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Polypyrrole is functionalized by deprotonation of its oxidized state, followed by a thiol-Michael addition reaction. It is found that this process produced emissive compositions. This feature is found to be diagnostic of the functionalization and relative solvation by water, wherein enhanced interactions with the solvent gave higher emission intensities. The thiol-conjugation method is shown to be general and can be extended to a range of polar, nonpolar, and aromatic materials. Thiol-conjugated materials retain the electroactivity characteristic of polypyrrole. The dual fluorescence and electroactivity of these thiol-conjugated nanoparticles suggest their potential as a sensing platform. [ABSTRACT FROM AUTHOR]

[Display omitted] Flow battery is a safe and scalable energy storage technology in effectively utilizing clean power and mitigating carbon emissions from fossil fuel consumption. In the present work, we demonstrate an aqueous colloid flow battery (ACFB) with well-dispersed colloids based on nano-sized Prussian blue (PB) cubes, aiming at expanding the chosen area of various nano redox materials and lowering the cost of chemicals. Taking advantage of the two redox pairs of PB, the developed all-PB cell employing a low-cost dialysis membrane with the synthesized PB on both sides displays an open-circuit voltage (OCV) of 0.74 V. Moreover, when paired with an organic tetra pyridine macrocycle the cell with PB as positive electrolyte exhibits an OCV of 1.33 V and a capacity fade rate of 0.039 %/cycle (0.8 %/day). Redox-active colloids exhibit enduring physicochemical stability, with no evident structural or morphological changes after extensive cycling, highlighting their potential for cost-effective and reliable ACFB energy storage. [ABSTRACT FROM AUTHOR]

Introduction: Decades of research on cannabidiol (CBD) have identified thousands of purported cellular effects, and many of these have been proposed to correlate with a vast therapeutic potential. Yet despite the large volume of findings fueling broad optimism in this regard, few have translated into any demonstrable clinical benefit or even notable side effects. Therein resides the great paradox of CBD: a drug that appears to affect almost everything in vitro does not clearly do much of anything in a clinical setting. Areas covered: Comparative critical evaluation of literature searched in PubMed and Google Scholar discovers multiple instances of inconsistent and contradictory findings regarding the pharmacology and clinical effects of CBD, as well as several uncelebrated reports that suggest potential explanations for these observations. Many of those effects attributed to the ostensible pharmacologic activity of cannabidiol are almost certainly the product of false-positive experimental results and artifactual findings that are unlikely to be realized under physiologic conditions. Expert opinion: Concerns regarding the physiological relevance and translational potential of in vitro findings across the field of cannabinoid research are both far-reaching and demanding of attention in the form of appropriate experimental controls that remain almost universally absent. [ABSTRACT FROM AUTHOR]

• Experiments are presented detailing particle migration in inertial Taylor–Couette flow of complex fluids. • Particles are observed to migrate oppositely within Taylor vortices with inelastic and elastic fluids. • A weaker elastic fluid shows a transition between an initial migration to the center of the Taylor vortices, switching to migration to the perimeter of the vortices as rotation rate is increased. • A preliminary numerical Euler-Euler calculation using a White–Metzner constitutive model captures the migration. A drilling process comprises a drill-pipe rotating within a borehole where fluid is pumped down the pipe and returns, with drilled cuttings, along the annulus. Predominantly the axis of the system is horizontal. Thus, in the absence of axial flow the process geometry is that of a Taylor–Couette flow. Formulated drilling fluids themselves are usually regarded as Bingham or Hershel-Bulkley in nature, but nevertheless encompass elastic behaviour. We have thus studied the distribution of dense (i.e. sedimenting) non-Brownian solid particles in Taylor–Couette flow of model drilling fluids as a function of center body rotation speed. In all cases Taylor vortices are formed above some critical, fluid dependent, Taylor number. However, depending on the fluid properties, particles decorate the vortices differently: particles in a polymeric fluid move to the centroids of the vortices, whereas in a colloidal fluid they move to the outer periphery of the vortices, as previously observed for Newtonian fluids. With a mixed fluid, a clear transition between the two regimes is found. We postulate that this behaviour is a result of a balance between elastically derived lift forces and inertially driven Saffman lift forces acting antagonistically on the particles. [ABSTRACT FROM AUTHOR]

This study presents a novel approach for the controlled synthesis and real-time characterization of crosslinked hyaluronic acid (HA) hydrogels utilizing a microfluidic platform coupled with hyphenated electrospray-differential mobility analysis (ES-DMA). By precisely controlling key synthesis parameters within the microfluidic environment, including pH, temperature, reaction time, and the molar ratio of HA to crosslinker (1,4-butanediol diglycidyl ether, BDDE), we successfully synthesized HA hydrogels with tailored size and properties. The integrated ES-DMA system provides rapid, in-line analysis of hydrogel particle size and distribution, enabling real-time monitoring and optimization of the synthesis process. Furthermore, small-angle x-ray scattering (SAXS) was employed to complement ES-DMA analysis, providing valuable insights into the internal structure and extent of crosslinking within the synthesized hydrogels. The evolution of the number-based particle size distribution revealed a strong correlation with the synthesis conditions, demonstrating the high degree of controllability achieved by this integrated approach. This novel methodology offers a promising platform for the high-throughput synthesis of uniform and well-defined hydrogel nanoparticles with enhanced traceability, paving the way for advancements in various applications including drug delivery, tissue engineering, and biomaterials., Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper., (Copyright © 2025. Published by Elsevier Inc.)

Background: The impact of intraoperative starch-based fluid therapy on postoperative kidney dysfunction in patients undergoing major abdominal surgery is uncertain. Low molecular weight starch is expected to cause less postoperative kidney dysfunction., Methods: This retrospective study evaluated the impact of intraoperative 6% hydroxyethyl starch on postoperative renal dysfunction. The primary outcome of this study was postoperative acute kidney injury as per KDIGO definition within 72 hours of surgery., Results: This study analysed data from 461 patients with a median (interquartile range) age of 45 (33-58) years, and 48.2% of all patients were female. The proportion (95% confidence interval) of patients who developed acute kidney injury was 0.18 (0.14-0.21); 62.9% of patients had acute kidney injury stage I, 32% had acute kidney injury stage II, and the rest were acute kidney injury stage III. In the propensity score-matched sample, the average treatment effect of intraoperative colloid use on postoperative serum creatinine at day 3 (p = 0.32), duration of postoperative intensive care unit stay (p = 0.97), duration of hospital stay (p = 0.37), postoperative worst international normalised ratio (p = 0.92), and postoperative transfusion requirement (p = 0.40) were not statistically significant., Conclusion: Intraoperative use of low molecular weight hydroxyethyl starch use was not associated with postoperative kidney dysfunction and coagulopathy in adult patients undergoing major open abdominal surgery., Competing Interests: Declaration of conflicting interestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article.