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3. Image-guided moderately hypofractionated radiotherapy for localized prostate cancer: a multicentric retrospective study (IPOPROMISE)

Author

Ingrosso, Gianluca, Ponti, Elisabetta, Francolini, Giulio, Caini, Saverio, Fondelli, Simona, Santini, Roberto, Valeriani, Maurizio, Rago, Luciana, Duroni, Giacomo, Bruni, Alessio, Augurio, Antonietta, Tramacere, Francesco, Trippa, Fabio, Russo, Donatella, Bottero, Marta, Tamburo, Maria, Parisi, Silvana, Borghesi, Simona, Lancia, Andrea, Gomellini, Sara, Scoccianti, Silvia, Stefanacci, Marco, Vullo, Gianluca, Statuto, Teodora, Miranda, Giulia, Santo, Bianca, Di Marzo, Alessandro, Bellavita, Rita, Vinciguerra, Annamaria, Livi, Lorenzo, Aristei, Cynthia, Bertini, Niccolò, Orsatti, Carolina, and Detti, Beatrice

Published
2024
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4. Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI

Author

Francesca Guida, Monica Iannotta, Anna Lauritano, Rosmara Infantino, Emanuela Salviati, Roberta Verde, Livio Luongo, Eduardo Maria Sommella, Fabio Arturo Iannotti, Pietro Campiglia, Sabatino Maione, Vincenzo Di Marzo, and Fabiana Piscitelli

Subjects
Traumatic brain injury, Alzheimer’s disease, APP-SWE mice, Dementia, Endocannabinoidome, Serotonin, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Background Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular determinants on long-term consequences, such as dementia and Alzheimer’s disease (AD). Methods Here, we carried out behavioural studies and an extensive biomolecular analysis, including inflammatory cytokines, gene expression and the combination of LC-HRMS and MALDI-MS Imaging to elucidate the targeted metabolomics and lipidomics spatiotemporal alterations of brains from wild-type and APP-SWE mice, a genetic model of AD, at the presymptomatic stage, subjected to mild TBI. Results We found that brain injury does not affect cognitive performance in APP-SWE mice. However, we detected an increase of key hallmarks of AD, including Aβ1-42 levels and BACE1 expression, in the cortices of traumatized transgenic mice. Moreover, significant changes in the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), occurred, including increased levels of the endocannabinoid 2-AG in APP-SWE mice in both the cortex and hippocampus, and N-acylserotonins, detected for the first time in the brain. The gene expression of enzymes for the biosynthesis and inactivation of eCBs and eCB-like mediators, and some of their main molecular targets, also underwent significant changes. We also identified the formation of heteromers between cannabinoid 1 (CB1) and serotonergic 2A (5HT2A) receptors, whose levels increased in the cortex of APP-SWE mTBI mice, possibly contributing to the exacerbated pathophysiology of AD induced by the trauma. Conclusions Mild TBI induces biochemical changes in AD genetically predisposed mice and the eCBome may play a role in the pathogenetic link between brain injury and neurodegenerative disorders also by interacting with the serotonergic system.

Published
2024
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5. Towards a Scalable Compute Continuum Platform Applied to Electrical Energy Forecasting

Author

Moussa, Mohamad, Abdennahder, Nabil, Couturier, Raphaël, Di Marzo Serugendo, Giovanna, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Zeinalipour, Demetris, editor, Blanco Heras, Dora, editor, Pallis, George, editor, Herodotou, Herodotos, editor, Trihinas, Demetris, editor, Balouek, Daniel, editor, Diehl, Patrick, editor, Cojean, Terry, editor, Fürlinger, Karl, editor, Kirkeby, Maja Hanne, editor, Nardelli, Matteo, editor, and Di Sanzo, Pierangelo, editor

Published
2024
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7. The European Innovation Network as a hub for medicines innovation in Europe

Author

Agricola, Eleonora, Auriche-Benichou, Caroline, Baiao, Helena, Blanquie, Oriane, Bodea, Teodora, Boráň, Tomáš, Borg, John-Joseph, Cordo’, Valentina, Di Marzo, Maria, Dmowski Rugholm, Lars, Ehmann, Falk, Hauksdóttir Hvannberg, Rúna, Herold, Ralf, Irs, Alar, Jurkovič Mlakar, Simona, Klaus, Robert, Kolehmainen, Juha, Lahorte, Christophe, Löbker, Wiebke, Mäkinen Salmi, Anna, Nuevo Ordoñez, Yoana, O’Dwyer, Laurence, Pasmooij, Anna Maria Gerdina, Saeterdal, Ingvil, Spakova, Bronislava, Starokozhko, Viktoriia, Ziegele, Bettina, and Zywiec, Katarzyna

Published
2024
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8. Corrigendum: Oral ultramicronized palmitoylethanolamide: plasma and tissue levels and spinal antihyperalgesic effect

Author

Stefania Petrosino, Marika Cordaro, Roberta Verde, Aniello Schiano Moriello, Gabriele Marcolongo, Carlo Schievano, Rosalba Siracusa, Fabiana Piscitelli, Alessio F. Peritore, Rosalia Crupi, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea, and Vincenzo Di Marzo

Subjects
absorption, hyperalgesia, inflammation, micronization, palmitoylethanolamide, Therapeutics. Pharmacology, RM1-950
Published
2024
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9. The human milk endocannabinoidome and neonatal growth in gestational diabetes

Author

Alice Fradet, Sophie Castonguay-Paradis, Camille Dugas, Julie Perron, Gabrielle St-Arnaud, Isabelle Marc, Alain Doyen, Nicolas Flamand, Fadil Dahhani, Vincenzo Di Marzo, Alain Veilleux, and Julie Robitaille

Subjects
gestational diabetes mellitus, human milk, mediators of endocannabinoidome, Npalmitoyl-ethanolamine (PEA), Weight-for-age z-score (WAZ), Diseases of the endocrine glands. Clinical endocrinology, RC648-665
Abstract

ObjectiveEndocannabinoids and their N-acyl-ethanolamines (NAEs) and 2monoacyl-glycerols (2-MAGs) congeners are involved in the central and peripheral regulation of energy homeostasis, they are present in human milk and are associated with obesity. Infants exposed in utero to gestational diabetes mellitus (GDM) are more likely to develop obesity. The objective of this cross-sectional study is to compare the profile of eCBome mediators in milk of women with gestational diabetes (GDM+) and without (GDM-) and to assess the association with offspring growth. The hypothesis is that the eCBome of GDM+ human milk is altered and associated with a difference in infant growth.MethodsCirculating eCBome mediators were measured by LC-MS/MS in human milk obtained at 2 months postpartum from GDM+ (n=24) and GDM- (n=29) women. Infant weight and height at 2 months were obtained from the child health record. Z-scores were calculated.ResultsCirculating Npalmitoylethanolamine (PEA) was higher in human milk of GDM+ women than in GDM- women (4.9 ± 3.2 vs. 3.3 ± 1.7, p=0.04). Higher levels were also found for several 2monoacyl-glycerols (2-MAGs) (p

Published
2024
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10. PEA-OXA restores cognitive impairments associated with vitamin D deficiency-dependent alterations of the gut microbiota

Author

Francesca Guida, Monica Iannotta, Michela Perrone, Rosmara Infantino, Giada Giorgini, Antimo Fusco, Ida Marabese, Iolanda Manzo, Carmela Belardo, Emanuele Di Martino, Salvatore Pagano, Serena Boccella, Cristoforo Silvestri, Livio Luongo, Vincenzo Di Marzo, and Sabatino Maione

Subjects
Vitamin D deficiency, Cognition, Synaptic plasticity, Gut microbiota, Electrophysiology, PEA-OXA, Therapeutics. Pharmacology, RM1-950
Abstract

There is a growing evidence suggesting the association of vitamin D deficiency (VDD) and cognitive impairment. In this study we evaluated the possible involvement of gut microbiota in the cognitive impairments mediated by VDD and investigated the effects of pharmacological treatment with the oxazoline derivative of the aliamide palmitoylethanolamide, 2-Pentadecyl-2-oxazoline (PEA-OXA). Mice were submitted to behavioural, biochemical and electrophysiological analysis to assess whether their vitamin D status affected cognitive performance together with gut microbiota composition. In VDD mice we found cognitive malfunctioning associated with reduced neuroplasticity, indicated by impaired long term potentiation, and neuroinflammation at the hippocampal level. Importantly, PEA-OXA counteracted the cognitive impairments and modified the biochemical and functional changes induced by VDD. Additionally, PEA-OXA treatment enhanced gut microbiota diversity, which tended to be decreased by VDD only in female mice, elevated the relative abundance of lactic and butyric acid-producing families, i.e. Aerococcaceae and Butyricicoccaceae, and reversed the VDD-induced decrease of butyrate-producing beneficial genera, such as Blautia in female mice, and Roseburia in male mice. These data provide novel insights for a better understanding of the cognitive decline induced by VDD and related gut dysbiosis and its potential therapeutic treatment.

Published
2024
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12. Perspectives of European Patient Advocacy Groups on Volunteer Registries and Vaccine Trials: VACCELERATE Survey Study

Author

Sophia Themistocleous, Christos D Argyropoulos, Paris Vogazianos, George Shiamakkides, Evgenia Noula, Andria Nearchou, Andreas Yiallouris, Charalampos Filippou, Fiona A Stewart, Markela Koniordou, Ioannis Kopsidas, Helena H Askling, Sirkka Vene, Amandine Gagneux-Brunon, Jana Baranda Prellezo, Elena Álvarez-Barco, Jon Salmanton-García, Janina Leckler, Alan J Macken, Ruth Joanna Davis, Anna Maria Azzini, Charis Armeftis, Margot Hellemans, Romina Di Marzo, Catarina Luis, Ole F Olesen, Olena Valdenmaiier, Stine Finne Jakobsen, Pontus Nauclér, Odile Launay, Patrick Mallon, Jordi Ochando, Pierre van Damme, Evelina Tacconelli, Theoklis Zaoutis, Oliver A Cornely, and Zoi Dorothea Pana

Subjects
Public aspects of medicine, RA1-1270
Abstract

BackgroundThe VACCELERATE Pan-European Scientific network aims to strengthen the foundation of vaccine trial research across Europe by following the principles of equity, inclusion, and diversity. The VACCELERATE Volunteer Registry network provides access to vaccine trial sites across the European region and supports a sustainable volunteer platform for identifying potential participants for forthcoming vaccine clinical research. ObjectiveThe aim of this study was to approach members of patient advocacy groups (PAGs) across Europe to assess their willingness to register for the VACCELERATE Volunteer Registry and their perspectives related to participating in vaccine trials. MethodsIn an effort to understand how to increase recruitment for the VACCELERATE Volunteer Registry, a standardized survey was developed in English and translated into 8 different languages (Dutch, English, French, German, Greek, Italian, Spanish, and Swedish) by the respective National Coordinator team. The online, anonymous survey was circulated, from March 2022 to May 2022, to PAGs across 10 European countries (Belgium, Cyprus, Denmark, France, Germany, Greece, Ireland, Italy, Spain, and Sweden) to share with their members. The questionnaire constituted of multiple choice and open-ended questions evaluating information regarding participants’ perceptions on participating in vaccine trials and their willingness to become involved in the VACCELERATE Volunteer Registry. ResultsIn total, 520 responses were collected and analyzed. The PAG members reported that the principal criteria influencing their decision to participate in clinical trials overall are (1) the risks involved, (2) the benefits that will be gained from their potential participation, and (3) the quality and quantity of information provided regarding the trial. The survey revealed that, out of the 520 respondents, 133 individuals across all age groups were “positive” toward registering in the VACCELERATE Volunteer Registry, with an additional 47 individuals reporting being “very positive.” Respondents from Northern European countries were 1.725 (95% CI 1.206-2.468) times more likely to be willing to participate in the VACCELERATE Volunteer Registry than respondents from Southern European countries. ConclusionsFactors discouraging participants from joining vaccine trial registries or clinical trials primarily include concerns of the safety of novel vaccines and a lack of trust in those involved in vaccine development. These outcomes aid in identifying issues and setbacks in present registries, providing the VACCELERATE network with feedback on how to potentially increase participation and enrollment in trials across Europe. Development of European health communication strategies among diverse public communities, especially via PAGs, is the key for increasing patients’ willingness to participate in clinical studies.

