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Abstract Background Type 2 diabetes mellitus (T2DM), one of the most common public diseases threatening human health, is always accompanied by infection. Though there are still a variety of flaws in the treatment of some infectious diseases, metabolomics provides a fresh perspective to explore the relationship between T2DM and infection. Our research aimed to investigate the association between plasma free amino acids (PFAAs) and T2DM complicated with infection in Chinese patients. Methods A cross-sectional study was conducted from May 2015 to August 2016. We retrieved the medical records of 1032 inpatients with T2DM from Liaoning Medical University First Affiliated Hospital and we used mass spectrometry to quantify 23 PFAAs. Infections contained 15 individual categories that could be retrieved from the database. Principal component analysis was used to extract factors of PFAAs. Multi-variable binary logistic regression was used to obtain odds ratios (OR) and their 95% confidence intervals (CI). Results Among 1032 inpatients,109 (10.6%) had infectious diseases. Six factors, accounting for 68.6% of the total variance, were extracted. Factor 4 consisted of Glu, Asp and Orn. Factor 5 consisted of Hcy and Pip. After adjusting for potential confounders, factor 4 was positively correlated with T2DM complicated with infection in Chinese T2DM patients (OR: 1.27, 95%CI: 1.06–1.52). Individual Hcy in factor 5 was positively associated with T2DM complicated with infection (OR: 1.33, 95%CI: 1.08–1.64). Furthermore, factor 4 (OR: 1.44, 95%CI: 1.11–1.87), Orn (OR: 1.01, 95%CI: 1.00-1.02) and Hcy (OR: 1.56, 95%CI: 1.14–3.14) were positively associated with bacterial infection in Chinese T2DM patients, while factor 5 (OR: 0.71, 95%CI: 0.50-1.00) was negatively associated with bacterial infection. Conclusions Urea cycle-related metabolites (Orn, Asp, Glu) and Hcy were positively associated with T2DM complicated with infection in China. Orn and Hcy were positively associated with bacterial infection in T2DM patients in China.

Optical neural networks (ONNs) have recently attracted extensive interest as potential alternatives to electronic artificial neural networks, owing to their intrinsic capabilities in parallel signal processing with reduced power consumption and low latency. Preliminary confirmation of parallelism in optical computing has been widely performed by applying wavelength division multiplexing (WDM) to the linear transformation of neural networks. However, interchannel crosstalk has obstructed WDM technologies from being deployed in nonlinear activation on ONNs. Here, we propose a universal WDM structure called multiplexed neuron sets (MNS), which applies WDM technologies to optical neurons and enables ONNs to be further compressed. A corresponding backpropagation (BP) training algorithm was proposed to alleviate or even annul the influence of interchannel crosstalk in MNS-based WDM-ONNs. For simplicity, semiconductor optical amplifiers are employed as an example of MNS to construct a WDM-ONN trained using the new algorithm. The results show that the combination of MNS and the corresponding BP training algorithm clearly downsizes the system and improves the energy efficiency by a factor of 10 while providing similar performance to traditional ONNs.