1. Urinary Prostaglandin E2 Excretion and the Risk of Cardiovascular and Kidney Disease
- Author
-
Frank Geurts, Layal Chaker, Anna C. van der Burgh, Deirdre Cronin‐Fenton, Robert A. Fenton, and Ewout J. Hoorn
- Subjects
cardiovascular disease ,chronic kidney disease ,prostaglandin E2 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Background Inhibition of prostaglandin synthesis by nonsteroidal anti‐inflammatory drugs is associated with cardiovascular mortality and kidney disease. This study hypothesizes that urinary prostaglandin E2 (PGE2) and PGE2 metabolite (PGEM) excretions are markers of cardiovascular and kidney health, because they reflect both systemic and kidney‐derived PGE2 production. Methods and Results PGE2 and PGEM were measured in spot urine samples from 2291 participants (≥55 years old) of the population‐based Rotterdam Study. Urinary PGE2 and PGEM excretions were analyzed using linear regression analyses to identify cross‐sectional associations with cardiovascular risk factors and baseline estimated glomerular filtration rate (eGFR). Longitudinal associations with cardiovascular mortality and kidney outcomes (eGFR
- Published
- 2024
- Full Text
- View/download PDF