Published
2024
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13. The sac evolution imaging follow-up after endovascular aortic repair: An international expert opinion-based Delphi consensus study

Author

Beck, Adam W., Hertault, Adrien, Savlania, Ajay, Froio, Alberto, Giaquinta, Alessia, Zimmermann, Alexander, Psyllas, Anastasios, Wanhainen, Anders, Marchetti, Andrea Ascoli, Queiroz, Andre Brito, Kahlberg, Andrea, Reyes-Valdivia, Andrés, Schanzer, Andres, Tambyraja, Andrew, Freyrie, Antonio, Lorido, Antonio, Millon, Antoine, Ippoliti, Arnaldo, Abai, Babak, Mees, Barend, Reutersberg, Benedikt, Maurel, Blandine, Michel, Bosiers, Wahlgren, Carl Magnus, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Raphaël, Coscas, Clair, Daniel, Dawson, David L., Arnaoutakis, Dean J., Böckler, Dittmar, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Ducasse, Eric, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Benedetto, Filippo, Speziale, Francesco, Stilo, Francesco, Álvarez-Marcos, Francisco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Lanza, Gaetano, Philipp, Geisbüsch, Geenberg, George, Jung, Georg, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Faggioli, Gianluca, de Donato, Gianmarco, Simonte, Gioele, Colacchio, Giovanni, De Caridi, Giovanni, Pratesi, Giovanni, Spinella, Giovanni, Torsello, Giovanni, Leong Tan, Glenn Wei, Magee, Gregory A., Verhagen, Hence, Andrew, Holden, Koleilat, Issam, Ohman, J. Westley, de Vries, J.P.P.M., Budtz-Lilly, Jacob, Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Orion, Kristine C., Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Hakimi, Maani, Sheahan, Malachi, Khashram, Manar, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Davies, Mark G., Czerny, Martin, Orrico, Matteo, Eagleton, Matthew J., Smeds, Matthew R., Taurino, Maurizio, Wohlauer, Max, Sharafuddin, Mel J., Anna-Leonie, Menges, Reijnen, Michel, Antonello, Michele, Piazza, Michele, Settembre, Nicla, Mouawad, Nicolas J., Tsilimparis, Nikolaos, Dias, Nuno, Martinelli, Ombretta, Frigatti, Paolo, Sirignano, Pasqualino, Chong, Patrick, Bevis, Paul, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Vriens, Patrick, Pulli, Raffaele, Bellosta, Raffaello, Micheli, Raimondo, Veeraswamy, Ravi, Cuff, Robert, Chiappa, Roberto, Gattuso, Roberto, Pini, Rodolfo, Dalman, Ronald L., Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Hofer, Simone, Yusuf, Syed W., Ronchey, Sonia, Bartoli, Stefano, Bonvini, Stefano, Camparini, Stefano, Fazzini, Stefano, Pirrelli, Stefano, Hörer, Tal, Bisdas, Theodosios, Vasudevan, Thodur, Lattmann, Thomas, Wyss, Thomas Rudolf, Maldonado, Thomas, Pfammatter, Thomas, Kölbel, Tilo, Jakimowicz, Tomasz, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Riambau, Vincent, Palazzo, Vincenzo, Makaloski, Vladimir, Von Allmen, Regula S., Dorigo, Walter, Mansour, Wassim, Van den Eynde, Wouter, Tinelli, Giovanni, D’Oria, Mario, Sica, Simona, Mani, Kevin, Rancic, Zoran, Resch, Timothy Andrew, Beccia, Flavia, Azizzadeh, Ali, Da Volta Ferreira, Marcelo Martins, Gargiulo, Mauro, Lepidi, Sandro, Tshomba, Yamume, Oderich, Gustavo S., and Haulon, Stéphan

Published
2024
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14. Plasma endocannabinoidome and fecal microbiota interplay in people with HIV and subclinical coronary artery disease: Results from the Canadian HIV and Aging Cohort Study

Author

Mboumba Bouassa, Ralph-Sydney, Giorgini, Giada, Silvestri, Cristoforo, Muller, Chanté, Nallabelli, Nayudu, Alexandrova, Yulia, Durand, Madeleine, Tremblay, Cécile, El-Far, Mohamed, Chartrand-Lefebvre, Carl, Messier-Peet, Marc, Margolese, Shari, Flamand, Nicolas, Costiniuk, Cecilia T., Di Marzo, Vincenzo, and Jenabian, Mohammad-Ali

Published
2024
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16. Editor's Choice – Outcomes of Off the Shelf Outer Branched Versus Inner Branched Endografts in the Treatment of Thoraco-Abdominal Aortic Aneurysm in the B.R.I.O. (BRanched Inner – Outer) Study Group

Author

Spertino, Andrea, Grego, Franco, Esposito, Davide, Bastianon, Martina, Lenti, Massimo, Isernia, Giacomo, Ferrer, Ciro, Piffaretti, Gabriele, Mauri, Francesca, Mezzetto, Luca, Mastrorilli, Davide, Silingardi, Roberto, Leone, Nicola, Tshomba, Yamume, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Pulli, Raffaele, Fargion, Aaron, Pratesi, Carlo, Di Marzo, Luca, Di Girolamo, Alessia, Orticelli, Assunta, Michelagnoli, Stefano, Chisci, Emiliano, Fazzini, Stefano, Oddi, Fabio Massimo, Ippoliti, Arnaldo, Piazza, Michele, Squizzato, Francesco, Pratesi, Giovanni, Parlani, Gianbattista, Simonte, Gioele, Giudice, Rocco, Mansour, Wassim, Veraldi, Gian Franco, Gennai, Stefano, and Antonello, Michele

Published
2024
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17. Open Surgical Conversion of Popliteal Endograft Infection: Case Reports and Literature Review

Author

Marta Ascione, Ada Dajci, Rocco Cangiano, Antonio Marzano, Andrea Molinari, Francesca Miceli, Alessia Di Girolamo, Cristiana Leanza, Alessandra Oliva, Luca Di Marzo, and Wassim Mansour

Subjects
popliteal aneurysm, endograft infection, popliteal endograft infection, open surgical conversion, Biology (General), QH301-705.5
Abstract

Background: Endovascular treatment of popliteal aneurysms (PA) has increased in the last few years, quickly becoming the main treatment performed in many vascular centers, based on the acceptable and promising outcomes reported in the literature. However, endograft infections after endovascular popliteal aneurysm repair (EPAR) are the most dangerous complications to occur as they involve serious local compromise and usually require open surgical conversion and device explantation to preserve the affected extremity. Case report: We report two patients who were admitted to the emergency room of our hospital for pain and edema in the lower leg. Both patients had undergone exclusion of a ruptured PA a few years before by endovascular graft. CTA testing showed a significant volume of fluid-corpuscular collection related to perianeurysmal abscess collection in both cases. Blood cultures and drained material cultures were positive for Staphylococcus capitis in the first case and S. aureus in the second. Prophylactic antibiotics were administered for 10 days, then patients underwent an open surgical conversion with the complete explantation of endovascular material and a femoro-popliteal bypass using an autologous vein in the first case and a biological bovine pericardium prosthesis in the second case. The infective department of our hospital had defined a discharged specific antibiotic therapy for each patient, based on intraoperative microbiological samples. Furthermore, we have examined the literature and found six more cases described in case report articles that refer to popliteal graft infections by different microorganisms, mostly presenting acute limb ischemia as the first symptom and suggesting endograft explantation with open conversion and autologous vein bypass as the commonest therapeutic choice. Conclusions: The open surgical conversion of popliteal endograft infection is the best strategy to manage peripheral infection after an endovascular popliteal aneurysm repair procedure.

Published
2024
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18. Streamlining Tax and Administrative Document Management with AI-Powered Intelligent Document Management System

Author

Giovanna Di Marzo Serugendo, Maria Assunta Cappelli, Gilles Falquet, Claudine Métral, Assane Wade, Sami Ghadfi, Anne-Françoise Cutting-Decelle, Ashley Caselli, and Graham Cutting

Subjects
AI, administrative documents, data mapping to RDF, document classification, document management system, information extraction, Information technology, T58.5-58.64
Abstract

Organisations heavily dependent on paper documents still spend a significant amount of time managing a large volume of documents. An intelligent document management system (DMS) is presented to automate the processing of tax and administrative documents. The proposed system fills a gap in the landscape of practical tools in the field of DMS and advances the state of the art. This system represents a complex process of integrated AI-powered technologies that creates an ontology, extracts information from documents, defines profiles, maps the extracted data in RDF format, and applies inference through a reasoning engine. The DMS was designed to help all those companies that manage their clients’ tax and administrative documents daily. Automation speeds up the management process so that companies can focus more on value-added services. The system was tested in a case study that focused on the preparation of tax returns. The results demonstrated the efficacy of the system in providing document management service.

Published
2024
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19. Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication

Author

Rosaria Villano and Vincenzo Di Marzo

Subjects
organic synthesis, N-(3-acyloxyacyl)glycines, N-acyl amino acids, gut microbiota metabolites, endocannabinoidome, Organic chemistry, QD241-441
Abstract

The synthesis of some N-(3-acyloxyacyl)glycines, an interesting class of bioactive gut microbiota metabolites, is described. This procedure involves seven reaction steps using the commercially available Meldrum’s acid to obtain highly pure products, in normal or deuterated form. The key point of the synthetic strategy was the use of commendamide t-butyl ester as a synthetic intermediate, a choice that allowed the removal of the protecting group at the end of the synthetic procedure without degrading of the other ester bond present in the molecule. The developed synthetic sequence is particularly simple, uses readily available reagents and involves a limited number of purifications by chromatographic column, with a reduction in the volume of solvent and energy used.

Published
2024
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20. The Impact of the CB2 Cannabinoid Receptor in Inflammatory Diseases: An Update

Author

Volatiana Rakotoarivelo, Thomas Z. Mayer, Mélissa Simard, Nicolas Flamand, and Vincenzo Di Marzo

Subjects
inflammatory diseases, inflammation, cannabinoid, endocannabinoid, cannabinoid receptor, Organic chemistry, QD241-441
Abstract

The emergence of inflammatory diseases is a heavy burden on modern societies. Cannabis has been used for several millennia to treat inflammatory disorders such as rheumatism or gout. Since the characterization of cannabinoid receptors, CB1 and CB2, the potential of cannabinoid pharmacotherapy in inflammatory conditions has received great interest. Several studies have identified the importance of these receptors in immune cell migration and in the production of inflammatory mediators. As the presence of the CB2 receptor was documented to be more predominant in immune cells, several pharmacological agonists and antagonists have been designed to treat inflammation. To better define the potential of the CB2 receptor, three online databases, PubMed, Google Scholar and clinicaltrial.gov, were searched without language restriction. The full texts of articles presenting data on the endocannabinoid system, the CB2 receptor and its role in modulating inflammation in vitro, in animal models and in the context of clinical trials were reviewed. Finally, we discuss the clinical potential of the latest cannabinoid-based therapies in inflammatory diseases.

