1. Role of PCSK9 inhibitors in venous thromboembolism: current evidence and unmet clinical needs.
- Author
-
Zuin M, Corsini A, Dalla Valle C, De Rosa C, Maloberti A, Mojoli M, Rizzo M, Ciccirillo F, Madrid A, Riccio C, Grimaldi M, Colivicchi F, Oliva F, and Temporelli PL
- Subjects
- Humans, Treatment Outcome, Serine Proteinase Inhibitors therapeutic use, Serine Proteinase Inhibitors adverse effects, Proprotein Convertase 9 metabolism, Risk Factors, Anticholesteremic Agents therapeutic use, Anticholesteremic Agents adverse effects, Biomarkers blood, Venous Thromboembolism drug therapy, Venous Thromboembolism blood, Venous Thromboembolism prevention & control, Venous Thromboembolism diagnosis, PCSK9 Inhibitors
- Abstract
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) have recently emerged as promising therapeutic agents for lowering low-density lipoprotein cholesterol and reducing the risk of cardiovascular events. Moreover, preliminary evidence from randomized controlled trials (RCTs) suggests that PCSK9i may also offer beneficial effects for patients following venous thromboembolism (VTE), with the most significant reductions in risk appearing over time, particularly beyond the first year of treatment. However, there is a lack of randomized controlled data supporting their efficacy and safety in conjunction with standard anticoagulation therapy. This article aims to critically evaluate the existing evidence for the use of PCSK9i as a complementary therapy for VTE risk reduction, while also identifying unmet clinical and research needs and proposing potential strategies to address these knowledge gaps., (© The Author(s) 2024. Published by Oxford University Press on behalf of the European Society of Cardiology.)
- Published
- 2025
- Full Text
- View/download PDF