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1. Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India.

Author

Babu, Senbagavalli Prakash, Ezhumalai, Komala, Raghupathy, Kalaivani, Karoly, Meagan, Chinnakali, Palanivel, Gupte, Nikhil, Paradkar, Mandar, Devarajan, Arutselvi, Dhanasekaran, Mythili, Thiruvengadam, Kannan, Dauphinais, Madolyn Rose, Gupte, Akshay N, Shivakumar, Shrivijay Balayogendra, Thangakunam, Balamugesh, Christopher, Devasahayam Jesudas, Viswanathan, Vijay, Mave, Vidya, Gaikwad, Sanjay, Kinikar, Aarti, and Kornfeld, Hardy

Subjects
DRUG therapy for tuberculosis, MORTALITY risk factors, PATIENT compliance, RISK assessment, POISSON distribution, RESEARCH funding, MICROBIAL sensitivity tests, MULTIPLE regression analysis, TREATMENT effectiveness, DESCRIPTIVE statistics, AGE distribution, ANTITUBERCULAR agents, LONGITUDINAL method, SURVEYS, RESEARCH, TREATMENT failure, DISEASE relapse, CONFIDENCE intervals, REGRESSION analysis, EMPLOYMENT, EVALUATION, DISEASE risk factors
Abstract

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes. [ABSTRACT FROM AUTHOR]

Published
2024
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2. Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India.

Author

Prakash Babu S, Ezhumalai K, Raghupathy K, Karoly M, Chinnakali P, Gupte N, Paradkar M, Devarajan A, Dhanasekaran M, Thiruvengadam K, Dauphinais MR, Gupte AN, Shivakumar SB, Thangakunam B, Christopher DJ, Viswanathan V, Mave V, Gaikwad S, Kinikar A, Kornfeld H, Horsburgh CR, Chandrasekaran P, Hochberg NS, Salgame P, Gupta A, Roy G, Ellner J, Sinha P, and Sarkar S

Subjects
Humans, India epidemiology, Male, Prospective Studies, Female, Adult, Middle Aged, Treatment Outcome, Young Adult, Risk Factors, Adolescent, Cohort Studies, Treatment Failure, Aged, Tuberculosis, Pulmonary drug therapy, Tuberculosis, Pulmonary mortality, Tuberculosis, Pulmonary epidemiology, Antitubercular Agents therapeutic use
Abstract

In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes., Competing Interests: Potential conflicts of interest. The authors: No reported conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed., (© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.)

Published
2024
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