Published
2024
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22. Early non compliance to enhanced recovery pathway might be an alert for underlying complications following colon surgery

Author

Muratore, Andrea, Tamini, Nicolò, Beretta, Luigi, Azzola, Marco, Radrizzani, Danilo, Borghi, Felice, Missana, Giancarlo, Scatizzi, Marco, Totis, Mauro, Crespi, Michele, Bima, Carlo, Bouzari, Hedayat, Valenti, Antonio, Ceretti, Andrea Pisani, Polastri, Roberto, Longhin, Roberta, Maurizi, Angela, Cassini, Diletta, Di Marzo, Francesco, Fumagalli, Sergio, Muratori, Simone, Casati, Massimiliano, Ceresoli, Marco, Pedrazzani, Corrado, Pellegrino, Luca, Ficari, Ferdinando, and Braga, Marco

Published
2024
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23. Investigating the alterations of endocannabinoidome signaling in the human small intestine in the context of obesity and type 2 diabetes

Author

Volatiana Rakotoarivelo, Bénédicte Allam-Ndoul, Cyril Martin, Laurent Biertho, Vincenzo Di Marzo, Nicolas Flamand, and Alain Veilleux

Subjects
Obesity, Insulin resistance, Diabetes, Endocannabinoids, Monoacylglycerols (MAGs), N-Acyl-ethanolamines (NAEs), Science (General), Q1-390, Social sciences (General), H1-99
Abstract

Background: Human studies have linked obesity-related diseases, such as type-2 diabetes (T2D), to the modulation of endocannabinoid signaling. Cannabinoid CB1 and CB2 receptor activation by the endocannabinoids (eCBs) 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (AEA), both derived from arachidonic acid, play a role in homeostatic regulation. Other long chain fatty acid-derived endocannabinoid-like molecules have extended the metabolic role of this signaling system through other receptors. In this study, we aimed to assess in depth the interactions between the circulating and intestinal tone of this extended eCB system, or endocannabinoidome (eCBome), and their involvement in the pathogenesis of diabetes. Methods: Plasma and ileum samples were collected from subjects with obesity and harboring diverse degrees of insulin resistance or T2D, who underwent bariatric surgery. The levels of eCBome mediators and their congeners were then assessed by liquid chromatography coupled to tandem mass spectrometry, while gene expression was screened with qPCR arrays. Findings: Intestinal and circulating levels of eCBome mediators were higher in subjects with T2D. We found an inverse correlation between the intestinal and circulating levels of monoacylglycerols (MAGs). Additionally, we identified genes known to be implicated in both lipid metabolism and intestinal function that are altered by the context of obesity and glucose homeostasis. Interpretation: Although the impact of glucose metabolism on the eCBome remains poorly understood in subjects with advanced obesity state, our results suggest a strong causative link between altered glucose homeostasis and eCBome signaling in the intestine and the circulation.

Published
2024
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29. Elective Surgical Repair of Popliteal Artery Aneurysms with Posterior Approach vs. Endovascular Exclusion: Early and Long Term Outcomes of Multicentre PARADE Study

Author

Adami, Daniele, Andreini, Marco, Scarati, Valentina, Pulli, Raffaele, Pratesi, Carlo, Fargion, Aaron Thomas, Biancofiore, Brigida, Grego, Franco, Squizzato, Francesco, Piazza, Michele, Colacchio, Elda Chiara, Ruffino, Maria Antonella, Robaldo, Alessandro, Bertoglio, Luca, Baggi, Paolo, Verrengia, Apollonia, Ippoliti, Arnaldo, Oddi, Fabio Massimo, Ascoli Marchetti, Andrea, Di Marzo, Luca, Mansour, Wassim, Di Girolamo, Alessia, Marzano, Antonio, Kotelis, Drosos, Zielasek, Christian, Papazoglou, Dimitrios D., Perkmann, Reinhold, Pipitone, Marco D., Taurino, Maurizio, Sirignano, Pasqualino, Romano, Elisa, Lenti, Massimo, Isernia, Giacomo, Simonte, Gioele, Fino, Gianluigi, Veraldi, Gian F., Mezzetto, Luca, Angiletta, Domenico, Zacà, Sergio, Ringold, Margot, Sodero, Francesca, Pitoulias, Georgios, Chatzelas, Dimitrios A., Traina, Luca, Zenunaj, Gladiol, Khashram, Manar, Ghamri, Nusr, Lovelock, Thomas M., D’Elia, Marcello, Hamdy, Ayman, Biasi, Lukla, Sanjay, Patel, Lepidi, Sandro, D’Oria, Mario, Badalamenti, Giovanni, Ruggiero, Massimo G., Desantis, Claudio, Filippi, Federico, Anzaldi, Manfredi, Siani, Andrea, Accrocca, Federico, Gabrielli, Roberto, Bartoli, Stefano, Martelli, Massimiliano, Micheli, Raimondo, Gugliotta, Maria C., Besias, Nikolaos, Roditis, Konstantinos, Usai, Marco V., Tshomba, Yamume, Natola, Marco, Scurto, Lucia, Korosoglou, Grigorios, Schoefthaler, Christoph, Jehn, Amila, Davies, Robert, Maritati, Gabriele, Ghosh, Shantonu Kumar, Donas, Konstantinos P., Pitoulias, Apostolos G., Avranas, Konstantinos, Bafile, Gennaro, Martelli, Eugenio, Cavallo, Eduardo, Caronno, Roberto, Alberti, Aldo, Volpe, Pietro, Massara, Mafalda, Alberti, Antonino, Zappadu, Sara, Troisi, Nicola, Bertagna, Giulia, Saratzis, Athanasios, Zayed, Hany, Torsello, Giovanni B., Dorigo, Walter, Antonello, Michele, Prouse, Giorgio, Bonardelli, Stefano, and Berchiolli, Raffaella

Published
2024
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30. Urgent endovascular repair of juxtarenal/pararenal aneurysm by off-the-shelf multibranched endograft

Author

Antonello, M., Arzola, H., Austerman, M., Berekoven, B., Bertoglio, L., Bonardelli, S., Bonvini, S., Cappiello, A., Cecere, F., Chiesa, R., Dias, N., Di Marzo, L., D'Oria, M., Faggioli, G., Ferrer, C., Fontaine, V., Freyrie, A., Gallitto, E., Gargiulo, M., Giudice, R., Haulon, S., Isernia, G., Leone, N., Lepidi, S., Mani, K., Mansour, W., Melissano, G., Melloni, A., Melo, R., Mendes Pedro, L., Mezzetto, L., Mitta, N., Nana, P., Oikonou, K., Panuccio, G., Perini, P., Pini, R., Pratesi, G., Pulli, R., Piazza, M., Kahlber, A., Karelis, A., Katsargyris, A., Kolbel, T., Silingardi, R., Simonte, G., Spath, P., Squizzato, F., Tinelli, G., Torrealba, J., Tsilimparis, N., Wanhainen, A., Vacirca, A., Veraldi, G., Gallitto, Enrico, Faggioli, Gianluca, Austermann, Martin, Kölbel, Tilo, Tsilimparis, Nikolas, Dias, Nuno, Melissano, Germano, Simonte, Gioele, Katsargyris, Athanasios, Oikonomou, Kyriakos, Mani, Kevin, Pedro, Luis Mendes, Cecere, Fabrizio, Haulon, Stephan, and Gargiulo, Mauro

Published
2024
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31. Outcomes of off-the-shelf preloaded inner branch device for urgent endovascular thoraco-abdominal aortic repair in the ItaliaN Branched Registry of E-nside EnDograft

Author

Antonello, Michele, Piazza, Michele, Squizzato, Francesco, Spezia, Matteo, Grego, Franco, Pratesi, Giovanni, Spinella, Giovanni, Esposito, Davide, Bastianon, Martina, Tshomba, Yamume, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Gaggiano, Andrea, Vento, Vincenzo, Carbonari, Luciano, Gatta, Emanuele, Lenti, Massimo, Simonte, Gioele, Isernia, Giacomo, Parlani, Giambattista, Piffaretti, Gabriele, Frigatti, Paolo, Scrivere, Paola, Furlan, Federico, Veraldi, Gian Franco, Mezzetto, Luca, Gennai, Stefano, Leone, Nicola, Silingardi, Roberto, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Costantini Brancadoro, Emidio, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Compagnoni, Nicola Monzio, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Ronchey, Sonia, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Bertoglio, Luca, Volpe, Pietro, Massara, Mafalda, Milite, Domenico, and Xodo, Andrea

Published
2024
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32. Long-Term Results of Surgical Treatment for Popliteal Artery Entrapment Syndrome

Author

Wassim Mansour, Francesca Miceli, Alessia Di Girolamo, Ada Dajci, Antonio Marzano, Rocco Cangiano, Marta Ascione, and Luca di Marzo

Subjects
popliteal entrapment syndrome, duplex ultrasound, musculotendinous section, venous bypass, Medicine (General), R5-920
Abstract

Introduction: Popliteal artery entrapment syndrome (PAES) is a rare disease of the lower limbs, mainly affecting young patients, due to extrinsic compression of the neurovascular bundle at the popliteal fossa. The aim of this study was to describe our experience during a median 15-year period. Methods: Patients treated for PAES in our institution from 1979 to 2024 were included. Preoperative, intraoperative, and postoperative data were analyzed. Results: A total of 47 patients with a total of 78 limbs were treated. Duplex ultrasound with active maneuvers was performed in all limbs (100%). Angiography was performed in almost all patients (97.4%), computed tomography angiography in 56 (71.8%), and magnetic resonance angiography in 22 (28.2%). Concerning surgical treatment, musculotendinous section was performed in 60 limbs (76.9%), and autologous venous bypass was achieved in 18 limbs (23.1%). The rates for freedom from target lesion revascularization—meaning that no significant stenosis or occlusion during follow-up required revascularization—and 15-year primary patency were 92.4% and 98%, respectively. Conclusion: Long-term results of surgical treatment for PAES seem to be very satisfying. Myotomy with or without arterial reconstruction using venous bypass can lead to good patency at 15 years of follow-up.

Published
2024
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33. Computational Tool for Aircraft Fuel System Analysis

Author

Marcela A. D. Di Marzo, Pedro G. Calil, Hossein Nadali Najafabadi, Viviam Lawrence Takase, Carlos H. B. Mourão, and Jorge H. Bidinotto

Subjects
aircraft fuel systems, aircraft fuel gauging, fuel quantity estimation, sensor data simulation, fuel probe readings signals, synthetic data generation, Motor vehicles. Aeronautics. Astronautics, TL1-4050
Abstract

Fuel level gauging in aircraft presents a significant flight mechanics challenge due to the influence of aircraft movements on measurements. Moreover, it constitutes a multidimensional problem where various sensors distributed within the tank must converge to yield a precise and single measurement, independent of the aircraft’s attitude. Furthermore, fuel distribution across multiple tanks of irregular geometries complicates the readings even further. These issues critically impact safety and economy, as gauging errors may compromise flight security and lead to carrying excess weight. In response to these challenges, this research introduces a multi-stage project in aircraft fuel gauging systems, as a continuum of studies, where this first article presents a computational tool designed to simulate aircraft fuel sensor data readings as a function of fuel level, fuel tank geometry, sensor location, and aircraft attitude. Developed in an open-source environment, the tool aims to support the statistical inference required for accurate modeling in which synthetic data generation becomes a crucial component. A discretization procedure accurately maps fuel tank geometries and their mass properties. The tool, then, intersects these geometries with fuel-level planes and calculates each new volume. It integrates descriptive geometry to intersect these fuel planes with representative capacitive level-sensing probes and computes the sensor readings for the simulated flight conditions. The method is validated against geometries with analytical solutions. This process yields detailed fuel measurement responses for each sensor inside the tank, and for different analyzed fuel levels, providing insights into the sensors’ signals’ non-linear behavior at each analyzed aircraft attitude. The non-linear behavior is also influenced by the sensor saturation readings at 0 when above the fuel level and at 1 when submerged. The synthetic fuel sensor readings lay the baseline for a better understanding on how to compute the true fuel level from multiple sensor readings, and ultimately optimizing the amount of used sensors and their placement. The tool’s design offers significant improvements in aircraft fuel gauging accuracy, directly impacting aerostructures and instrumentation, and it is a key aspect of flight safety, fuel management, and navigation in aerospace technology.

