1. The effectiveness of coronary computed tomography angiography and functional testing for the diagnosis of obstructive coronary artery disease: results from the individual patient data Collaborative Meta-Analysis of Cardiac CT (COME-CCT)
- Author
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Peter Schlattmann, Viktoria Wieske, Keno K. Bressem, Theresa Götz, Georg M. Schuetz, Daniele Andreini, Gianluca Pontone, Hatem Alkadhi, Jörg Hausleiter, Elke Zimmermann, Bernhard Gerber, Abbas A. Shabestari, Matthijs F. L. Meijs, Akira Sato, Kristian A. Øvrehus, Shona M. M. Jenkins, Juhani Knuuti, Ashraf Hamdan, Bjørn A. Halvorsen, Vladimir Mendoza-Rodriguez, Johannes Rixe, Yung-Liang Wan, Christoph Langer, Sebastian Leschka, Eugenio Martuscelli, Said Ghostine, Jean-Claude Tardif, Alejandra Rodríguez Sánchez, Robert Haase, and Marc Dewey
- Subjects
Computed tomography angiography ,Functional stress testing ,Exercise-ECG ,Single-photon emission computed tomography ,Diagnostic accuracy ,Medical physics. Medical radiology. Nuclear medicine ,R895-920 - Abstract
Abstract Aim To determine the effectiveness of functional stress testing and computed tomography angiography (CTA) for diagnosis of obstructive coronary artery disease (CAD). Methods and results Two-thousand nine-hundred twenty symptomatic stable chest pain patients were included in the international Collaborative Meta-Analysis of Cardiac CT consortium to compare CTA with exercise electrocardiography (exercise-ECG) and single-photon emission computed tomography (SPECT) for diagnosis of CAD defined as ≥ 50% diameter stenosis by invasive coronary angiography (ICA) as reference standard. Generalised linear mixed models were used for calculating the diagnostic accuracy of each diagnostic test including non-diagnostic results as dependent variables in a logistic regression model with random intercepts and slopes. Covariates were the reference standard ICA, the type of diagnostic method, and their interactions. CTA showed significantly better diagnostic performance (p
- Published
- 2024
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