1. Extracellular matrix in leg basal cell carcinoma: Possible pathogenetic role of chronic venous insufficiency.
- Author
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Sala, Ana Carolina Apolinário, Ueda, Pedro H. H., Buffo, Thais H., Velho, Paulo E. N. F., Pelegati, Vitor B., Cesar, Carlos L., Cintra, Maria L., Vieira‐Damiani, Gislaine, and Amstalden, Eliane Maria Ingrid
- Subjects
BASAL cell carcinoma ,VENOUS insufficiency ,EXTRACELLULAR matrix ,SECOND harmonic generation - Abstract
This article explores the possible role of chronic venous insufficiency (CVI) in the development of basal cell carcinoma (BCC) in the lower extremities. While ultraviolet radiation (UVR) exposure is a known risk factor for BCC, this study suggests that CVI may also be a predisposing factor. The researchers used second harmonic generation (SHG) microscopy to analyze the texture of collagen fibers in biopsies of cancer-free margins of leg BCC. They found evidence of collagen remodeling in the perineoplastic extracellular matrix (ECM) of BCC, similar to what is observed in CVI. These findings support the hypothesis that CVI may play a role in the development of leg BCC. [Extracted from the article]
- Published
- 2024
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