1. The Hox protein Antennapedia orchestrates Drosophila adult flight muscle development.
- Author
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Poliacikova G, Aouane A, Caruso N, Brouilly N, Maurel-Zaffran C, Graba Y, and Saurin AJ
- Subjects
- Animals, Antennapedia Homeodomain Protein metabolism, Antennapedia Homeodomain Protein genetics, Transcription Factors metabolism, Transcription Factors genetics, Drosophila melanogaster growth & development, Drosophila melanogaster metabolism, Drosophila melanogaster genetics, Cell Differentiation, Muscles metabolism, Drosophila metabolism, Drosophila growth & development, Drosophila genetics, Larva growth & development, Larva metabolism, Homeodomain Proteins metabolism, Homeodomain Proteins genetics, Muscle Development, Drosophila Proteins metabolism, Drosophila Proteins genetics, Flight, Animal physiology, Gene Expression Regulation, Developmental
- Abstract
Muscle development and diversity require a large number of spatially and temporally regulated events controlled by transcription factors (TFs). Drosophila has long stood as a model to study myogenesis due to the highly conserved key TFs involved at all stages of muscle development. While many studies focused on the diversification of Drosophila larval musculature, how distinct adult muscle types are generated is much less characterized. Here, we identify an essential regulator of Drosophila thoracic flight muscle development, the Hox TF Antennapedia (Antp). Correcting a long-standing belief that flight muscle development occurs without the input of Hox TFs, we show that Antp intervenes at several stages of flight muscle development, from the establishment of the progenitor pool in the embryo to myoblast differentiation in the early pupa. Furthermore, the precisely regulated clearance of Hox in the developing flight muscle fibers is required to allow for fibrillar muscle fate diversification, setting these muscles apart from all other adult tubular muscle types.
- Published
- 2024
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