseases among doctors was strikingly high (55.12%). More than two‐thirds of the surveyed physicians would recommend self‐treatment in the dermatology field. As the literature on this topic is yet scarce, further studies are required to corroborate data collected in this study.

Background: Open reduction and internal fixation with plate is one of the most widely used treatments for distal third humeral shaft fractures. The purpose of this study was to report the outcomes of the treatment of distal third humeral shaft fractures with posterior minimally invasive plate osteosynthesis (MIPO) with segmental isolation of the radial nerve. Methods: We performed an observational, retrospective, consecutive, monocentric, continuous multioperator study. We reviewed 22 distal third humeral shaft fractures treated with posterior MIPO in our institution with an extra-articular distal humerus plate from 2018 to 2021. Inclusion was limited to functionally independent patients with displaced fractures involving the junction of the middle and distal thirds of the humerus and minimum 12-month follow-up for implant removal. We assessed clinical outcomes including range of motion; QuickDASH score; Mayo Elbow Performance Score; and Constant-Murley score. Results: The average follow-up period of the sample was 31.7 ± 11.6 months (range, 15.7-51.3 months). The average elbow flexion and extension were 146.4° ± 7.3° (range, 120°-150°) and −0.7° ± 3.3° (range, −15° to 0°), respectively. The average shoulder anterior flexion, elevation, and abduction were 178.6° ± 3.6° (range, 170°-180°), 179.1° ± 2.9° (range, 170°-180°), and 140.9° ± 14.8° (range, 110°-160°), respectively. The average external rotation was 88.6° ± 6.4 (range, 65°-90°). The mean visual analog scale score for pain was 1.0 ± 1.6 (range, 0-5) and the mean Mayo Elbow Performance Score was 90.5 ± 9.9 (range, 70-100). The mean QuickDASH and Constant–Murley scores were 4.7 ± 6.8 (range, 0-20.5) and 95.5 ± 5.1 (range, 81-100), respectively. Two patients presented with relevant compromise of radial nerve motor function postoperatively (M3 and M2; the more compromised was preoperative injury). All patients recovered radial nerve neuropraxia within six weeks postoperatively. All fractures achieved union. The average anteroposterior and lateral axis were 175.0 ± 3.6 (168.0°-180.0°) and 177.5 ± 2.0 (173.0°-180.0°), respectively. No superficial or deep infection was reported. No cases of re-displacement of fracture, implant failure, or any other implant-related complication in follow-up were reported. No patient required plate withdrawal. Conclusion: The results of this study demonstrate that the posterior MIPO technique is a reliable option for treating distal third shaft humeral fractures. The radial nerve must be identified and protected in all cases to prevent palsy.

Abstract Pityriasis rubra pilaris (PRP) can be triggered by viruses, such as cytomegalovirus, Epstein‐Barr virus, varicella zoster, human immunodeficiency virus and, more exceptionally, SARS‐CoV‐2. We report an additional case of PRP following COVID‐19 infection. Given the existing literature and the close temporal association, we suggest a possible causal relationship. We speculate that an altered immune response with a genetic predisposition for PRP may have played a role in our patient. We highlight the development of PRP as part of the spectrum of COVID‐19 skin‐related conditions.

This review article focuses on agrivoltaic production systems (AV). The transition towards renewable energy sources, driven by the need to respond to climate change, competition for land use, and the scarcity of fossil fuels, has led to the consideration of new ways to optimise land use while producing clean energy. AV systems not only generate energy but also allow agricultural and livestock yields to be maintained or even increased under PV structures, offering a sustainable production strategy that may be more acceptable to local communities than traditional PV installations. This review assesses the technical feasibility of AV systems, the environmental, economic and social benefits, as well as the challenges faced and the legal framework regulating their implementation. It is highlighted that despite the advantages in land use efficiency and dual food and energy production, there are important challenges related to the initial investment required, the need for technological adaptation, social and regulatory obstacles, or the effects of shading on production. This paper underlines the importance of further research and development of these systems to overcome technical and economic constraints and maximise their potential benefits. It is concluded that although they present significant challenges, AV management offers promising opportunities to improve land efficiency and contribute to several sustainable development goals.

Breast cancer (BRCA) remains a significant global health challenge due to its prevalence and lethality, exacerbated by the development of resistance to conventional therapies. Therefore, understanding the molecular mechanisms underpinning chemoresistance is crucial for improving therapeutic outcomes. Human deoxycytidine triphosphate pyrophosphatase 1 (DCTPP1) has emerged as a key player in various cancers, including BRCA. DCTPP1, involved in nucleotide metabolism and maintenance of genomic stability, has been linked to cancer cell proliferation, survival, and drug resistance. This study evaluates the role of DCTPP1 in BRCA prognosis and chemotherapy response. Data from the Cancer Genome Atlas Program (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO) repositories, analyzed using GEPIA and Kaplan–Meier Plotter, indicate that high DCTPP1 expression correlates with poorer overall survival and increased resistance to chemotherapy in BRCA patients. Further analysis reveals that DCTPP1 gene expression is up-regulated in non-responders to chemotherapy, particularly in estrogen receptor (ER)-positive, luminal A subtype patients, with significant predictive power. Additionally, in vitro studies show that DCTPP1 gene expression increases in response to 5-fluorouracil and doxorubicin treatments in luminal A BRCA cell lines, suggesting a hypothetical role in chemoresistance. These findings highlight DCTPP1 as a potential biomarker for predicting chemotherapy response and as a therapeutic target to enhance chemotherapy efficacy in BRCA patients.

High rates of fertilizer applications potentially have significant environmental consequences, such as soil and water contamination and biodiversity loss. This study aimed to compare the use of biofertilizers and inorganic fertilizers in a broccoli crop to determine their impact on soil microorganism abundance, microbial community structure, functional gene diversity, yield, and greenhouse gas emissions. Four different fertilization treatments were designed: (i) inorganic fertilizers applied at a rate to cover the nutritional demands of the crop (F100); (ii) 50% of the rate of inorganic fertilizers added in F100 (F50); (iii) F50 + the application of a formulation of various bacteria (BA); and (iv) F50 + the application of a formulation of bacteria and non-mycorrhizal fungi (BA + FU). The results showed that reduced fertilization and the addition of both biofertilizer products had no significant effect on soil nutrients, microbial population, microbial activity, or yield when compared to conventional inorganic fertilization. Thus, microbial inoculants were ineffective in enhancing soil microbial abundance and activity, and there were no changes in GHG emissions or crop yields. Nonetheless, crop yield was positively related to total soil N, microbial activity, and CO2 emissions, confirming the positive effect of soil biodiversity on production. The application of biofertilizers can help reduce mineral fertilization in a broccoli crop with no negative effect on yield. [ABSTRACT FROM AUTHOR]

En este artículo, se presenta una reflexión sobre cómo el conocimiento explícito y tácito tuvo incidencia en el desarrollo de innovaciones en siete empresas del sector alimentario costarricense pertenecientes a la Cámara Costarricense de la Industria Alimentaria (CACIA). Lo anterior con el interés de derivar implicaciones para el sistema educativo costarricense. La investigación realizada se sustentó en un enfoque cualitativo, por medio de la aplicación de entrevistas semiestructuradas a agentes en cada una de las empresas. En los resultados, se constata que ambas formas de conocimiento jugaron un papel central en la consecución de diversas innovaciones, en cada una de las organizaciones. A la vez que derivan seis implicaciones para el sistema educativo, en su condición de institución socializadora y constructora de conocimientos y capacidades, para una sociedad que demanda personas innovadoras.