1. Artesunate inhibits vasculogenic mimicry in choroidal melanoma through HIF-1 α/ VEGF/PDGF pathway.
- Author
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Ma QY, Xu XY, Zhu YZ, Yao NN, Liu YC, Gao XD, Zhang Q, and Luo WJ
- Subjects
- Humans, Signal Transduction drug effects, Cell Line, Tumor, Male, Cell Proliferation drug effects, Hypoxia-Inducible Factor 1, alpha Subunit metabolism, Melanoma metabolism, Melanoma drug therapy, Melanoma pathology, Choroid Neoplasms drug therapy, Choroid Neoplasms metabolism, Choroid Neoplasms pathology, Platelet-Derived Growth Factor metabolism, Vascular Endothelial Growth Factor A metabolism, Artesunate pharmacology, Neovascularization, Pathologic metabolism, Neovascularization, Pathologic drug therapy, Neovascularization, Pathologic pathology
- Abstract
Choroidal melanoma (CM), a highly metastatic eye tumor, exhibits vasculogenic mimicry (VM) facilitated by hypoxia-induced angiogenesis. This study explored the inhibitory impact of the anti-malarial drug Artesunate (ART) on CM VM through modulation of the HIF-1α/VEGF/PDGF pathway. Immunohistochemistry (IHC) confirmed VM in CM with elevated VEGF and PDGF expression. Hypoxia promoted CM proliferation, upregulating HIF-1α, VEGF and PDGF. VEGF and PDGF enhanced CM migration, invasion and VM, with HIF-1α playing a crucial role. ART mitigated VM formation by suppressing the HIF-1α/VEGF/PDGF pathway, highlighting its potential as an anti-tumor agent in CM., Competing Interests: Declaration of Competing Interest The authors declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Elsevier GmbH. All rights reserved.)
- Published
- 2024
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