Published
2024
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34. Clinical and Radiological Outcomes of Accessory Renal Artery Exclusion during Endovascular Repair of Abdominal Aortic Aneurysms

Author

Alessia Di Girolamo, Marta Ascione, Francesca Miceli, Alireza Mohseni, Chiara Pranteda, Pasqualino Sirignano, Maurizio Taurino, Luca di Marzo, and Wassim Mansour

Subjects
abdominal aortic aneurysm, endovascular aneurysm repair, accessory renal artery, embolization, renal function, Medicine (General), R5-920
Abstract

Background: Accessory renal arteries (ARAs) frequently coexist with abdominal aortic aneurysms (AAA) and can influence treatment. This study aimed to retrospectively analyze the ARA’s exclusion effect on patients undergoing standard endovascular aneurysm repair for AAA. Methods: The study focused on medium- and long-term outcomes, including type II endoleak, aneurysmal sac changes, mortality, reoperation rates, renal function, and infarction post-operatively. Results: 76 patients treated with EVAR for AAA were included. One hundred and two ARAs were identified: 69 originated from the neck, 30 from the sac, and 3 from the iliac arteries. The ARA treatment was embolization in 15 patients and coverage in 72. Technical success was 100%. One-month post-operative computed tomography angiography (CTA) revealed that 76 ARAs (74.51%) were excluded. Thirty-day complications included renal deterioration in 7 patients (9.21%) and a blood pressure increase in 15 (19.73%). During follow-up, 16 patients (21.05%) died, with three aneurysm-related deaths (3.94%). ARA-related type II endoleak (T2EL) was significantly associated with the ARA’s origin in the aneurysmatic sac. Despite reinterventions were not significantly linked to any factor, post-operative renal infarction was correlated with an ARA diameter greater than 3 mm and ARA embolization. Conclusion: ARAs can influence EVAR outcomes, with anatomical and procedural factors associated with T2EL and renal infarction. Further studies are needed to optimize the management of ARAs during EVAR.

Published
2024
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35. The Sac Evolution Imaging Follow-Up after EVAR: an international expert opinion-based Delphi consensus study

Author

Tinelli, G, D’Oria, M, Sica, S, Mani, K, Rancic, Z, Resh, T, Beccia, F, Azizzadeh, A, Da Volta Ferreira, M, Gargiulo, M, Lepidi, S, Tshomba, Y, Oderich, G, Haulon, S, Beck, A, Hertault, A, Savlania, A, Froio, A, Giaquinta, A, Zimmermann, A, Psyllas, A, Wanhainen, A, Marchetti, A, Queiroz, A, Kahlberg, A, Reyes-Valdivia, A, Schanzer, A, Edinburgh Vascular, A, Freyrie, A, Lorido, A, Millon, A, Ippoliti, A, Abai, B, Mees, B, Reutersberg, B, Maurel, B, Michel, B, Wahlgren, C, Cavazzini, C, Setacci, C, Lee, C, Ferrer, C, Bicknell, C, Raphaël, C, Clair, D, Dawson, D, Arnaoutakis, D, Böckler, D, Kotelis, D, Mujagic, E, Chisci, E, Cieri, E, Gallitto, E, Marone, E, Ducasse, E, Verzini, F, Pecoraro, F, Serracino-Inglott, F, Benedetto, F, Speziale, F, Stilo, F, Álvarez-Marcos, F, Pagliariccio, G, Piffaretti, G, Lanza, G, Philipp, G, Geenberg, G, Jung, G, Melissano, G, Veraldi, G, Parlani, G, Faggioli, G, de Donato, G, Simonte, G, Colacchio, G, De Caridi, G, Pratesi, G, Spinella, G, Torsello, G, Leong Tan, G, Magee, G, Verhagen, H, Andrew, H, Koleilat, I, Ohman, J, de Vries, J, Budtz-Lilly, J, Black, J, Eldrup-Jorgensen, J, Hockley, J, Bath, J, Sobocinski, J, van Herwaarden, J, Reinhard, K, Orion, K, Amankwah, K, Bertoglio, L, di Marzo, L, Garriboli, L, Rizzo, L, Hakimi, M, Sheahan, M, Khashram, M, Schermerhorn, M, Lescan, M, Conrad, M, Davies, M, Czerny, M, Orrico, M, Eagleton, M, Smeds, M, Taurino, M, Wohlauer, M, Sharafuddin, M, Anna-Leonie, M, Reijnen, M, Antonello, M, Piazza, M, Settembre, N, Mouawad, N, Tsilimparis, N, Dias, N, Martinelli, O, Frigatti, P, Sirignano, P, Chong, P, Bevis, P, Dimuzio, P, Henke, P, Düppers, P, Holt, P, Helmiö, P, Vriens, P, Pulli, R, Bellosta, R, Micheli, R, Veeraswamy, R, Cuff, R, Chiappa, R, Gattuso, R, Pini, R, Dalman, R, Milner, R, Scali, S, Bahia, S, Laukontaus, S, Trimarchi, S, Fernandez-Alonso, S, Deglise, S, Bellmunt-Montoya, S, Hofer, S, Yusuf, S, Ronchey, S, Bartoli, S, Bonvini, S, Camparini, S, Fazzini, S, Pirrelli, S, Hörer, T, Bisdas, T, Vasudevan, T, Lattmann, T, Wyss, T, Maldonado, T, Pfammatter, T, Kölbel, T, Jakimowicz, T, Donati, T, Tracci, M, Bracale, U, Tolva, V, Riambau, V, Palazzo, V, Makaloski, V, Regula S, V, Dorigo, W, Mansour, W, Van den Eynde, W, Tinelli, Giovanni, D’Oria, Mario, Sica, Simona, Mani, Kevin, Rancic, Zoran, Resh, Timothy Andrew, Beccia, Flavia, Azizzadeh, Ali, Da Volta Ferreira, Marcelo Martins, Gargiulo, Mauro, Lepidi, Sandro, Tshomba, Yamume, Oderich, Gustavo S., Haulon, Stephan, Beck, Adam W., Hertault, Adrien, Savlania, Ajay, Froio, Alberto, Giaquinta, Alessia, Zimmermann, Alexander, Psyllas, Anastasios, Wanhainen, Anders, Marchetti, Andrea Ascoli, Queiroz, Andre Brito, Kahlberg, Andrea, Reyes-Valdivia, Andrés, Schanzer, Andres, Edinburgh Vascular, Andrew Tambyraja, Freyrie, Antonio, Lorido, Antonio, Millon, Antoine, Ippoliti, Arnaldo, Abai, Babak, Mees, Barend, Reutersberg, Benedikt, Maurel, Blandine, Michel, Bosiers, Wahlgren, Carl Magnus, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Raphaël, Coscas, Clair, Daniel, Dawson, David L., Arnaoutakis, Dean J., Böckler, Dittmar, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Ducasse, Eric, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Benedetto, Filippo, Speziale, Francesco, Stilo, Francesco, Álvarez-Marcos, Francisco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Lanza, Gaetano, Philipp, Geisbüsch, Geenberg, George, Jung, Georg, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Faggioli, Gianluca, de Donato, Gianmarco, Simonte, Gioele, Colacchio, Giovanni, De Caridi, Giovanni, Pratesi, Giovanni, Spinella, Giovanni, Torsello, Giovanni, Leong Tan, Glenn Wei, Magee, Gregory A., Verhagen, Hence, Andrew, Holden, Koleilat, Issam, Ohman, J Westley, de Vries, J. P. P. M., Budtz-Lilly, Jacob, Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Orion, Kristine C., Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Hakimi, Maani, Sheahan, Malachi, Khashram, Manar, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Davies, Mark G., Czerny, Martin, Orrico, Matteo, Eagleton, Matthew J., Smeds, Matthew R., Taurino, Maurizio, Wohlauer, Max, Sharafuddin, Mel J., Anna-Leonie, Menges, Reijnen, Michel, Antonello, Michele, Piazza, Michele, Settembre, Nicla, Mouawad, Nicolas J., Tsilimparis, Nikolaos, Dias, Nuno, Martinelli, Ombretta, Frigatti, Paolo, Sirignano, Pasqualino, Chong, Patrick, Bevis, Paul, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Vriens, Patrick, Pulli, Raffaele, Bellosta, Raffaello, Micheli, Raimondo, Veeraswamy, Ravi, Cuff, Robert, Chiappa, Roberto, Gattuso, Roberto, Pini, Rodolfo, Dalman, Ronald L., Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Hofer, Simone, Yusuf, Syed W., Ronchey, Sonia, Bartoli, Stefano, Bonvini, Stefano, Camparini, Stefano, Fazzini, Stefano, Pirrelli, Stefano, Hörer, Tal, Bisdas, Theodosios, Vasudevan, Thodur, Lattmann, Thomas, Wyss, Thomas Rudolf, Maldonado, Thomas, Pfammatter, Thomas, Kölbel, Tilo, Jakimowicz, Tomasz, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Riambau, Vincent, Palazzo, Vincenzo, Makaloski, Vladimir, Regula S, Von Allmen, Dorigo, Walter, Mansour, Wassim, Van den Eynde, Wouter, Tinelli, G, D’Oria, M, Sica, S, Mani, K, Rancic, Z, Resh, T, Beccia, F, Azizzadeh, A, Da Volta Ferreira, M, Gargiulo, M, Lepidi, S, Tshomba, Y, Oderich, G, Haulon, S, Beck, A, Hertault, A, Savlania, A, Froio, A, Giaquinta, A, Zimmermann, A, Psyllas, A, Wanhainen, A, Marchetti, A, Queiroz, A, Kahlberg, A, Reyes-Valdivia, A, Schanzer, A, Edinburgh Vascular, A, Freyrie, A, Lorido, A, Millon, A, Ippoliti, A, Abai, B, Mees, B, Reutersberg, B, Maurel, B, Michel, B, Wahlgren, C, Cavazzini, C, Setacci, C, Lee, C, Ferrer, C, Bicknell, C, Raphaël, C, Clair, D, Dawson, D, Arnaoutakis, D, Böckler, D, Kotelis, D, Mujagic, E, Chisci, E, Cieri, E, Gallitto, E, Marone, E, Ducasse, E, Verzini, F, Pecoraro, F, Serracino-Inglott, F, Benedetto, F, Speziale, F, Stilo, F, Álvarez-Marcos, F, Pagliariccio, G, Piffaretti, G, Lanza, G, Philipp, G, Geenberg, G, Jung, G, Melissano, G, Veraldi, G, Parlani, G, Faggioli, G, de Donato, G, Simonte, G, Colacchio, G, De Caridi, G, Pratesi, G, Spinella, G, Torsello, G, Leong Tan, G, Magee, G, Verhagen, H, Andrew, H, Koleilat, I, Ohman, J, de Vries, J, Budtz-Lilly, J, Black, J, Eldrup-Jorgensen, J, Hockley, J, Bath, J, Sobocinski, J, van Herwaarden, J, Reinhard, K, Orion, K, Amankwah, K, Bertoglio, L, di Marzo, L, Garriboli, L, Rizzo, L, Hakimi, M, Sheahan, M, Khashram, M, Schermerhorn, M, Lescan, M, Conrad, M, Davies, M, Czerny, M, Orrico, M, Eagleton, M, Smeds, M, Taurino, M, Wohlauer, M, Sharafuddin, M, Anna-Leonie, M, Reijnen, M, Antonello, M, Piazza, M, Settembre, N, Mouawad, N, Tsilimparis, N, Dias, N, Martinelli, O, Frigatti, P, Sirignano, P, Chong, P, Bevis, P, Dimuzio, P, Henke, P, Düppers, P, Holt, P, Helmiö, P, Vriens, P, Pulli, R, Bellosta, R, Micheli, R, Veeraswamy, R, Cuff, R, Chiappa, R, Gattuso, R, Pini, R, Dalman, R, Milner, R, Scali, S, Bahia, S, Laukontaus, S, Trimarchi, S, Fernandez-Alonso, S, Deglise, S, Bellmunt-Montoya, S, Hofer, S, Yusuf, S, Ronchey, S, Bartoli, S, Bonvini, S, Camparini, S, Fazzini, S, Pirrelli, S, Hörer, T, Bisdas, T, Vasudevan, T, Lattmann, T, Wyss, T, Maldonado, T, Pfammatter, T, Kölbel, T, Jakimowicz, T, Donati, T, Tracci, M, Bracale, U, Tolva, V, Riambau, V, Palazzo, V, Makaloski, V, Regula S, V, Dorigo, W, Mansour, W, Van den Eynde, W, Tinelli, Giovanni, D’Oria, Mario, Sica, Simona, Mani, Kevin, Rancic, Zoran, Resh, Timothy Andrew, Beccia, Flavia, Azizzadeh, Ali, Da Volta Ferreira, Marcelo Martins, Gargiulo, Mauro, Lepidi, Sandro, Tshomba, Yamume, Oderich, Gustavo S., Haulon, Stephan, Beck, Adam W., Hertault, Adrien, Savlania, Ajay, Froio, Alberto, Giaquinta, Alessia, Zimmermann, Alexander, Psyllas, Anastasios, Wanhainen, Anders, Marchetti, Andrea Ascoli, Queiroz, Andre Brito, Kahlberg, Andrea, Reyes-Valdivia, Andrés, Schanzer, Andres, Edinburgh Vascular, Andrew Tambyraja, Freyrie, Antonio, Lorido, Antonio, Millon, Antoine, Ippoliti, Arnaldo, Abai, Babak, Mees, Barend, Reutersberg, Benedikt, Maurel, Blandine, Michel, Bosiers, Wahlgren, Carl Magnus, Cavazzini, Carlo, Setacci, Carlo, Lee, Cheong Jun, Ferrer, Ciro, Bicknell, Colin, Raphaël, Coscas, Clair, Daniel, Dawson, David L., Arnaoutakis, Dean J., Böckler, Dittmar, Kotelis, Drosos, Mujagic, Edin, Chisci, Emiliano, Cieri, Enrico, Gallitto, Enrico, Marone, Enrico Maria, Ducasse, Eric, Verzini, Fabio, Pecoraro, Felice, Serracino-Inglott, Ferdinand, Benedetto, Filippo, Speziale, Francesco, Stilo, Francesco, Álvarez-Marcos, Francisco, Pagliariccio, Gabriele, Piffaretti, Gabriele, Lanza, Gaetano, Philipp, Geisbüsch, Geenberg, George, Jung, Georg, Melissano, Germano, Veraldi, Gian Franco, Parlani, Gianbattista, Faggioli, Gianluca, de Donato, Gianmarco, Simonte, Gioele, Colacchio, Giovanni, De Caridi, Giovanni, Pratesi, Giovanni, Spinella, Giovanni, Torsello, Giovanni, Leong Tan, Glenn Wei, Magee, Gregory A., Verhagen, Hence, Andrew, Holden, Koleilat, Issam, Ohman, J Westley, de Vries, J. P. P. M., Budtz-Lilly, Jacob, Black, James, Eldrup-Jorgensen, Jens, Hockley, Joe, Bath, Jonathan, Sobocinski, Jonathan, van Herwaarden, Joost A., Reinhard, Kopp, Orion, Kristine C., Amankwah, Kwame, Bertoglio, Luca, di Marzo, Luca, Garriboli, Luca, Rizzo, Luigi, Hakimi, Maani, Sheahan, Malachi, Khashram, Manar, Schermerhorn, Marc, Lescan, Mario, Conrad, Mark, Davies, Mark G., Czerny, Martin, Orrico, Matteo, Eagleton, Matthew J., Smeds, Matthew R., Taurino, Maurizio, Wohlauer, Max, Sharafuddin, Mel J., Anna-Leonie, Menges, Reijnen, Michel, Antonello, Michele, Piazza, Michele, Settembre, Nicla, Mouawad, Nicolas J., Tsilimparis, Nikolaos, Dias, Nuno, Martinelli, Ombretta, Frigatti, Paolo, Sirignano, Pasqualino, Chong, Patrick, Bevis, Paul, DiMuzio, Paul, Henke, Peter, Düppers, Philip, Holt, Peter, Helmiö, Päivi, Vriens, Patrick, Pulli, Raffaele, Bellosta, Raffaello, Micheli, Raimondo, Veeraswamy, Ravi, Cuff, Robert, Chiappa, Roberto, Gattuso, Roberto, Pini, Rodolfo, Dalman, Ronald L., Milner, Ross, Scali, Salvatore T., Bahia, Sandeep, Laukontaus, Sani, Trimarchi, Santi, Fernandez-Alonso, Sebastian, Deglise, Sebastien, Bellmunt-Montoya, Sergi, Hofer, Simone, Yusuf, Syed W., Ronchey, Sonia, Bartoli, Stefano, Bonvini, Stefano, Camparini, Stefano, Fazzini, Stefano, Pirrelli, Stefano, Hörer, Tal, Bisdas, Theodosios, Vasudevan, Thodur, Lattmann, Thomas, Wyss, Thomas Rudolf, Maldonado, Thomas, Pfammatter, Thomas, Kölbel, Tilo, Jakimowicz, Tomasz, Donati, Tommaso, Tracci, Margaret, Bracale, Umberto Marcello, Tolva, Valerio Stefano, Riambau, Vincent, Palazzo, Vincenzo, Makaloski, Vladimir, Regula S, Von Allmen, Dorigo, Walter, Mansour, Wassim, and Van den Eynde, Wouter

