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During the COVID-19 pandemic, many families experienced financial and health stressors associated with parental employment. Using multi-informant and daily-diary data from a nationwide U.S. sample of parents and children (626 dyads; 18,780 daily assessments across 30 days: May 18, 2020-June 1, 2020, October 19, 2020-November 2, 2020; parents: M[subscript age] = 43, 15% male; children: M[subscript age] = 15, 42% male; 36% Black, 26% White, 14% multiracial, 12% Latinx, 11% Asian American, and 1% Native American), this intensive longitudinal study investigated: (a) the mediating role of health stress and financial stress in the link between parental employment status and psychosocial adjustment among adolescents and their parents and (b) whether this link differed by families' socioeconomic status or receipt of government subsidies. Results indicated that families who experienced job loss tended to report higher levels of health stress and financial stress, which in turn was associated with heightened negative affect and poorer sleep quality for both parents and adolescents. When parents work from home (WFH), families tended to have lower levels of health stress and financial stress, which in turn weakened the positive links with negative affect and sleep quality. Lower- (vs. higher-) income families experienced weaker protective effects associated with WFH arrangements. Government subsidies were associated with lower stress and better psychosocial outcomes in families experiencing job loss.