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The role of human activity in shaping the terrestrial environment has been a core scientific issue of interest across various disciplines. However, it remains unclear whether there are significant differences in the patterns of the anthropogenic impact on the terrestrial environment in terms of spatial and temporal dimensions, and we are yet to identify the underlying factors that have driven it. Here, we present an analysis of sporopollen and geochemical proxies from a section of the Anjiangbei site (AJB) on the Yunnan Plateau, spanning the Ming–Qing period, in order to explore the spatio-temporal variation in the anthropogenic impact on the terrestrial environment in the Lake Dian basin. Integrating the reported multidisciplinary evidence, we aim to reveal the influencing factors of anthropogenic impact. Our results show that there were remarkable differences in anthropogenic impact on the terrestrial environment in the Lake Dian basin between the Late Bronze Age and the Ming–Qing period. Changes in crop vegetation and the forest were all affected by human activity in the Lake Dian basin during the two periods, and were more evident during the Ming–Qing period. The heavy metal pollution in the soil was obvious during the Ming–Qing period. The increase in the intensity of human activity, especially the rise in population, could be attributed to changes in the hydrological environment in the Lake Dian basin during the Late Bronze Age and to geopolitical change during the Ming–Qing period. This study reveals the different patterns in human impact on the terrestrial environment in the Lake Dian basin during the Late Bronze Age and the Ming–Qing period, providing new evidence to enable a deeper understanding of past human–environment interactions on the Yunnan Plateau. [ABSTRACT FROM AUTHOR]

Background: Hepatocellular carcinoma (HCC) is one of the most common and deadly cancers worldwide. POC1 centriolar protein A ( POC1A ) is a gene encoding a protein that plays a key role in the centrosome, and is one of the two isoforms of POC1. To date, the expression of POC1A in HCC and its potential as a biomarker and tumor therapeutic target have not been examined. This study aimed to explore the effect of POC1A on patients with HCC and its potential mechanism., Methods: This study investigated the role of POC1A in the occurrence and development of HCC. It analyzed the expression of POC1A in various types of HCC patients and its effect on survival using HCC patient information from the Gene Expression Omnibus (GEO), The Cancer Genome Atlas (TCGA), the Human Protein Atlas (HPA), and the Hepatocellular Carcinoma Cell DataBase (HCCDB). It then explored the major enrichment pathways and gene functions of POC1A in HCC using the gene set enrichment analysis (GSEA) method and examined its protein-protein interactions (PPIs). Finally, it predicted the potential transcription factors (TFs) and target microRNAs (miRNAs) of POC1A , and analyzed the single nucleotide variation (SNV) and copy number variation (CNV) mutations of POC1A and the related genes in HCC, as well as their effects on immune cells., Results: The results showed that POC1A was significantly overexpressed in HCC and was significantly associated with a poor prognosis. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that POC1A was mainly involved in the regulation of cell-cycle pathways and chromosome segregation functions. POC1A showed significant interactions with NUDC and PPARG, and they both had different numbers of SNV and CNV mutations in the HCC samples. In relation to immunity, the high expression of POC1A and its reciprocal genes may play an important role in B cells and macrophages., Conclusions: In general, our findings suggest that POC1A overexpression could have an important effect on the development of HCC by regulating cell-cycle pathways, and that it could serve as a novel prognostic biomarker and a potential therapeutic target for HCC., Competing Interests: Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tcr.amegroups.com/article/view/10.21037/tcr-23-2398/coif). The authors have no conflicts of interest to declare., (2024 AME Publishing Company. All rights reserved.)