Abstract

Objective: Management of follow-up protocols after endovascular aortic repair (EVAR), vary significantly between centres and is not standardized according to the sac regression. By designing an international expert-based Delphi consensus, the study aimed to create recommendations on follow-up after EVAR according to sac evolution. Methods: Eight facilitators created appropriate statements regarding the study topic that were voted, using a 4-point Likert scale, by a selected panel of international experts using a three-round modified Delphi consensus process. Based on the experts' responses, only those statements reaching a Grade A (full agreement ≥75%) or B (overall agreement ≥80% and full disagreement <5%) were included in the final document. Results: One-hundred and seventy-four participants were included in the final analysis, and each voted the initial 29 statements related to the definition of sac regression (Q1-Q9), EVAR follow-up (Q10-Q14), and the assessment and role of sac regression during follow-up (Q15-Q29). At the end of the process, 2 statements (6.9%) were rejected, 9 statements (31%) received a grade B consensus strength, and 18 (62.1%) reached a grade A consensus strength. Out of twenty-seven final statements, fifteen statements (55.6%) were classified as grade I, while twelve (44.4%) were classified as grade II. Experts agreed that sac regression should be considered an important indicator of EVAR success and always be assessed during follow-up after EVAR. Conclusions: Based on the elevated strength and high consistency of this international expert-based Delphi consensus, most of the statements might guide current clinical management of follow-up after EVAR according to the sac regression. Future studies are needed to clarify debated issues.

Published
2024

36. Effect of centre volume on pathological outcomes and postoperative complications after surgery for colorectal cancer: results of a multicentre national study

