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Your search keyword '"Chang, Qinghua"' showing total 9 results
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9 results on '"Chang, Qinghua"'

4. Tumor‐targeted and microenvironment‐activatable iron‐based nMOF for synergistic inducing ferroptosis.

Author

Gao, Fangxin, Xie, Yaqing, Zhang, Pan, Chang, Qinghua, Zhang, Enli, Shen, Jingyi, Liang, Lili, and Zong, Zhihui

Subjects
IRON overload, INHIBITION of cellular proliferation, REACTIVE oxygen species, IRON ions, TUMOR treatment
Abstract

Ferroptosis is a new form of cell death that relies on iron and involves an imbalance of intracellular reactive oxygen species (ROS), which is expected to help alleviate bottlenecks in tumor treatment. Herein, a sorafenib‐loaded folic acid‐armored iron‐based nMOF was designed for synergistic inducing ferroptosis of tumors. The particle size of the synthesized SM@F is about 210nm, and the drug loading rate is 24.74%. SM@F can be degraded and releases sorafenib and iron ions slowly, resulting in intracellular drug release and iron overload after being highly uptaken by SMMC‐7721 cells. SM@F can effectively inhibit the proliferation of SMMC‐7721 cells, and this effect can be significantly attenuated by ferroptosis inhibitors. Mechanistic investigations revealed that SM@F could increase the content of ROS, and lipid peroxides; decrease the content of glutathione (GSH); and down‐regulate the GXP4 expression in SMMC‐7721 cells. The results indicate that the synthesized SM@F could effectively inhibit the proliferation of tumor cells with synergistic inducing ferroptosis. [ABSTRACT FROM AUTHOR]

Published
2024
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5. An interesting electrocardiogram caused by lead reversal.

Author

Li, Changjun, Wang, Nan, Chang, Qinghua, and Pan, Dianzhu

Subjects
BUNDLE-branch block, RIGHT heart atrium, LEFT heart atrium, ELECTROCARDIOGRAPHY
Abstract

Background: During normal sinus rhythm, atrial depolarization is conducted from right atrium to left atrium through Bachmann's bundle, and a normal P wave axis which is measured on the frontal plane is between 0º and + 75º. The change of P wave polarity is helpful for the analysis of origin point. Case presentation: We report a patient with negative P wave in lead I. The characteristics of QRS complex in leads V1 to V6 are helpful to preliminarily differential diagnosis. The 12-lead electrocardiogram (ECG) with correct limb leads (right arm-left arm) placement shows sinus rhythm with complete right bundle branch block (RBBB). Conclusions: The change of P wave polarity as well as characteristics of QRS complex can help identify limb-lead reversals. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Upgrading Effects of Supercritical Carbon Dioxide Extraction on Physicochemical Characteristics of Chinese Low-Rank Coals

Author

Li, Hongjun, Chang, Qinghua, Dai, Zhenghua, Chen, Xueli, Yu, Guangsuo, and Wang, Fuchen

Abstract

The effects of supercritical carbon dioxide (SCCO2) extraction on coal composition, coal rank, pore structure, and combustion reactivity of three typical Chinese low-rank coals (LRCs) were investigated in this study. The results show that the SCCO2extraction process has significantly reduced the moisture content and increased the fixed carbon content of LRCs. The oxygen/carbon atomic ratio of upgraded LRCs decreases, indicating that the coal rank of upgraded LRCs improves after SCCO2extraction, which is consistent to the findings from Fourier transform infrared spectroscopy. The specific surface area and total pore volume of upgraded Hu Lun Bei Er (HLBE) and Zhao Tong (ZT) lignite increase significantly with extraction time and temperature. Thermogravimetric analysis shows that the combustion process of upgraded LRCs is moving toward the high-temperature region and its burnout temperature (Tb) increases. The average reactivity rate (kmean), maximum reactivity rate (kmax), and comprehensive reactivity parameter (S) increase obviously for upgraded HLBE and ZT lignite, whereas they decrease slightly for upgraded Xin Jiang sub-bituminous coal, indicating that the combustion reactivity of upgraded lignite is enhanced by the SCCO2extraction process.

Published
2024
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9. A man with palpitations.

Author

Chang Q, Li C, and Jin Y

Subjects
Humans, Male, Arrhythmias, Cardiac diagnosis, Arrhythmias, Cardiac etiology, Diagnosis, Differential, Electrocardiography
Abstract

Competing Interests: Competing interests: The BMJ has judged that there are no disqualifying financial ties to commercial companies. The authors declare the following other interests: none.

Published
2024
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