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Your search keyword '"Deantoni, Chiara"' showing total 16 results
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16 results on '"Deantoni, Chiara"'

1. Management of radiation-induced oral mucositis in head and neck cancer patients: a real-life survey among 25 Italian radiation oncology centers

Author

Bergamaschi, Luca, Vincini, Maria Giulia, Zaffaroni, Mattia, Pepa, Matteo, Angelicone, Ilaria, Astone, Antonio, Bergamini, Cristiana, Buonopane, Sergio, Conte, Mario, De Rosa, Nicola, Deantoni, Chiara, Dell’Oca, Italo, Di Gennaro, Davide, Di Muzio, Nadia, Osti, Mattia Falchetto, Federico, Manuela, Ferini, Gianluca, Franzese, Ciro, Gatti, Marco, Grillo, Antonietta, Iorio, Vincenzo, Manzo, Roberto, Marmiroli, Luca, Martin, Giuseppe, Mazzuca, Federica, Molinaro, Maria Angela, Muto, Matteo, Pacelli, Roberto, Pepe, Alfonsina, Perillo, Annarita, Russo, Donatella, Salerno, Francesca, Spadaro, Pietro, Viola, Anna, Iorio, Giuseppe Carlo, Muto, Paolo, Ricardi, Umberto, and Alterio, Daniela

Published
2024
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3. The impact of nutritional intervention on quality of life and outcomes in patients with head and neck cancers undergoing chemoradiation.

Author

Cardellini, Sara, Deantoni, Chiara Lucrezia, Paccagnella, Matteo, Casirati, Amanda, Pontara, Andrea, Marinosci, Alessandro, Tresoldi, Moreno, Giordano, Leone, Chiara, Anna, Dell'Oca, Italo, Di Muzio, Nadia Gisella, Caccialanza, Riccardo, and Mirabile, Aurora

Subjects
BODY composition, NUTRITION counseling, WEIGHT loss, PROGRESSION-free survival, DIETARY supplements, HEAD & neck cancer
Abstract

Introduction: Chemoradiotherapy in head and neck cancer patients has a curative intent but often deteriorates nutritional status leading to sarcopenia and cachexia. Methods: In this observational and single-centered study, a prospective evaluation of several biochemical and anthropometrical parameters, weight loss, handgrip strength, visual analogue scale of appetite, questionnaires associated with malnutrition & quality of life and body composition (obtained by Bioelectrical Impedance Vector Analysis) was performed before and after high-dose cisplatin chemotherapy combined with radiotherapy in 60 patients affected by head and neck cancer. Oral nutritional supplements were used to reach the correct number of daily calories and proteins. Results and discussion: All patients completed radiotherapy as planned and the 96,4% of them did not interrupt chemotherapy for toxicity, reaching a total dose of at least 200mg/m2. Despite a rapid deterioration of body composition during treatment, nutritional support helped patients to maintain (or in some cases improve) anthropometric parameters from the end of chemoradiotherapy to the following 3 months. Low prealbumin and albumin pre-treatment led to higher risk of toxicities with consequent reduction of cisplatin dose intensity, whereas weight at the end of the treatment seems to be an interesting predicting factor for disease free and overall survival (p=0.007; p=0.015). [ABSTRACT FROM AUTHOR]

Published
2024
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5. 2516: NTCP model of acute toxicity after whole breast irradiation: training and extended validation

Author

Cicchetti, Alessandro, Vincenzi, Monica, Castriconi, Roberta, Mangili, Paola, Fodor, Andrei, Gabellini, Maria Giulia Ubeira, Chiara, Anna, Deantoni, Chiara, Midulla, Martina, Mori, Martina, Pasetti, Marcella, Palazzo, Gabriele, Tummineri, Roberta, Torrisi, Miriam, Rancati, Tiziana, Vecchio, Antonella del, Di Muzio, Nadia G, and Fiorino, Claudio

Published
2024
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9. Impact of low skeletal muscle mass in oropharyngeal cancer patients treated with radical chemo-radiotherapy: A mono-institutional experience

Author

Deantoni, Chiara L., Mirabile, Aurora, Chiara, Anna, Giannini, Laura, Midulla, Martina, Del Vecchio, Antonella, Fiorino, Claudio, Fodor, Andrei, Di Muzio, Nadia G., and Dell’Oca, Italo

Abstract

Aims: Low skeletal muscle mass index (SMI) has recently emerged as an independent prognostic factor in oncological patients and it is linked with poor survival and higher treatment toxicity. The present study aims to determine the possible impact of low SMI on survival and acute toxicity in oropharyngeal patients.Methods: Seventy-six patients with locally advanced oropharyngeal squamous cell carcinoma (stage III-IVC) were treated in our institution with Helical TomoTherapy® (HT - Accuray, Maddison, WI, USA) between 2005 and 2021. All patients received concomitant platinum-based chemotherapy (CT) (at least 200 mg/m2). The SMI was determined using the calculation of cross-sectional area at C3. Twenty patients (26%) presented pre-treatment low SMI, according to Chargi definitions.Results: All patients concluded the treatment. Thirteen patients with low SMI (65%) and 22 patients with normal SMI (39%) presented acute toxicity greater than or equal to grade 3, but this difference was not statistically significant (p-value = 0.25). Overall survival was analyzed in 65 patients, excluding those who finished CT-RT less than six months before the analysis. Overall survival was significantly lower in low SMI versus normal SMI patients (p-value = 0.035). Same difference was observed in N0-N2a patients, suggesting an important role of SMI also in lower nodal burden and putatively better prognosis.Conclusions: Although the results are limited to a small population, our case series has the advantage to be very homogeneous in patients and treatment characteristics. In our setting, SMI demonstrated a crucial impact on overall survival. Further investigation with larger samples is necessary to confirm our results to improve patient outcomes.

Published
2024
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