Author

Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, Palisi, M, Danese, F, Cherubini, V, Perotti, S, Carvello, M, Carbone, F, Luberto, A, Calafiore, E, De Lucia, F, Sacchi, M, Sasia, D, Giuffrida, M, Ballauri, E, Cardile, M, Armentano, S, Beltrami, E, Preve, G, Vercellone, B, Mozzon, M, Folliero, C, Lirusso, C, Vecchiato, M, Ziccarelli, A, Gattesco, D, Moretti, L, Crestale, S, Banchini, F, Capelli, P, Romboli, A, Palmieri, G, Conti, L, Rizzi, N, Bonfili, D, De Manzini, N, Germani, P, Osenda, E, Cortinovis, S, Giunta, C, Fracon, S, Abdallah, H, Bogoni, S, Portolani, N, Nascimbeni, R, Molfino, S, Tiberio, G, Garosio, I, Lamperti, G, Rigosa, D, Ercolani, G, Solaini, L, Cavaliere, D, Avanzolini, A, D'Acapito, F, Chiarella, L, Di Pietrantonio, D, Annunziata, D, Piccolo, R, Sorrentino, M, Pansini, M, Cojutti, A, Graziano, M, Callegari, F, Balzarotti, L, Dameno, V, Cattaneo, A, Santolamazza, G, Altieri, C, Magarini, R, Pietrabissa, A, Dominioni, T, Pugliese, L, Peri, A, Botti, M, Salvetti, F, Boni, L, Cassinotti, E, Baldari, L, Messina, V, D'Abrosca, V, Cianci, P, Tumolo, R, Gattulli, D, Restini, E, Minafra, M, Sederino, M, Bottalico, B, Pilati, P, Franzato, B, Mattara, G, De Simoni, O, Barina, A, Tonello, M, Muratore, A, Calabro, M, Federico Pipitone, N, Cuzzola, B, Van Nood, E, Passuello, N, Frasson, A, Mammano, E, Faccio, L, Vittadello, F, Bressan, A, Sarzo, G, Tamini, N, Oldani, M, Cigagna, L, Carissimi, F, De Carlo, G, Baccalini, E, Nespoli, L, Giordano, A, Cantafio, S, Grifoni, L, Matani, D, Livi, S, Delogu, D, Scognamillo, F, Marrosu, A, Guerrini, L, Ugolini, G, Ghignone, F, Frascaroli, G, Albertini, N, Zattoni, D, Taffurelli, G, Montroni, I, Colombo, F, Danelli, P, Bondurri, A, Maffioli, A, Bonomi, A, Pezzoli, I, Cammarata, F, Goletti, O, Molteni, M, Assisi, A, Quartierini, G, Da Lio, C, Verdi, D, Mondi, I, Peluso, C, Macchi, L, Tanzanu, M, Zanzi, F, Pellegrini, S, Andreuccetti, J, D'Alessio, R, Pignata, G, De Capua, M, Canfora, I, Ottaviani, L, Lepiane, P, Balla, A, De Carlo, A, Saraceno, F, Scaramuzzo, R, Guida, A, Aguzzi, D, Bellora, P, Gentilli, S, Monni, M, Nikaj, H, Cillara, N, Cannavera, A, Deserra, A, Margiani, C, Cabula, R, Dettori, M, Gramignano, G, Lezoche, G, Ortenzi, M, Orlandoni, E, Curzi, F, Vitali, F, Capomagi, P, Palmieri, M, Del Rio, P, Bonati, E, Loderer, T, Cozzani, F, Rossini, M, Agnesi, S, Capolupo, G, Caricato, M, Carannante, F, Masciana, G, Marrelli, M, Miacci, V, Lauricella, S, Tonini, V, Cervellera, M, Pisconti, S, Lozito, C, Shahu, J, Mongelli, C, Morelli, G, Sartarelli, L, Sica, G, Siragusa, L, Bagaglini, G, Franceschilli, M, Bellato, V, Fiorani, C, Taddei, A, Risaliti, M, Bartolini, I, Ringressi, M, Tirloni, L, Laface, L, Abate, E, Casati, M, Gobbi, P, Opocher, E, Mariani, N, Ceretti, A, Giovenzana, M, Giuliani, B, Sironi, M, Grossi, U, Zanus, G, Santoro, G, Brizzolari, M, De Leo, E, Novello, S, Aquilino, K, Milardi, F, Olmi, S, Uccelli, M, Bonaldi, M, Cesana, G, Bindi, M, Galleano, R, Langone, A, Botto, M, Franceschi, A, Gambino, E, Ronconi, M, Casiraghi, S, Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., Celentano V., Rottoli, M, Spinelli, A, Pellino, G, Gori, A, Calini, G, Flacco, M, Manzoli, L, Poggioli, G, Romano, A, Belvedere, A, Lanci, A, Parlanti, D, Vago, G, Pezzuto, A, Canavese, A, Dajti, G, Cardelli, S, Catalioto, C, Russo, I, Violante, T, Morezzi, D, Maurino, L, Filippone, E, Cuicchi, D, Bernante, P, Jovine, E, Lombardi, R, Masetti, M, Cipressi, C, Offi, M, Larotonda, C, Puglisi, S, Barbosa, A, Vaiana, R, Bianchi, P, Tonti, C, Codignola, C, Zorcolo, L, Restivo, A, Deidda, S, Marchetti, M, Ippolito, L, Spolverato, G, Pucciarelli, S, Marchegiani, F, Ghio, G, Zagolin, G, Glavas, D, Tomassi, M, Rosati, R, Elmore, U, Gozzini, L, Calef, R, Puccetti, F, Cossu, A, Vignali, A, Morino, M, Allaix, M, Cannata, G, Lombardi, E, Ammirati, C, Piceni, C, Buccianti, P, Balestri, R, Puccini, M, Pezzati, D, D'Ischia, R, Asta, V, Sargenti, B, Taddei, G, Bonari, F, Boni, G, Ferrero, A, Mineccia, M, Gonella, F, 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Casole, G, Ciulla, S, Terrosu, G, Calandra, S, Scarpa, E, Cherchi, V, Martinuzzo, L, Clocchiatti, L, Muschitiello, D, Romanzi, A, Vignati, B, Vannelli, A, Scolaro, R, Milanesi, M, Rossi, F, Canonico, G, Anastasi, A, Nelli, T, Barlettai, M, Fratarcangeli, R, Di Martino, C, Damigella, A, Adinolfi, E, Birindelli, A, Taglietti, L, Dester, S, Fleres, F, Cucinotta, E, Viscosi, F, Biondo, S, Badessi, G, Catarsini, N, Mazzeo, C, Rega, D, Delrio, P, Cervone, C, Aversano, A, De Franciscis, S, Di Marzo, M, Marra, B, Pace, U, Amato, A, Batistotti, P, Mina, E, Serventi, A, Lapolla, P, Mingoli, A, Sapienza, P, Brachini, G, Cirillo, B, Fiori, E, Crocetti, D, Clementi, I, Martines, G, Picciariello, A, Tomasicchio, G, Dibra, R, Trigiante, G, Rinaldi, M, Lantone, G, Porcu, A, Perra, T, Scanu, A, Feo, C, Fancellu, A, Cossu, M, Ginesu, G, Patriti, A, Coletta, D, Petrelli, F, Greco, P, Spadoni, C, Cassiani, G, Bianchini, F, Arganini, M, Bianchini, M, Perotti, B, Palmeri, M, Scabini, S, Deiana, S, Carganico, G, Pertile, D, Soriero, D, Fioravanti, E, Sperotto, B, Nardo, B, Paglione, D, Crocco, V, Doni, M, Osso, M, Perri, R, Sampietro, G, Corbellini, C, Lorusso, L, Manzo, C, Cigognini, M, Baldi, C, Palomba, G, Aprea, G, Capuano, M, Basile, R, Tutino, R, Massani, M, Marinelli, L, Canitano, N, Pilia, T, Podda, M, Pisanu, A, Murzi, V, Incani, S, Frongia, F, Esposito, G, Luglio, G, Tropeano, F, Pagano, G, Spina, E, De Simone, G, Cricri, M, Catena, F, Vallicelli, C, Zanini, N, Ronconi, D, Favi, F, Mazzucchelli, C, Convertini, G, Vincenti, L, Andriola, V, Bizzoca, C, Fabbri, N, Fazzin, M, Pesce, A, Gennari, S, Torchiaro, M, Severi, S, Frontali, A, Bracchetti, G, Granieri, S, Cotsoglou, C, Carlini, M, Lisi, G, Spoletini, D, Mastrangeli, M, Campanelli, M, Manigrasso, M, Milone, M, De Palma, G, Vertaldi, S, Chini, A, Maione, F, Marello, A, Selvaggi, F, Sciaudone, G, Selvaggi, L, Tasselli, F, Fuschillo, G, Oddis, L, Grande, S, Grande, M, Ascanelli, S, Chimisso, L, Aisoni, F, Rossin, E, Pepe, F, Marchetti, F, Picardi, B, Rossi, S, Del Monte, S, Picarelli, M, Muttillo, I, Ratto, C, Marra, A, Parello, A, Litta, F, Campenni, P, De Simone, V, Pata, F, Riboni, C, Rausa, E, Celentano, V, Rottoli M., Spinelli A., Pellino G., Gori A., Calini G., Flacco M. E., Manzoli L., Poggioli G., Romano A., Belvedere A., Lanci A. L., Parlanti D., Vago G., Pezzuto A. P., Canavese A., Dajti G., Cardelli S., Catalioto C., Russo I. S., Violante T., Morezzi D., Maurino L., Filippone E., Cuicchi D., Bernante P., Jovine E., Lombardi R., Masetti M., Cipressi C., Offi M. F., Larotonda C., Puglisi S. B., Barbosa A., Vaiana R., Bianchi P. M., Tonti C., Codignola C., Zorcolo L., Restivo A., Deidda S., Marchetti M. E., Ippolito L., Spolverato G., Pucciarelli S., Marchegiani F., Ghio G., Zagolin G., Glavas D., Tomassi M., Rosati R., Elmore U., Gozzini L., Calef R., Puccetti F., Cossu A., Vignali A., Morino M., Allaix M. E., Cannata G., Lombardi E., Ammirati C. A., Piceni C., Buccianti P., Balestri R., Puccini M., Pezzati D., D'Ischia R., Asta V. F., Sargenti B., Taddei G., Bonari F., Boni G., Ferrero A., Mineccia M., Gonella F., Palisi M., Danese F., Cherubini V., Perotti S., Carvello M., Carbone F., Luberto A., Calafiore E., De Lucia F., Sacchi M., Sasia D., Giuffrida M. C., Ballauri E., Cardile M., Armentano S., Beltrami E., Preve G., Vercellone B., Mozzon M., Folliero C., Lirusso C., Vecchiato M., Ziccarelli A., Gattesco D., Moretti L., Crestale S., Banchini F., Capelli P., Romboli A., Palmieri G., Conti L., Rizzi N., Bonfili D., De Manzini N., Germani P., Osenda E., Cortinovis S., Giunta C., Fracon S., Abdallah H., Bogoni S., Portolani N., Nascimbeni R., Molfino S., Tiberio G. A. M., Garosio I., Lamperti G., Rigosa D., Ercolani G., Solaini L., Cavaliere D., Avanzolini A., D'Acapito F., Chiarella L. L., Di Pietrantonio D., Annunziata D., Piccolo R., Sorrentino M., Pansini M., Cojutti A., Graziano M., Callegari F., Balzarotti L., Dameno V. R., Cattaneo A., Santolamazza G., Altieri C., Magarini R., Pietrabissa A., Dominioni T., Pugliese L., Peri A., Botti M., Salvetti F., Boni L., Cassinotti E., Baldari L., Messina V., D'Abrosca V., Cianci P., Tumolo R., Gattulli D., Restini E., Minafra M., Sederino M. G., Bottalico B., Pilati P., Franzato B., Mattara G., De Simoni O., Barina A., Tonello M., Muratore A., Calabro M., Federico Pipitone N. S., Cuzzola B., Van Nood E. H., Passuello N., Frasson A., Mammano E., Faccio L., Vittadello F., Bressan A., Sarzo G., Tamini N., Oldani M., Cigagna L., Carissimi F., De Carlo G., Baccalini E., Nespoli L., Giordano A., Cantafio S., Grifoni L., Matani D., Livi S., Delogu D., Scognamillo F., Marrosu A., Guerrini L., Ugolini G., Ghignone F., Frascaroli G., Albertini N., Zattoni D., Taffurelli G., Montroni I., Colombo F., Danelli P., Bondurri A., Maffioli A., Bonomi A., Pezzoli I., Cammarata F., Goletti O., Molteni M., Assisi A., Quartierini G., Da Lio C., Verdi D., Mondi I., Peluso C., MacChi L., Tanzanu M., Zanzi F., Pellegrini S., Andreuccetti J., D'Alessio R., Pignata G., De Capua M., Canfora I., Ottaviani L., Lepiane P., Balla A., De Carlo A., Saraceno F., Scaramuzzo R., Guida A., Aguzzi D., Bellora P., Gentilli S., Monni M., Nikaj H., Cillara N., Cannavera A., Deserra A., Margiani C., Cabula R., Dettori M., Gramignano G., Lezoche G., Ortenzi M., Orlandoni E. S., Curzi F., Vitali F., Capomagi P., Palmieri M., Giuffrida M., Del Rio P., Bonati E., Loderer T., Cozzani F., Rossini M., Agnesi S., Capolupo G. T., Caricato M., Carannante F., Masciana G., Marrelli M., Miacci V., Lauricella S., Tonini V., Cervellera M., Pisconti S., Lozito C., Shahu J., Mongelli C., Morelli G., Sartarelli L., Sica G. S., Siragusa L., Bagaglini G., Guida A. M., Franceschilli M., Bellato V., Fiorani C., Taddei A., Risaliti M., Bartolini I., Ringressi M. N., Tirloni L., Laface L., Abate E., Casati M., Gobbi P., Opocher E., Mariani N. M., Ceretti A. P., Giovenzana M., Giuliani B., Sironi M., Grossi U., Zanus G., Santoro G. A., Brizzolari M., De Leo E., Novello S., Aquilino K., Milardi F., Olmi S., Uccelli M., Bonaldi M., Cesana G. C., Bindi M., Galleano R., Langone A., Botto M., Franceschi A., Gambino E., Ronconi M., Casiraghi S., Casole G., Ciulla S. L., Terrosu G., Calandra S., Scarpa E., Cherchi V., Martinuzzo L., Clocchiatti L., Muschitiello D., Romanzi A., Vignati B., Vannelli A., Scolaro R., Milanesi M., Rossi F., Canonico G., Anastasi A., Nelli T., Barlettai M., Fratarcangeli R., Di Martino C., Damigella A., Adinolfi E., Birindelli A., Taglietti L., Dester S. E., Fleres F., Cucinotta E., Viscosi F., Biondo S. A., Badessi G., Catarsini N., Mazzeo C., Rega D., Delrio P., Cervone C., Aversano A., De Franciscis S., Di Marzo M., Marra B., Pace U., Amato A., Batistotti P., Mina E., Serventi A., Lapolla P., Mingoli A., Sapienza P., Brachini G., Cirillo B., Fiori E., Crocetti D., Clementi I., Martines G., Picciariello A., Tomasicchio G., Dibra R., Trigiante G., Rinaldi M., Lantone G., Porcu A., Perra T., Scanu A. M., Feo C. F., Fancellu A., Cossu M. L., Ginesu G. C., Patriti A., Coletta D., Petrelli F., Greco P. A., Spadoni C., Cassiani G., Bianchini F., Arganini M., Bianchini M., Perotti B., Palmeri M., Scabini S., Deiana S., Carganico G., Pertile D., Soriero D., Fioravanti E., Sperotto B., Nardo B., Paglione D., Crocco V., Doni M., Osso M., Perri R., Sampietro G. M., Corbellini C., Lorusso L., Manzo C. A., Cigognini M., Baldi C., Palomba G., Aprea G., Capuano M., Basile R., Tutino R., Massani M., Marinelli L., Canitano N., Pilia T., Podda M., Pisanu A., Murzi V., Incani S., Frongia F., Esposito G., Luglio G., Tropeano F. P., Pagano G., Spina E., De Simone G., Cricri M., Catena F., Vallicelli C., Zanini N., Ronconi D., Favi F., Mazzucchelli C., Convertini G., Vincenti L., Andriola V., Bizzoca C., Feo C. V., Fabbri N., Fazzin M., Pesce A., Gennari S., Torchiaro M., Severi S., Frontali A., Bracchetti G., Granieri S., Cotsoglou C., Carlini M., Lisi G., Spoletini D., Mastrangeli M. R., Campanelli M., Manigrasso M., Milone M., De Palma G. D., Vertaldi S., Chini A., Maione F., Marello A., Selvaggi F., Sciaudone G., Selvaggi L., Tasselli F. M., Fuschillo G., Oddis L., Grande S., Grande M., Ascanelli S., Chimisso L., Aisoni F., Rossin E., Pepe F., Marchetti F., Picardi B., Rossi S., Del Monte S. R., Picarelli M., Muttillo I. A., Ratto C., Marra A. A., Parello A., Litta F., Campenni P., De Simone V., Pata F., Riboni C., Rausa E., and Celentano V.

