Search

Your search keyword '"Burrows, Kaiping"' showing total 7 results
Start Over Author "Burrows, Kaiping" Publication Year Range This year
7 results on '"Burrows, Kaiping"'

3. Leptin’s Inverse Association with Brain Morphology and Depressive Symptoms – A Discovery and Confirmatory Study Across Two Independent Samples

Author

Zhang, Ye, primary, Munshi, Soumyabrata, additional, Burrows, Kaiping, additional, Kuplicki, Rayus, additional, Figueroa-Hall, Leandra K., additional, Aupperle, Robin L., additional, Khalsa, Sahib S., additional, Teague, T. Kent, additional, Yasuyuki, Taki, additional, Paulus, Martin P., additional, Savitz, Jonathan, additional, and Zheng, Haixia, additional

Published
2024
Full Text
View/download PDF

5. Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward.

Author

May, April C, Burrows, Kaiping, Kuplicki, Rayus, Paulus, Martin P, and Stewart, Jennifer L

Subjects
*REWARD (Psychology), *DOPAMINERGIC neurons, *FUNCTIONAL magnetic resonance imaging, *AMPHETAMINES, *MONETARY incentives, *NUCLEUS accumbens, *OREXINS
Abstract

Background: Dysregulated ventral striatum function has been proposed as one important process occurring in individuals with substance use disorder. This study investigates the role of altered reward and loss anticipation, which is an important component of impaired decision-making, impulsivity, and vulnerability to relapse in individuals with amphetamine use disorder (AMP). Aims: To determine whether AMP is associated with blunted striatum, prefrontal cortex, and insula signals during win and loss anticipation. Methods: Participants with and without AMP (AMP+ n = 46, AMP− n = 90) from the Tulsa 1000 study completed a monetary incentive delay (MID) task during functional magnetic resonance imaging. Results: Group main effects indicated that: (1) AMP+ exhibited lower bilateral caudate/putamen and left nucleus accumbens signal than AMP− across anticipation of wins and losses; and (2) AMP+ showed slower reaction times than AMP− during loss anticipation. Group*condition interactions demonstrated that AMP+ exhibited greater right amygdala signal than AMP− while anticipating large wins, a pattern that reversed when anticipating small losses. Left caudate/putamen attenuations in AMP+ during small loss anticipation were also evident. Groups did not differ in prefrontal or insula signals. Conclusions: AMP+ individuals have altered neural processing and response patterns during reward and loss anticipation, potentially reflecting impairments in dopamine function, which may influence their decision-making and reactions to different win/loss scenarios. These findings help to explain why AMP+ have difficulty with decision-making and exhibit a heightened focus on immediate rewards or punishments. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder

Author

Munshi, Soumyabrata, Alarbi, Ahlam M., Zheng, Haixia, Kuplicki, Rayus, Burrows, Kaiping, Figueroa-Hall, Leandra K., Victor, Teresa A., Aupperle, Robin L., Khalsa, Sahib S., Paulus, Martin P., Teague, T. Kent, and Savitz, Jonathan

Abstract

A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin of these immune changes remains unclear. Here we tested the hypothesis that abnormalities in endoplasmic reticulum (ER) stress, inflammasome activity and mitochondrial biogenesis contribute to the development of systemic inflammation in MDD. RT-qPCR was used to measure mRNA expression of key organellar genes from peripheral blood mononuclear cells (PBMCs) isolated from 186 MDD and 67 healthy control (HC) subjects. The comparative CT(2-ΔΔCT) method was applied to quantify mRNA expression using GAPDHas the reference gene. After controlling for age, sex, BMI, and medication status using linear regression models, expression of the inflammasome (NLRC4and NLRP3) and the ER stress (XBP1u, XBP1s, and ATF4) genes was found to be significantly increased in the MDD versus the HC group. Sensitivity analyses excluding covariates yielded similar results. After excluding outliers, expression of the inflammasome genes was no longer statistically significant but expression of the ER stress genes (XBP1u, XBP1s, and ATF4) remained significant and the mitochondrial biogenesis gene, MFN2, was significantly increased in the MDD group. NLRC4and MFN2were positively correlated with serum C-reactive protein concentrations, while ASCtrended significant. The altered expression of inflammasome activation, ER stress, and mitochondrial biogenesis pathway components suggest that dysfunction of these organelles may play a role in the pathogenesis of MDD.

Published
2024
Full Text
View/download PDF

7. Increased expression of ER stress, inflammasome activation, and mitochondrial biogenesis-related genes in peripheral blood mononuclear cells in major depressive disorder.

Author

Munshi S, Alarbi A, Zheng H, Kuplicki R, Burrows K, Figueroa-Hall L, Victor T, Aupperle R, Khalsa S, Paulus M, Teague TK, and Savitz J

Abstract

A subset of major depressive disorder (MDD) is characterized by immune system dysfunction, but the intracellular origin of these immune changes remains unclear. Here we tested the hypothesis that abnormalities in the endoplasmic reticulum (ER) stress, inflammasome activity and mitochondrial biogenesis contribute to the development of systemic inflammation in MDD. RT-qPCR was used to measure mRNA expression of key organellar genes from peripheral blood mononuclear cells (PBMCs) isolated from 186 MDD and 67 healthy control (HC) subjects. The comparative CT (2 -ΔΔCT ) method was applied to quantify mRNA expression using GAPDH as the reference gene. After controlling for age, sex, BMI, and medication status using linear regression models, expression of the inflammasome ( NLRC4 and NLRP3 ) and the ER stress ( XBP1u , XBP1s , and ATF4 ) genes was found to be significantly increased in the MDD versus the HC group. After excluding outliers, expression of the inflammasome genes was no longer statistically significant but expression of the ER stress genes ( XBP1u , XBP1s , and ATF4 ) and the mitochondrial biogenesis gene, MFN2 , was significantly increased in the MDD group. ASC and MFN2 were positively correlated with serum C-reactive protein concentrations. The altered expression of inflammasome activation, ER stress, and mitochondrial biogenesis pathway components suggest that dysfunction of these organelles may play a role in the pathogenesis of MDD., Competing Interests: CONFLICTS OF INTEREST The authors declare no competing financial interests in relation to the work described in the paper.

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results