Search

A convenient and atom-economical protocol for the construction of multisubstituted 2-aminoquinoline N-oxides using readily available starting materials anthranil and arylacetonitrile has been reported. The KHMDS mediated process tolerates various protecting groups of –OH, halo groups, and heterocycles. The ring-opening/reconstruction reaction with C3-aryl anthranils provided densely-arene-substituted 2-aminoquinoline N-oxides, which are otherwise difficult to synthesize. Overall, the ring-opening/reconstruction reaction involves C–O bond cleavage and C–C and C–N bond formation events. [ABSTRACT FROM AUTHOR]

This document provides information on the synthesis and characterization of various isoxazole compounds. The compounds were synthesized using specific reactions and their yields, physical properties, and spectroscopic data are reported. The information presented can be useful for researchers studying isoxazole compounds and their properties. The authors acknowledge the support of DST and SCXRD LAB, SAIF, IIT Madras for single-crystal X-ray analysis. Supporting information for the article is available online. [Extracted from the article]