Abstract

Background: The association between volume, complications and pathological outcomes is still under debate regarding colorectal cancer surgery. The aim of the study was to assess the association between centre volume and severe complications, mortality, less-than-radical oncologic surgery, and indications for neoadjuvant therapy. Methods: Retrospective analysis of 16,883 colorectal cancer cases from 80 centres (2018-2021). Outcomes: 30-day mortality; Clavien-Dindo grade >2 complications; removal of ≥ 12 lymph nodes; non-radical resection; neoadjuvant therapy. Quartiles of hospital volumes were classified as LOW, MEDIUM, HIGH, and VERY HIGH. Independent predictors, both overall and for rectal cancer, were evaluated using logistic regression including age, gender, AJCC stage and cancer site. Results: LOW-volume centres reported a higher rate of severe postoperative complications (OR 1.50, 95% c.i. 1.15-1.096, P = 0.003). The rate of ≥ 12 lymph nodes removed in LOW-volume (OR 0.68, 95% c.i. 0.56-0.85, P < 0.001) and MEDIUM-volume (OR 0.72, 95% c.i. 0.62-0.83, P < 0.001) centres was lower than in VERY HIGH-volume centres. Of the 4676 rectal cancer patients, the rate of ≥ 12 lymph nodes removed was lower in LOW-volume than in VERY HIGH-volume centres (OR 0.57, 95% c.i. 0.41-0.80, P = 0.001). A lower rate of neoadjuvant chemoradiation was associated with HIGH (OR 0.66, 95% c.i. 0.56-0.77, P < 0.001), MEDIUM (OR 0.75, 95% c.i. 0.60-0.92, P = 0.006), and LOW (OR 0.70, 95% c.i. 0.52-0.94, P = 0.019) volume centres (vs. VERY HIGH). Conclusion: Colorectal cancer surgery in low-volume centres is at higher risk of suboptimal management, poor postoperative outcomes, and less-than-adequate oncologic resections. Centralisation of rectal cancer cases should be taken into consideration to optimise the outcomes.

Published
2024

37. State of Agricultural E-Government Services to Farmers in Tanzania: Toward the Participatory Design of a Farmers Digital Information System (FDIS)

Author

Gilbert Exaud Mushi, Pierre-Yves Burgi, and Giovanna Di Marzo Serugendo

Subjects
agriculture, e-Government services, ICT services, sustainable agriculture, Farmers Digital Information System (FDIS), Tanzania, Agriculture (General), S1-972
Abstract

The projected population increase and drastic climate changes are a great setback to food security through sustainable agriculture. However, governments need to play key roles in supporting the agriculture sector, which creates considerable employment and contributions to most countries’ Gross Domestic Product (GDP) outcomes. In many countries, the governments already support the agriculture sector with services based on Information and Communication Technology (ICT) to reach many stakeholders, including smallholder farmers. This paper investigated the status of e-Government services in the agriculture sector for farmers in order to understand the functions and scope of e-services, the challenges faced by farmers, both addressed and unaddressed, and the challenges of ICT-based services for farmers and other stakeholders in Tanzania. We used a qualitative research approach to interview the Ministry of Agriculture, farmers, extension workers, and agriculture processing industries. The main finding reveals that e-government services play a major role in the agriculture sector in Tanzania. Our results show that the pre-existing ICT services identified for farmers cannot meet the needs of farmers in a complete farming cycle. Moreover, lack of awareness, digital illiteracy, and poor infrastructure are the major challenges faced by farmers and other stakeholders when it comes to ICT-based services. These results justify the need for a comprehensive digital platform, particularly the proposed Farmers Digital Information System (FDIS) to enable farmers and other stakeholders to access essential services in a complete farming cycle for a more sustainable agriculture.

Published
2024
Full Text
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38. Divertor Tokamak Test facility project: status of design and implementation

Author

Francesco Romanelli, on behalf of DTT Contributors, D. Abate, E. Acampora, D. Agguiaro, R. Agnello, P. Agostinetti, M. Agostini, A. Aimetta, R. Albanese, G. Alberti, M. Albino, E. Alessi, S. Almaviva, M. Alonzo, R. Ambrosino, P. Andreoli, M. Angelone, M. Angelucci, C. Angioni, A. Angrisani Armenio, P. Antonini, D. Aprile, G. Apruzzese, M. Aquilini, G. Aragone, P. Arena, M. Ariola, G. Artaserse, L. Aucone, A. Augieri, F. Auriemma, J. Ayllon Guerola, N. Badodi, B. Baiocchi, L. Balbinot, C. Baldacchini, A. Balestri, T. Barberis, G. Barone, L. Barucca, M. Baruzzo, S. Begozzi, V. Belardi, F. Belli, A. Belpane, F. Beone, S. Bertolami, S. Bianucci, S. Bifaretti, S. Bigioni, W. Bin, P. Boccali, B. Boeswirth, E. Bogazzi, R. Bojoi, S. Bollanti, T. Bolzonella, F. Bombarda, M. Bonan, N. Bonanomi, A. Bonaventura, L. Boncagni, M. Bonesso, D. Bonfiglio, R. Bonifetto, D. Bonomi, D. Borgogno, T. Borzone, S. Botti, E. Boz, F. Braghin, M. Brena, S. Brezinsek, M. Brombin, A. Bruschi, S. Buonocore, P. Buratti, D. Busi, G. Calabrò, M. Caldora, G. Calvo, G. Camera, G. Campana, S. Candela, V. Candela, F. Cani, L. Cantone, F. Capaldo, S. Cappello, M. Caponero, S. Carchella, A. Cardinali, D. Carnevale, L. Carraro, C. Carrelli, V. Casalegno, I. Casiraghi, C. Castaldo, A. Castaldo, G. Castro, A. Carpignano, F. Causa, R. Cavazzana, M. Cavedon, M. Cavenago, M. Cecchini, S. Ceccuzzi, G. Celentano, L. Celona, C. Centioli, G.V. Centomani, S. Cesaroni, A.G. Chiariello, R. Chomicz, C. Cianfarani, F. Cichocki, M. Cinque, A. Cioffi, M. Ciotti, M. Cipriani, S. Ciufo, V. Claps, G. Claps, V. Coccorese, D. Coccorese, A. Colangeli, T. Coltella, F. Consoli, F. Cordella, D. Corradini, O. Costa, F. Crea, A. Cremona, F. Crescenzi, F. Crisanti, G. Cristofari, G. Croci, A. Cucchiaro, D. D’Ambrosio, M. Dal Molin, M. Dalla Palma, F. Danè, C. Day, M. De Angeli, V. De Leo, R. De Luca, E. De Marchi, G. De Marzi, G. De Masi, E. De Nardi, C. De Piccoli, G. De Sano, M. De Santis, G. De Tommasi, A. Del Nevo, A. Delfino, A. Della Corte, P. Deodati, S. Desiderati, E. Di Ferdinando, M.G. Di Florio, G. Di Gironimo, L.E. Di Grazia, V. Di Marzo, F. Di Paolo, E. Di Pietro, M. Di Pietrantonio, M. Di Prinzio, A. Di Silvestre, A. Di Zenobio, R. Dima, A. Domenichelli, A. Doria, G. Dose, S. Dubbioso, S. Dulla, I. Duran, M. Eboli, M. Elitropi, E. Emanuelli, B. Esposito, P. Ettorre, C. Fabbri, F. Fabbri, M. Fadone, M.M. Faggiano, F. Falcioni, M.V. Falessi, F. Fanale, P. Fanelli, A. Fassina, M. Favaretto, G. Favero, M. Ferraris, F. Ferrazza, C. Ferretti, A. Ferro, N. Ferron, C. Fiamozzi Zignani, L. Figini, F. Filippi, M. Filippini, A. Fimiani, M. Fincato, F. Fiorenza, D. Fiorucci, D. Flammini, F. Flora, N. Fonnesu, P. Franz, L. Frassinetti, A. Frattolillo, R. Freda, R. Fresa, A. Frescura, P. Frosi, M. Fulici, M. Furno Palumbo, V. Fusco, P. Fusco, L. Gabellier, P. Gaetani, E. Gaio, E. Gajetti, A. Galatà, J. Galdon Quiroga, D.L. Galindo Huertas, S. Gammino, G. Gandolfo, S. Garavaglia, J. Garcia Lopez, M. Garcia Muñoz, P. Gaudio, M. Gelfusa, G. Gervasini, L. Giannini, M. Giarrusso, C. Gil, F. Giorgetti, E. Giovannozzi, G. Giruzzi, L. Giudicotti, M. Gobbin, G. Gorini, G. Granucci, D. Grasso, T. Grasso, S. Grazioso, H. Greuner, G. Griva, G. Grosso, S. Guerini, J.P. Gunn, V. Hauer, J. Hidalgo Salaverri, M. Hoppe, M. Houry, M. Hoelzl, A. Iaboni, M. Iafrati, A. Iaiunese, V. Imbriani, D. Indrigo, P. Innocente, F. Koechl, B. Končar, A. Kryzhanovskyy, L. Laguardia, D.A. Lampasi, C. Lanchi, F. Lanzotti, A. Lanzotti, M. Laquaniti, F. Leone, J. Li, M. Libè, F. Lisanti, D. Liuzza, F. Locati, R. Lombroni, R. Lorenzini, P. Lorusso, L. Lotto, J. Loureiro, F. Lucca, T. Luda Di Cortemiglia, P. Maccari, G. Maddaluno, S. Magagnino, G. Manca, A. Mancini, P. Mandalà, B. Mandolesi, F. Mandrile, G. Manduchi, S. Manfrin, M. Manganelli, P. Mantica, G. Marchiori, N. Marconato, G. Marelli, A. Mariani, A. Marin, R. Marinari, M. Marinelli, F. Marino, P. Marino, D. Marocco, R. Marsilio, E. Martelli, P. Martin, F. Martinelli, G. Martini, R. Martone, A. Marucci, D. Marzullo, V. Masala, D. Mascali, F. Mascari, A. Masi, N. Massanova, S. Mastrostefano, M. Mattei, G. Mauro, S. Mauro, C. Meineri, L. Melaragni, A. Mele, P. Meller, S. Meloni, I. Menicucci, G. Messina, L. Mezi, G. Miccichè, M. Micheletti, S. Migliori, D. Milanesio, F. Milazzo, R. Milazzo, P. Minelli, S. Minucci, F. Mirizzi, M. Missirlian, D. Monarca, C. Monti, M. Mori, A. Moriani, L. Morici, A. Moro, F. Moro, P. Mosetti, R. Mozzillo, A. Murari, A. Muraro, D. Murra, P. Muscente, S. Musumeci, L. Muzzi, G.F. Nallo, F. Napoli, E. Nardon, E. Naselli, R. Neu, M. Nocente, M. Notazio, S. Nowak, E. Ocello, A. Oliva, V. Orsetti, A. Orsini, F.P. Orsitto, M. Ortino, M. Ottavi, G. Paccagnella, D. Pacella, I. Pagani, N. Paganucci, A. Pagliaro, V. Palazzolo, M. Palermo, S. Palomba, F. Panza, D. Paoletti, M. Parisi, R. Pasqualotto, S. Passarello, M. Passoni, T. Patton, L. Pelliccia, A. Peloso, A. Pepato, E. Perelli, A. Perencin, S. Peruzzo, A. Pesenti, N. Pedroni, P. Petrolini, V. Piergotti, A. Pidatella, L. Pigatto, M. Pillon, T. Pinna, S. Pipolo, S. Piras, C. Piron, L. Piron, A. Pironti, M. Pistilli, D. Placido, A. Pizzuto, P. Platania, A. Polimadei, F. Pollastrone, G.M. Polli, N. Pomaro, F. Pompili, C. Ponti, F. Porcelli, V. Prandelli, A. Previti, A. Princiotta, G. Pucino, F. Quaglia, A. Quercia, F. Raffaelli, G. Ramogida, G. Ranieri, B. Raspante, D. Ravarotto, G.L. Ravera, A. Reale, P. Rebesan, M. Recchia, D. Regine, F. Renno, B. Riccardi, D. Ricci, D. Rigamonti, M. Ripani, N. Rispoli, S. Roccella, G. Rocchi, H. Roche, M. Romanato, F. Romanelli, G. Romanelli, R. Romaniello, A. Romano, M. Romano, R. Romano, R. Rossi, G. Rubinacci, G. Rubino, S. Rubino, J. Rueda Rueda, A. Rufoloni, C. Salvia, P. Salvini, M. Scarpari, A. Salvitti, L. Salvò, S. Sandri, F. Santoro, A. Satriano, L. Savoldi, C. Scardino, G. Schettini, S. Schmuck, J. Scionti, M. Scisciò, M. Scungio, K. Sedlak, L. Senni, G. Sias, A. Sibio, A. Simonetto, L. Singh, A. Sirignano, C. Sozzi, I. Spada, S. Spagnolo, L. Spinicci, G. Spizzo, M. Spolaore, C. Stefanini, H. Strobel, F. Subba, F. Taccogna, B. Taheri, C. Tantos, A. Tarallo, M. Tarantino, G. Tardini, M. Tardocchi, P. Tarfila, A. Tenaglia, C. Terlizzi, D. Terranova, D. Testa, E. Testa, R. Testoni, V. Toigo, G. Torrisi, A. Trotta, G. Trovato, E. Tsitrone, A. Tuccillo, O. Tudisco, M. Turcato, S. Turtù, A. Uccello, M. Ugoletti, O. Uras, M. Uras, M. Utili, V. Vaccaro, F. Valentini, L. Valletti, M. Valisa, D. Van Eester, D. Vanzan, E. Vassallo, G. Vecchi, M. Vellucci, I. Venneri, G. Ventura, M. Veranda, L. Verdini, C. Verona, G. Verona Rinati, F. Veronese, N. Vianello, F. Viganò, O. Villano, R. Villari, F. Villone, P. Vincenzi, V. Vitale, F. Vivio, G. Vlad, M. Wischmeier, H.S. Wu, I. Wyss, R. Zanino, B. Zaniol, F. Zanon, A. Zappatore, G. Zavarise, P. Zito, A. Zoppoli, M. Zucchetti, M. Zuin, and P. Zumbolo

Subjects
divertor, exhaust, plasma scenarios, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

An overview is presented of the progress since 2021 in the construction and scientific programme preparation of the Divertor Tokamak Test (DTT) facility. Licensing for building construction has been granted at the end of 2021. Licensing for Cat. A radiologic source has been also granted in 2022. The construction of the toroidal field magnet system is progressing. The prototype of the 170 GHz gyrotron has been produced and it is now under test on the FALCON facility. The design of the vacuum vessel, the poloidal field coils and the civil infrastructures has been completed. The shape of the first DTT divertor has been agreed with EUROfusion to test different plasma and exhaust scenarios: single null, double null, X-divertor and negative triangularity plasmas. A detailed research plan is being elaborated with the involvement of the EUROfusion laboratories.

Published
2024
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39. Effect of a Probiotic Beverage Enriched with Cricket Proteins on the Gut Microbiota: Composition of Gut and Correlation with Nutritional Parameters

Author

Chaima Dridi, Mathieu Millette, Stephane Salmieri, Blanca R. Aguilar Uscanga, Sebastien Lacroix, Tommaso Venneri, Elham Sarmast, Zahra Allahdad, Vincenzo Di Marzo, Cristoforo Silvestri, and Monique Lacroix

Subjects
cricket protein hydrolysates, probiotics, gut microbiota, nutritional quality, metagenomics, Chemical technology, TP1-1185
Abstract

The health and balance of the gut microbiota are known to be linked to diet composition and source, with fermented products and dietary proteins potentially providing an exceptional advantage for the gut. The purpose of this study was to evaluate the effect of protein hydrolysis, using a probiotic beverage enriched with either cricket protein (CP) or cricket protein hydrolysates (CP.Hs), on the composition of the gut microbiota of rats. Taxonomic characterization of the gut microbiota in fecal samples was carried out after a 14-day nutritional study to identify modifications induced by a CP- and CP.H-enriched fermented probiotic product. The results showed no significant differences (p > 0.05) in the diversity and richness of the gut microbiota among the groups fed with casein (positive control), CP-enriched, and fermented CP.H-enriched probiotic beverages; however, the overall composition of the microbiota was altered, with significant modifications in the relative abundance of several bacterial families and genera. In addition, fermented CP.H-enriched probiotic beverages could be related to the decrease in the number of potential pathogens such as Enterococcaceae. The association of gut microbiota with the nutritional parameters was determined and the results showed that digestibility and the protein efficiency ratio (PER) were highly associated with the abundance of several taxa.

Published
2024
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40. High-Grade Infection after Branched Endovascular Aortic Repair in Patient with Recent COVID-19 Hospitalization

Author

Alireza Mohseni, Alessia Di Girolamo, Rocco Cangiano, Marta Ascione, Luca di Marzo, and Wassim Mansour

Subjects
COVID-19, thoracoabdominal aortic aneurysm, post-intervention complications, bacterial superinfection, Medicine (General), R5-920
Abstract

In the context of the COVID-19 pandemic, the global healthcare landscape has undergone significant transformations, particularly impacting the management of complex medical conditions such as aortic aneurysms. This study focuses on a 76-year-old female patient with a history of extensive cardiovascular surgeries, including aortic valve replacement, Bentall operation, and Frozen Elephant Trunk procedure, who presented with a type II thoracoabdominal aortic aneurysm post-COVID-19 recovery. A comprehensive frailty assessment using the Modified Frailty Index and a two-phase endovascular approach for aneurysm treatment, considering the patient’s frailty and complex medical history was performed. Upon successful aneurysm management, the patient’s postoperative course was complicated by COVID-19 reinfection and Enterococcus faecalis superinfection, highlighting the increased risk of bacterial superinfections and the challenges posed by antimicrobial resistance in COVID-19 patients. The study underscores the necessity of vigilant postoperative surveillance and a multidisciplinary approach in managing such complex cases, highlighting the importance of personalized care strategies, integrating cardiovascular and infectious disease management, and adapting healthcare practices to the unique challenges of the pandemic. This case contributes to the evolution of knowledge on managing aortic aneurysms in the COVID-19 era, advocating for patient-centric treatment approaches and continuous research into long-term patient outcomes.

Published
2024
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42. Gluteal Artery Access to Embolize False Lumen of Type B Aortic Dissection in Marfan Patient

Author

Dajci, Ada, primary, Mansour, Wassim, additional, Di Marzo, Luca, additional, Mohseni, Alireza, additional, Andrea, Molinari, additional, Faccenna, Federico, additional, Nardis, Pier Giorgio, additional, Di Girolamo, Alessia, additional, Marzano, Antonio, additional, Stellacci, Chiara, additional, Cece, Antonio, additional, and Ascione, Marta, additional

Published
2024
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45. Astrocytic Cannabinoid Receptor 1 Promotes Resilience by Dampening Stress-Induced Blood-Brain Barrier Alterations and Inflammation

Author

Dudek, Katarzyna Anna, primary, Paton, Sam E.J., additional, Collignon, Adeline, additional, Lebel, Manon, additional, Lavoie, Olivier, additional, Bouchard, Jonathan, additional, Kaufmann, Fernanda Neutzling, additional, Dion-Albert, Laurence, additional, Clavet-Fournier, Valerie, additional, Binder, Luisa B., additional, Manca, Claudia, additional, Flamand, Nicolas, additional, Guzman, Manuel, additional, Campbell, Matthew, additional, Turecki, Gustavo, additional, Mechawar, Naguib, additional, Lavoie-Cardinal, Flavie, additional, Silvestri, Cristoforo, additional, Di Marzo, Vincenzo, additional, and Menard, Caroline, additional

Published
2024
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48. Outcomes of Off the Shelf Outer Branched Versus Inner Branched Endografts in the Treatment of Thoraco-abdominal Aortic Aneurysm in the B.R.I.O. (BRanched Inner – Outer) Study Group

Author

Piazza, Michele, primary, Squizzato, Francesco, additional, Pratesi, Giovanni, additional, Parlani, Gianbattista, additional, Simonte, Gioele, additional, Giudice, Rocco, additional, Mansour, Wassim, additional, Veraldi, Gian Franco, additional, Gennai, Stefano, additional, Antonello, Michele, additional, Spertino, Andrea, additional, Grego, Franco, additional, Di Gregorio, Sara, additional, Lenti, Massimo, additional, Isernia, Giacomo, additional, Ferrer, Ciro, additional, Piffaretti, Gabriele, additional, Mauri, Francesca, additional, Mezzetto, Luca, additional, Mastrorilli, Davide, additional, Silingardi, Roberto, additional, Leone, Nicola, additional, Tshomba, Yamume, additional, Donati, Tommaso, additional, Sica, Simona, additional, Tinelli, Giovanni, additional, Pulli, Raffaele, additional, Fargion, Aaron, additional, Pratesi, Carlo, additional, Di Marzo, Luca, additional, Di Girolamo, Alessia, additional, Orticelli, Assunta, additional, Mechelagnoli, Stefano, additional, Chisci, Emiliano, additional, Fazzini, Stefano, additional, Oddi, Fabio Massimo, additional, and Ippoliti, Arnaldo, additional

Published
2024
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50. Computational Tool for Aircraft Fuel System Analysis

Author

Di Marzo, Marcela A. D., Calil, Pedro G., Nadali Najafabadi, Hossein, Takase, Viviam Lawrence, Mourao, Carlos H. B., Bidinotto, Jorge H., Di Marzo, Marcela A. D., Calil, Pedro G., Nadali Najafabadi, Hossein, Takase, Viviam Lawrence, Mourao, Carlos H. B., and Bidinotto, Jorge H.

Abstract

Fuel level gauging in aircraft presents a significant flight mechanics challenge due to the influence of aircraft movements on measurements. Moreover, it constitutes a multidimensional problem where various sensors distributed within the tank must converge to yield a precise and single measurement, independent of the aircraft's attitude. Furthermore, fuel distribution across multiple tanks of irregular geometries complicates the readings even further. These issues critically impact safety and economy, as gauging errors may compromise flight security and lead to carrying excess weight. In response to these challenges, this research introduces a multi-stage project in aircraft fuel gauging systems, as a continuum of studies, where this first article presents a computational tool designed to simulate aircraft fuel sensor data readings as a function of fuel level, fuel tank geometry, sensor location, and aircraft attitude. Developed in an open-source environment, the tool aims to support the statistical inference required for accurate modeling in which synthetic data generation becomes a crucial component. A discretization procedure accurately maps fuel tank geometries and their mass properties. The tool, then, intersects these geometries with fuel-level planes and calculates each new volume. It integrates descriptive geometry to intersect these fuel planes with representative capacitive level-sensing probes and computes the sensor readings for the simulated flight conditions. The method is validated against geometries with analytical solutions. This process yields detailed fuel measurement responses for each sensor inside the tank, and for different analyzed fuel levels, providing insights into the sensors' signals' non-linear behavior at each analyzed aircraft attitude. The non-linear behavior is also influenced by the sensor saturation readings at 0 when above the fuel level and at 1 when submerged. The synthetic fuel sensor readings lay the baseline for a better und, Funding Agencies|EMBRAER S.A.; Brazilian National Council for Scientific and Technological Development (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico-CNPq); CNPq [147629/2019-5]

Published
2024
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